Up-regulated P21(CIP1) expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis

Journal of Cellular Biochemistry

Volumn 64, Issue 3, 1997, Pages 434-446

  Duttaroy, Atanu ^a,b   Qian, Jing Fang ^a,b   Smith, James S ^c   Wang, Eugenia ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; CDKN1A PROTEIN, MOUSE; COMPLEMENTARY RNA; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; IMMEDIATE EARLY GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REGULATORY MECHANISM; ANIMAL; BAGG ALBINO MOUSE; CULTURE TECHNIQUE; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; RNA PROBE; UPREGULATION;

ANIMALIA;

ANIMALS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLASTS; IMMUNOBLOTTING; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; RNA PROBES; RNA, ANTISENSE; TRANSFECTION; UP-REGULATION;

EID: 0030614969     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19970301)64:3<434::AID-JCB10>3.0.CO;2-G     Document Type: Article

References (56)

1. Brugarolas J, Chandrasekharan C, Gordon JI, Beach D, Jacks T, Hanon GJ (1995): Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377:552-657.
2. Chen J, Jackson PK, Kirschner MW, Dutta A (1995): Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374:386-388.
3. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH (1993): Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362:849-852.
4. 1 checkpoint control. Cell 82:675-684.
5. 1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 8:2540-2551.
6. 1 arrest. Cell 76:1013-1023.
7. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons PR, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993): WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
8. 1 arrest and apoptosis. Cancer Res 54:1169-1174.
9. Evans G, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC (1992): Induction of apoptosis in fibroblasts by c-myc oncoproteins. Cell 69:119-128.
10. Freeman RS, Estus S, Johnson EM (1994): Analysis of cell cycle-related genes in post-mitotic neurons: Selective induction of cyclin D1 during programmed cell death. Neuron 12:343-355.
11. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992): Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
12. Gazitt Y, Erdos GW (1994): Fluctuations and ultrastructural localization of oncoproteins and cell cycle regulatory proteins during growth and apoptosis of synchronized AGF cells. Cancer Res 54:950-960.
13. Graham F, Eb VD (1973): A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 2:456-457.
14. Gu Y, Turck CW, Morgan DO (1993): Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366:707-710.
15. INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 8:2939-2952.
16. Halevy O, Novitch BG, Spicer DB, Skepek SX, Rhee J, Hanon GJ, Beach D, Lassar A (1995): Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267:1018-1021.
17. Hanon GJ, Beach D (1994): p15 INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371: 257-261.
18. 1 cyclin-dependent kinases. Cell 75:805-816.
19. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connel-Crowley L, Swindell E, Fox MP, Wei N (1995): Inhibition of cyclin dependent kinases by p21. Mol Cell Biol 6:387-400.
20. Hirai H, Roussel MF, Kato J-Y, Ashmun RA, Sherr CJ (1995): Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15:2672-2681.
21. Johnson M, Dimitrov D, Vojta PJ, Barret JC, Noda A, Pereira-Smith OM, Smith JR (1994): Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/ WAF1/p21 RNA in human cells. Mol Carcinogen 11: 59-64.
22. Laemmli UK (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
23. Lee MH, Reynisdottir I, Massague J (1995): Cloning of p57 KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 9:639-649.
24. Lehoux JG, Lefebvre A, De Medices E, Bastin M, Belisle S, Bellabarba D (1987): Effect of ACTH on cholesterol and steroid synthesis in adrenocortical tissues. J Steroid Biochem 27:1151-1160.
25. Li R, Waga S, Hanon GJ, Beach D, Stillman B (1994): Differential effects by the CDK inhibitor on PCNA dependent DNAreplication and repair. Nature 371:534-537.
26. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993): p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849.
