Antigen-specific cytokine response to hepatitis C virus core epitopes in HIV/hepatitis C virus-coinfected patients

AIDS

Volumn 13, Issue 11, 1999, Pages 1313-1322

  Woitas, Rainer P ^a,b   Rockstroh, Jürgen K ^a,b   Beier, Imke ^a,b,c   Jung, Günther ^a,b   Kochan, Bettina ^a,b   Matz, Bertfried ^a,b   Brackmann, Hans H ^a,b   Sauerbruch, Tilman ^a,b   Spengler, Ulrich ^a,b,c  

^a Department of Internal Medicine I ^*  (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cytokines; Flow cytometry; Infectious immunity virus; T helper type 1; T helper type 2

Indexed keywords

CD30 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HEPATITIS C ANTIGEN; INDINAVIR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LAMIVUDINE; NEVIRAPINE; SAQUINAVIR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

ADULT; AGED; ANTIGENS, CD3; ANTIGENS, CD30; CYTOKINES; EPITOPES, T-LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIGENS; HIV INFECTIONS; HIV-1; HUMANS; IMMUNODOMINANT EPITOPES; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RNA, VIRAL; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS; VIRAL CORE PROTEINS;

EID: 0032866484     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199907300-00007     Document Type: Article

References (75)

1. Dienstag JL. Non-A, non-B hepatitis: recognition, epidemiology, and clinical features. Gastroenlero/ogy 1983, 85:439-462.
2. Alter H), Purcell RH, Shin JVV, et al. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engt1 Med 1989, 321:1494-1500.
3. Darby SC, Ewart D\V, Ciangrande PLF, et al. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. lancet 1997, 350:1425-1431.
4. Rockstroh JK, Spengler U, Sudhop T, et al. Immunosuppression may lead to progression of hepatitis C virus-associated liver disease in hemophiliacs coinfected with HIV. Am ] Gastroenteml 1996, 91:2563-2568.
5. Botarelli P, Brunetto MR, Minutello MA, et al. T-Iymphocyte response to hepatitis C virus in different clinical courses of infection. Castroentero/ogy 1993, 104:580-587.
6. Lechmann M, Ihlenfeldt HG, Braunschweiger l, et al. T and B cell responses to different hepatitis C virus antigens in patients with chronic hepatitis C infection and in healthy antiHCV blood donors without viremia. Hepato/ogy 1996, 24:790-795.
7. Ferrari C, Valli A, Galati L, et al. T-cell response to structural and nonstructural hepatitis C virus antigens in persistent and self-limited hepatitis C virus infections. Hepato/ogy 1994, 19:286-295.
8. Eyster ME, Diamondstone LS, Lien JM, Ehmann VVC, Quan S, Coedert JJ. Natural history of hepatitis C virus infection in multitransfused hemophiliacs: effect of coinfection with human immunodeficiency virus. The Multicenter Hemophilia Cohort Study. J Acquired Immune Defic Syndr 1993, 6:602-610.
9. Eyster ME, Fried MW, Di Bisceglie A, Coedert JJ. Increasing hepatitis C virus RNA levels in hemophiliacs relationship to human immunodeficiency virus infection and liver disease. Multicenter Hemophilia Cohort Study. Blood 1994, 84:1020-1023.
10. Dorrucci M, Pezzotti P, Phillips AN, Lepri AC, Rezza C. Coinfection of hepatitis C virus with human immunodeficiency virus and progression to AIDS. Italian Seroconversion Study. ] Infect Dis 1995, 172:1503-1508.
11. Cribier B, Schmitt C, Rey D, Lang JM, Kim A, Stoli KF. Role of endogenous interferon in hepatitis C virus (HCV) infection and in coinfection by HIV and HCV. Res Virol 1996, 147:263-266.
12. Clerici M, Shearer CM. A Thl-Th2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993, 14:107-111.
13. Mosmann TR, Subash S. The expanding universe of T-cell subsets: Thl, Th2 and more. Immunol Today 1996, 17:138-146.
14. Romagnani S, Maggi E, Del Prête G. HIV can induce a TH1 to THO shift, and preferentially replicates in CD4+ T-cell clones producing TH2-type cytokines. Res Immunol 1994, 145:611-617.
15. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996, 383:787-793.
16. Sad S, Marcotte R, Mosmann TR. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ cells secreting Th1 or Th2 cytokines. Immunity 1995, 2:271-279.
17. Del Prête C, Maggi E, Pizzolo G, Romagnani S. CD30, Th2 cytokines and HIV infection: a complex and fascinating link. Immunol Today 1995, 16:76-80.
18. Del Prête G, De Carli M, Almerigogna F, et al. Preferential expression of CD30 by human CD4+ T cells producing Th2type cytokines. FASEB11995, 9:81-86.
