Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders

Journal of Affective Disorders

Volumn 40, Issue 1-2, 1996, Pages 7-13

  Manki, Hiroshi ^a   Kanba, Shigenobu ^a   Muramatsu, Taro ^b   Higuchi, Susumu ^b   Suzuki, Eiji ^a   Matsushita, Sachio ^b   Ono, Yutaka ^a   Chiba, Hiromi ^a   Shintani, Futoshi ^a   Nakamura, Makoto ^a   Yagi, Gohei ^a   Asai, Masahiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KURIHAMA NATIONAL HOSPITAL   (Japan)

Author keywords

Bipolar disorder; Dopamine receptor; Dopamine transporter; Major depression; Mood disorder; Polymorphism

Indexed keywords

DOPAMINE RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; GENETICS; HUMAN; MAJOR CLINICAL STUDY; MALE; MOOD; PRIORITY JOURNAL;

EID: 0030576998     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-0327(96)00035-3     Document Type: Article

References (35)

1. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders. 3rd Edn - Revised, American Psychiatric Association, Washington, DC.
2. Arinami, T., Itokawa, M., Enguchi, H., Tagaya, H., Yano, S., Shimizu, H., Hamaguchi, H. and Toru, M. (1994) Association of dopamine D2 receptor molecular variant with schizophrenia. Lancet 343, 703-704.
3. Baron, M., Freimer, N.F., Risch, N., Lerer, B., Alexander, J.R., Straub, R.E., Asokan, S., Das, K., Peterson, A., Amos, J., Endicott, J., Otto, J. and Gilliam, T.C. (1993) Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nature Genet. 3, 49-55.
4. Benjamin, J.B., Li, L., Patterson, C., Greenberg, B.D., Murphy, D.L. and Hamer, D.H. (1996) Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nature Genet. 12, 81-84.
5. Craddock, N. and McGuffin, P. (1993) Approaches to the genetics of affective disorders. Ann. Med. 25, 317-322.
6. De bruyn, A., Mendelbaum, K., Sandkuijl, L.A., Delvenne, V., Hirsch, D., Staner, L., Mendlewicz, J. and Van Broeckhoven, C. (1994) Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11. Am. J. Psychiatry 151, 102-106.
7. Detera-Wadleich, S.D., Berrettini, W.H., Goldin, L.R., Boorman, D., Anderson, S. and Gershon, E.S. (1987) Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees. Nature 325, 806-808.
8. Ebstein, R.P., Novick, O., Umansky, R., Priel, B., Osher, Y., Blaine, D., Bennett, E.R., Nemanov, L., Katz, M. and Belmaker, R.H. (1996) Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Genet. 12, 78-80.
9. Egeland, J.A., Gerhard, D.S., Pauls, D.L., Sussex, J.N., Kidd, K.K., Allen, C.R., Hostetter, A.M. and Housman, D.E. (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325, 783-787.
10. Gejman, P.V., Ram, A., Gelernter, J., Friedman, E., Cao, Q., Pickar, D., Blum, K., Noble, E.P., Kranzler, H.R., O'Malley, S., Hamer, D.H., Whitsitt, F., Rao, P., DeLisi, L.E., Virkkunen, M., Linnoila, M., Goldman, D. and Gershon, E.S. (1994) No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. J. Am. Med. Ass. 271, 204-208.
11. Gill, M., McKeon, P. and Humphries, P. (1988) Linkage analysis of manic depression in an Irish family using H-ras 1 and INS DNA markers. J. Med. Genet. 25, 634-635.
12. Gingrich, J.A. and Caron, M.G. (1993) Recent advances in the molecular biology of dopamine receptors. Annu. Rev. Neurosci. 16, 299-321.
13. Giros, B., El Mestikawy, S., Godinot, N., Zheng, K., Han, H., Yang, F.T. and Caron, M.G. (1992) Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol. Pharmacol. 42, 383-390.
14. Higuchi, S., Muramatsu, T., Murayama, M. and Hayashida, M. (1994) Association of structural polymorphism of the dopamine D2 receptor gene and alcoholism. Biochem. Biophys. Res. Commun. 204, 1199-1205.
15. Higuchi, S., Muramatsu, T., Arai, H., Hayashida, M., Sasaki, H. and Trojanowski, J.Q. (1995) Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease. J. Neural. Transm. [P-D sect] 10, 107-113.
