The antigenic composition of Neospora caninum

International Journal for Parasitology

Volumn 29, Issue 8, 1999, Pages 1175-1188

  Hemphill, A ^a   Fuchs, N ^a   Sonda, S ^a   Hehl, A ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL PARASITOSIS; ANTIGENICITY; ARTICLE; DIAGNOSTIC VALUE; NEOSPORA CANINUM; NONHUMAN; PARASITE DEVELOPMENT; PARASITE IDENTIFICATION; VACCINE PRODUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CATTLE; COCCIDIOSIS; DOGS; HOST-PARASITE RELATIONS; MICE; MOLECULAR SEQUENCE DATA; NEOSPORA;

ANIMALIA; BOS TAURUS; CANIS FAMILIARIS; NEOSPORA CANINUM; PROTOZOA; TOXOPLASMA GONDII;

EID: 0032867330     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(99)00085-5     Document Type: Article

References (82)

1. Dubey JP, Lindsay DS. A review of Neospora caninum and neosporosis. Vet Parasitol 1996;67:1-59.
2. Hemphill A. The host-parasite relationship in neosporosis. Adv Parasitol 1999; 43, 47-104.
3. Dubey JP, Carpenter JL, Speer CA, Topper MJ, Uggla A. Newly recognized fatal protozoan disease of dogs. J Am Vet Med Assoc 1988;192:1269-85.
4. Dubey JP, Hanel AL, Lindsay DS, Topper MJ. Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission. J Am Vet Med Assoc 1988;193:12591263.
5. Dubey JP, Lindsay DS. Neosporosis. Parasitol Today 1993;9:452-8.
6. Bjerkås I, Mohn SF, Presthus J. Unidentified cyst-forming sporozoon causing encephalomyelitis and myositis in dogs. Zeitschr Parasitenkunde 1984;70:271-4.
7. Lindsay DS, Dubey JP. Immunohistochemical diagnosis of Neospora caninum in tissue sections. Am J Vet Res 1989;50:1981-3.
8. Bjerkås I, Dubey JP. Evidence that Neospora caninum is identical to the Toxoplasma-like parasite of Norwegian dogs. Acta Vet Scand 1991;32:407-10.
9. Lindsay DS, Speer CA, Toivio-Kinaucan MA, Dubey JP, Blagburn BL. Use of infected cultured cells to compare ultrastructural features of Neospora caninum from dogs and Toxoplasma gondii. Am J Vet Res 1993;54:103-6.
10. Thilsted JP, Dubey JP. Neosporosis-like abortions in a herd of dairy cattle. J Vet Diagn Invest 1989;1:205-9.
11. Anderson ML, Blanchard PC, Barr BC, Dubey JP, Hoffman RL, Conrad PA. Neosporalike protozoan infection as a major cause of abortion in California dairy cattle. J Am Vet Med Assoc 1991;198:241-4.
12. Barr BC, Anderson ML, Dubey JP, Conrad PA. Neospora-like protozoal infection associated with bovine abortions. Vet Pathol 1991;28:110-6.
13. Conrad PA, Barr BC, Sverlow KW et al. In vitro isolation and characterization of a Neospora sp. from aborted bovine fetuses. Parasitol 1993;106:239-49.
14. Barr BC, Rowe JD, Sverlow KW et al. Experimental reproduction of bovine fetal Neospora infection and death with a bovine Neospora isolate. J Vet Diagn Invest 1994;6:207-15.
15. Barr BC, Conrad PA, Breitmeyer R et al. Congenital Neospora infection in calves born from cows that had previously aborted Neospora-infected fetuses: four cases (1990-1992). J Am Vet Med Assoc 1993;202:113-7.
16. Cole RA, Lindsay DS, Blagburn BL, Sorjonen DC, Dubey JP. Vertical transmission of Neospora caninum in dogs. J Parasitol 1995;81:208-11.
17. Dubey JP, Lindsay DS. Transplacental Neospora caninum infection in cats. J Parasitol 1989;75:765-71.
18. McAllister MM, McGuire AM, Jolley WR, Lindsay DS, Trees AJ, Stobart RH. Experimental neosporosis in pregnant ewes and their offspring. Vet Pathol 1996;33:647-55.
19. Buxton D, Maley SW, Thomson KM, Trees AJ, Innes EA. Experimental infection of non-pregnant and pregnant sheep with Neospora caninum. J Comp Pathol 1997;117:1-16.
