Expressed Sequence Tag Analysis of the Bradyzoite Stage of Toxoplasma gondii: Identification of Developmentally Regulated Genes

Infection and Immunity

Volumn 66, Issue 4, 1998, Pages 1632-1637

  Manger, Ian D ^a   Hehl, Adrian ^a   Parmley, Steve ^b   Sibley, L David ^c   Marra, Marco ^d   Hillier, Ladeana ^d   Waterston, Robert ^d   Boothroyd, John C ^a,e  

^a STANFORD UNIVERSITY   (United States)

^b PALO ALTO MEDICAL FOUNDATION   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CBA MOUSE; GENE; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; HUMAN; MOLECULAR GENETICS; MOUSE; TOXOPLASMA;

AMINO ACID SEQUENCE; ANIMALS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE LIBRARY; GENES, PROTOZOAN; HUMANS; MICE; MICE, INBRED CBA; MOLECULAR SEQUENCE DATA; TOXOPLASMA;

EID: 0032036479     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.4.1632-1637.1998     Document Type: Article

References (36)

1. Ajioka, J., J. C. Boothroyd, B. P. Brunk, A. Hehl, L. Hillier, I. D. Manger, G. C. Overton, M. Marra, D. Roos, K. L. Wan, R. Waterston, and L. D. Sibley. 1998. Sequencing of ESTs from the protozoan parasite Toxoplasma gondii: efficient identification of genes and identification of phylogenetically restricted sequences of the Apicomplexa. Genome Res. 8:18-28.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1995. Current protocols in molecular biology, vol. 1 to 3. John Wiley and Sons. Inc., New York, N.Y.
3. Bohne, W., U. Gross, D. J. Ferguson, and J. Heesemann. 1995. Cloning and characterization of a bradyzoite-specifically expressed gene. Mol. Microbiol. 16:1221-1230.
4. Bohne, W., S. F. Parmley, S. Yang, and U. Gross. 1996. Bradyzoite-specific genes. Curr. Top. Microbiol. Immunol. 219:81-91.
5. Bohne, W., A. Wirsing, and U. Gross. 1997. Bradyzoite-specific gene expression in Toxoplasma gondii requires minimal genomic elements. Mol. Biochem. Parasitol. 85:89-98.
6. Boothroyd, J. C., A. B. Hehl, L. J. Knoll, and I. D. Manger. 1998. The surface of Toxoplasma: more and less. Int. J. Parasitol. 28:3-9.
7. Boothroyd laboratory home page, http://cmgm.stanford.edu/micro/boothroyd /toxo1.html.
8. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium. Anal. Biochem. 162:156-159.
9. Cornelissen, A. W., J. P. Overdulve, and M. van der Ploeg. 1984. Determination of nuclear DNA of five cucoccidian parasites, Isospora (Toxoplasma) gondii, Sarcocystis cruzi, Eimeria tenella, E. acervulina and Plasmodium berghei, with special reference to gamontogenesis and meiosis in I. (T.) gondii. Parasitology 88:531-553.
10. Denton, H., S. M. Brown, C. W. Roberts, J. Alexander, V. McDonald, K. W. Thong, and G. H. Coombs. 1996. Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii. Mol. Biochem. Parasitol. 76:23-29.
11. Denton, H., C. W. Roberts, J. Alexander, K. W. Thong, and G. H. Coombs. 1996. Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii. FEMS Microbiol. Lett. 137:103-108.
12. Dubey, J. P. 1993. Toxoplasma, Neospora, Sarcosystis, and other tissue cystforming coccidia of humans and animals, p. 1-158. In J. P. Kreier (ed.), Parasitic protozoa, vol. 6. Academic Press, New York, N.Y.
13. Gross, U., W. Bohne, C. G. Luder, R. Lugert, F. Seeber, C. Dittrich, F. Pohl, and D. J. Ferguson. 1996. Regulation of developmental differentiation in the protozoan parasite Toxoplasma gondii. J. Eukaryot. Microbiol. 43:114S-116S.
14. Hehl, A. B., T. Krieger, and J. C. Boothroyd. 1997. Identification and characterization of SRS1, a Toxoplasma gondii surface antigen upstream of and related to SAG1. Mol. Biochem. Parasitol. 89:271-282.