27. Luo Y, Hurwitz J, Massague J (1995): Cell-cycle inhibition by independent CDK and PCNA binding domains in p21CIP1. Nature 375:159-161.
28. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T (1995): p53-dependent and -independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9:935-944.
29. Matsuoka S, Edwards M, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ (1995): p57 kip2, a structurally distinct member of the p21 CIP1/Cdk-inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9:650-662.
30. Merlo GR, Basolo F, Fiore L, Duboc L, Hynes NE (1995): p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin. J Cell Biol 128:1185-1196.
31. ink4. Mol Cell Biol 15:2682-2688.
32. 0 and entry into the cell cycle of cells expressing p21 Sdi1 antisense RNA. Proc Natl Acad Sci 92:4352-4356.
33. Nakanishi M, Robetorye RS, Adami GR, Pereira-Smith OM, Smith JR (1995b): Identification of the active region of the DNA synthesis inhibitory gene p21 Sdi1/CIP1/ WAF1. EMBO J 14:555-563.
34. Nishioka WK, Welsh RM (1994): Susceptibility to T lymphocyte-induced apoptosis is a function of the proliferative status of the target. J Exp Med 179:769-774.
35. Noda A, Ning YI, Venable SF, Pereira-Smith OM, Smith JR (1994): Cloning of senescent cell-derived inhibitor of DNA synthesis using an expression screen. Exp Cell Res 211: 90-98.
36. Noonberg SB, Scott GK, Hunt CA, Benz CC (1994): Highly sensitive Northern hybridization of rare mRNA using a positively charged nylon membrane. Biotechniques 16: 1075-1078.
37. Pandey S, Wang E (1994): Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2 and RB phosphorylation, resembling events of early cell cycle traverse. J Cell Biochem 56:1-16.
38. Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge S (1995): p53-independent expression of p21 Cip1 in muscle and other terminally differentiating cells. Science 267:1024-1027.
39. Polyak K, Lee MH, Erdjument-Bromage H, Tempst P, Masague J (1994): Cloning of p27 KIP1, a cyclin-dependent kinase inhibitor and potential mediator of extracellular antimitogenic signals. Cell 78:59-66.
40. Rao L, Debbas M, Sabbatini P, Hockenberry D, Korsmeyer S, White E (1992): The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci 89:7742-7746.
41. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ (1991): bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879-888.
42. Serrano M, Hanon GJ, Beach D (1993): A new regulatory motif in cell cycle control causing specific inhibition of cyclinD/cdk4. Nature 366:704-708.
43. 1 phase progression: Cycling on cue. Cell 79:551-555.
44. Shi V, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP, Green DR (1992): Role of c-myc activation-induced apoptotic cell death in T cell hybridomas. Science 263:212-214.
45. 1 checkpoint does not decrease cell survival following DNA damage. Cancer Res 53:4164-4168.
46. Steller H (1995): Mechanisms and genes of cellular suicide. Science 267:1445-1449.
47. Strasser A, Harris AW, Corby S (1991): bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889-899.
48. Towbin H, Staehelin T, Gordon J (1979): Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci 76:4350-4354.
49. Toyoshima H, Hunter T (1994): p27, a novel inhibitor of G cyclin-Cdk protein kinase activity, is related to p21. Cell 78:67-74.
50. Vaux DL, Haecker G, Strasser A (1994): An evolutionary perspective on apoptosis. Cell 76:777-779.
51. Voelkel-Johnson C, Entingh AJ, Wold WSM, Gooding LR, Laster SM (1995): Activation of intra-cellular proteases is an early event in TNF-induced apoptosis. J Immunol 154:1707-1716.
52. Waga S, Hanon GJ, Beach D, Stillman B (1994): The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:574-578.
53. Wang E, Pandey S (1995): Down-regulation of statin, a nonproliferation-specific nuclear protein, and up-regulation of c-myc after initiation of programmed cell death in mouse fibroblasts. J Cell Physiol 163:155-163.
54. Wyllie AH (1995): The genetic regulation of apoptosis. Curr Opin Genet Dev 5:97-104.
55. Xiong Y, Hanon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993): p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704.
56. Zhang H, Hanon GJ, Beach D (1994): p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8:1750-1758.