IGF-I stimulation of muscle protein synthesis in the awake rat: Permissive role of insulin and amino acids

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 1 33-1, 1996, Pages

  Jacob, Ralph ^a   Xiaoyue, H U ^a   Niederstock, Doug ^a   Kasan, Syed ^a   McNulty, Patrick H ^a   Sherwin, Robert S ^a   Young, Lawrence H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

insulin like growth factor I

Indexed keywords

AMINO ACID; INSULIN; MUSCLE PROTEIN; SOMATOMEDIN C;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GASTROCNEMIUS MUSCLE; HEART MUSCLE METABOLISM; INSULIN BLOOD LEVEL; MALE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SOLEUS MUSCLE; WAKEFULNESS;

EID: 13344268999     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.1.e60     Document Type: Article

References (33)

1. Ashford, A. J., and V. M. Pain. Effect of diabetes on the rates of synthesis and degradation of ribosomes in rat muscle and liver in vivo. J. Biol. Chem. 261: 4059-4065, 1986.
2. Baxter, R. C. Insulin-like growth factor (IGF) binding proteins: the role of serum IGFBPs in regulating IGF availability. Acta Paediatr. Scand. 372: 107-114, 1991.
3. Behringer, R. R., T. M. Lewin, C. J. Quaife, R. D. Palmiter, R. L. Brinster, and A. J. D'ercole. Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice. Endocrinology 127: 1033-1039, 1990.
4. Boulware, S. D., W. V. Tamborlane, L. S. Mathews, and R. S. Sherwin. Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E130-E133, 1992.
5. Castellino, P., L. Luzi, D. C. Simonson, M. Haymond, and R. A. DeFronzo. Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. J. Clin. Invest. 80: 1784-1793, 1987.
6. Chen, Y., K. E. Bornfeldt, A. Arner, E. Jennische, U. Malmqvist, B. Uvelius, and H. J. Arnqvist. Increase in insulin-like growth factor I in hypertrophying smooth muscle. Am J. Physiol. 266 (Endocrinol. Metab. 29): E224-E229, 1994.
7. Cohick, W. S., A. Gockerman, and D. R. Clemmons. Vascular smooth muscle cells synthesize two forms of insulin-like growth factor binding proteins which are regulated differently by the insulin-like growth factors. J. Cell. Physiol. 157: 52-60, 1993.
8. Devol, D. L., P. Rotwein, J. L. Sadow, J. Novakofski, and P. J. Bechtel. Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E89-E95, 1990.
9. Donohue, T. J., L. D. Dworkin, M. N. Lango, K. Fliegner, R. P. Lango, J. A. Benstein, W. R. Slater, and V. M. Catanese. Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy. Circulation 89: 799-809, 1994.
10. Douglas, R. G., P. D. Gluckman, K. Ball, B. Breier, and J. H. F. Shaw. The effects of infusion of insulinlike growth factor (IGF) 1, IGF-2, and insulin on glucose and protein metabolism in fasted lambs. J. Clin. Invest. 88: 614-622, 1991.
11. Eliahi, D., M. McAloon-Dyke, N. K. Fukagawa, A. L. Sclater, G. A. Wong, R. P. Shannon, K. L. Minaker, J. M. Miles, A. H. Rubenstein, C. J. Vandepol, H.-P. Guler, W. R. Good, J. J. Seaman, and R. R. Wolfe. Effects of recombinant human IGF-I on glucose and leucine kinetics in men. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E831-E838, 1993.
12. Fryburg, D. A. Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E331-E336, 1994.
13. Fuller, S. J., J. R. Mynett, and P. H. Sugden. Stimulation of cardiac protein synthesis by insulin-like growth factors. Biochem J. 282: 85-90, 1992.
14. Furlanetto, R. W., L. E. Underwood, J. J. Van Wyk, and A. J. D'Ercole. Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J. Clin. Invest. 60: 648-657, 1977.
15. Guler, H. P., J. Zapf, E. Scheiwiller, and E. R. Froeseh. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomizedrats. Proc. Natl. Acad. Sci. USA 85: 4889-4893, 1988.
16. Gulve, E. A., and J. F. Dice. Regulation of protein synthesis and degradation in L8 myotubes. Biochem. J. 260: 377-387, 1989.