15. Huskinson-Mark, J., F. G. Araujo, and J. S. Remington. 1991. Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii. J. Infect. Dis. 164:170-171.
16. Kasper, L. H. 1989. Identification of stage-specific antigens of Toxoplasma gondii. Infect. Immun. 57:668-672.
17. Knoll, L. J., and J. C. Boothroyd. 1998. Isolation of developmentally regulated genes from Toxoplasma gondii by a gene trap with the positive and negative selectable marker hypoxanthine-xanthine-guanine phosphoribosyl-transferase. Mol. Cell. Biol. 18:807-814.
18. Lee, N. H., K. G. Weinstock, E. F. Kirkness, J. A. Earle-Hughes, R. A. Fuldner, S. Marmaros, A. Glodek, J. D. Gocayne, M. D. Adams, A. R. Kerlavage, C. M. Fraser, and J. C. Venter. 1995. Comparative expressed-sequence-tag analysis of differential gene expression profiles in pc-12 cells before and after nerve growth factor treatment. Proc. Natl. Acad. Sci. USA 92:8303-8307.
19. Liang, P., L. Averboukh, and A. B. Pardee. 1994. Methods of differential display, p. 3-16. In K. W. Adolph (ed.), Methods in molecular genetics, vol. 5. Gene and chromosome analysis, part C. Academic Press, Inc., San Diego, Calif.
20. Luft, B. J., and J. S. Remington. 1992. Toxoplasmic encephalitis in AIDS. Clin. Infect. Dis. 15:211-222.
21. Malarial Genome Project home page. http://www.sanger.ac.uk/Projects /P_falciparum/.
22. Manger, I. D., A. B. Hehl, and J. C. Boothroyd. The surface of Toxoplasma tachyzoites is dominated by a family of GPI-anchored antigens related to SAG1. Submitted for publication.
23. Manger, I. D., A. B. Hehl, and J. C. Boothroyd. Unpublished data.
24. Odberg-Ferragut, C., M. Soete, A. Engels, B. Samyn, A. Loyens, J. Van Beeumen, D. Camus, and J. F. Dubremetz. 1996. Molecular cloning of the Toxoplasma gondii sag4 gene encoding an 18 kDa bradyzoite specific surface protein. Mol. Biochem. Parasitol. 82:237-244.
25. Ortega, E., and J. C. Boothroyd. Unpublished data.
26. Parmley, S. F. Unpublished results.
27. Parmley, S. F., L. M. Weiss, and S. Yang. 1995. Cloning of a bradyzoite-specific gene of Toxoplasma gondii encoding a cytoplasmic antigen. Mol. Biochem. Parasitol. 73:253-257.
28. Parmley, S. F., S. Yang, G. Harth, L. D. Sibley, A. Sucharczuk, and J. S. Remington. 1994. Molecular characterization of a 65-kilodalton Toxoplasma gondii antigen. Mol. Biochem. Parasitol. 66:283-296.
29. Prince, J. B., F. G. Araujo, J. S. Remington, J. L. Burg, J. C. Boothroyd, and S. D. Sharma. 1989. Cloning of cDNAs encoding a 28 kilodalton antigen of Toxoplasma gondii. Mol. Biochem. Parasitol. 34:3-13.
30. Sibley, L. D., and D. K. Howe. 1996. Genetic basis of pathogenicity in toxoplasmosis. Curr. Top. Microbiol. Immunol. 219:3-15.
31. Soete, M., D. Camus, and J. F. Dubremetz. 1994. Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro. Exp. Parasitol. 78:361-370,
32. Soete, M., B. Fortier, D. Camus, and J. F. Dubremetz. 1993. Toxoplasma gondii: kinetics of bradyzoite-tachyzoite interconversion in vitro. Exp. Parasitol. 76:259-264.
33. Tomavo, S., B. Fortier, M. Soete, C. Ansel, D. Camus, and J. F. Dubremetz. 1991. Characterization of bradyzoite-specific antigens of Toxoplasma gondii. Infect. Immun. 59:3750-3753.
34. Toxoplasma Database of Clustered Expressed Sequence Tags. http://daphne .humgen.upenn.edu:1024/toxodb/ver_1/toxodb.html.
35. Yang, S., and S. F. Parmley. 1995. A bradyzoite stage-specifically expressed gene of Toxoplasma gondii. Mol. Biochem. Parasitol. 73:291-294.
36. Yang, S., and S. F. Parmley. 1997. Toxoplasma gondii expresses two distinct lactate dehydrogenase homologous genes during its life cycle in intermediate hosts. Gene 184:1-12.