Allogeneic hematopoietic transplantation as adoptive immunotherapy: Induction of graft-versus-malignancy as primary therapy

Hematology/Oncology Clinics of North America

Volumn 13, Issue 5, 1999, Pages 1041-1057

  Champlin, R ^a   Khouri, I ^a   Kornblau, S ^a   Marini, F ^a   Anderlini, P ^a   Ueno, N T ^a   Molldrem, J ^a   Giralt, S ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUDARABINE;

ADOPTIVE IMMUNOTHERAPY; ALLOGRAFT; BONE MARROW TRANSPLANTATION; COMPARATIVE STUDY; DRUG EFFECT; DRUG MEGADOSE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LEUKEMIA; LYMPHOCYTIC INFILTRATION; PRIORITY JOURNAL; REVIEW;

EID: 0032857134     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8588(05)70108-8     Document Type: Article

References (113)

1. + donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant Blood 91 1998 3671
2. J.H. Antin Graft-versus-leukemia: No longer an epiphenomenon Blood 82 1993 2273
3. J.H. Antin J.L.M. Ferrara Cytokine dysregulation and acute graft-versus-host disease Blood 80 1992 2964
4. J.F. Apperley L. Jones G. Hale Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse Bone Marrow Transplant 1 1986 53
5. J.F. Apperley F. Rassool A. Parriera Philadelphia-positive metaphases in the marrow after bone marrow transplantation for chronic granulocytic leukemia Am J Hematol 22 1986 19
6. A. Bacigalupo M. Soracco F. Vassallo Donor lymphocyte infusions (DLI) in patients with chronic myeloid leukemia following allogeneic bone marrow transplantation Bone Marrow Transplant 19 1997 927
7. A. Bacigalupo M.T. Van Lint D. Occhini Increased risk of leukemia relapse with high-dose cyclosporine A after allogeneic marrow transplantation for acute leukemia Blood 77 1991 1423
8. P.G. Beatty Minor histocompatibility antigens Exp Hematol 21 1993 1514
9. P.G. Beatty National heart, lung, and blood institute (NHLBI) workshop on the importance of minor histocompatibility antigens in marrow transplantation Exp Hematol 25 1997 548
10. W.I. Bensinger C.D. Buckner C. Anasetti Allogeneic marrow transplantation for multiple myeloma: An analysis of risk factors on outcome Blood 88 1996 2787
11. C. Bonini G. Ferrari S. Verzeletti HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia Science 276 1997 1719
12. M. Brenner S. Porcelli Antigen presentation: A balanced diet Science 277 1997 332
13. A.A. Cardoso M.J. Seamon H.M. Afonso Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells Blood 90 1997 549
14. M. Cavazzana-Calvo J.L. Stephan S. Sarnacki Attenuation of graft-versus-host disease and graft rejection by ex vivo immunotoxin elimination of alloreactive T cells in an H-2 haplotype disparate mouse combination Blood 83 1994 288
15. R. Champlin Graft-versus-leukemia without graft-versus-host disease: An elusive goal of bone marrow transplantation Semin Hematol 29 suppl 2 1992 46
16. R.E. Champlin Separation of graft-vs-host disease and graft-vs-leukemia against chronic myelogenous leukemia Exp Hematol 23 1995 1148
17. + T lymphocytes for prevention of graft-versus-host disease after allogeneic bone marrow transplantation Blood 76 1990 418
18. R.E. Champlin J. Jansen W. Ho Retention of graft-versus-leukemia using selective depletion of CD8 positive T lymphocytes for prevention of graft versus host disease following bone marrow transplantation for chronic myelogenous leukemia Transplant Proc 23 1991 1695
19. R.E. Champlin I. Khouri S. Giralt Induction of graft-vs-leukemia as a therapeutic modality American Society of Clinical Oncology Education Book 1 1997 54
20. R.H. Collins Jr O. Shpilberg W.R. Drobyski Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation J Clin Oncol 15 1997 433
21. J.O. Cullis Y.Z. Jiang A.P. Schwarer Donor leukocyte infusions for chronic myeloid leukemia in relapse after allogeneic bone marrow transplantation Blood 79 1992 1379
