Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity

Journal of Cell Biology

Volumn 135, Issue 4, 1996, Pages 1139-1150

  Sleeman, Jonathan ^a   Rudy, Wolfgang ^a   Hofmann, Martin ^a   Moll, Jürgen ^a   Herrlich, Peter ^a   Ponta, Helmut ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; HYALURONIC ACID; TUNICAMYCIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL CONTACT; CONTROLLED STUDY; DIMERIZATION; EXTRACELLULAR MATRIX; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN VARIANT; RAT;

ANIMALIA;

EID: 0029825416     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.4.1139     Document Type: Article

References (41)

1. Aruffo, A., I. Stamenkovic, M. Melnick, C.B. Underhill, and B. Seed. 1990. CD44 is the principal cell surface receptor for hyaluronate. Cell. 61:1303-1313.
2. Bartolazzi, A., A. Nocks, A Aruffo, F. Spring, and I. Stamenkovic. 1996. Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. J. Cell Biol. 132:1199-1208.
3. Bennett, K., B. Modrell, B. Greenfield, A. Bartolazzi, I. Stamenkovic, R. Peach, D. Jackson, F. Spring, and A. Aruffo. 1995. Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons. J. Cell Biol. 131:1623-1633.
4. Diamond, M., and T. Springer. 1993. A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J. Cell Biol. 120:545-556.
5. Dougherty, G., D. Cooper, J. Memory, and R. Chiu. 1994. Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1. J. Biol. Chem. 269:9074-9078.
6. Dustin, M., D. Olive, and T. Springer. 1989. Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3. J. Exp. Med. 169:503-517.
7. Goldstein, L., D. Zhou, L. Picker, C. Minty, R. Bargatze, J. Ding, and E. Butcher. 1989. A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell. 56:1063-1072.
8. German, C. 1985. High efficiency gene transfer into mammalian cells. In DNA Cloning: A Practical Approach, D. Glover, editor. IRL Press, Oxford. 143-190.
9. Günthert, U., M. Hofmann, W. Rudy, S. Reber, M. Zöller, I. Haußmann, S. Matzku, A. Wenzel, H. Ponta, and P. Herrlich. 1991. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell. 65:13-24.
10. Hardwick, C, K. Hoare, R. Owens, H.-P. Hohn, M. Hook, D. Moore, V. Cripps, L. Austen, D. Nance, and E. Turley. 1992. Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility. J. Cell Biol. 117:1343-1350.
11. Harlow, E., and D. Lane. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 726 pp.
12. He, Q., J. Lesley, R. Hyman, K. Ishihara, and P. Kincade. 1992. Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J. Cell Biol. 119:1711-1719.
13. Heider, K.-H., M. Hofmann, E. Horst, F. van den Berg, H. Ponta, P. Herrlich, and S.T. Pals. 1993. A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J. Cell Biol. 120:227-233.
14. Herrlich, P., M. Zöller, S.T. Pals, and H. Ponta. 1993. CD44 splice variants: metastases meet lymphocytes. Immunol. Today. 14:395-399.
15. Isacke, C. 1994. The role of the cytoplasmic domain in regulating CD44 function. J. Cell Sci. 107:2353-2359.
16. Katoh, S., Z. Zheng, K. Oritani, T. Shimozato, and P. Kincade. 1995. Glycosylation of CD44 negatively regulates its recognition of hyaluronan. J. Exp. Med. 182:419-429.
17. Knudson, C., and W. Knudson. 1993. Hyaluronan binding proteins in development, tissue homeostasis and disease. FASEB (Fed. Am. Soc. Exp. Biol.) J. 7:1233-1241.
18. Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
19. Lesley, J., and R. Hyman. 1992. CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur. J. Immunol. 22:2719-2723.
20. Lesley, J., R. Schulte, and R. Hyman. 1990. Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgp-1. Exp. Cell Res. 187:224-233.
21. Lesley, J., R. Hyman, and P.W. Kincade. 1993. CD44 and its interaction with the cellular matrix. Adv. Immunol. 54:271-335.
22. Lesley, J., N. English, A. Perschl, J. Gregoroff, and R. Hyman. 1995. Variant cell lines selected for alterations in the function of the hyaluronan receptor CD44 show differences in glycosylation. J. Exp. Med. 182:431-437.
23. Liao, H.X., M.C. Levesque, K. Patton, B. Bergamo, D. Jones, M.A. Moody, M.J. Telen, and B.F. Haynes. 1993. Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. J. Immunol. 151:6490-6499.
24. Lokeshwar, V., and L. Bourguignon. 1991. Posttranslational protein modification and expression of Ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis. J. Biol. Chem. 266:17983-17989.
25. Matzku, S., D. Komitowski, M. Mildenburger, and M. Zöller. 1983. Characterisation of BSp73, a spontaneous rat tumor and its in vivo selected variants showing different metastasizing capacities. Invasion Metastasis. 3:109-123.
26. Matzku, S., A. Wenzel, S. Liu, and M. Zöller. 1989. Antigenic differences between metastatic and nonmetastatic BSp73 rat tumor variants characterized by mononclonal antibodies. Cancer Res. 49:1294-1299.
27. McCourt, P., B. Ek, N. Forsberg, and S. Gustafson. 1994. Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan. J. Biol. Chem. 269: 30081-30084.
28. Miller, A., and G. Rosman. 1989. Improved retroviral vectors for gene transfer and expression. Biotechniques. 7:980-990.
29. Morgenstern, J., and H. Land. 1990. Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:3587-3596.
30. Murakami, S., Y. Shimabukuro, Y. Miki, T. Saho, E. Hino, D. Kasai, T. Nozaki, Y. Kusumoto, and H. Okada. 1994. Inducible binding of human lymphocytes to hyaluronate via CD44 does not require cytoskeleton association but does require new protein synthesis. J. Immunol. 152:467-477.
31. Neame, P., J. Christner, and J. Baker. 1986. The primary structure of link protein from rat chondrosarcoma proteoglycan aggregate. J. Biol. Chem. 261: 3519-3535.
32. r detected only on CD4-positive T blasts. Mol. Immunol. 24:1281-1290.
33. Perschl, A., J. Lesley, N. English, I. Trowbridge, and R. Hyman. 1995. Role of CD44 cytoplasmic domain in hyaluronan binding. Eur. J. Immunol. 25: 495-501.
34. Rudy, W., M. Hofmann, R. Schwartz-Albiez, M. Zöller, K.-H. Heider, H. Ponta, and P. Herrlich. 1993. The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior. Cancer Res. 53:1262-1268.
35. Sherman, L., J. Sleeman, P. Herrlich, and H. Ponta. 1994. Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression. Curr. Opin. Cell Biol. 6:726-733.
36. Sleeman, J.P. 1993. Xenopus A-myb is expressed during early spermatogenesis. Oncogene. 8:1931-1941.
37. Sleeman, J.P., S. Arming, J. Moll, A. Hekele, W. Rudy, L. Sherman, G. Kreil, H. Ponta, and P. Herrlich. 1996. Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells. Cancer Res. In press.
38. Thomas, L., H.R. Byers, J. Vink, and I. Stamenkovic. 1992. CD44H regulates tumor cell migration on hyaluronate-coated substrate. J. Cell Biol. 118:971-977.
39. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:4350-4354.
40. Underhill, C.B., G. Chi-Rosso, and B.P. Toole. 1983. Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells. J. Biol. Chem. 258:8086-8091.
41. Yang, B., B.L. Yang, R.C. Savani, and E.A. Turley. 1994. Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO (Eur. Mol. Biol. Organ.) J. 13: 286-296.