Chromosome fragmentation resulting from an inability to repair transposase-induced DNA double-strand breaks in PCNA mutants of Drosophila

Mutagenesis

Volumn 13, Issue 1, 1998, Pages 57-60

  Henderson, Daryl S ^a   Glover, David M ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DNA; TRANSPOSASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DROSOPHILA; MITOSIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; TRANSPOSON;

ANIMALS; CHROMOSOME BREAKAGE; DNA; DNA DAMAGE; DNA REPAIR; DNA TRANSPOSABLE ELEMENTS; DROSOPHILA; FEMALE; MALE; MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; TRANSPOSASES;

ANIMALIA;

EID: 0031982685     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/13.1.57     Document Type: Article

References (39)

1. Ayyagari, R., Impellizzeri, K.J., Yoder, B.L., Gary, S.L. and Burgers, P.M.J. (1995) A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair. Mol. Cell. Biol., 15, 4420-4429.
2. Badie, C. et al. (1995) Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient. Cancer Res., 55, 1232-1234.
3. Banga, S.S., Velazquez, A. and Boyd, J.B. (1991) P transposition in Drosophila provides a new tool for analyzing postreplication repair and double-strand break repair. Mutat. Res., 255, 79-88.
4. Beall, E.L. and Rio, D.C. (1996) Drosophila IRBP/Ku p70 corresponds to the mutagen-sensitive mus309 gene and is involved in P-element excision in vivo. Genes Dev., 10, 921-933.
5. Celis, J.E. and Madsen, P. (1986) Increased nuclear cyclin/PCNA antigen staining of non S-phase transformed human cells engaged in nucleotide excision DNA repair. FEBS Lett., 209, 277-283.
6. Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc. Natl Acad. Sci. USA, 93, 11597-11602.
7. Engels, W.R., Benz, W.K., Preston, C.R., Graham, P.L., Phillis, R.W. and Robertson, H.M. (1987) Somatic effects of P element activity in Drosophila melanogaster: pupal lethality. Genetics, 117, 745-757.
8. Engels, W.R., Johnson-Schlitz, D.M., Eggleston, W.B. and Sved, J. (1990) High-frequency P element loss in Drosophila is homolog-dependent. Cell, 62, 515-525.
9. Finnie, N.J., Gottlieb, T.M., Blunt, T., Jeggo, P.A. and Jackson, S.P. (1995) DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl Acad. Sci. USA, 92, 320-324.
10. Frankenberg-Schwager, M. (1990) Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells. Radiat. Environ. Biophys., 29, 273-292.
11. Frosina, G., Fortini, P., Rossi, O., Carrozzino, F., Raspaglio, G., Cox, L.S., Lane, D.P., Abbondandolo, A. and Dogliotti, E. (1996) Two pathways for base excision repair in mammalian cells. J Biol. Chem., 271, 9573-9578.
12. Gatti, M. and Goldberg, M.L. (1991) Mutations affecting cell division in Drosophila. Methods Cell Biol., 35, 543-586.
13. Gloor, G.B., Nassif, N.A., Johnson-Schlitz, D.M., Preston, C.R. and Engels, W.R. (1991) Targeted gene replacement in Dmsophila via P element-induced gap repair. Science, 253, 1110-1117.
14. Gonzalez, C. and Glover, D.M. (1993) Techniques for studying mitosis in Drosophila. In Fantes, P. and Brooks, R. (eds), The Cell Cycle: A Practical Approach. IRL Press, Oxford, UK, pp. 143-175.
15. Haber, J.E. (1995) In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases. BioEssays, 17, 609-620.
16. Hari, K.L., Santerre, A., Sekelsky, J.J., McKim, K.S., Boyd, J.B. and Hawley, R.S. (1995) The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene. Cell, 82, 815-821.
17. Henderson, D.S., Banga, S.S., Grigliatti, T.A. and Boyd, J.B. (1994) Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA. EMBO J., 13, 1450-1459.