20. Buxton D, Maley SW, Wright S, Thomson KM, Rae AG, Innes AE. The pathogenesis of experimental neosporosis in pregnant sheep. J Comp Pathol 1998;118:267-79.
21. Lindsay DS, Rippey NS, Powe TA, Sartin EA, Dubey JP, Blagburn BL. Abortion, fetal death, and stillbirth in pregnant pygmy goats inoculated with tachyzoites of Neospora caninum. American J Vet Res 1995;56:1176-80.
22. Cole RA, Lindsay DS, Blagburn BL, Dubey JP. Vertical transmission of Neospora caninum in mice. J Parasitol 1995;81:730-2.
23. Long MT, Baszler TV. Fetal loss in Balb/c mice infected with Neospora caninum. J Parasitol 1996;82:608-11.
24. Jensen L, Jensen TK, Lind P, Hendriksen SA, Uggla A, Bille-Hansen V. Experimental porcine neosporosis. APMIS 1998;106:475-82.
25. Barr BC, Conrad PA, Sverlow KW, Tarantal AF, Hendrickx AG. Experimental fetal and transplacental Neospora infection in the nonhuman primate. Lab Invest 1994;71:236-42.
26. Uggla A, Stenlund S, Holmdahl OJ et al. Oral Neospora caninum inoculation of neonatal calves. Int J Parasitol 1998;28:1467-72.
27. Dubey JP, Lindsay DS. Transplacental Neospora caninum infection in dogs. Am J Vet Res 1989;50:1578-9.
28. Dubey JP, Lindsay DS, Lipscomb T P. Neosporosis in cats. Vet Pathol 1990;27:335-9.
29. McAllister MM, Jolley WR, Wills RA, Lindsay DS, McGuire AM, Tranas JD. Oral inoculation of cats with tissue cysts of Neospora caninum. Am J Vet Res 1998;59:441-4.
30. McAllister MM, Dubey JP, Lindsay DS, Jolley WR, Wills RA, McGuire AM. Dogs are definitive hosts of Neospora caninum. Int J Parasitol 1998;28:1473-8.
31. Ellis J, Luton K, Baverstock PR, Brindley PJ, Nimmo KA, Johnson AM. The phylogeny of Neospora caninum. Mol Biochem Parasitol 1994;64:303-11.
32. Marsh AE, Barr BC, Packham AE, Conrad PA. Description of a new Neospora species. J Parasitol 1998;84:983-91.
33. Dubey JP, Beattie CP. Toxoplasmosis of animals and man. Boca Raton, FL: CRC Press, 1988.
34. Hemphill A, Gottstein B, Kaufmann H. Adhesion and invasion of bovine endothelial cells by Neospora caninum. Parasitol 1996;112:183-97.
35. Lindsay DS, Dubey JP. Evaluation of anti-coccidial drugs' inhibition of Neospora caninum development in cell cultures. J Parasitol 1989;75:990-2.
36. Lindsay DS, Rippey NS, Cole RA et al. Examination of the activities of 43 chemotherapeutic agents against Neospora caninum tachyzoites in cultured cells. Am J Vet Res 1994;55:976-81.
37. Lindsay DS, Butler JM, Rippey NS, Blagburn BL. Demonstration of synergistic effects of sulfonamides and dihydrofolate reductase/thymidylate synthase inhibitors against Neospora caninum tachyzoites in cultured cells, and characterization of mutants resistant to pyrimethamine. Am J Vet Res 1996;57:68-72.
38. Lindsay DS, Butler JM, Blagburn BL. Efficacy of decoquinate against Neospora caninum tachyzoites in cell culture. Vet Parasitol 1997;68:35-40.
39. Howe DK, Mercier C, Messina M, Sibley LD. Expression of Toxoplasma gondii genes in the closely related apicomplexan parasite Neospora caninum. Mol Biochem Parasitol 1997;86:29-36.
40. Beckers CJ, Wakefield T, Joiner KA. The expression of Toxoplasma proteins in Neospora caninum and the identification of a gene encoding a novel rhoptry protein. Mol Biochem Parasitol 1997;89:209-23.
41. Boothroyd JC, Black M, Bonnefoy S et al. Genetic and biochemical analysis of development in Toxoplasma gondii. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 1997;352:1347-54.
42. Ellis JT. Polymerase chain reaction approaches for the detection of Neospora caninum and Toxoplasma gondii. Int J Parasitol 1998;28:1053-60.
