Acquired antibiotic resistance in lactic acid bacteria from food

Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology

Volumn 76, Issue 1-4, 1999, Pages 115-137

  Teuber, Michael ^a   Meile, Leo ^a   Schwarz, Franziska ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Antibiotic resistance; Entrococcus; Food; Lactobacillus; Lactococcus

Indexed keywords

AMPICILLIN; AVOPARCIN; CARBENICILLIN; CEPHALOSPORIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COLISTIN; DICLOXACILLIN; ERYTHROMYCIN; FUSIDIC ACID; GENTAMICIN; IMIPENEM; KANAMYCIN; METRONIDAZOLE; NALIDIXIC ACID; NITROFURANTOIN; NORFLOXACIN; OXACILLIN; PENICILLIN G; PIPERACILLIN; POLYMYXIN B; STREPTOMYCIN; SULFAMETHOXAZOLE; SULFONAMIDE; TEICOPLANIN; TETRACYCLINE; TRIMETHOPRIM; UNINDEXED DRUG; VANCOMYCIN;

AGRICULTURE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTERIAL GENE; BACTERIAL GENETICS; CONFERENCE PAPER; DAIRY PRODUCT; ENTEROCOCCUS; FERMENTATION; FOOD; FOOD CHAIN; GENE INSERTION SEQUENCE; HUMAN; INTESTINE FLORA; LACTIC ACID BACTERIUM; LACTOBACILLUS; LISTERIA MONOCYTOGENES; MEAT; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; STREPTOCOCCUS; TRANSPOSON;

ANIMALS; CHEESE; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, MICROBIAL; FOOD MICROBIOLOGY; GRAM-POSITIVE BACTERIA; HUMANS; LACTOCOCCUS LACTIS; LISTERIA MONOCYTOGENES; MEAT; MILK; STAPHYLOCOCCUS AUREUS;

EID: 0032861380     PISSN: 00036072     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1002035622988     Document Type: Conference Paper

References (120)

1. Ahn C, Collins-Thompson D, Duncan C & Stiles ME (1992) Mobilization and location of the genetic determinant of chloramphenicol resistance from Lactobacillus plantarum caTC2R. Plasmid 27: 169-176
2. Ainsa JA, Blokpoel MCJ, Otal I, Young DB, de Smet KAL & Martin C (1998) Molecular doing and characterization of tap, a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis. J. Bacteriol. 180: 5836-5843
3. Antony SJ, Stratton CW & Dummer JS (1996) Lactobacillus bacteremia: description of the clinical course in adult patients without endocarditis. Clin. Infect. Dis. 23: 773-778
4. Aarestrup FM, Bager F, Jensen NE, Madsen M, Meyling A & Wegener HC (1998) Resistance to antimicrobial agents used for animal therapy in pathogenic-, zoonotic- and indicator bacteria isolated from different food animals in Denmark: a baseline study for the Danish Integrated Antimicrobial Resistance Monitoring Programme (DANMAP). APMIS 106: 745-770
5. Arthur M & Courvalin P (1994) Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob. Agents Chemother. 37: 1563-1571
6. Baquero F, Negir MC, Morosini MI & Blazquez J (1997) The antibiotic selection process: concentration-specific amplification of low-level resistant populations. In: Antibiotic Resistance. Origins, evolution, selection and spread (pp. 87-105). Chadwick DJ & Goode J (Eds.) John Wiley & Sons, Chichester
7. Bates J, Jordens Z & Selkon JB (1993) Evidence for an animal origin of vancomycin-resistant enterococci. The Lancet 342: 490-49
8. Batish VK & Ranganathan B (1986) Antibiotic susceptibility of deoxyribonuclease-positive enterococci isolated from milk and milk products and their epidemiological significance. Int. J. Food Microbiol. 16: 203-206
9. Berg T, Firth N, Apisiridej S, Hettiaratchi A, Leelaporn A & Skurray R A (1998) Complete nucleotide sequence of pSK41: Evolution of staphylococcal conjugative multiresistance plasmids. J. Bacteriol. 180: 4350-4359