22. M. De Beuger A. Bakker J.J. van Rood Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte defined non-MHC antigens J Immunol 149 1992 1788
23. R. DeLage R.J. Soiffer K. Dear Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia Blood 78 1991 2759
24. W.R. Drobyski C.A. Keever M.S. Roth Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: Efficacy and toxicity of a defined T-cell dose Blood 82 1993 2310
25. B. Eibl H. Schwaighofer D. Nachbaur Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer Blood 88 1996 1501
26. L.M. Faber J. Van der Hoeven E. Goulmy Recognition of clonogenic leukemic cells, remission bone marrow and HLA-identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen-specific cytotoxic T lymphocytes J Clin Invest 96 1995 877
27. L.M. Faber S.A.P. Van Luxemburg-Heijs R. Willemze Generation of leukemia-reactive cytotoxic T lymphocyte clones from the HLA-identical bone marrow donor of a patient with leukemia J Exp Med 176 1992 1283
28. J.H.F. Falkenburg H.M. Goselink D. Van der Harst Growth inhibition of clonogeneic leukemic precursor cells by minor histocompatibility antigen specific cytotoxic T lymphocytes J Exp Med 174 1991 27
29. A. Fefer M.A. Cheever P.D. Greeberg Identical-twin (syngeneic) marrow transplantation for hematologic cancers J Natl Cancer Inst 76 1986 1269
30. J.L.M. Ferrara S. Abhyankar D.G. Gilliland Cytokine storm of graft-versus-host disease: A critical effector role for interleukin-1 Transplant Proc 25 1993 1216
31. J.L.M. Ferrara H.J. Deeg Mechanisms of disease: Graft-versus-host disease N Engl J Med 324 1991 667
32. J.L.M. Ferrara F.J. Guillen P.J. van Dijken Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease Transplantation 47 1989 50
33. R.P. Gale R.E. Champlin How does bone marrow transplantation cure leukemia? Lancet 2 1984 28
34. R.P. Gale M.M. Horowitz R.C. Ash Identical-twin bone marrow transplants for leukemia Ann Intern Med 120 1994 646
35. G. Gahrton S. Tura P. Ljungman Allogeneic bone marrow transplantation in multiple myeloma N Engl J Med 325 1991 1267
36. G. Gahrton S. Tura P. Ljungman Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma J Clin Oncol 13 1995 1312
37. L. Garderet V. Snell D. Przepiorka Effective depletion of alloreactive lymphocytes from peripheral blood mononuclear cell preparations Transplantation 67 1999 124
38. S.A. Giralt R.E. Champlin Leukemia relapse after allogeneic bone marrow transplantation: A review Blood 84 1994 3603
39. S. Giralt A. Cohen R. Mehra Preliminary results of fludarabine/melphalan or 2CDA/melphalan as preparative regimens for allogeneic progenitor cell transplantation in poor candidates for conventional myeloablative conditioning Blood 90 1997 1853a
40. S. Giralt E. Estey M. Albitar Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: Harnessing graft-versus-leukemia without myeloablative therapy Blood 89 1997 4531
41. S. Giralt J. Hester Y. Huh CD8+ depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: Graft vs leukemia without graft vs. host disease Blood 86 1995 4337
42. B. Glass L. Uharek M. Zeis Graft-versus-leukaemia activity can be predicted by natural cytotoxicity against leukaemia Br J Haematol 93 1996 412
43. J.M. Goldman R.P. Gale M.M. Bortin Bone marrow transplantation for chronic myelogenous leukemia in chronic phase: Increased risk of relapse associated with T-cell depletion Ann Intern Med 108 1988 806
44. E. Goulmy P. Voogt C. Van Els The role of minor histocompatibility antigens in GvHD and rejection: A mini-review Bone Marrow Transplant 7 suppl 1 1991 49
45. M. Hauch M.V. Gazzola T. Small Anti-leukemia potential of interleukin-2 activated natural killer cells after bone marrow transplantation for chronic myelogenous leukemia Blood 75 1990 2250
46. G.R. Hill J.M. Crawford K.R. Cooke Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines Blood 90 1997 3204
47. T. Hoffmann M. Theobald D. Bunjes Frequency of bone marrow T cells responding to HLA-identical non-leukemic and leukemic stimulator cells Bone Marrow Transplant 12 1993 1