16. Hodgkinson, S., Sherrington, R., Gurling, H., Marchbanks, R., Reeders, S., Mallet, J., McInnis, M., Petursson, H. and Brynjolfsson, J. (1987) Molecular genetic evidence for heterogeneity in manic depression. Nature 325, 805-806.
17. Itokawa, M., Arinami, T., Futamura, N., Hamaguchi, H. and Toru, M. (1993) A structural polymorphism of human dopamine D2 receptor, D2(Ser311 → Cys). Biochem. Biophys. Res. Commun. 196, 1369-1375.
18. Kelsoe, J.R., Ginns, E.I., Egeland, J.A., Gerhard, D.S., Goldstein, A.M., Bale, S.J., Pauls, D.L., Long, R.T., Kidd, K.K., Conte, G., Housman, D.E. and Paul, S.M. (1989) Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342, 238-243.
19. Lannfelt, L., Sokoloff, P., Martres M.P., Pilon, C., Giros, B., Jonsson, E., Sedvall, G. and Schwartz, J.C. (1992) Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders. Psychiatr. Genet. 2, 249-256.
20. Lim, L.C., Nöthen, M.M., Körner, J., Rietschel, M., Castle, D., Hunt, N., Propping, P., Murray, R. and Gill, M. (1994) No evidence of association between dopamine D4 receptor variants and bipolar affective disorder. Am. J. Med. Genet. 54, 259-263.
21. Macciardi, F., Cavallini, M., Petronis, A., Marino, C., Verga, M., Cauli, G., Serretti, A., Kennedy, J.L. and Smeraldi, E. (1994) The D4 receptor gene and mood disorders: an association study. Am. J. Hum. Genet. 55, A336 (Abstract).
22. Mendlewicz, J., Simon, P., Sevy, S., Charon, F., Brocas, H., Legros, S. and Vassart, G. (1987) Polymorphic DNA marker on X chromosome and manic depression. Lancet i, 1230-1232.
23. Muramatsu, T., Higuchi, S., Murayama, M., Matsushita, S. and Hayashida, M. (1996) Association between alcoholism and the dopamine D4 receptor gene. J. Med. Genet. 33, 113-115.
24. Nurnberger, J.I. Jr. and Gershon, E.S. (1992) Genetics. In E.S. Paykel (Ed.), Handbook of Affective Disorders. 2nd Edn. Churchill Livingstone, Edinburgh, pp. 131-148.
25. Pauls, D.L., Gerhard. D.S., Lacy, L.G., Hostetter, A.M., Allen, C.R., Bland, S.D., LaBuda, M.C. and Egeland, J.A. (1991) Linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of Amish pedigree 110. Genomics 11, 730-736.
26. Pérez de Castro, I., Torres, P., Fernandez, P.J., Saiz, R.J. and Llinares, C. (1994) No association between dopamine D4 receptor polymorphism and manic depressive illness. J. Med. Genet. 31, 897-898.
27. Rietschel, M., Nöthen, M.M., Lannfelt, L., Sokoloff, P., Schwartz, J.C., Lanczik, M., Fritze, J., Cichon, S., Fimmers, R., Körner, J., Möller, H.J. and Propping, P. (1993) A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder. Psychiatry Res. 46, 253-259.
28. Ross, E.M. (1989) Signal sorting and amplification through G protein-coupled receptors. Neuron 3, 141-152.
29. Sano, A., Kondoh, K., Kakimoto, Y. and Kondo, I. (1993) A 40-nucleotide repeat polymorphism in the human dopamine transporter gene. Hum. Genet. 91, 405-406.
30. Seeman, P., Lee, T., Chau-Wong, M. and Wong, K. (1976) Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261, 717-719.
31. Shaikh, S., Ball, D., Craddock, N., Castle, D., Hunt, N., Mant, R., Owen, M., Collier, D. and Gill, M. (1993) The dopamine D3 receptor gene: no association with bipolar affective disorder. J. Med. Genet. 30, 308-309.
32. Sobell, J.L., Heston, L.L. and Sommer, S.S. (1992) Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. Genomics 12, 1-6.
33. Van Tol, H.H.M., Wu, C.M., Guan, H.C., Ohara, K., Bunzow, J.R., Civelli, O., Kennedy, J., Seeman, P., Niznik, H.B. and Jovanovic, V. (1992) Multiple dopamine D4 receptor variants in the human population. Nature 358, 149-152.
34. Vandenbergh, D.J., Persico, A.M., Hawkins, A.L., Griffin, C.A., Li, X., Jabs, E.W. and Uhl, G.R. (1992) Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 14, 1104-1106.
35. Willner, P. (1995) Dopamine mechanisms in depression and mania. In F.E. Bloom and D.J. Kupfer. (Eds.), Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, NY, pp. 921-931.