19. Maggi E, Annunziato F, Manetti R, et al. Activation of HIV expression by CD30 triggering in CD4+ T cells from HIVinfected individuals. Immunity 1995, 3:251-255.
20. Manetti R, Annunziato F, Biagiotti R, et al. CD30 expression by CD8+ T cells producing type 2 helper cytokines. Evidence for large numbers of CD8 + CD30+ T cell clones in human immunodeficiency virus infection. J Exp Med 1994, 180:2407-2411.
21. Pizzolo G, Vinante F, Morosato L, et al. High serum level of the soluble form of CD30 molecule in the early phase of HIV-1 infection as an independent predictor of progression to AIDS. A/DS1994, 8:741-745.
22. Romagnani S, Del Prête G, Maggi E, Chilosi M, Caligaris CF, Pizzolo G. CD30 and type 2 T helper (Th2) responses. I Leukoc Biol 1995, 57:726-730.
23. Meyaard L, Hovenkamp E, Keet IP, et at. Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production.) Immunol 1996, 157:2712-2718.
24. Graziosi C, Pantaleo G, Gantt KR, et al. Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. Science 1994, 265:248-252.
25. Barcellini W, Rizzardi GP, Borghi'MO, Fain C, Lazzarin A, Meroni PL. TH1 and Th2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS 1994,8:757-762.
26. Meyaard L, Otto SA, Keet IP, van Lier RA, Miedema F. Changes in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection. Blood 1994, 84:4262-4268.
27. Maggi E, Mazzetti M, Ravina A, et al. Ability of HIV to promote a Thl to THO shift and to replicate preferentially in TH2 and THO cells. Science 1994, 265:244-248.
28. Fakoya A, Matear PM, Filley E, et al. HIV infection alters the production of both type 1 and 2 cytokines but does not induce a polarized type 1 or 2 state. AIDS 1997, 11:1445-1452.
29. Klein SA, Dobmeyer JM, Dobmeyer TS, et al. Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry. AIDS 1997, 11:1111-1118.
30. Alzona M, Jack HM, Fisher Rl, Ellis TM. IL-12 activates IFNgamma production through the preferential activation of CD30H- T cells. ; Immunol 1995, 154:9-16.
31. Alzona M, Jack HM, Fisher Rl, Ellis TM. CD30 defines a subset of activated human T cells that produce IFN-gamma and IL-5 and exhibit enhanced B cell helper activity. J Immunol 1994, 153:2861-2867.
32. Woitas RP, Lechmann M, Jung G, Kaiser R, Sauerbruch T, Spengler U. CD30 induction and cytokine profiles in hepatitis C specific peripheral blood T lymphocytes. ) Immunol 1997, 159:1012-1018.
33. Agrawal B, Reddish M, Longenecker BM. CD30 expression on human CD8+ T cells isolated from peripheral blood lymphocytes of normal donors. ] Immunol 1996, 157:3229-3234.
34. Saiki K, Celfand DH, Stoffel S, et al. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988, 239:487-491.
35. van Gemen B, Kievits T, Schukkink R, et aJ. Quantification of HIV-VRNA in plasma using NASBA during HIV-1 primary infection. ; Virol Methods 1993, 64:177-187.
36. Imberti L, Cariani E, Bettinardi A, Zonaro A, Albertini A, Primi D. An immunoassay for specific amplified HCV sequences. J Virol Methods 1991, 34:233-243.
37. Choo Q-L, Weiner AJ, Overby LR, Houghton M. Isolation of a cDNA derived from a blood-borne non-A non-B viral hepatitis genome. Science 1990, 244:359-362.
38. King DS, Fields CC, Fields CB. A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis. Int] Peptide Protein Res 1990, 36:255-266.
39. North ME, Ivory K, Funauchi M, Webster ADB, Lane AC, Farrant J. Intracellular cytokine production by human CD4 + and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and threecolour flow cytomelry. Clin Exp Immunol 1996, 105:517-522.
40. Picker U, Singh MK, Zdraveski Z, et al. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cylometry. Blood 1995, 86:1408-1419.
41. Prussin C, Metcalfe DD. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cylokine antibodies. / Immunol Methods 1995, 188:117-128.
42. Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cylometry. ] Immunol Methods 1993, 159:197-207.
43. Pohlmann R, Kruger S, Hasilik A, von Figura K. Effect of monensin on intracellular transport and receptor-mediated endocylosis of lysosomal enzymes. Biochem I 1984, 217:649-658.
44. Tartakoff AM. Perturbation of vesicular traffic with the carboxylic ionophore monensin. Cell 1983, 32:1026-1028.
45. Sander B, Andersson J, Andersson U. Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure. Immunol Rev 1991, 119:65-93.
46. Cleric! M, Fusi ML, Ruzzante S, et al. Type 1 and type 2 cytokines in HIV infection -a possible role in apoptosis and disease progression. Ann Med 1997, 29:185-188.