10. Bolhuis H, Poelarends G, van Veen HW, Poolman B, Driessen AJM & Konings WN (1995) The lactococcal ImrP gene encodes a proton motive force-dependent drug transporter. J. Biol. Chem. 270: 26092-26098
11. Brockmann E, Jacobsen BL, Hertel C, Ludwig W, Schleifer KH (1998) Monitoring of genetically modified Lactococcus lactis in gnotobiotic and conventional rats by using antibiotic resistance markers and specific probe or primer based methods. System. Appl. Microbiol. 19: 203-212
12. Celli J & Trieu-Cuot P (1998) Circularization of Tn916 is required for expression of the transposon-encoded transfer functions: characterization of long tetracycline-inducible transcripts reading through the attachment site. Mol. Microbiol. 28: 103-117
13. Charpentier E, Gerbaud G & Courvalin P (1994) Presence of the Listeria tetracycline resistance gene tet(S) in Enterococcus faecalis. Antimicrob. Agents Chemother. 38: 2330-2335
14. Charpentier E, Gerbaud G, Jacquet C, Recourt J & Courvalin P (1995) Incidence of antibiotic resistance in Listeria species. J. Infect. Dis. 172: 277-281
15. Charteris WP, Kelly PM, Morelli L & Collins JK (1998) Antibiotic susceptibility of potentially probiotic Bifidobacterium isolates from the human gastrointestinal tract. Lett. Appl. Microbiol. 26: 333-337
16. Clewell DB (1994) Bacterial Conjugation (DB Clewell, Ed.). Plenum Press, New York
17. Clewell DB, Flannagan SE & Jaworsky DD (1995) Unconstrained bacterial promiscuity: the Tn916-Tn1545 family of conjugative transposons. Trends Microbiol. 3: 229-236
18. Climo M, Sharma VK & Archer GL (1996) Identification and characterization of the origin of conjugative transfer (oriT) and gene (nes) encoding a single-stranded endonuclease on the staphylococcal plasmid pGO1. J. Bacteriol. 178: 4975-4983
19. Corpet EE (1988) Antibiotic resistance from food (letter). New England J. Med. 318: 1206-1067
20. Curragh HJ & Collins MA (1992) High levels of spontaneous drug resistance in Lactobacillus. J. Appl. Bacteriol. 73: 31-36
21. Davies JE (1994) Inactivation of antibiotics and the dissemination of resistance genes. Science 264: 375-382
22. Davies JE (1997) Origins, acquisition and dissemination of antibiotic resistance determinants. In: Chadwick DJ & Goode J (Eds.) Antibiotic Resistance. Origins, evolution, selection and spread (pp. 15-27). John Wiley & Sons, Chichester
23. De Fabrizio SV, Parada JL & Ledford RA (1994) Antibiotic resistance of Lactococcus lactis - an approach of genetic determinants location through a model system. Microbiologie-Aliments-Nutritions 12: 307-315
24. Dellaglio F, Dicks LMT & Torriani S (1995) The genus Leuconostoc. In: Wood BJB & Holzapfel WH (Eds.) The Genera of Lactic Acid Bacteria (pp. 235-278). Blackie Academic & Professional, London
25. Dessart SR & Steenson LR (1991) High frequency intergeneric and intrageneric conjugal transfer of drug resistance plasmids in Leuconostoc mesenteroides ssp. cremoris. J. Dairy Sci. 74: 2912-2919
26. Devriese LA & Pot B (1995) The genus Enterococcus. In: Wood BJB and Holzapfel WH (Eds.) The genera of lactic acid bacteria (pp. 327-367). Blackie Academic & Professional, London
27. De Vos WM & Simons GFM (1994) Gene cloning and expression systems in Lactococci. In: Gasson MJ & de Vos WM (Eds.) Genetics and Biotechnology of Lactic Acid Bacteria (pp. 52-105). Blackie Acadmic & Professional, London
28. Dodd HM, Horn N, Gasson MJ (1990) Analysis of the genetic determinant for production of the peptide antibiotic nisin. J. Gen. Microbiol. 136: 555-566
