Image analysis of morphological change during arachidonic acid production by Mortierella alpina 1S-4

Journal of Bioscience and Bioengineering

Volumn 87, Issue 4, 1999, Pages 489-494

  Higashiyama, Kenichi ^a   Fujikawa, Shigeaki ^a   Park, Enoch Y ^b   Okabe, Mitsuyasu ^b  

^a SUNTORY LTD   (Japan)

^b SHIZUOKA UNIVERSITY   (Japan)

Author keywords

Arachidonic acid; Image analysis; Morphology; Mortierella alpina

Indexed keywords

ARACHIDONIC ACID;

ARACHIDONIC ACID METABOLISM; ARTICLE; COST EFFECTIVENESS ANALYSIS; FERMENTATION; IMAGE ANALYSIS; MORTIERELLA ALPINA; MYCELIUM; NONHUMAN; VISCOSITY;

MORTIERELLA ALPINA;

EID: 0032914297     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1389-1723(99)80098-X     Document Type: Article

References (26)

1. 1. Gill, I. and Valivety, R.: Polyunsaturated fatty acid, part I: occurrence, biological activities and application. Trends in Biotechnol., 15, 401-409 (1997).
2. 2. Shinmen, Y., Shimizu, S., Akimoto, K., Kawashima, H., and Yamada, H.: Production of arachidonic acid by Mortierella fungi. Appl. Microbiol. Biotechnol., 31, 11-16 (1989).
3. 3. Higashiyama, K., Yaguchi, T., Akimoto, K., Fujikawa, S., and Shimizu, S.: Enhancement of arachidonic acid production by Mortierella alpina 1S-4. J. Am. Oil Chem. Soc., 75, 1501-1505 (1998).
4. 4. Higashiyama, K., Murakami, K., Tsujimura, H., Matsumoto, N., and Fujikawa, S.: Effects of dissolved oxygen on the morphology of and arachidonic acid production by Mortierella alpina 1S-4. Biotechnol. Bioeng., 63, 442-448 (1999).
5. 5. Jareonkitmongkol, S., Kawashima, H., Shirasaka, N., Shimizu, S., and Yamada, H.: Production of dihomo-γ-linolenic acid by a Δ5-desaturase-defective mutant of Mortierella alpina 1S-4. Appl. Environ. Microbiol., 58, 2196-2200 (1992).
6. 6. Jareonkitmongkol, S., Kawashima, H., Shimizu, S., and Yamada, H.: Production of 5,8,11-cis-eicosatrienoic acid by a Δ12-desaturase-defective mutant of Mortierella alpina 1S-4. J. Am. Oil Chem. Soc., 69, 939-944 (1992).
7. 7. Park E. Y.: Application of image analysis for efficient cultivation of microorganisms. Recent Res. Devel. in Biotechnol. Bioeng., 1, 37-58 (1998).
8. 8. Yang, Y. K., Morikawa, M., Shimizu, H., Shioya, S., Suga, K., Nihira, T., and Yamada, Y.: Image analysis of mycelial morphology in virginiamycin production by batch culture of Streptomyces virginiae. J. Ferment. Bioeng., 81, 7-12 (1996).
9. 9. Tamura, S., Park, Y., and Okabe, M.: Change of mycelial morphology in tylosin production by batch culture of Streptomyces fradiae under various shear conditions. J. Ferment. Bioeng., 83, 523-528 (1997).
10. 10. Johansen, C. L., Coolen, L., and Hunik, J. H.: Influence of morphology on product formation in Aspergillus awamori during submerged fermentations. Biotechnol. Prog., 14, 233-240 (1998).
11. 11. Carlsen, M., Spohr, A. B., Nielsen, J., and Villadsen, J.: Morphology and physiology of an α-amylase producing strain of Aspergillus oryzae during batch cultivations. Biotechnol. Bioeng., 49, 266-276 (1996).