43. Björkman C, Lunden A, Holmdahl OJM, Barber J, Trees AJ, Uggla A. Neospora caninum in dogs: detection of antibodies by ELISA using an iscom antigen. Parasite Immunol 1994;16:643-8.
44. Paré J, Hietala SK, Thurmond MC. An enzyme-linked immunosorbent assay (ELISA) for serological diagnosis of Neospora sp. infection in cattle . J Vet Diagn Invest 1995;7:352-59.
45. Dubey JP, Lindsay DS, Adams DS et al. Serologic responses of cattle and other animals infected with Neospora caninum. Am J Vet Res 1996;57:320-36.
46. Osawa T, Wastling J, Maley S, Buxton D, Innes E A. A multiple antigen ELISA to detect Neospora-specific antibodies in bovine sera, bovine fetal fluids, ovine and caprine sera. Vet Parasitol 1998;79:19-34.
47. Packham AE, Sverlow KW, Conrad PA et al. A modified agglutination test for Neospora caninum: development, optimization, and comparison to the indirect fluorescent-antibody test and enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol 1998;5:467-73.
48. Romand S, Thulliez P, Dubey JP. Direct agglutination test for serologic diagnosis of Neospora caninum infection. Parasitol Res 1998;60:50-3.
49. Louie K, Sverlow KW, Barr BC, Anderson M L, Conrad PA. Cloning and characterization of two recombinant Neospora protein fragments and their use in sero- diagnosis of bovine neosporosis. Clinic Diagn Lab Immunol 1997;4:692-9.
50. Lally NC, Jenkins MC, Dubey JP. Evaluation of two Neospora caninum recombinant antigens for use in an ELISA for the diagnosis of bovine neosporosis. Clinic Diagn Lab Immunol 1996;3:275-9.
51. Cole RA, Lindsay DS, Dubey JP, Blagburn BL. Detection of Neospora caninum in tissue sections using a murine monoclonal antibody. J Vet Diagn Invest 1993;5:579-84.
52. Cole RA, Lindsay DS, Dubey JP, Toivio-Kinnucan MA, Blagburn BL. Characterization of a murine monoclonal antibody generated against Neospora caninum by western blot analysis and immunoelectron microscopy. Am J Vet Res 1994;55:1717-22.
53. Baszler TV, Knowles DP, Dubey JP, Gay JM, Mathison BA, McElwain TF. Serological diagnosis of bovine neosporosis by Neospora caninum monoclonal antibody-based competitive inhibition ELISA. J Clin Microbiol 1996;34:1423-8.
54. Sasai K, Lillehoj HS, Hemphill A et al. A chicken monoclonal antibody identifies a common epitope which is present on the apicomplexan coccidian parasites. J Parasitol 1998;84:654-6.
55. Björkman C, Hemphill A. Characterization of Neospora caninum iscom antigens using monoclonal antibodies. Parasite Immunol 1998;20:73-80.
56. Björkman C, Holmdahl J, Uggla A. An indirect enzyme linked immunoassay (ELISA) for demonstration of antibodies to Neospora caninum in serum and milk of cattle. Vet Parasitol 1997;68:251-6.
57. Howe DK, Crawford AC, Lindsay D, Sibley LD. The p29 and p35 immunodominant antigens of Neospora caninum tachyzoites are homologous to the family of surface antigens of Toxoplasma gondii. Infect Immun 1998;66:5322-8.
58. Barta JR, Dubey JP. Characterization of anti-Neospora caninum hyperimmune rabbit serum by Western blot analysis and immunoelectron microscopy. Parasitol Res 1992;78:689-94.
59. Bjerkas I, Jenkins MC, Dubey JP. Identification and characterization of Neospora caninum tachyzoite antigens useful for diagnosis of neosporosis. Clinic Diagn Lab Immunol 1994;1:214-21.
60. Lally NC, Jenkins M, Lidell S, Dubey JP. A dense granule protein (NCDG1) gene from Neospora caninum. Mol Biochem Parasitol 1997;87:239-43.
61. Liddell S, Lally NC, Jenkins MC, Dubey JP. Isolation of the cDNA encoding a dense granule associated antigen (NCDG2) of Neospora caninum. Mol Biochem Parasitol 1998;93:153-8.