48. M.M. Horowitz R.P. Gale P.M. Sondel Graft-versus-leukemia reactions after bone marrow transplantation Blood 75 1990 555
49. T.P. Hughes G.J. Morgan P. Martiat Detection of residual leukemia after bone marrow transplant for chronic myeloid leukemia: Role of polymerase chain reaction in predicting relapse Blood 77 1991 874
50. Y.-Z. Jiang A.J. Barrett Cellular and cytokine mediated effects of CD4-positive lymphocyte lines generated in vitro against chronic myelogenous leukemia Exp Hematol 23 1995 1167
51. Y.Z. Jiang A.J. Barrett J.M. Goldman Association of natural killer cell immune recovery with a graft-versus-leukemia effect independent of graft-versus-host disease following allogeneic bone marrow transplantation Ann Hematol 74 1997 1
52. Y.-Z. Jiang E.J. Kanfer D. Macdonald Graft-versus-leukaemia following allogeneic bone marrow transplantation: Emergence of cytotoxic T lymphocytes reacting to host leukaemia cells Bone Marrow Transplant 8 1991 253
53. + T lymphocytes can exert cytotoxicity to chronic myeloid leukaemia cells processing and presenting exogenous antigen Br J Haematol 93 1996 606
54. F. Keil O.A. Haas G. Fritsch Donor leukocyte infusion for leukemic relapse after allogeneic marrow transplantation: Lack of residual donor hematopoiesis predicts aplasia Blood 89 1997 3113
55. E. Kelemen T. Masszi P. Reményi Reduction in the frequency of transplant-related complications in patients with chronic myeloid leukemia undergoing BMT preconditioned with a new, non-myeloablative drug combination Bone Marrow Transplant 21 1998 747
56. N.A. Kernan B. Dupont Minor histocompatibility antigens and marrow transplantation N Engl J Med 334 1996 323
57. I. Khouri M. Keating M. Korbling Transplant Lite: Induction of graft-versus-leukemia using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor cell transplantation as treatment for lymphoid malignancies J Clin Oncol 16 1998 2817
58. I. Khouri M.J. Keating D. Przepiorka Engraftment and induction of GVL with fludarabine-based non-ablative preparative regimen in patients with chronic lymphocytic leukemia Blood 88 suppl 1 1996 301a
59. H.J. Kolb A. Schattenberg J.M. Goldman Graft-vs-leukemia effect of donor lymphocyte transfusions in marrow grafted patients Blood 86 1995 2041
60. R. Korngold J. Sprent T cell subsets and graft-versus-host disease Transplantation 44 1987 335
61. R. Korngold J. Sprent Variable capacity of L3 T4 + T cells to cause lethal graft versus host disease across minor histocompatibility barriers in mice J Exp Med 165 1987 52
62. M. Lee I. Khouri R. Champlin Detection of minimal residual disease by polymerase chain reaction of bcr/abl transcripts in chronic myelogenous leukaemia following allogeneic bone marrow transplantation Br J Haematol 82 1992 708
63. H.M. Lokhorst A. Schattenberg J.J. Cornelissen Donor leukocyte infusions are effective in relapsed multiple myeloma after allogeneic bone marrow transplantation Blood 90 1997 4206
64. S. Mackinnon L. Barnett G. Heller Minimal residual disease is more common in patients who have mixed T-cell chimerism after bone marrow transplantation for chronic myelogenous leukemia Blood 83 1994 3409
65. S. Mackinnon E.B. Papadopoulos M.H. Carabasi Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: Separation of graft-versus-leukemia responses from graft-versus-host disease Blood 86 1995 1261
66. J.O. Manilay D.A. Pearson J.J. Sergio Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning: Regimen Transplantation 66 1998 96
67. W.A.F. Marijt W.F.J. Veenhof A. Brand Minor histocompatibility antigen-specific cytotoxic T cell lines, capable of lysing human hematopoietic progenitor cells, can be generated in vitro by stimulation with HLA-identical bone marrow cells J Exp Med 173 1991 101