29. Doucet-Populaire F, Trieu-Cuot P, Dosbaa I, Andremont A & Courvalin P (1991) Inducible transfer of conjugative Transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tracts of gnotobiotic mice. Antimicrob. Agents & Chemother. 35: 185-187
30. Dougherty BA, Hill C, Weidman JF, Richardson DR, Venter JC & Ross RP (1998) Sequence and analysis of the 60 kb conjugative, bacteriocin-producing plasmid pMRC01 from Lactococcus lactis DPC3147. Mol. Microbiol. 29: 1029-1038
31. Elisha BG & Courvalin P (1995) Analysis of genes encoding D-alanine: D-alanine ligase-related enzymes in Leuconostoc mesenteroides and Lactobacillus spp. Gene 152: 79-83
32. Elmer GW, Surawics ChM & McFarland LV (1996) Biotherapeutic agents. A neglected modality for the treatment and prevention of selected intestinal and vaginal infections. J. Am. Med. Assoc. 275: 870-876
33. Falkiner FR (1998) The consequences of antibiotic use in horticulture. J. Antimicrob. Chemother. 41: 429-431
34. Flannagan SE, Zitzow LA, Su YA & Clewell DB (1994) Complete nucleotide sequence of the 18-kb conjugative transposon Tn916 fromEnterococcus faecalis. Plasmid 32: 350-354
35. Foley S, Bron S, Venema G, Daly C & Fitzgerald GF (1996) Molecular analysis of the replication origin of the Lactococcus lactis plasmid pCI305. Plasmid 36: 125-141
36. Fons M, Hégé T, Ladiré M, Raibaud P, Ducluzeau R & Maguin E (1997) Isolation and characterization of a plasmid from Lactobacillus fermentum conferring erythromycin resistance. Plasmid 37: 199-203
37. François B, Charles M & Courvallin P (1997) Conjugative transfer of tet(S) between strains of Enterococcus faecalis is associated with the exchange of large fragments of chromosomal DNA. Microbiology 143: 2145-2154
38. Gasson MJ & Davies FL (1980) Conjugal transfer of the drug resistance plasmid pAMβ1 in the lactic streptococci. FEMS Microbiol. Lett. 7: 51-53
39. Gasson MJ & Fitzgerald GF (1994) Gene transfer systems and transposition. In: Gasson MJ & de Vos WM (Eds.) Genetics and Biotechnology of Lactic Acid Bacteria (pp. 1-51). Blackie Academic & Professional, London
40. Giraffa G, Carminati D & Neviani E (1997) Enterococci isolated from dairy products: a review of risks and potential technological use. J. Food Protect. 60: 732-738
41. Grüneberg RN & Hryniewicz W (1998) Clinical relevance of a European collaborative study on comparative susceptibility of Gram-positive clinical isolates to teichoplanin and vancomycin. Intern. J. Antimicrob. Ag. 10: 271-277
42. Guédon G, Bourgoin F, Pébay M, Roussel Y, Colmin C, Simonet JM & Decaris B (1995) Characterization and distribution of two insertion sequences, IS1191 and iso-IS981, in Streptococcus thermophilus: does intergeneric transfer of insertion sequences occur in lactic acid bacteria co-cultures? Mol. Microbiol. 16: 69-78
43. Guiney M & Urwin G (1993) Frequency and antimicrobial susceptibility of clinical isolates of enterococci. Eur. J. Clin. Microbiol. Infect. Dis. 12: 362-366
44. Hadorn K, Kayser FH & Hächler H (1994) Miniplasmid derived from Listeria monocytogenes multiresistance plasmid pWDB100 upon conjugal transfer into Staphylococcus epidermidis carries chloramphenicol resistance gene identical with staphylococcal gene. System. Appl. Microbiol. 17: 492-500
45. Hadorn K, Hächler H, Schaffner A & Kayser FH (1993) Genetic characterization of plasmid-encoded multiple antibiotic resistance in a strain of Listeria monocytogenes causing endocarditis. Eur. J. Clin. Microbiol. Infect. Dis. 12: 928-937
