Abrogation of cyclin D1 expression predisposes lung cancer cells to serum deprivation-induced apoptosis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 276, Issue 4 20-4, 1999, Pages

  Driscoll, Barbara ^a   Buckley, Susan ^a   Barsky, Lora ^a   Weinberg, Kenneth ^a   Anderson, Kathryn D ^a   Warburton, David ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

Antisense

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CYCLIN D1; CYCLINE; DIMETHYL SULFOXIDE; DNA; EPIDERMAL GROWTH FACTOR; GLUTATHIONE; KERATINOCYTE GROWTH FACTOR; SINGLE STRANDED DNA; SOMATOMEDIN C;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DEPLETION; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM;

EID: 0032900935     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.276.4.l679     Document Type: Article

References (56)

1. Aboussekhra, A., M. Biggerstaff, M. K. Shivji, J. A. Vilpo, V. Moncollin, V. N. Podust, M. Protic, U. Hubscher, J. M. Egly, and R. D. Wood. Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell 80: 859-868, 1995.
2. Arber, N., Y. Doki, E. K. Han, A. Sgambato, P. Zhou, N. H. Kim, T. Doherty, M. G. Klein, P. R. Holt, and I. B. Weinstein. Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res. 57: 1569-1574, 1997.
3. Atabay, C., C. M. Cagnoli, E. Kharlamov, M. D. Ikanomovic, and H. Manev. Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and glutamate receptor antagonists. J. Neurosci. Res. 43: 465-475, 1996.
4. Ayyagari, R., K. J. Impellezzeri, B. L. Yoder, S. L. Gary, and P. M. Burgers. A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and repair. Mol. Cell. Biol. 15: 4420-4429, 1995.
5. Buckley, S., L. Barskey, B. Driscoll, K. D. Anderson, K. Weinberg, and D. Warburton. Apoptosis and DNA damage in type 2 alveolar epithelial cells cultured from hyperoxic rats. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L714-L720, 1998.
6. Cordon-Cardo, C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am. J. Pathol. 147: 545-560, 1995.
7. Cox, L. S., and D. P. Lane. Tumor suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. Bioessays 17: 501-508, 1994.
8. Del Sal, G., M. Murphy, E. M. Ruaro, D. Lazarevic, A. J. Levine, and C. Schneider. Cyclin D1 and p21/waf1 are both involved in p53 growth suppression. Oncogene 12: 177-185, 1996.
9. Deterding, R. R., T. Yanos, A. M. Havill, C. R. Jacoby, J. M. Shannon, W. S. Simonet, and R. J. Mason. Keratinocyte growth factor prevents bleomycin lung injury in rats (Abstract). Am. J. Respir. Crit. Care Med. 151: A198, 1995.
10. Dive, C. Avoidance of apoptosis as a mechanism of drug resistance. J. Intern. Med. Suppl. 740: 139-145, 1997.
11. Driscoll, B., L. Wu, S. Buckley, F. L. Hall, K. D. Anderson, and D. Warburton. Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L941-L949, 1997.
12. Dufourny, B., J. Alblas, H. A. van Teefelen, F. M. van Schaik, B. van der Burg, P. H. Steenbergh, and J. S. Sussenbach. Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J. Biol. Chem. 272: 31163-31171, 1997.
13. CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis. J. Cell. Biochem. 64: 434-446, 1997.
14. El-Deiry, W. S. Role of oncogenes in resistance and killing by cancer therapeutic agents. Curr. Opin. Oncol. 9: 79-87, 1997.
15. Ellerby, L. M., H. M. Ellerby, S. M. Park, A. L. Holleran, A. N. Murphy, G. Fiskum, D. J. Kane, M. P. Testa, C. Kayalar, and D. E. Bredesen. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J. Neurochem. 67: 1259-1267, 1996.
16. Epperly, M., L. Berry, A. Halloran, and J. S. Greenberger. Inhibition of G1-phase arrest induced by ionizing radiation in hematopoietic cells by overexpression of genes involved in the G1/S-phase transition. Radiat. Res. 143: 245-254, 1995.
17. Freeman, R. S., S. Estus, and E. M. Johnson, Jr. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12: 343-355, 1994.
18. Furlanetto, R. W., S. E Harwell, and K. K. Frick. Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. Mol. Endocrinol. 8: 510-517, 1994.
19. Han, E. K., M. Begemann, A. Sgambato, J. W. Soh, Y. Doki, W. Q. Xing, W. Liu, and I. B. Weinstein. Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis. Cell Growth Differ. 7: 699-710, 1996.
20. Henderson, D. S., and D. M. Glover. Chromosome fragmentation resulting from an inability to repair transposase-induced DNA double-strand breaks in PCNA mutants of Drosophila. Mutagenesis 13: 57-60, 1998.
21. Hinds, P. W., S. F. Dowdy, E. N. Eaton, A. Arnold, and R. A. Weinberg. Function of a human cyclin gene as an oncogene. Proc. Natl. Acad. Sci. USA 91: 709-713, 1994.
22. Hockenbery, D. M., Z. N. Oltvai, X. M. Yin, C. L. Milliman, and S. J. Korsmayer. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251, 1993.
23. Jung, Y.-K., M. Miura, and J. Yuan. Suppression of interleukin-1β-converting enzyme-mediated cell death by insulin-like growth factor. J. Biol. Chem. 271: 5112-5117, 1996.
24. Kaneko, Y., and A. Tsukamoto. Apoptosis and nuclear levels of p53 protein and proliferating cell nuclear antigen in human hepatoma cells cultured with tumor promoters. Cancer Lett. 91: 11-17, 1995.
25. Kornmann, M., N. Arber, and M. Korc. Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum. J. Clin. Invest. 101: 344-352, 1998.
26. Latham, K. M., S. W. Eastman, A. Wong, and P. W. Hinds. Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases. Mol. Cell. Biol. 16: 4445-4455, 1996.
27. Lee, H. H., W. H. Chiang, S. H. Chiang, Y. C. Liu, J. Hwang, and S. Y. Ng. Regulation of cyclin D1, DNA topoisomerase I, and proliferating cell nuclear antigen promoters during the cell cycle. Gene Expr. 4: 95-109, 1995.
28. Li, R., G. J. Hannon, D. Beach, and B. Stillman. Subcellular distribution of p21 and PCNAin normal and repair-deficient cells following DNA damage. Curr. Biol. 6:189-199, 1996.
29. Lowe, S. W., T. Jacks, D. E. Housman, and H. E. Ruley. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc. Natl. Acad. Sci. USA 91: 2026-2030, 1994.
30. Merchant, A. K., T. L. Loney, and J. Maybaum. Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells. Oncogene 13: 2631-2637, 1996.
31. Merritt, A. J., C. S. Potten, C. J. Kemp, J. A. Hickman, A. Balmain, and D. P. Lane. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54: 614-617, 1994.
32. Nuydens, R., M. de Jong, G. Van Den Kieboom, C. Heers, G. Dispersyn, F. Cornelissen, R. Nuyens, M. Borgers, and H. Geerts. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J. Neurochem. 70: 1124-1133, 1998.
33. Otori, K., Y. Yano, N. Takada, C. C. Lee, S. Hayashi, S. Otani, and S. Fukushima. Reversibility and apoptosis in rat urinary bladder papillomatosis induced by uracil. Carcinogenesis 18: 1485-1489, 1997.
34. Pan, Z. Q., J. T. Reardon, L. Li, H. Flores-Rozas, R. Legerski, A. Sancar, and J. Hurwitz. Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21. J. Biol. Chem. 270: 22008-22016, 1995.
35. Pandey, S., and E. Wang. Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell cycle traverse. J. Cell Biochem. 58: 135-150, 1995.
36. Parrizas, M., A. R. Saltiel, and D. LeRoith. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J. Biol. Chem. 272: 154-161, 1997.
37. Powis, G., M. Briehl, and J. Oblong. Redox signaling and the control of cell growth and death. Pharmacol. Ther. 68: 149-173, 1995.
38. Quelle, D. E., R. A. Ashmun, S. A. Shurtleff, J.-Y. Kato, D. Bar-Sagi, M. F. Roussel, and C. J. Sherr. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent flbroblasts. Genes Dev. 7: 1559-1571, 1993.
39. Radulescu, R. T. The "LXCXE" hydropathic superfamily of ligands for retinoblastoma protein: a proposal. Med. Hypotheses 44: 28-31, 1995.
40. Schauer, I. E., S. Siriwrdana, T. A. Langan, and R. A Scalfani. Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer. Proc. Natl. Acad. Sci. USA 91: 7827-7831, 1994.
41. Schrump, D. S., A. Chen, and U. Consoli. Inhibition of lung cancer proliferation by antisense cyclin Dl. Cancer Gene Ther. 3: 131-135, 1996.
42. Sell, C., R. Baserga, and R. Rubin. Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. Cancer Res. 55: 303-306, 1995.
43. Sherr, C. J. Cancer cell cycles. Science 274: 1672-1677, 1996.
44. Skotzko, M., L. Wu, W. F. Anderson, E. M. Gordon, and F. H. Hall. Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. Cancer Res. 55: 5493-5498, 1995.
45. Slater, A. F., C. Stefan, I. Nobel, D. J. van den Dobblesteen, and S. Orrenius. Signaling mechanisms and oxidative stress in apoptosis. Toxicol. Lett. 82-83:149-153, 1995.
46. Sofer-Levi, Y., and D. Resnitzky. Apoptosis induced by ectopic expression of cyclin D1 but not cyclin E. Oncogens 13: 2431-2437, 1996.
47. Stewart, B. W. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J. Natl. Cancer Inst. 86: 1286-1296, 1994.
48. Strasser, A., D. C. Huang, and D. L. Vaux. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumorigenesis and resistance to chemotherapy. Biochim. Biophys. Acta 1333: F151-F178, 1997.
49. Voehringer, D. W., D. J. McConkey, T. J. McDonnell, S. Brisbay, and R. E. Meyn. Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc. Natl. Acad. Sci. USA 95: 2956-2960, 1998.
50. Wang, H.-G., J. A. Millan, A. D. Cox, C. J. Der, U. R. Rapp, T. Beck, H. Zha, and J. C. Reed. R-ras promotes apoptosis caused by growth factor deprivation via a bcl-2 suppressible mechanism. J. Cell Biol. 129: 1103-1114, 1995.
51. Weinstein, I. B. Relevance of cyclin D1 and other molecular markers to cancer chemoprevention. J. Cell. Biochem. 25: 23-28, 1996.
52. White, E. Life, death, and the pursuit of apoptosis. Genes Dev. 10: 1-15, 1996.
53. Xiong, Y., H. Zhang, and D. Beach. D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505-514, 1992.
54. Xu, Y., Q. Nguyen, D. C. Lo, and M. J. Czaja. c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors. J. Cell. Physiol. 170: 192-199, 1997.
55. Yamauchi, Y., A. Tanaka, K. Yamaguchi, M. Kobayashi, S. Shimamura, and F. Hanaoka. Apoptosis was promoted at a non-permissive temperature in DNA replication-defective temperature-sensitive mutants of mouse FM3A cells. Exp. Cell Res. 238: 317-323, 1998.
56. Zhou, P., W. Jiang, Y. Zhang, S. M. Kahn, L. Schieren, R. M. Santella, and I. B. Weinstein. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cells. Oncogene 11: 571-580, 1995.