18. Iliakis, G. (1991) The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. BioEssays, 13, 641-648.
19. Jeggo, P.A., Taccioli, G.E. and Jackson, S.P. (1995) Menage à trois: double strand break repair, V(D)J recombination and DNA-PK. BioEssays. 17, 949-957.
20. Jessberger, R., Schär, P., Robins, P, Ferrari, E., Riwar, B. and Hübscher, U. (1997) Regulation of DNA metabolic enzymes upon induction of preB cell development and V(D)J recombination: up-regulation of DNA polymerase δ. Nucleic Acids Res., 25, 289-296.
21. Kelman, Z. (1997) PCNA: structure, function and interactions. Oncogene, 14, 629-640.
22. LaBaer, J., Garrett, M.D., Stevenson, L.F., Slingerland, J.M., Sandhu, C., Chou, H.S., Fattaey, A. and Harlow, E. (1997) New functional activities for the p21 family of CDK inhibitors. Genes Dev., 11, 847-862.
23. Li, X., Li, J., Harrington, J., Lieber, M.R. and Burgers, P.M.J. (1995) Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen. J. Biol. Chem., 270, 22109-22112.
24. Lieber, M.R., Grawunder, U., Wu, X. and Yaneva, M. (1997) Tying loose ends: roles of ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr. Opin. Genet. Dev., 7, 99-104.
25. Lindsley, D.L. and Zimm, G.G. (1992) The Genome of Drosophila melanogaster. Academic Press, San Diego, CA.
26. Matsumoto, Y., Kim, K. and Bogenhagen, D.F. (1994) Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair. Mol. Cell. Biol., 14, 6187-6197.
27. McConnell, M., Miller, H., Mozzherin, D.J., Quamina, A., Tan, C.-K., Downey, K.M. and Fisher, P.A. (1996) The mammalian DNA polymerase δ-proliferating cell nuclear antigen-template-primer complex: molecular characterization by direct binding. Biochemistry, 35, 8268-8274.
28. Miura, M., Domon, M., Sasaki, T. and Takasaki, Y. (1992) Induction of proliferating cell nuclear antigen (PCNA) complex formation in quiescent fibroblasts from a xeroderma pigmentosum patient. J. Cell Physiol., 150, 370-376.
29. Morgan, W.F., Day, J.P., Kaplan, M.I., McGhee, E.M. and Limoli, C.L. (1996) Genomic instability induced by ionizing radiation. Radiat. Res., 146, 247-258.
30. Nassif, N., Penney, J., Pal, S., Engels, W.R. and Gloor, G.B. (1994) Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair. Mol. Cell. Biol., 14, 1613-1625.
31. Nichols, A.F. and Sancar, A. (1992) Purification of PCNA as a nucleotide excision repair protein. Nucleic Acids Res., 20, 2441-2446.
32. Pagano, M., Theodoras, A.M., Tam, S.W. and Draetta, G.F. (1994) Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev., 8, 1627-1639.
33. Rio, D.C., Barnes, G., Laski, F.A., Rine, J. and Rubin, G.M. (1988) Evidence for Drosophila P element transposase acitivity in mammalian cells and yeast. J. Mol. Biol., 200, 411-115.
34. Roiha, H., Rubin, G.M. and O'Hare, K. (1988) P element insertions and rearrangements at the singed locus of Drosophila melanogaster. Genetics, 119, 75-83.
35. Shivji, M.K.K., Kenny, M.K. and Wood, R.D. (1992) Proliferating cell nuclear antigen is required for DNA excision repair. Cell, 69, 367-374.
36. Toschi, L. and Bravo, R. (1988) Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis. J. Cell Biol., 107, 1623-1628.
37. + cell cycle checkpoint pathway. Mol. Biol. Cell, 7, 651-662.
38. Waga, S., Bauer, G. and Stillman, B. (1994) Reconstitution of complete SV40 DNA replication with purified replication factors. J. Biol. Chem., 269, 10923-10934.
39. Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair. Oncogene, 14, 2313-2321.