62. Cesbron-Delauw MF, Lecordier L, Mercier C. Role of secretory dense granule organelles in the pathogenesis of toxoplasmosis. Curr Top Microbiol Immunol 1996;219:59-65.
63. Hemphill A, Gottstein B. Identification of a major surface protein on Neospora caninum tachyzoites. Parasitol Res 1996;82:497-504.
64. Hemphill A, Fuchs N, Sonda S, Gottstein B, Hentrich B. Identification and partial characterization of a 36 kD surface protein on Neospora caninum tachyzoites. Parasitol 1996;115:371-80.
65. Hemphill A, Felleisen R, Connolly B, Gottstein B, Hentrich B, Müller N. Characterization of a cDNA clone encoding Nc-p43, a major Neospora caninum surface protein. Parasitol 1997;115:581-90.
66. Sonda S, Fuchs N, Connolly B, Fernandez P, Gottstein B, Hemphill A. The major 36 kDa Neospora caninum tachyzoite surface protein is closely related to the major Toxoplasma gondii surface antigen 1. Mol Biochem Parasitol 1998;97:97-108.
67. Hemphill A, Gajendran N, Sonda S et al. Identification and characterization of a dense granule-associated protein in Neospora caninum tachyzoites. Int J Parasitol 1998;28:429-38.
68. Fuchs N, Sonda S, Gottstein B, Hemphill A. Differential expression of cell surface- and dense granule-associated Neospora caninum proteins in tachyzoites and bradyzoites. J Parasitol 1998;84:753-8.
69. Tomavo S. The major surface proteins of Toxoplasma gondii: structures and functions. Curr Top Microbiol Immunol 1996;219:45-54.
70. McAllister MM, Parmley SF, Weiss LM, Welch VJ, McGuire AM. An immunohistochemical method for detecting bradyzoite antigen (BAG5) in Toxoplasma gondii-infected tissues cross-reacts with a Neospora caninum bradyzoite antigen. J Parasitol 1996;82:354-5.
71. + T-cells protect against lethal toxoplasmosis in mice infected with Neospora caninum. Infect Immun 1998;66:1554-60.
72. Lindsay DS, Blagburn BL, Dubey JP. Infection of mice with Neospora caninum (Protozoa: Apicomplexa) does not protect against challenge with Toxoplasma gondii. Infect Immun 1990;58:2699-700.
73. Lindsay DS, Lenz SD, Dykstra CC, Blagburn BL, Dubey JP. Vaccination of mice with Neospora caninum: response to oral challenge with Toxoplasma gondii oocysts. J Parasitol 1998;84:311-5.
74. Lunden A, Marks J, Maley SW, Innes EA. Cellular immune responses in cattle experimentally infected with Neospora caninum. Parasite Immunol 1998;20:519-26.
75. Marks J, Lunden A, Harkins D, Innes E. Identification of Neospora antigens recognized by CD4 T-cells and immune sera from experimentally infected cattle. Parasite Immunol 1998;20:303-9.
76. Ajioka JW, Boothroyd JC, Brunk BP et al. Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa. Genome Res 1998;8:18-28.
77. Ajioka JW. Toxoplasma gondii: ESTs and gene discovery. Int J Parasitol 1998;28:1025-31.
78. Hehl A, Manger ID, Boothroyd JC. Genetic analysis in Toxoplasma: gene discovery with expressed sequence tags and rapid mapping of natural polymorphisms. METHODS: A companion to Methods Enzymol 1997;13:89-102.
79. Manger ID, Hehl A, Parmley S et al. Expressed sequence tag analysis of the bradyzoite stage of Toxoplasma gondii: identification of developmentally regulated genes. Infect Immun 1998;66:1632-7.
80. Naitza S, Spano F, Robson KJH, Crisanti A. The thrombospondin-related protein family of apicomplexan parasites: the gears of the cell invasion machinery. Parasitol Today 1998;14:479-84.
81. Black MW, Boothroyd JC. Development of a stable episomal shuttle vector for Toxoplasma gondii. J Biol Chem 1998;273:3972-9.
82. Thompson JD, Higgins DG, Gibson TJ. CLUSTALW: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994;22:4673-80.