Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation

Blood

Volumn 89, Issue 8, 1997, Pages 3048-3054

  Storb, Rainer ^a   Yu, Cong ^b   Wagner, John L ^b   Deeg, H Joachim ^b   Nash, Richard A ^b   Kiem, Hans Peter ^b   Leisenring, Wendy ^b   Shulman, Howard ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; HISTOCOMPATIBILITY ANTIGEN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADOLESCENT; ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; DOG; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HISTOCOMPATIBILITY; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; SUBCUTANEOUS DRUG ADMINISTRATION; WHOLE BODY RADIATION;

EID: 0030896219     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.8.3048     Document Type: Article

References (31)

1. Yu C, Storb R, Mathey B, Deeg HJ, Schuening FG, Graham TC, Seidel K, Burnett R, Wagner JL, Shulman H, Sandmaier BM: DLA-identical bone marrow grafts after low-dose total body irradiation: Effects of high-dose corticosteroids and cyclosporine on engraftment. Blood 86:4376, 1995
2. Deeg HJ, Storb R, Weiden PL, Raff RF, Sale GE, Atkinson K, Graham TC, Thomas ED: Cyclosporin A and methotrexate in canine marrow transplantation: Engraftment, graft-versus-host disease, and induction of tolerance. Transplantation 34:30, 1982
3. Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Doney K, Farewell V, Hansen J, Hill R, Lum L, Martin P, McGuffin R, Sanders J, Stewart P, Sullivan K, Witherspoon R, Yee G, Thomas ED: Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia? N Engl J Med 314:729, 1986
4. Yu C, Storb R, Deeg HJ, Schuening FG, Nash RA, Graham T: Synergism between mycophenolate mofetil and cyclosporine in preventing graft-versus-host disease in lethally irradiated dogs given DLA-nonidentical unrelated marrow grafts. Blood 86:577a, 1995 (abstr) (suppl 1)
5. Burnett RC, Francisco LV, DeRose SA, Storb R, Ostrander EA: Identification and characterization of a highly polymorphic microsatellite marker within the canine MHC class I region. Mamm Genome 6:684, 1995
6. Wagner JL, Burnett RC, DeRose SA, Francisco LV, Storb R, Ostrander EA: Histocompatibility testing of dog families with highly polymorphic microsatellite markers. Transplantation 62:876, 1996
7. Wagner JL, Burnett RC, Works J, Storb R: Molecular analysis of the DLA-DRBB1 polymorphism. Tissue Antigens 48:554, 1996
8. Storb R, Raff RF, Graham T, Appelbaum FR, Deeg HJ, Schuening FG, Shulman H, Pepe M: Marrow toxicity of fractionated versus single dose total body irradiation is identical in a canine model. Int J Radiat Oncol Biol Phys 26:275, 1993
9. n polymorphisms to determine the origin of blood cells after allogeneic canine marrow grafting. Transplantation 58:701, 1994
10. 32P-postlabeling assay. Carcinogenesis 13:1475, 1992
11. Ochs HD, Storb R, Thomas ED, Kolb H-J, Graham TC, Mickelson E, Parr M, Rudolph RH: Immunologic reactivity in canine marrow graft recipient. J Immunol 113:1039, 1974
12. Moore PF, Rossitto PV, Danilenko DM, Wielenga JJ, Raff RF, Severns E: Monoclonal antibodies specific for canine CD4 and CD8 define functional T-lymphocyte subsets and high density expression of CD4 by canine neutrophils. Tissue Antigens 40:75, 1992
13. Hill RS, Petersen FB, Storb R, Appelbaum FR, Doney K, Dahlberg S, Ramberg R, Thomas ED: Mixed hematologic chimerism after allogeneic marrow transplantation for severe aplastic anemia is associated with a higher risk of graft rejection and a lessened incidence of acute graft-versus-host disease. Blood 67:811, 1986
14. Andreani M, Nesci S, Manna M, Tonucci P, Agostinelli F, Talevi N, Donati M, Rapa S, Ripalti M, Lucarelli G: Origin of different hematologic lineages in stable mixed chimeras after BMT in thalassemia, in Beuzard Y, Lubin B, Rosa J (eds): Sickle Cell Disease and Thalassaemias: New Trends in Therapy (vol 234). Colloque INSERM, John Libbey Eurotext Ltd, 1995, p 581
15. Nesci S, Manna M, Andreani M, Fattorini P, Graziosi G, Lucarelli G: Mixed chimerism in thalassemic patients after bone marrow transplantation. Bone Marrow Transplant 10:143, 1992
16. Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, Mentzer WC, Davies SC, Ohene-Frempong K, Bernaudin F, Matthews DC, Storb R, Sullivan KM: Bone marrow transplantation for sickle cell disease. N Engl J Med 335:369, 1996
17. Reinsmoen NL, Jackson A, McSherry C, Ninova D, Wiesner RH, Kondo M, Krom RAF, Hertz MI, Bolman RM III, Matas AJ: Organ-specific patterns of donor antigen-specific hyporeactivity and peripheral blood allogeneic microchimerism in lung, kidney, and liver transplant recipients. Transplantation 60:1546, 1995
18. Hisanaga M, Hundrieser J, Böker K, Uthoff K, Raddatz G, Wahlers T, Wonigeit K, Pichlmayr R, Schlitt HJ: Development, stability, and clinical correlations of allogeneic microchimerism after solid organ transplantation. Transplantation 61:40, 1996
19. Starzl TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M: Cell migration, chimerism, and graft acceptance. Lancet 339:1579, 1992
20. Starzl TE, Demetris AJ, Trucco M, Zeevi A, Ramos H, Terasaki P, Rudert WA, Kocova M, Ricordi C, Ildstad S, Murase N: Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation 55:1272, 1993
21. Shapiro R, