Mouse mutants and cardiac development: New molecular insights into cardiogenesis

Circulation Research

Volumn 78, Issue 3, 1996, Pages 349-353

  Rossant, J ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

cardiogenesis; genetic mutations; mouse

Indexed keywords

CONNEXIN 43; HOMEODOMAIN PROTEIN; INTEGRIN; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL MODEL; CELL ADHESION; CELL COMMUNICATION; CELL JUNCTION; CONGENITAL HEART MALFORMATION; GENE MUTATION; GENETIC REGULATION; HEART DEVELOPMENT; MOUSE; NEURAL TUBE DEFECT; NEUROFIBROMATOSIS; NONHUMAN; ONCOGENE C MYB; PHENOTYPE; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0030046595     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.78.3.349     Document Type: Short Survey

References (60)

1. Copp AJ. Death before birth: clues from gene knockouts and mutations. Trends Genet. 1995;11:87-93.
2. Brandon EP, Idzerda RL, McKnight GS. Targeting the mouse genome: a compendium of knockouts: I. Curr Biol. 1995;5:625-634.
3. Brandon EP, Idzerda RL, McKnight GS. Targeting the mouse genome: a compendium of knockouts: II. Curr Biol. 1995;5:758-765.
4. Brandon EP, Idzerda RL, McKnight GS. Targeting the mouse genome: a compendium of knockouts: III. Curr Biol. 1995;5:873-881.
5. Yang JT, Rayburn H, Hynes RO. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development. 1995;121:549-560.
6. Reaume AG, de Sousa PA, Kulkarni S, Langille BW, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267: 1831-1834.
7. Thomas SA, Matsumoto AM, Palmiter RD. Noradrenaline is essential for mouse fetal development. Nature. 1995;374:643-646.
8. Chisaka O, Capecchi MR. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox 1.5. Nature. 1991;350:473-479.
9. Lau MMH, Stewart CEH, Liu Z, Bhatt H, Rotwein P, Stewart CE. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev. 1994;8:2953-2963.
10. Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA. Tumour predisposition in mice heterozygous for a targeted mutation in NF1. Nat Genet. 1994;7:353-361.
11. Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg A, Jenkins NA, Parada LF, Copeland NG. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 1994;8:1019-1029.
12. Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995;9:1654-1666.
13. Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson FJ, Alt FW. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 1992;6:2248-2257.
14. Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 1992;6:2235-2247.
15. Sawai S, Shimono A, Wakamatsu Y, Palmes C, Hanaoka K, Kondoh H. Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. Development. 1993;117:1445-1455.
16. Moens CB, Stanton BR, Parada LF, Rossant J. Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development. 1993;119: 485-499.
17. Leveen P, Pekny M, Gebre-Medhin, S, Swolin B, Larsson E, Betsholtz C. Mice deficient for PDGFβ show renal, cardiovascular and hematological abnormalities. Genes Dev. 1994;8:1875-1887.
18. Sucov HM, Dyson E, Gumeringer CL, Price J, Chien KR, Evans RM. RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 1994;8:1007-1018.
19. Kastner P, Grondona JM, Mark M, Gansmuller A, LeMeur M, Decimo D, Vonesch J-L, Dolle P, Chambon P. Genetic analysis of RXRα developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell. 1994;78: 987-1003.
20. Franz T. Persistent truncus arteriosus in the Splotch mutant mouse. Anat Embryol. 1989;180:457-464.
21. Franz T. The Splotch (Sp1H) and Splotch-delayed (Spd) alleles: differential phenotypic effects on neural crest and limb musculature. Anat Embryol. 1993;187:371-377.
22. Chen Z, Friedrich GA, Soriano P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994;8:2293-2301.
23. Zhou Q-Y, Quaife CJ, Palmiter RD. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature. 1995;374:640-643.
24. Gurtner GC, Davis V, Li H, McCoy MJ, Sharpe A, Cybulsky MI. Targeted disruption of the murine VCAM1 gene: essential role of VCAM1 in chorioallantoic fusion and placentation. Genes Dev. 1995;9:1-14.
25. Kwee L, Baldwin HS, Shen HM, Stewart CL, Buck C, Buck CA, Labow M. Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM1) deficient mice. Development. 1995;121:489-503.
26. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R. WT-1 is required for early kidney development. Cell. 1993;74:679-691.
27. Olson E. Regulation of muscle transcription by the MyoD family: the heart of the matter. Circ Res. 1993;72:1-6.
28. Rudnicki MA, Schnegelsberg PNJ, Stead RH, Braun T, Arnold H-H, Jaenisch R. MyoD or Myf5 is required for the formation of skeletal muscle. Cell. 1993;75:1351-1359.
29. Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 1993;364:501-506.
30. Nabeshima Y, Hanaoka K, Hayasaka M, Esumi E, Li S, Nabeshima Y. Myogenin gene disruption results in perinatal lethality because of severe muscle defect. Nature. 1993;364:532-535.
31. Zhang W, Behringer RR, Olson EN. Inactivation of the myogenic bHLH gene MRF4 results in upregulation of myogenin and rib anomalies. Genes Dev. 1995;9:1388-1399.
32. Heikinheimo M, Scrandrett JM, Wilson DB. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev Biol. 1994;164:361-373.
33. Edmondson DG, Lyons GE, Martin JF, Ohlson E. Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development. 1994;120:1251-1263.
34. Komuro I, Izumo S. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci U S A. 1993;90:8145-8149.
35. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development. 1993;119:419-431.
36. Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development. 1993;118: 719-729.
37. Kariya K, Farrance IK, Simpson PC. Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1 adrenergic-and a beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter. J Biol Chem. 1993;268:26658-26662.
38. Blackwood EM, Eisenman RN. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. 1991;251:1211-1217.
39. Prendergast GC, Lawe D, Ziff EB. Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and Ras cotransformation. Cell. 1991;65:395-407.
40. Green S, Chambon P. Nuclear receptors enhance our understanding of transcriptional regulation. Trends Genet. 1988;4: 309-314.
41. Evans RM. The steroid and thyroid hormone receptor superfamily. Science. 1988;240:889-895.
42. Giguere V. Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signalling. Endocr Rev. 1994; 15:61-79.
43. Kastner P, Leid M, Chambon P. The role of nuclear retinoic acid receptors in the regulation of gene expression. In: Blomhoff R, ed. Vitamin A in Health and Disease. New York, NY: Marcel Dekker Inc; 1994:189-238.
44. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P. Function of retinoic acid receptor γ (RARγ) in the mouse. Cell. 1993;73:643-658.
45. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P. High postnatal lethality and testis degeneration in retinoic acid receptor α (RARα) mutant mice. Proc Natl Acad Sci U S A. 1993;90:7225-7229.
46. Li E, Sucov HM, Lee K-F, Evans RM, Jaenisch R. Normal development and growth of mice carrying a targeted disruption of the α1 retinoic acid receptor gene. Proc Natl Acad Sci U S A. 1993;90: 1590-1594.
47. Mendelsohn C, Mark M, Dolle P, Dierich A, Gaub M-P, Krust A. Lampron C, Chambon P. Retinoic acid receptor β2 (RARβ2) null mutant mice appear normal. Dev Biol. 1994;166:246-258.
48. Luo J, Pasceri P, Conlon RA, Rossant J, Giguere V. Mice lacking all isoforms of retinoic acid receptorβ develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995;52:1-11.
49. Wilson JG, Warkanay J. Aortic arch and cardiac anomalies in the offspring of vitamin A deficient rats. Am J Anat. 1949;85:113-155.
50. Hunt P, Krumlauf R. Hox codes and positional specification in vertebrate embryonic axes. Annu Rev Cell Biol. 1992;8:227-256.
51. Tassabehji M, Read AP, Newton VE, Harris R, Balling R, Gruss P, Strachan T. Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature. 1992; 355:635-636.
52. Epstein DJ, Vekemans M, Gros P. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell. 1992;67:767-774.
53. Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P. Pax-3, a novel murine DNA-binding protein expressed during early neurogenesis. EMBO J. 1991;10:1135-1147.
54. Riccardi VM. Neurofibromatosis: past, present and future. N Engl J Med. 1991;324:1283-1285.
55. Ballester R, Marchuk D, Boguski M, Saulino A, Letcher R, Wigler M, Collins FS. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell. 1990;63:851-859.
56. Xu G, O'Connell P, Viskochil D, Cawthon R, Robertson M, Culver M, Dunn D, Stevens J, Gesteland R, White R, Weiss R. The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell. 1990;62:599-608.
57. Huynh DP, Nechiporuk T, Pulst SM. Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. Dev Biol. 1994;161:538-551.
58. Beyer EC, Paul DL, Goodenough DA. Connexin family of gap junction proteins. J Membr Biol. 1990;116:187-194.
59. Kanter HL, Saffitz JE, Beyer EC. Cardiac myocytes express multiple gap junction proteins. Circ Res. 1992;70:438-444.
60. Veenstra RD, Wang H-Z, Westphale EM, Beyer EC. Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart. Circ Res. 1992;71:1277-1283.