-
1
-
-
0029903713
-
Redesigning drug discovery
-
Glaxo-Wellcome (1996) Redesigning drug discovery. Nature (London) 384 (Suppl.), 1-5
-
(1996)
Nature (London)
, vol.384
, Issue.SUPPL.
, pp. 1-5
-
-
-
2
-
-
84995665814
-
Combinatorial chemistry and new drugs
-
Plunkett, M. J., and Ellman, J. A. (1997) Combinatorial chemistry and new drugs. Sci. Am. 55-59
-
(1997)
Sci. Am.
, pp. 55-59
-
-
Plunkett, M.J.1
Ellman, J.A.2
-
3
-
-
0030015794
-
Recombinant technique and gonadotropins production: New era in reproductive medicine
-
Shoham, Z., and Insler, V. (1996) Recombinant technique and gonadotropins production: new era in reproductive medicine. Fertil. Steril. 66, 187-201
-
(1996)
Fertil. Steril.
, vol.66
, pp. 187-201
-
-
Shoham, Z.1
Insler, V.2
-
4
-
-
0026440307
-
Molecular basis of the specificity of binding of glycoprotein hormones to their receptors
-
Combarnous, V. (1992) Molecular basis of the specificity of binding of glycoprotein hormones to their receptors. Endocr. Rev. 13, 670-691
-
(1992)
Endocr. Rev.
, vol.13
, pp. 670-691
-
-
Combarnous, V.1
-
5
-
-
0032053545
-
Partially deglycosylated human choriogonadotropin, stabilized by intersubunit disulfide bonds, shows full bioactivity
-
Heikoop, J. C., van den Boogaart, P., de Leeuw, R., Rose, U. M., Mulders, J. W. M., and Grootenhuis, P. D. J. (1998) Partially deglycosylated human choriogonadotropin, stabilized by intersubunit disulfide bonds, shows full bioactivity. Eur. J. Biochem. 253, 354-356
-
(1998)
Eur. J. Biochem.
, vol.253
, pp. 354-356
-
-
Heikoop, J.C.1
Van Den Boogaart, P.2
De Leeuw, R.3
Rose, U.M.4
Mulders, J.W.M.5
Grootenhuis, P.D.J.6
-
7
-
-
0028890259
-
Glycoprotein hormones: Glycobiology of gonadotrophins, thyrotrophin and free a subunit
-
Thotakura, N. R., and Blithe, D. L. (1995) Glycoprotein hormones: glycobiology of gonadotrophins, thyrotrophin and free a subunit. Glycobiology 5, 3-10
-
(1995)
Glycobiology
, vol.5
, pp. 3-10
-
-
Thotakura, N.R.1
Blithe, D.L.2
-
8
-
-
0029833455
-
In vitro fertilisation. A review of drug therapy and clinical management
-
Jennings, J. C., Moreland, K., and Peterson, C. M. (1996) In vitro fertilisation. A review of drug therapy and clinical management. Drugs 52, 313-343
-
(1996)
Drugs
, vol.52
, pp. 313-343
-
-
Jennings, J.C.1
Moreland, K.2
Peterson, C.M.3
-
9
-
-
0031453639
-
Expression of recombinant glycoproteins in the simple eukaryote Dictyostelium discoideum
-
Slade, M., Emslie, K., and Williams, K. L. (1997) Expression of recombinant glycoproteins in the simple eukaryote Dictyostelium discoideum. Biotech. Genet. Engin. Rev. 14, 1-35
-
(1997)
Biotech. Genet. Engin. Rev.
, vol.14
, pp. 1-35
-
-
Slade, M.1
Emslie, K.2
Williams, K.L.3
-
10
-
-
0031056155
-
The production of recombinant glycoproteins with special reference to simple eukaryotes including Dictyostelium discoideum
-
Jung, E., and Williams, K. L. (1997) The production of recombinant glycoproteins with special reference to simple eukaryotes including Dictyostelium discoideum. Biotechnol. Appl. Biochem. 25, 3-8
-
(1997)
Biotechnol. Appl. Biochem.