46. Hammerum AM, Jensen LB, Aarestrup FM (1998) Detectin of the satA gene and transferability of virginiamycin resistance in Enterococcus faecium from food-animals. FEMS Microbiol. Lett. 168: 145-151
47. Handwerger S & Skoble J (1995) Identification of chromosomal mobile element conferring high-level vancomycin resistance in Enterococcus faecium. Antimicrob. Agents Chemother. 39: 2446-2453
48. Herrero M, Mayo B, Gonzales B & Suarez JE (1996) Evaluation of technologically important traits in lactic acid bacteria isolated from spontaneous fermentations. J. Appl. Bacteriol. 81: 565-570
49. Huycke MM, Sahm DF & Gilmore MS (1998) Multiple-drug resistant enterococci: The nature of the problem and agenda for the future. Emerging Infect. Dis. 4: 239-249
50. Janzen T, Kleinschmidt J, Neve H & Geis A (1992) Sequencing and characterization of pST1, a cryptic plasmid from Streptococcus thermophilus. FEMS Microbiol. Lett. 95: 175-180
51. Jensen LB, Fridmodt-Moller N & Aarestrup FM (1999) Presence of erm gene classes in Gram-positive bacteria of animal and human origin in Denmark. FEMS Microbiol. Lett. 170: 151-158
52. Jensen LB (1998) Internal variations in Tn1546-like elements due to the presence of IS1216V. FEMS Microbiol. Lett. 169: 349-354
53. Jett BD, Huycke M & Gilmore MS (1994) Virulence of enterococci. Clin. Microbiol. Rev. 7: 462-478
54. Khan E, Mack JPG, Katz RA, Kulkosky J & Skalka AM (1990) Retroviral integrase domain: DNA binding and the recognition of LTR sequences. Nucleic Acids Research 19: 851-861
55. Kilpper-Bälz R, Fischer G & Schleifer K-H (1982) Nucleic acid hybridization of group D streptococci. Curr. Microbiol. 7: 245-250
56. Klaenhammer TR & Sutherland SM (1980) Detection of plasmid deoxyribonucleic acid in an isolate of Lactobacillus acidophilus. Appl. Environ. Microbiol. 39: 671-674
57. Klare I, Heier H, Claus H, Böhme G, Marin S, Seltmann G, Hakenbeck R, Altanassova V & Witte W (1995) Enterococcus faecium strains with vanA-mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community. Microb. Drug Resistance 1: 265-272
58. Klare I, Heier H, Claus H, Reissbrodt R & Witte W (1995) vanA-mediated high-level glycopeptide resistance in Enterococcus faecium from animal husbandry. FEMS Microbiol. Lett. 125: 165-172
59. Klein G, Pack A & Reuter G (1998) Antibiotic resistance patterns of enterococci and occurrence of vancomycin-resistant enterococci in raw minced beef and pork in Germany. Appl. Environ. Microbiol. 64: 1825-1830
60. Kleinschmidt J, Soeding B, Teuber M & Neve H (1993) Evaluation of horizontal and vertical gene transfer and stability of heterologous DNA in Streptococcus thermophilus isolated from yogurt and yogurt starter cultures. System. Appl. Microbiol. 16: 287-295
61. Knudtson LM & Hartman PA (1993) Antibiotic resistance among enterococci isolates from environmental and clinical sources. J. Food Protect. 56: 489-492
62. Kullen MJ & Klaenhammer TR (1999) Genetic Modification of Intestinal Lactobacilli and Bifidobacteria. In: Tannock GW (Ed.) Probiotics, a critical review (pp. 65-83). Horizon Scientific Press, Wymondham
63. Leenhouts K, Bolhuis A, Venema G, Kok J (1998) Construction of a food-grade multiple-copy integration system for Lactococcus lactis. Appl. Microbiol. Biotechnol. 49: 417-423
64. Levy SB (1997) Antibiotic resistance: An ecological imbalance. In: Chadwick DJ & Goode J (Eds.) Antibiotic Resistance. Origins, evolution, selection and spread (pp. 1-14). John Wiley & Sons, Chichester