68. W.A.F. Marijt W.F.J. Veenhof E. Goulmy Minor histocompatibility antigens HA-1-, -2-, and -4-, and HY-specific cytotoxic T-cell clones inhibit human hematopoietic progenitor cell growth by a mechanism that is dependent on direct cell-cell contact Blood 82 1993 3778
69. A.M. Marmont M.M. Horowitz R.P. Gale T-cell depletion of HLA-identical transplants in leukemia Blood 78 1991 2120
70. D.A. Mavroudis S. Dermime J. Molldrem Specific depletion of alloreactive T cells in HLA-identical siblings: A method for separating graft-versus-host and graft-versus-leukaemia reactions Br J Haematol 101 1998 565
71. J.J. Molldrem E. Clave Y.Z. Jiang Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units Blood 90 1997 2529
72. J. Molldrem S. Dermime K. Parker Targeted T-cell therapy for human leukemia: Cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells Blood 88 1996 2450
73. N.C. Munshi R. Govindarajan R. Drake Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir Blood 89 1997 1334
74. + cells for prevention of graft-versus-host disease after bone marrow transplantation: A randomized controlled trial Transplantation 57 1994 82
75. K. Offit J.P. Burns I. Cunningham Cytogenetic analysis of chimerism and leukemia relapse in chronic myelogenous leukemia patients after T cell-depleted bone marrow transplantation Blood 75 1990 1346
76. H. Okumura H. Takamatsu T. Yoshida Donor leucocyte transfusions for relapse in myelodysplastic syndrome after allogeneic bone marrow transplantation Br J Haematol 93 1996 386
77. J.P. Okunewick D.L. Kociban L.L. Machen Evidence for a possible role of Asialo-GM1-positive cells in the graft-versus-leukemia repression of a murine type-C retroviral leukemia Bone Marrow Transplant 16 1995 451
78. J.P. Okunewick D.L. Kociban L.L. Machen The role of CD4 and CD8 T cells in the graft-versus-leukemia response in Rauscher murine leukemia Bone Marrow Transplant 8 1991 445
79. P.J. Orchard J.S. Miller R. McGlennen Graft-versus-leukemia is sufficient to induce remission in juvenile myelomonocytic leukemia Bone Marrow Transplant 22 1998 201
80. E.B. Papadopoulos M.H. Carabasi H. Castro-Malaspina T-cell–depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: Freedom from relapse in the absence of graft-versus-host disease Blood 91 1998 1083
81. C. Perreault F. Décary S. Brochu Minor histocompatibility antigens Blood 76 1990 1269
82. G. Pichert E.P. Alyea R.J. Soiffer Persistence of myeloid progenitor cells expressing BCR-ABL mRNA after allogeneic bone marrow transplantation for chronic myelogenous leukemia Blood 84 1994 2109
83. G. Pichert J. Ritz Clinical significance of bcr-abl gene rearrangement detected by the polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia Leuk Lymphoma 10 1993 1
84. D.L. Porter M.S. Roth S.J. Lee Adoptive immunotherapy with donor mononuclear cell infusions to treat relapse of acute leukemia or myelodysplasia after allogeneic bone marrow transplantation Bone Marrow Transplant 18 1996 975
85. P. Raanani F. Dazzi J. Sohal The rate and kinetics of molecular response to donor leucocyte transfusions in chronic myeloid leukaemia patients treated for relapse after allogeneic bone marrow transplantation Br J Haematol 99 1997 945
86. J.P. Radich G. Gehly T. Gooley Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: Results and implications in 346 patients Blood 85 1995 2632
87. S.L. Rahman P. Mahendra E. Nacheva Achievement of complete cytogenetic remission after two very low-dose donor leucocyte infusions in a patient with extensive cGvHD relapsing in accelerated phase post allogeneic BMT for CML Bone Marrow Transplant 21 1998 955
88. M.C. Rapanotti W. Arcese S. Buffolino Sequential molecular monitoring of chimerism in chronic myeloid leukemia patients receiving donor lymphocyte transfusion for relapse after bone marrow transplantation Bone Marrow Transplant 19 1997 703
89. G. Rondón S. Giralt Y. Huh Graft-versus-leukemia effect after allogeneic bone marrow transplantation for chronic lymphocytic leukemia Bone Marrow Transplant 18 1996 669
