Improvement of tylosin production from Streptomycesfradiae culture by decreasing the apparent viscosity in an air-lift bioreactor

Journal of Fermentation and Bioengineering

Volumn 86, Issue 4, 1998, Pages 413-417

  Choi, Du Bok ^a   Park, Enoch Y ^b   Okabe, Mitsuyasu ^b  

^a GIFU UNIVERSITY   (Japan)

^b SHIZUOKA UNIVERSITY   (Japan)

Author keywords

Air lift bioreactor; Low apparent viscosity; Streptomyces fradiae; Tylosin

Indexed keywords

ANTIBIOTICS; BACTERIA; BATCH CELL CULTURE; BIOREACTORS; VISCOSITY OF LIQUIDS;

AIR LIFT BIOREACTORS;

FERMENTATION;

TYLOSIN;

ARTICLE; BACTERIAL METABOLISM; BACTERIUM CULTURE; BIOREACTOR; CULTURE MEDIUM; DRUG SYNTHESIS; NITROGEN METABOLISM; NONHUMAN; STREPTOMYCES FRADIAE;

BACTERIA (MICROORGANISMS); GOSSYPIUM HIRSUTUM; PHARMAMEDIA; STREPTOMYCES FRADIAE;

EID: 0344972806     PISSN: 0922338X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0922-338X(99)89016-3     Document Type: Article

References (7)

1. Choi, D. B., Tamura. S., Park, Y., Okabe, M., Seriue, Y., and Takeda, S.: Efficient tylosin production from Streptomyces fradiae using rapeseed oil. J. Ferment. Bioeng., 82, 183-186 (1996).
2. Eiki, H., Gushima, H., Ishida, H., Saito, T., Oka, Y., and Osono, T.: Effect of mineral salts on apparent viscosity and a ratio of product components in josamycin fermentation. J. Ferment. Bioeng., 67, 345-349 (1989).
3. Eiki, H., Gushima, H., Saito, T., and Osono, T.: Effect of broth dilution and its application in josamycin fermentation. J. Ferment. Bioeng., 70, 104-107 (1990).
4. Park, Y., Ohta, N., and Okabe, M.: Neomycin production by partial immobilization Streptomyces fradiae on cellulose beads in an air-lift bioreactor. J. Ferment. Bioeng., 78, 265-268 (1994).
5. Okabe, M., Ohta, N., and Park, Y.: Itaconic acid production in an air-lift bioreactor using a modified draft tube. J. Ferment. Bioeng., 76, 117-122 (1993).
6. Schneider, W.: Phosphorous compounds in animal tissues. I. Extraction and estimation of deoxypentose nucleic acid. J. Biol. Chem., 161, 293-295 (1945).
7. Tamura, S., Park, Y., Toriyama, M., and Okabe, M.: Change of mycelial morphology in tylosin production by batch culture of Streptomyces fradiae under various shear conditions. J. Ferment. Bioeng., 83, 523-528 (1997).