65. Liassine N, Frei R, Jan I & Auckenthaler R (1998) Characterization of glycopeptide-resistant enterococci from a Swiss hospital. J. Clin. Microbiol. 36: 1853-1858
66. Lin ChF, Fung ZF, Wu ChL & Chung TCh (1996) Molecular characterization of a plasmid-borne (pTC82) chloramphenicol resistance determinant (cat-TC) from Lactobacillus reuteri G4. Plasmid 36: 116-124
67. Marra D & Scott JR (1999) Regulation of excision of the conjugative transposon Tn916. Mol. Microbiol. 31: 609-621
68. Macrina FL & Archer GL (1993) Conjugation and broad host range plasmids in streptococci and staphylococci. In: Clewell DB, (Ed.) Bacterial Conjugation (pp. 313-368). Plenum Press, New York
69. McDonald LC, Kuehnert MJ, Tenover FC & Jarvis WR (1997) Vancomycin-resistant enterococci outside the health-care setting: prevalence, sources, and public health implications. Emerging Infect. Dis. 3: 311-317
70. McKay L Funcional properties of plasmids in lactic streptococci. Antonie van Leeuwenhoek 49: 259-274
71. Mercenier A, Pouwels PH & Chassy BM (1994) Genetic engineering of lactobacilli, leuconostocs and Streptococcus thermophilus. In: Gasson MJ & de Vos WM (Eds.) Genetics and Biotechnology of Lactic Acid Bacteria (pp. 252-293). Blackie Academic & Professional, London
72. Ministry of Agriculture and Forestry (Finland) (1997) Tylosin and spiramycin as feed additives - Influence on the efficacy of therapeutic macrolides, Report from the Republic of Finland according to article 29 of the treaty between Member States of the European Union and the Republic of Finland on the scientific arguments for the adaptation to prohibit the use of tylosin and spiramycin as feed additives in animal nutrition by the National Veterinary and Food Research Institut (EELA) (E. Tast, T Honkanen-Buzalski & P Mannerkop, Eds.). Publications of Ministry of Agriculture and Forestry 5/1997, Helsinki
73. Ministry of Agriculture, Fisheries and Food (UK) (1998) A review of antimicrobial resistance in the food chain, July 1998. A technical report for MAFF. MAFF Publications, London
74. Ministry of Agriculture (Sweden), Government Official Reports 132 (1997) Antimicrobial feed additives. Report from the Commission on Antimicrobial Feed Additives. Norsteedts Tryckeri AG., Stockholm
75. National Research Council & Institute of Medicine (1998) The use of drugs in food animals: benefits and risks. National Academy Press, Washington
76. Neu HC (1992) The crisis in antibiotic resistance. Science 257: 1064-1973
77. Neve H, Geis A & Teuber M (1987) Conjugation, a common plasmid transfer mechanism in lactic acid streptococci of dairy starter cultures. System. Appl. Microbiol. 9: 151-157
78. Noble WC, Virani Z & Cree RGA (1992) Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus. FEMS Microbiol. Lett. 93: 195-198
79. Orberg PK & Sandine WE (1985) Survey of antimicrobial resistance in lactic streptococci. Appl. Environ. Microbiol. 49: 538-542
80. Pechmann H & Teuber M (1980) Plasmid pattern of Group N (lactic) Streptococci. Zbl. Bakt. I. Orig. Cl: 133-136
81. Perreten V, Kollöffel B & Teuber M (1997a) Conjugal transfer of the Tn916-like transposon TnFO1 from Enterococcus faecalis isolated from cheese to other Gram-positive bacteria. System. Appl. Microbiol. 20: 27-38
82. Perreten V, Schwarz F, Cresta L, Boeglin M, Dasen G & Teuber M (1997b) Antibiotic resistance spread in food. Nature 389: 801-802
83. Poyart-Salmeron C, Carlier C, Trieu-Cuot P, Courtieu AL & Courvalin P (1990) Transferable plasmid-mediated antibiotic resistance in Listeria monocytogenes. The Lancet 335: 1422-1426
