Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic ras

Cancer Research

Volumn 57, Issue 15, 1997, Pages 3180-3188

  Diugosz, Andrzej A ^a,d   Hansen, Laura ^a   Cheng, Christina ^a   Alexander, Natalie ^a   Denning, Mitchell F ^a,e   Threadgill, David W ^b,f   Magnuson, Terry ^b   Coffey Jr , Robert J ^c   Yuspa, Stuart H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR; KERATIN; ONCOPROTEIN; ONCOPROTEIN V RAS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; KERATINOCYTE; MITOGENESIS; MOUSE; NEWBORN; NONHUMAN; NUDE MOUSE; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN PAPILLOMA;

ANIMALS; APOPTOSIS; BROMODEOXYURIDINE; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENES, RAS; KERATINOCYTES; KERATINS; MICE; MICE, KNOCKOUT; NEOPLASM TRANSPLANTATION; PAPILLOMA; RECEPTOR, EPIDERMAL GROWTH FACTOR; TIME FACTORS;

EID: 0030755457     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Aaronson, S. A. Growth factors and cancer. Science (Washington DC), 254: 1146-1153, 1991
2. Lee, D. C., Luetteke, N. C., and Fetch, L. A. Transforming growth factor-α and its role in neoplastic progression. Cancer Treat. Res., 63: 233-254, 1992.
3. Yuspa, S. H. The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis-Thirty-third G. H. A. Clowes Memorial Award Lecture. Cancer Res., 54: 1178-1189, 1994.
4. Balmain, A., and Brown, K. Oncogene activation and chemical carcinogenesis. Adv. Cancer Res., 51: 147-182, 1988.
5. Brown, K., Quintanilla, M., Ramsden, M., Kerr, I. B., Young, S., and Balmain, A. v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis. Cell, 46: 447-456, 1986.
6. Roop, D. R., Lowy, D. R., Tambourin, P. E., Strickland, J., Harper, J. R., Balaschak, M., Spangler, E. F., and Yuspa, S. H. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature (Lond.), 323: 822-824, 1986.
7. Conti, C. J. Mutations of genes of the ras family in human and experimental tumors. Prog. Clin. Biol. Res., 376: 357-378, 1992.
8. Barbacid, M. ras oncogenes: their role in neoplasia. Eur. J. Clin. Invest., 20: 225-235, 1990.
9. Click, A. B., Sporn, M. B., and Yuspa, S. H. Altered regulation of TGF-β1 and TGF-α in primary keratinocytes and papillomas expressing v-Ha-ras. Mol. Carcinog., 4; 210-219, 1991.
10. Cheng, C., Tennenbaum, T., Dempsey, P. J., Coffey, R. J., Yuspa, S. H., and Dlugosz, A. A. Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor α mediates the induction of keratin 8 by the v-ras-Ha oncogene. Cell Growth & Differ., 4: 317-327, 1993.
11. Hashimoto, Y., Tajima, O., Hashiba, H., Nose, K., and Kuroki, T. Elevated expression of secondary, but not early, responding genes to phorbol ester tumor promoters in papillomas and carcinomas of mouse skin. Mol. Carcinog., 3: 302-308, 1990.
12. Rho, O., Beltran, L. M., Gimenez-Conti, I. B., and DiGiovanni, J. Altered expression of the epidermal growth factor receptor and transforming growth factor-α during multistage skin carcinogenesis in SENCAR mice. Mol Carcinog., 11: 19-28, 1994.
13. Xian, W., Kiguchi, K., Imamoto, A., Rupp, T., Zilberstein, A., and DiGiovanni, J. Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice. Cell Growth & Differ., 6: 1447-1455, 1995.
14. Cheng, C., Kilkenny, A. E., Roop, D., and Yuspa, S. H. The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes. Mol. Carcinog., 3: 363-373, 1990.
15. Ha-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands. Cancer Res., 55: 1883-1893, 1995.
16. Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., Barnard, J. A., Yuspa, S. H., Coffey, R. J., and Magnuson, T. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science (Washington DC), 269: 230-234, 1995.