90. C.M. Rooney C.A. Smith C.Y.C. Ng Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus related lymphoproliferation Lancet 345 1995 9
91. − phenotype are effectors of experimental cutaneous graft-versus-host disease Proc Natl Acad Sci U S A 88 1991 10890
92. C.L. Sawyers L. Timson E.S. Kawasaki Molecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction Proc Natl Acad Sci U S A 87 1990 563
93. A.M. Ship R. Carter T. Murray Irradiated donor lymphocyte infusion, a novel approach to prevent graft failure during allogeneic bone marrow transplant Proceedings of the American Society of Clinical Oncology 17 1998 74a
94. S. Slavin A. Nagler E. Naparstek Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases Blood 91 1998 756
95. J.A. Sosman K.R. Oettel S.D. Smith Specific recognition of human leukemic cells by allogeneic T cells: II. Evidence for HLA-D restricted determinants on leukemic cells that are crossreactive with determinants present on unrelated nonleukemic cells Blood 75 1990 2005
96. W.M. Smit M. Rijnbeek C.A.M. Van Bergen Generation of leukemia-reactive cytotoxic T lymphocytes from HLA-identical donors of patients with chronic myeloid leukemia using modifications of a limiting dilution assay Bone Marrow Transplant 21 1998 553
97. R. Storb C. Yu J.L. Wagner Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation Blood 89 1997 3048
98. K.M. Sullivan R. Storb C.D. Buckner Graft-versus-host disease as adoptive immunotherapy in patients with advanced hematologic neoplasms N Engl J Med 320 1989 828
99. E.D. Thomas Bone marrow transplantation for malignant disease J Clin Oncol 1 1983 517
100. E.D. Thomas The role of bone marrow transplantation for eradication of malignant disease Cancer 10 1969 1963
101. P. Tiberghien C.W. Reynolds J. Keller Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: An approach for specific in vivo donor T-cell depletion after bone marrow transplantation Blood 84 1994 1333
102. G. Tricot D.H. Vesole S. Jagannath Graft-versus-myeloma effect: Proof of principle Blood 87 1996 1196
103. R.L. Truitt A.A. Atasoylu Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow Bone Marrow Transplant 8 1991 51
104. N.T. Ueno G. Rondón N.Q. Mirza Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer J Clin Oncol 16 1998 986
105. K.W. Van Besien M. De Lima S.A. Giralt Management of lymphoma recurrence after allogeneic transplantation: The relevance of graft-versus-lymphoma effect Bone Marrow Transplant 19 1997 977
106. D. Van der Harst E. Goulmy J.H.F. Falkenburg Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones Blood 83 1994 1060
107. F. Van Rhee F. Lin J.O. Cullis Relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: The case for giving donor leukocyte transfusions before the onset of hematologic relapse Blood 83 1994 3377
108. F. Van Rhee D. Savage J. Blackwell Adoptive immunotherapy for relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: Equal efficacy of lymphocytes from sibling and matched unrelated donors Bone Marrow Transplant 21 1998 1055
109. L.F. Verdonck H.M. Lokhorst A.W. Dekker Graft-versus-myeloma effect in two cases Lancet 347 1996 800
110. E.A. Walter P.D. Greenberg M.J. Gilbert Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor N Engl J Med 333 1995 1038
111. P.L. Weiden N. Flournoy E.D. Thomas Antileukemic effect of graft-versus-host disease in human recipients of allogeneic marrow grafts N Engl J Med 300 1979 1068
112. P.L. Weiden K.M. Sullivan N. Flournoy for the Seattle Marrow Transplant Team. Antileukemic effect of chronic graft-versus-host disease: Contribution to improved survival after allogeneic marrow transplantation N Engl J Med 304 1981 1529
113. M. Zeis L. Uharek B. Glass Allogeneic NK cells as potent antileukemic effector cells after allogeneic bone marrow transplantation in mice Transplantation 59 1995 1734