Partially deglycosylated human choriogonadotropin, stabilized by intersubunit disulfides bonds, shows full bioactivity

European Journal of Biochemistry

Volumn 253, Issue 1, 1998, Pages 354-356

  Heikoop, Judith C ^a   Van Den Boogaart, Paul ^a   De Leeuw, Renato ^a   Rose, Ursula M ^a   Mulders, John W M ^a   Grootenhuis, Peter D J ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Bioactivity; Glycoprotein; Human choriogonadotropin; Protein engineering; Signal transduction

Indexed keywords

CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DEGLYCOSYLATION; DISULFIDE BOND; DRUG ACTIVITY; DRUG RECEPTOR BINDING; GENETIC ENGINEERING; HUMAN; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; CHO CELLS; CHORIONIC GONADOTROPIN; CRICETINAE; DISULFIDES; DRUG STABILITY; GLYCOSYLATION; HUMANS; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, LH; SIGNAL TRANSDUCTION; TEMPERATURE;

ANIMALIA;

EID: 0032053545     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2530354.x     Document Type: Article

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