, vol.25
, pp. 3-8
-
-
Jung, E.1
Williams, K.L.2
-
11
-
-
0031034484
-
Random mutagenesis of the cAMP chemoattractant receptor, cAR1, of Dictyostelium
-
Kim, J-Y., Caterina, M.J., Milne, J. L. S., Lin, K. C., Borleis, J. A., and Devreotes, P. N. (1997) Random mutagenesis of the cAMP chemoattractant receptor, cAR1, of Dictyostelium. J. Biol. Chem. 272, 2060-2068
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 2060-2068
-
-
Kim, J.-Y.1
Caterina, M.J.2
Milne, J.L.S.3
Lin, K.C.4
Borleis, J.A.5
Devreotes, P.N.6
-
12
-
-
0028858532
-
Expression of the human muscarinic receptor gene m2 in Dictyostelium discoideum
-
Voith, G., and Dingermann, T. (1995) Expression of the human muscarinic receptor gene m2 in Dictyostelium discoideum. Bio/Technology 13, 1225-1229
-
(1995)
Bio/Technology
, vol.13
, pp. 1225-1229
-
-
Voith, G.1
Dingermann, T.2
-
13
-
-
0029870412
-
Functional expression of rat GLUT 1 glucose transporter in Dictyostelium discoideum
-
Cohen, N. R., Knecht, D. A., and Lodish, H. F. (1996) Functional expression of rat GLUT 1 glucose transporter in Dictyostelium discoideum. Biochem. J. 315, 971-975
-
(1996)
Biochem. J.
, vol.315
, pp. 971-975
-
-
Cohen, N.R.1
Knecht, D.A.2
Lodish, H.F.3
-
14
-
-
0025895731
-
Expression of the human antithrombin III in the cellular slime mould Dictyostelium discoideum
-
Dingermann, T., Troidl, E.-M., Broker, M., and Nerke, K. (1991) Expression of the human antithrombin III in the cellular slime mould Dictyostelium discoideum. Appl. Microbiol Biotechnol. 35, 496-503
-
(1991)
Appl. Microbiol Biotechnol.
, vol.35
, pp. 496-503
-
-
Dingermann, T.1
Troidl, E.-M.2
Broker, M.3
Nerke, K.4
-
15
-
-
0030920571
-
Evaluation of subunit truncation and the nature of the spacer for single chain human gonadotropins
-
Heikoop, J. C., van Beuningen-de Vaan, M. J. A.C. M., van den Boogaart, P., and Grootenhuis, P. D. J. (1997) Evaluation of subunit truncation and the nature of the spacer for single chain human gonadotropins. Eur. J. Biochem. 245, 656-662
-
(1997)
Eur. J. Biochem.
, vol.245
, pp. 656-662
-
-
Heikoop, J.C.1
Van Beuningen-De Vaan, M.J.A.C.M.2
Van Den Boogaart, P.3
Grootenhuis, P.D.J.4
-
16
-
-
0031692251
-
Expression of a bioactive, single chain choriogonadotropin in Dictyostelium discoideum
-
Heikoop, J. C., Grootenhuis, P. D. J., Blaauw, M., Veldema, J. S., van Haastert, P. J. M., and Linskens, M. H. K. Expression of a bioactive, single chain choriogonadotropin in Dictyostelium discoideum. Eur. J. Biochem., 256, 359-363
-
Eur. J. Biochem.
, vol.256
, pp. 359-363
-
-
Heikoop, J.C.1
Grootenhuis, P.D.J.2
Blaauw, M.3
Veldema, J.S.4
Van Haastert, P.J.M.5
Linskens, M.H.K.6
-
17
-
-
0008792636
-
Chorionic gonadotropins: Comparative studies and comments on relationships to other glycoprotein hormones
-
Segal, S. J., ed Plenum Press, New York
-
Moore, W. T., Burleigh, B. D., and Ward, D. N. (1980) Chorionic gonadotropins: comparative studies and comments on relationships to other glycoprotein hormones. In Chorionic Gonadotropin (Segal, S. J., ed) pp. 89-126, Plenum Press, New York
-
(1980)
Chorionic Gonadotropin
, pp. 89-126
-
-
Moore, W.T.1
Burleigh, B.D.2
Ward, D.N.3
-
18
-
-
0027459706
-
-
Huang, J., Ujihara, M., Xia, H., Chen, F., Yoshida, H., and Puett, D. (1993) Mol. Cell. Endocr. 90, 211-218
-
(1993)
Mol. Cell. Endocr.
, vol.90
, pp. 211-218
-
-
Huang, J.1
Ujihara, M.2
Xia, H.3
Chen, F.4
Yoshida, H.5
Puett, D.6
-
19
-
-
0028133413
-
Plasmid maintenance functions encoded on Dictyostelium discoideum nuclear plasmid Dpdl
-
Hughes, J. E., Kiyosawa, H., and Welker, D. L. (1994) Plasmid maintenance functions encoded on Dictyostelium discoideum nuclear plasmid Dpdl. Mol. Cell. Biol. 14, 6117-6124
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6117-6124
-
-
Hughes, J.E.1
Kiyosawa, H.2
Welker, D.L.3
-
20
-
-
0024967181
-
Codon usage and gene expression level in Dictyostelium discoideum: Highly expressed genes do 'prefer' optimal codons
-
Sharp, P. M., and Devine, M. (1989) Codon usage and gene expression level in Dictyostelium discoideum: highly expressed genes do 'prefer' optimal codons. Nucleic Acids Res. 17, 5029-5039
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 5029-5039
-
-
Sharp, P.M.1
Devine, M.2
-
21
-
-
85016731055
-
Using PCR to engineer DNA
-
Erlich, H. A., ed Stockton Press, New-York
-
Higuchi, R. (1989) Using PCR to engineer DNA. In PCR Technology; Principles and Applications for DNA Amplification (Erlich, H. A., ed) pp. 61-70, Stockton Press, New-York
-
(1989)
PCR Technology; Principles and Applications for DNA Amplification
, pp. 61-70
-
-
Higuchi, R.1
-
22
-
-
0030873203
-
Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins
-
Heikoop, J. C., van den Boogaart, P., Mulders, J. W. M., and Grootenhuis, P. D. J. (1997) Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins. Nature Biotechnol. 15, 658-662
-
(1997)
Nature Biotechnol.