12. 12. Vanhoutte, B., Pons, M. N., Thomas, C. R., Louvel, L., and Vivier, H.: Characterization of Penicillium chrysogenum physiology in submerged cultures by color and monochrome image analysis. Biotechnol. Bioeng., 48, 1-11 (1995).
13. 13. Paul, G. C. and Thomas, C. R.: A structured model for hyphal differentiation and penicillin production using Penicillium chrysogenum. Biotechnol. Bioeng., 51, 558-572 (1996).
14. 14. Justen, P., Paul, G. C., Nienow, A. W., and Thomas, C. R.: Dependence of Penicillium chrysogenum growth, morphology, vacuolation and productivity in fed-batch fermentations on impeller type and agitation intensity. Biotechnol. Bioeng., 59, 762-775 (1998).
15. 15. Harvey, L. M., McNeil, B., Berry, D. R., and White, S.: Autolysis in batch cultures of Penicillin chrysogenum at varying agitation rates. Enzyme Microb. Technol., 22, 446-458 (1998).
16. 16. Ratledge, C.: Microbial lipids: commercial realities or academic curiosities, p. 1-15. In Kyle, D. J. and Ratledge, C. (ed.), Industrial applications of single cell oils. AOCS Press, Illinois (1992).
17. 17. Davies, R. J., Holdsworth, J. E., and Reader, S. L.: The effect of low oxygen uptake rate on the fatty acid profile of the oleaginous yeast Apiotrichum curvatum. Appl. Microbiol. Biotechnol., 33, 569-573 (1990).
18. 18. Davies, R. J., Holdsworth, J. E., and Reader, S. L.: The effect of low oxygen uptake rate on the fatty acid profile of the oleaginous yeast Apiotrichum curvatum. Appl. Microbiol. Biotechnol., 34, 832-833 (1991).
19. 19. Thomas, K., Rutter, A., Suller, M., Harwood, J., and Lloyd, D.: Oxygen induces fatty acid (n-6)-desaturation independently of temperature in Acanthamoeba castellanii. FEBS Lett., 425, 171-174 (1998).
20. 20. Higashiyama, K., Yaguchi, T., Akimoto, K., Fujikawa, S., and Shimizu, S.: Effects of mineral addition on the growth morphology of and arachidonic acid production by Mortierella alpina 1S-4. J. Am. Oil Chem. Soc., 75, 1815-1819 (1998).
21. 21. Shimizu, S., Kawashima, H., Shinmen, Y., Akimoto, K., and Yamada, H.: Production of eicosapentaenoic acid by Mortierella fungi. J. Am. Oil Chem. Soc., 65, 1455-1459 (1988).
22. 22. Granger, L. M., Perlot, P., and Pareilleux, A.: Efficiency of fatty acid synthesis by oleaginous yeasts: prediction of yield and fatty acid cell content from consumed C/N ratio by a simple method. Biotechnol. Bioeng., 42, 1151-1156 (1993).
23. 23. Cui, Y. Q., van der Lans, R. G. J. M., and Luyben, K. C. A.M.: Effect of agitation intensities on fungal morphology of submerged fermentation. Biotechnol. Bioeng., 55, 715-726 (1997).
24. 24. Olsvik, E., Tucker, K. G., Thomas, C. R., and Kristiansen, B.: Correlation of Aspergillus niger broth rheological properties with biomass concentration and the shape of mycelial aggregates. Biotechnol. Bioeng., 42, 1046-1052 (1993).
25. 25. Choi, D. B., Park, E. Y., and Okabe, M.: Improvement of tylosin production from Streptomyces fradiae culture by decreasing the apparent viscosity in an air-lift bioreactor. J. Ferment. Bioeng., 86, 413-417 (1998).
26. 26. Braun, S. and Vecht-Lifshitz, S. E.: Mycelial morphology and metabolite production. Trends in Biotechnol., 9, 63-68 (1991).