17. Ito, H., M. Hiroe, Y. Hirata, M. Tsujino, S. Adachi, M. Shichiri, A. Koike, A. Nogami, and F. Marumo. Insulin-like growth factor 1 induces hypertrophy with enhanced expression of muscle specific genes in culture rat cardiomyocytes. Circulation 87: 1715-1721, 1993.
18. Jacob, R., E. Barrett, G. Plewe, K. D. Fagin, and R. S. Sherwin. Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. J. Clin. Invest. 83: 1717-1723, 1989.
19. Koea, J. B., R. G. Douglas, B. H. Breier, J. H. F. Shaw, and P. D. Gluckman. Synergistic effect of insulin-like growth factor-I administration on the protein-sparing effects of total parenteral nutrition in fasted lambs. Endocrinology 131: 643-648, 1992.
20. Kupfer, J. M., and S. A. Rubin. Differential regulation of insulin-like growth factor I by growth hormone and thyroid hormone in the heart of juvenile hypophysectomized rats. J. Mol. Cell. Cardiol. 24: 631-639, 1992.
21. Kupfer, S. R., L. E. Underwood, R. C. Baxter, and D. R. Clemmons. Enhancement of the anabolic effects of growth hormone and insulin-like growth factor 1 by the use of both agents simultaneously. J. Clin. Invest. 91: 391-396, 1993.
22. Louard, R. J., D. A. Fryburg, R. A. Gelfand, and E. J. Barrett. Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle. J. Clin. Invest. 90: 2348-2354, 1992.
23. Mauras, N., F. F. Horber, and M. W. Haymond. Low dose recombinant human insulin-like growth factor-I fails to affect protein anabolism but inhibits islet cell secretion in humans. J. Clin. Endocrinol. Metab. 75: 1192-1197, 1992.
24. McNulty, P. H., L. H. Young, and E. J. Barrett. Response of rat heart and skeletal muscle to insulin and amino acid infusion. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E958-E965, 1993
25. Monier, S., and Y. L. Marchand-Brustel. Effects of insulin and IGF-I on RNA synthesis in isolated soleus muscle. Mol. Cell. Endocrinol. 37: 109-114, 1984.
26. Pain, V. M., and P. J. Garlick. Effect of streptozoticin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo. J. Biol. Chem. 249: 4510-4514, 1974.
27. Russell-Jones, D. L., A. M. Urapleby, T. R. Hennessy, S. B. Bowes, F. Shojaee-Moradie, K. D. Hopkins, N. C. Jackson, J. M. Kelly, R. H. Jones, and P. H. Sonksen. Use of leucine clamp to demonstrate that IGF-I actively stimulates protein synthesis in normal humans. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E591-E598, 1994.
28. Turkalj, I., U. Keller, R. Ninnis, S. Vosmeer, and W. Stauffacher. Effect of increasing doses of recombinant human insulin-like growth factor I on glucose, lipid and leucine metabolism in man. J. Clin Endocrinol. Metab. 75: 1186-1191, 1992.
29. Turner, J. D., P. Rotwein, J. Novakofski, and P. J. Beehtel. Induction of mRNA for IGF-I and -II during growth hormone-stimulated muscle hypertrophy. Am. J. Physiol. 255 (Endocrinol. Metab. 18): E513-E517, 1988.
30. Walker, J. L., M. G. Malinowska, T. E. Romer, J. B. Pucilowska, and L. E. Underwood. Effects of the infusion of insulin-like growth factor in a child with growth hormone insensitivity syndrome (Laron dwarfism). N. Engl. J. Med. 324: 1483-1488, 1991.
31. Watt, P. W., M. E. Corbett, and M. J. Rennie. Stimulation of protein synthesis in pig skeletal muscle by infusion of amino acids during constant insulin availability. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E453-E460, 1992.
32. Young, L. H., D. M. Dahl, D. Rauner, and E. J. Barrett. Physiological hyperinsulinemia inhibits myocardial protein degradation in vivo in the canine heart. Cire. Res. 71: 393-400, 1992.
33. Young, L. H., W. Stirewalt, P. McNulty, J. H. Revkin, and E. J. Barrett. Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo. Am. J. Pkysiol. 267 (Endocrinol. Metab. 30): E337-E342, 1994.