, vol.15
, pp. 658-662
-
-
Heikoop, J.C.1
Van Den Boogaart, P.2
Mulders, J.W.M.3
Grootenhuis, P.D.J.4
-
23
-
-
0028239813
-
Crystal structure of human chorionic gonadotropin
-
Lapthorn, A. J., Harris, D. C., Littlejohn, A., Lustbader, J. W., Canfield, R. E., Machin, K. J., Morgan, F. J., and Isaacs, N. W. (1994) Crystal structure of human chorionic gonadotropin. Nature (London) 369, 455-461
-
(1994)
Nature (London)
, vol.369
, pp. 455-461
-
-
Lapthorn, A.J.1
Harris, D.C.2
Littlejohn, A.3
Lustbader, J.W.4
Canfield, R.E.5
Machin, K.J.6
Morgan, F.J.7
Isaacs, N.W.8
-
24
-
-
0028773646
-
Structure of the human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein
-
Wu, H., Lustbader, J. W., Liu, Y., Canfield, R. E., and Hendrickson, W. A. (1994) Structure of the human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein. Structure 2, 545-558
-
(1994)
Structure
, vol.2
, pp. 545-558
-
-
Wu, H.1
Lustbader, J.W.2
Liu, Y.3
Canfield, R.E.4
Hendrickson, W.A.5
-
25
-
-
0025880137
-
Delineation via site-directed mutagenesis of the carboxyl-terminal region of human choriogonadotropin beta required for subunit assembly and biological activity
-
Chen, F., and Puett, D. J. (1991) Delineation via site-directed mutagenesis of the carboxyl-terminal region of human choriogonadotropin beta required for subunit assembly and biological activity. J. Biol. Chem. 266, 6904-6908
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 6904-6908
-
-
Chen, F.1
Puett, D.J.2
-
26
-
-
0030606149
-
HCG-β residues 94-96 alter LH activity without appearing to make key receptor contacts
-
Han, Y., Bernard, M. P., and Moyle, W. R. (1996) HCG-β residues 94-96 alter LH activity without appearing to make key receptor contacts. Mol. Cell. Endocr. 124, 151-161
-
(1996)
Mol. Cell. Endocr.
, vol.124
, pp. 151-161
-
-
Han, Y.1
Bernard, M.P.2
Moyle, W.R.3
-
27
-
-
0011958990
-
High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries
-
Yanofsky, S. D., Baldwin, D. N., Butler, J. H., Holden, F R., Jacobs, J. W., Balasubramanian, P., Chinn, J. P., Cwirla, S. E., Peters-Bhatt, E., Whitehorn, E. A., Tate, E. H., Akeson, A., Bowlin, T. L., Dower, W. J., and Barrett, R. W. (1996) High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries. Proc. Natl. Acad. Sci. U. S. A. 93, 7381-7386
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 7381-7386
-
-
Yanofsky, S.D.1
Baldwin, D.N.2
Butler, J.H.3
Holden, F.R.4
Jacobs, J.W.5
Balasubramanian, P.6
Chinn, J.P.7
Cwirla, S.E.8
Peters-Bhatt, E.9
Whitehorn, E.A.10
Tate, E.H.11
Akeson, A.12
Bowlin, T.L.13
Dower, W.J.14
Barrett, R.W.15
-
28
-
-
9444236174
-
Small peptides as potent mimetics of the protein hormone erythropoietin
-
Wrighton, N. C., Farrell, F. X., Chang, R., Kashyap, A. K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K., and Dower, W. J. (1996) Small peptides as potent mimetics of the protein hormone erythropoietin. Science 273, 458-463
-
(1996)
Science
, vol.273
, pp. 458-463
-
-
Wrighton, N.C.1
Farrell, F.X.2
Chang, R.3
Kashyap, A.K.4
Barbone, F.P.5
Mulcahy, L.S.6
Johnson, D.L.7
Barrett, R.W.8
Jolliffe, L.K.9
Dower, W.J.10
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