84. Quednau M, Ahrne S, Petersson AC & Molin G (1998) Antibiotic-resistant strains of Enterococcus isolated from Swedish and Danish retailed chicken and pork. J. Appl. Microbiol. 84: 1163-1170
85. Reilly A & Käferstein F (1997) Food safety hazards and the application of the principles of the hazard analysis and critical control point (HACCP) system for their control in aquaculture production. Aquaculture Res. 28: 735-752
86. Rice LB & Carias LL (1997) Transfer of Tn5385, a composite, multiresistance chromosomal element from Enterococcus faecalis. J. Bacteriol. 180: 714-721
87. Rice LB (1998) Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants. Antimicrob. Agents Chemother. 42: 1871-1877
88. Rinckel LA & Savage DC (1990) Characterization of plasmids and plasmid-borne macrolide resistance from Lactobacillus sp. strains. Plasmid 23: 100-133
89. Rollins LR, Lee LN & LeBlanc DJ (1985) Evidence for a disseminated erythromycin resistance determinant mediated by Tn917-like sequences among group D streptococci isolated from pigs, chickens, and humans. Antimicrob. Agents Chemother. 27: 439-444
90. Sami M, Yamashita H, Hirono T, Kadokura H, Kitamoto K, Yoda K & Yamasaki M (1997) Hop-resistant Lactobacillus brevis contains novel plasmid harboring a multidrug resistance-like gene. J. Fermentation & Bioengineering 84: 1-6
91. Schäfer A, Jahns A, Geis A & Teuber M (1991) Distribution of the IS elements ISS1 and IS904 in lactococci. FEMS Microbiology Letters 80: 311-318
92. Schleifer KH & Ludwig W (1995) Phylogenetic relationships of lactic acid bacteria. In: Wood BJB & Holzapfel WH (Eds.) The Genera of Lactic Acid Bacteria (pp. 7-18). Blackie Academic & Professional, London
93. Schmalreck AF, Teuber M, Reininger W & Hartl A (1975) Structural features determining the antibiotic potencies of natural and synthetic hop bitter resins, their precursors and derivatives. Canad. J. Microbiol. 21: 205-212
94. Schmieger H & Schicklmaier P (1999) Transduction of multiple drug resistance of Salmonella enterica serovar thyphimurium DT104. FEMS Microbiol. Lett. 170: 251-256
95. Schwarz F, Perreten V & Teuber M (1999) Mef214, a putative efflux protein, of Lactococcus lactis subsp. lactis K214 conferring increased macrolide resistance in Escherichia coli. (paper submitted).
96. Scott JR (1992) Sex and the single circle: conjugative transposition. J. Bacteriol. 174: 6005-6010
97. Sgorbati B, Biavati B & Palenzona D (1995) The genus Bifidobacterium. In: Wood BJB & Holzapfel WH (Eds.). The Genera of Lactic Acid Bacteria (pp. 279-306). Blackie Academic & Professional, London
98. Sievers M, Teuber M, Wirsching F, Perreten V, Eisenring R, Fähndrich P, Schlaepfer S, Krusch U, Simm Ch & Löhmer A (1993) Antibiotic resistance properties of enterococci and staphylococci from fermented food. FoodMicro '93, Book of Abstracts (pp. 191)
99. Simpson WJ, Hammond JRM & Miller RB (1988) Avoparcin and vancomycin: Useful antibiotics for the isolation of brewery lactic acid bacteria. J. Appl. Bacteriol. 64: 299-310
100. Simpson WJ & Taguchi H (1995) The genus Pediococcus, with notes on the genera Tetratogenococcus and Aerococcus. In: The Genera of Lactic Acid Bacteria (pp. 125-172). Blackie Academic & Professional, London
101. Soeding B, Kleinschmidt J, Teuber M & Neve H (1993) Assessment of abilities of conjugal transfer and stability of pAMβ1 in dairy lactobacilli with emphasis on thermophilic and nonstarter lactobacilli. System. Appl. Microbiol. 16: 296-302
