Distribution of the CCR5 gene 32-base pair deletion in Israeli ethnic groups

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 20, Issue 1, 1999, Pages 81-84

  Kantor, Rami ^a,b   Gershoni, Jonathan M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

AIDS; CCR5; Epidemiology; Ethnic groups; HIV; Israelis

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; BASE PAIRING; CLINICAL ARTICLE; DELETION MUTANT; ETHNIC GROUP; GENE DELETION; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; ISRAEL; JEW; PRIORITY JOURNAL;

HUMAN IMMUNODEFICIENCY VIRUS 1; PIERINAE; RNA VIRUSES;

EID: 0032900150     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199901010-00012     Document Type: Article

References (26)

1. 8+ T cells. Science 1995;270:1811-15.
2. Paxton WA, Martin SR, Tse D, et al. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nat Med 1996; 2:412-17.
3. Feng Y, Broder CC, Kennedy PE, Berger EA. HIV entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1988;272:872-7.
4. Deng H, Liu R, Ellmeier W, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 1996;381:661-6.
5. 4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996;381:667-73.
6. Doranz BJ, Rucker J, Yi Y, et al. A dual-tropic primary HIV-1 isolate that uses fuscin and the b-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 1996;85:1149-58.
7. Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1a, MIP-1b receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996;272:1955-58.
8. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 1996;86:367-77.
9. Zimmerman PA, Buckler-White A, Alkhatib G, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 1997;3:23-36.
10. Bleul CC, Farzan M, Choe H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996;382:829-33.
11. Oberlin E, Amara A, Bachelerie F, et al. The CXC chemokine SDF-I is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 1996;382:833-35.
12. Arenzana-Seisdedos F, Virelizier JL, Rousset D. HIV blocked by chemokine antagonist. Nature 1996;383:400.
13. Simmons G, Clapham PR, Picard L, et al. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 1997;276:276-9.
14. Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996;382:722-5.
15. Huang Y, Paxton WA, Wolinski SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996;2:1240-3.
16. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 1996;273:1856-62.
17. Michael NL, Chang G, Louie LG, et al. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat Med 1997;3:338-40.
18. Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet 1997;16:100-3.
19. Eugen-Olsen J, Iversen AKN, Garred P, et al. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS 1997;11:305-10.
20. Voevodin A, Samilchuk E, Dashti S. A survey for 32 nucleotide deletion in the CCR-5 chemokine receptor gene (Δccr-5) conferring resistance to human immunodeficiency virus type 1 in different ethnic groups and in chimpanzees. J Med Virol 1998;55:147-51.
21. Libert F, Cochaux P, Beckman G, et al. The Δccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. Hum Mol Genet 1998:7:399-406.
22. Stephens JC, Reich DE, Goldstein DB, et al. Dating the origin of the CCR5-Δ32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet 1998;62:1507-15.
23. Bonné-Tamir B, Adam A. Genetic diversities among Jews. Diseases and markers at the DNA level. New York: Oxford University Press, 1992.
24. Goodman RM, Motulsky AG. Genetic diseases among Ashkenazi Jews. New York: Raven Press, 1979.
25. Motulsky AG. Jewish diseases and origins. Nat Genet 1995:9:99-101.
26. Ankori Z. Origins and history of Ashkenazi Jewry (8th to 18th century). In Goodman RM, Motulsky AG, eds. Genetic diseases among Ashkenazi Jews. New York: Raven Press, 1979:25-27.