47. Waldrop SL, Pitcher CJ, Peterson DM, Maino VC, Picker U. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry. ] Clin Invest 1997, 99:1739-1750.
48. Sanders ME, Makgoba MW, Sharrow SO, et al. Human memory T lymphocytes express increased levels ot three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-y production. ; Immunol 1988, 140:1401-1407.
49. Pinto LA, Sullivan J, Berzofsky JA, et aJ. ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. ] Clin Invest 1995, 96:867-876.
50. Koziel MJ, Wong DK, Dudley D, Houghton M, Walker BD. Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons. ] Infect Dis 1997, 176:859-866.
51. Clerici M, Berzofsky JA, Shearer CM, et al. HIV-1 exposure indicated by HIV-specific T helper cell responses before detection of infection by polymerase chain reaction and serum antibodies, j Infect Dis 1991, 164:178-182.
52. Clerici M, Ciorgi N, Chou CC, et al. Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. y/nfectD/s 1992, 165:1012-1019.
53. Clerici M, Levin JM, Kessler HA, et al. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood. JAMA 1994, 271:42-46.
54. Alonso K, Pontiggia P, Medenica R, Rizzo 5. Cytokine patterns in adults with AIDS. Immunol Invest 1997,-Z6:341-350.
55. Rutschmann OT, Negro F, Hirschel B, Hadengue A, Anwar D, Perrin LH. Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients coinfected with HIV./ Infect Dis 1998, 177:783-785.
56. Weiner AJ, Christopherson C, Hall JE, et al. Sequence variation in hepatitis C viral isolates.; Hepatol 1991, 13:56-14.
57. Degermann S, Pria E, Adorini L. Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway. / Immunol 1996, 157:3260-3269.
58. Krown SE, Niedzvviecki D, Bhalla RB, Flomenberg N, Bundow D, Chapman D. Relationship and prognostic value of endogenous interferon-alpha, beta 2-microglobulin, and neopterin serum levels in patients with Kaposi sarcoma and AIDS. I AIDS 1991, 4:871-880.
59. Mildvan D, Machado SC, Wilets I, Crossberg SE. Endogenous interferon and triglycéride concentrations to assess response to zidovudine in AIDS and advanced AIDS-related complex. Lancet 1992, 339:453-456.
60. Fan J, Bass HZ, Fahey JL. Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection. J Immunol 1993, 151:5031-5040.
61. Napoli J, Bishop GA, McCuiness PH, Painter DM, McCauchghan . CVV. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Thl-associated cytokines. Hepato/ogy 1996, 4:759-765.
62. Hamann D, Hilkens CMU, Crogan JL, el al. CD30 expression does not discriminate between human Thl- and Th2-type T cells. J Immunol 1996, 156:1387-1391.
63. VVoitas RP, Sauerbruch T, Spengler U. Bystander T-cell clones in chronic hepatitis C [letter]. Gastroentero/ogy 1997, 113:1050-1051.
64. Roglic M, MacPhee RD, Duncan SR, Sattler FR, Theophilopoulos AN. T cell receptor (TCR) BV gene repertoires and clonal expression of CD4 cells in patients with HIV infection. Clin Exp Immunol 1997, 107:21-30.
65. Gorochov G, Neumann AU, Kereveur A, et al. Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nature Med 1998, 4:215-221.
66. Connors M, Kovacs JA, Krevat D, et al. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nature Med 1997, 3:533-540.
67. Knight SC, Patterson S. Bone marrow-derived dendritic cells, infection with human immunodeficiency virus, and immunopathology. Annu Rev Immunol 1997, 15:593-615.
68. Hengel H, Koszinowski UH. Interference with antigen processing by viruses. Curr Opin Immunol 1997, 9:470-476.
69. McMichael AJ, Phillips RE. Escape of human immunodeficiency virus from immune control. Annu Rev Immunol 1997, 15:271-296.
70. Amakawa R, Hakem A, Kundig TM, et al. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell 1996, 84:551-562.
71. Gruss HJ, Boiani N, Williams DE, Armitage RJ, Smith CA, Goodwin RG. Pleiotropic effects of the CD30 ligand on CD30expressing cells and lymphoma cell lines. Blood 1994, 83:2045-2056.
72. Ellis TM, Simms PE, Slivnick DJ, Jack HM, Fisher RI. CD30 is a signal-transducing molecule that defines a subset of human activated CD4SRO+ T cells. J Immunol 1993, 151:2380-2389.-
73. Nakamura T, Lee RK, Nam SY, et al. Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma. j Immunol 1997, 158:2090-2098.
74. Nakamura T, Lee RK, Nam SY, Podack ER, Bottomly K, Flavell RA. Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. J Immunol 1997, 158:2648-2653.
75. Wiley SR, Coodwin RG, Smith CA. Reverse signaling via CD30 ligand. J Immunol 1996, 157:3635-3639.