102. Sozzi T & Smiley MB (1980) Antibiotic resistances of yogurt starter cultures Streptococcus thermophilus and Lactobacillus bulgaricus. Appl. Environ. Microbiol. 40: 862-865
103. Tannock GW (1987) Conjugal transfer of plasmid pAMβ1 in Lactobacillus reuteri and between lactobacilli and Enterococcus faecalis. Appl. Environ. Microbiol. 53: 2693-2695
104. Tannock GW (1998) Probiotics. A critical review. Horizon Scientific Press, Wymondham
105. Tannock GW, Luchansky JB, Miller L, Connell H, Thode-Andersen S, Mercer AA & Klaenhammer TR (1994) Molecular characterization of a plasmid-borne (pGT633) erythromycin resistance determinant (ermGT) from Lactobacilllus reuteri 100-163. Plasmid 31: 60-71
106. Teuber M and Schmalreck AF (1973) Membrane leakage in Bacillus subtilis 168 induced by the hop constituents lupulone, humulone, isohumulone and humulinic acid. Arch. Mikrobiol. 94: 159-171
107. Teuber M (1993) Lactic acid bacteria. In: J Rehm, Reed G, Pühler A & Stadler P (Eds.) 'Biotechnology' Vol. 1, 2nd edition (pp. 326-365). Verlag Chemie, Weinheim
108. Teuber M (1995) The genus Lactococcus. In Wood BJB & Holzapfel WH (Eds.) The Genera of Lactic Acid Bacteria (pp. 173-234). Blackie Academic & Professional, London
109. Teuber M, Perreten V & Wirsching F (1996) Antibiotikumresistente Bakterien: eine neue Dimension in der Lebensmittelmikrobiologie. Lebensmittel-Technologie 29: 182-199
110. Thal LA, Chow JW, Mahayni R, Bonilla H, Perri MB, Donabedia SA, Silverman J, Taber S & Zervos MJ (1995) Characterization of antimicrobial resistance in enterococci of animal origin. Antimicrob. Agents Chemother. 39: 2112-2115
111. Trieu-Cuot P, de Cespédès G, Bentorcha F, Delbos F, Gaspar E & Horaud T (1993) Study of heterogeneity of chloramphenicol acetyltransferase (CAT) genes in streptococci and enterococci by polymerase chain reaction: Characterization of a new CAT determinant. Antimicrob. Agents Chemother. 37: 2593-2598
112. Van den Braak N, van Belkum A, van Keulen M, Vliegenthart J, Verbrugh HA & Endtz HP (1998) Molecular characterization of vancomycin-resistant enterococci from hospitalized patients and poultry products in the Netherlands. J. Clin. Microbiol. 36: 1927-1932
113. Van Veen HW & Konings WN (1998) The ABC family of multidrug transporters in microorganisms. Biochim. Biophys. Acta 1365, 31-36
114. Vescovo M, Morelli L & Bottazzi V (1982) Drug resistance plasmids in Lactobacillus acidophilus and Lactobacillus reuteri. Appl. Environ. Microbiol. 43: 50-56
115. Von Wright A & Räty K (1993) The nucleotide sequence for the replication region of pVS40, a lactococcal food grade cloning vector. Lett. Appl. Microbiol. 17: 25-28
116. Watanabe T (1963) Infective heredity of multiple drug resistance in bacteria. Bacteriol. Rev. 27: 87-115
117. WHO (1997) The medical impact of the use of antimicrobials in food animals. Report of a WHO Meeting, Berlin, Germany, 13-17 October 1997. WHO, Geneva
118. Witte W (1998) Medical consequences of antibiotic use in agriculture. Science 279: 996-997
119. Wu K, An FY & Clewell DB (1999) Enterococcus faecalis Pheromone-responding plasmid pAD1 gives rise to an aggregation (clumping) response when cells are exposed to subinhibitory concentrations of chloramphenicol, erythromycin or tetracycline. Plasmid 41: 82-88
120. Wüst J, Zbinden R & Kayser FH (1998) Die Empfindlichkeit von Bakterien gegen Chemotherapeutika (Zürich 1996). Praxis 87: 403-412