Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: A double-label autoradiographic study in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 3, 1996, Pages 481-489

  Dalton Dietrich, W ^a,b   Alonso, Ofelia ^a   Busto, Raul ^a   Prado, Ricardo ^a   Dewanjee, Sumit ^a   Dewanjee, Mrinal K ^a   Ginsberg, Myron D ^a  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Brain trauma; Cerebral blood flow; Platelets; Vasoactive substances

Indexed keywords

IODOPHENAZONE C 14; THROMBOCYTE IN 111; TROPOLONE IN 111;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN REGION; CONTROLLED STUDY; HEMODYNAMICS; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION;

EID: 9244243663     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199605000-00015     Document Type: Article

References (48)

1. Adams JH, Gennarelli TA, Graham DI (1982) Brain damage in non-missile head injury: observations in man and subhuman primates. In: Thomas Smith W, Cavanagh JB (eds). Recent Advances in Neuropathology. Edinburgh, Churchill Livingstone, pp 165-190
2. + at critical levels of brain ischemia. Stroke 8:51-57
3. Bouma GJ, Muizelaar JP (1992) Cerebral blood flow, cerebral blood volume, and cerebrovascular reactivity after severe head injury. J Neurotrauma 9(suppl 1):S333-S348
4. Chan PH, Schmidley JW, Fishman RA, Longar SM (1984) Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals. Neurology 34:315-320
5. Cortez SC, McIntosh TK, Noble LJ (1989) Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res 482:272-282
6. Dewanjee MK, Fuster V, Rao SA, Forshaw PL, Kaye MP(1983) Noninvasive radioisotopic technique for detection of platelet deposition on mitral valve prostheses and quantitation of visceral microembolism in dogs. Mayo Clin Proc 58:307-314
7. DeWitt DS, Jenkins LW, Wei EP, Lutz H, Becker DP, Kontos HA (1986) Effects of fluid-percussion brain injury on regional cerebral blood flow and pial arteriolar diameter. J Neurosurg 64:787-794
8. 2 levels in rats. J Neurotrauma 5:303-313
9. 111In]-labeled platelet study. Stroke 24:1534-1540
10. Dietrich WD, Prado R, Watson BD, Busto R, Ginsberg MD (1991) Hemodynamic consequences of common carotid artery thrombosis and thrombogenically activated blood in rats. J Cereb Blood Flow Metab 11:957-965
11. Dietrich WD, Alonso O, Busto R, Globus MY-T, Ginsberg MD (1994a) Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat. Acta Neuropathol 87:250-258
12. Dietrich WD, Alonso O, Halley M (1994b) Early microvascular and neuronal consequences of traumatic brain injury: a light and electron microscopic study in rats. J Neurotrauma 11: 289-301
13. Dietrich WD, Alonso O, Busto R, Ginsberg MD (1994c) Widespread metabolic depression and reduced somatosensory circuit activation following traumatic brain injury in rats. J Neurotrauma 11:629-640
14. Dixon CE, Lyeth BG, Povlishock JT, Findling RL, Hamm RJ, Marmarou A, Young HF, Hayes RL (1987) A fluid percussion model of experimental brain injury in the rat. J N eurosurg 67: 110-119
15. 2. Stroke 8:480-483
16. Fieschi C, Battistini N, Beduschi A, Boselli L, Rassana M (1974) Regional cerebral blood flow and intraventricular pressure in acute head injuries. J Neurol Neurosurg Psychiatry 37:1378-1388
17. Graham DI, Adams JH, Doyle D (1978) Ischemic brain damage in fatal non-missile head injury. J Neurol Sci 39:213-234
18. Hayes RL, Jenkins LW, Lyeth BG et al (1988) Regional rates of glucose utilization in the cat following concussive head injury. J Neurotrauma 5:121-137
19. Hayes RL, Jenkins LW, Lyeth BG (1991) Neurotransmitter-mediated mechanisms of traumatic brain injury: acethycholine and excitatory amino acids. J Neurotrauma 9(suppl 1):173-187
20. Hekmatpanah J, Hekmatpanah CR (1985) Microvascular alterations following cerebral contusion in rats. J Neurosurg 62: 888-897
21. Hovda DA, Becker DB, Katayama Y (1992) Secondary injury and acidosis. J Neurotrauma 9(suppl 1):S47-S60
22. Ishige N, Pitts LH, Berry I, Carlson SG, Nishimura MC, Moseley ME, Weinstein PR (1987) The effect of hypoxia on traumatic head injury in rats: alterations in neurologic function, brain edema, and cerebral blood flow. J Cereb Blood Flow Metab 7:759-767
