A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels

Biophysical Journal

Volumn 70, Issue 3, 1996, Pages 1303-1315

  VanDongen, Antonius M J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL;

ALGORITHM; ARTICLE; ION CONDUCTANCE; PROBABILITY; SIGNAL NOISE RATIO;

EID: 0030033867     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79687-X     Document Type: Article

References (29)

1. Akaike, H. 1981 Modern development of statistical methods. In Trends and Progress in System Identification. IFAC Series for Graduates, Research Workers and Engineers, Vol. 1. P. Eykhoff, editor. Pergamon, Oxford. 169-184.
2. Auerbach, A., and F. Sachs. 1983. Flickering of a nicotinic ion channel to a subconductance state. Biophys. J. 42:1-10.
3. Chung, S. H., V. Krishnamurthy, and J. B. Moore. 1991. Adaptive processing techniques based on hidden Markov models for characterizing very small channel currents buried in noise and deterministic interferences. Philos. Trans. R. Soc. Lond. Biol. 334:357-384.
4. Chung, S H., J. B. Moore, L. Xia, L. S. Premkumar, and P. W. Gage. 1990. Characterization of single channel currents using digital signal processing techniques based on Hidden Markov models. Philos. Trans. R. Soc. Lond. Biol. 329:265-285.
5. Colquhoun, D., and F. J. Sigworth. 1983. Fitting and statistical analysis of single-channel records. In Single-Channel Recording. E. Neher and B. Sakmann, editors. Plenum Press, New York. 191-263.
6. Cox, D. R., and D. V. Hinkley. 1974. Theoretical Statistics. Chapman and Hall Ltd., London.
7. Draber, S., and R. Schultze. 1994. Detection of jumps in single-channel data containing subconductance levels. Biophys. J. 67:1404-1413.
8. Ferguson, W. B., O. B. McManus, and K. L. Magleby. 1993. Opening and closing transitions for BK channels often occur in two steps via sojourns through a brief lifetime subconductance state. Biophys. J. 65:702-714.
9. Geletyuk, V. I., and V. N. Kazachenko. 1985. Single Cl channels in molluscan neurones: multiplicity of conductance states. J. Membr. Biol. 86:9-15.
10. Hamill, O. P., J. Bormann, and B. Sakmann. 1983. Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA. Nature. 305:805-808.
11. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch. 391:85-100.
12. Matsuda, H. 1988. Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells. J. Physiol. 397:237-258.
13. Nagy, K. 1987. Subconductance states of single sodium channels modified by chloramine-T and sea anemone toxin in neuroblastoma cells. Eur. Biophys. J. 15.129-132.
14. Neher, E., and B. Sakmann. 1976. Single-channel currents recorded from membrane of denervated frog muscle fibers Nature. 260:799-802.
15. Neher, E., and C. F. Stevens. 1977. Conductance fluctuations and ionic pores in membranes. Annu. Rev. Biophys. Bioeng. 6:345-381.
16. Nilius, B., J. Vereecke, and E. Carmeliet. 1989. Different conductance states of the bursting Na channel in guinea-pig ventricular myocytes. Pfluegers Arch. 413:242-248.
17. Patlak, J. B. 1988. Sodium channel subconductance levels measured with a new variance-mean analysis J. Gen. Physiol. 92:413-430.
18. Patlak, J. B. 1993. Measuring kinetics of complex single ion channel data using mean-variance histograms. Biophys. J. 65:29-42.
19. Rao, S. S. 1984. Optimization: theory and applications. Wiley Eastern Limited, New Delhi.
20. Root, M. J , and R. Mackinnon. 1994. Two identical noninteracting sites in an ion channel revealed by proton transfer. Science. 265:1852-1856.
21. Sachs, F. 1983. Automated analysis of single-channel records. In Single-Channel Recording. E. Neher and B. Sakmann. editors. Plenum Press, New York 265-285.
22. Sachs, F., J. Neil, and N. Barkakati. 1982. The automated analysis of data from single ionic channels. Pfluegers Archiv. Eur. J. Physiol. 395: 331-340.
23. Savitsky, A., and M. J. E. Golay. 1964. Smoothing and differentiation of data by simplified least squares procedures. Anal Chem. 36:1627-1639.
24. Sigworth, F. J. 1983. An example of analysis. In Single-Channel Recording B. Sakmann and E. Neher, editors. Plenum Press, New York. 301-321.
25. Sigworth, F. J., and S. M. Sine. 1987. Data transformations for improved display and fitting of single channel dwell-time histograms. Biophys. J. 52.1047-1054.
26. Silverman, B. W. 1986. Density estimation for statistics and data analysis. Chapman and Hall, New York.
27. Steinler, J., Y. Termonia, and J. Deltour. 1972. Comments on smoothing and differentiating data by simplified least square procedure. Anal. Chem. 44:1906-1909.
28. Tyerman, S D., and G. P. Findlay. 1992. Multiple conductances in the large K channel from Chara corallina shown by a transient analysis method. Biophys. J. 61:736-749.
29. VanDongen, A. M. J. 1992. TRANSIT: a new algorithm for analyzing single channel data containing multiple conductance levels. Biophys. J. 61:A256.