23. Jenkins LW, Moszynski K, Lyeth BG, Lewelt W, DeWitt DS, Allen A, Dixon CE, Povlishock JT, Majewski TJ, Clifton GL, Young HF, Becker DP, Hayes RL (1989) Increased vulnerability of the mildly traumatized brain to cerebral ischemia: The use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury. Brain Res 477:211-224
24. Jiang JY, Lyeth BG, Clifton GL, Jenkins LW, Hamm RJ, Hayes RL (1991) Relationship between body and brain temperature in traumatically brain-injured rodents. J Neurosurg 74:492-496
25. Jiang JY, Lyeth BG, Kapasi MZ, Jenkins LW, Povlishock JT (1992) Moderate hypothermia reduces blood-brain barrier disruption following traumatic brain injury in the rat. Acta Neuropathol 84:495-500
26. 111In-labeled radiopharmaceuticals in rat tissues. J Nucl Med 33:1825-1835
27. Katayama Y, Becker DP, Tamura T. Hovda DA (1990) Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurgery 73:889-900
28. Lewelt W, Jenkins LW, Miller JD (1980) Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain. J Neurosurg 53:500-511
29. Lindsberg PJ, Hallenbeck JM, Feuerstein G (1991) Platelet-activating factor in stroke and brain injury. Ann Nenrol 30: 117-129
30. Marion DW, Darby J, Yonas H (1991) Acute regional cerebral blood flow changes caused by severe head injuries. J Neurosurg 74:407-414
31. Muir JK, Boerschel M, Ellis EF (1992) Continuous monitoring of post-traumatic cerebral blood flow using laser-doppler flowmetry. J Neurotrauma 9:355-362
32. Obrist WD, Langfitt TW, Dolinskas CA, Jaggi JL, Segawa H (1983) Factors relating to intracranial hypertension in acute head injury. In: Intracranial Pressure V (Ishii S, Nagai H, Brock M, eds). Berlin, Springer, pp 491-494
33. Obrist WD, Langfitt TW, Jaggi JL, Obrist WD, Langfitt TW, Jaggi JL, Cruz J, Gennarelli TA (1984) Cerebral blood flow and metabolism in comatose patients with acute head injury. J Neurosurg 61:241-253
34. Povlishock JT, Becker DP, Sullivan HG. Miller JD (1978) Vascular permeability alterations to horseradish peroxidase in experimental brain injury. Brain Res 153:223-239
35. Reivich M (1974) Blood flow metabolism couple in brain. In: Brain dysfunction in metabolic disorders (Plum F, ed). New York, Raven Press, pp 125-140
36. Robertson CS, Contant CF, Narayan RK, Grossman RG (1992) Cerebral blood flow, AVDo2, and neurologic outcome in head-injured patients. J Neurotrauma 9(suppl 1):S349-358
37. Roy CS, Sherrington CS (1890) On the regulation of the blood supply of the brain. J Physiol (London) 11:85-108
38. 14C]antipyrine. Am J Physiol 234:H59-H66
39. Steiger H-J, Aaslid R, Stooss R, Seiler RW (1994) Transcranial doppler monitoring in head injury: Relations between type of injury, flow velocities, vasoreactivity, and outcome. Neurosurgery 34:79-86
40. Tanno H, Nockels RP, Pitts LH, Noble LJ (1992) Breakdown of the blood-brain barrier after fluid percussive brain injury in the rat. Part I: Distribution and time course of protein extravasation. J Neurotrauma 9:21-32
41. Thompson JA, Wei EP, Kontos HA (1984) Inhibition by ketanserin of serotonin-induced cerebral arteriolar constriction. Stroke 15:1021-1024
42. Unterberg AW, Anderson BJ, Clarke GD, Marmarou A (1988) Cerebral energy metabolism following fluid-percussion brain injury in cats. J Neurosurg 68:594-600
43. Wei EP, Dietrich WD, Povlishock JP, Navari RM, Kontos HA (1980) Functional, morphological and metabolic abnormalities of the microcirculation after concussive brain injury in cats. Circ Res 40:37-47
44. Yamakami I, McIntosh TK (1989) Effects of traumatic brain injury on regional cerebral blood flow in rats as measured with radiolabeled microspheres. J Cereb Blood Flow Metab 9: 117-124
45. Yoshino A, Hovda DA, Kawamata T, Katayama Y, Becker DB (1991) Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyperand subsequent hypometabolic state. Brain Res 561:106-119
46. Young W (1988) Secondary CNS injury. J Neurotrauma 5:219-221
47. Yuan X-Q, Prough DS, Smith TL, DeWitt DS (1988) The effects of traumatic brain injury on regional cerebral blood flow in rats. J Neurotrauma 5:289-301
48. Zilles L (1985) The cortex of the rat. A stereotaxic atlas. Berlin Heidelberg, Springer-Verlag.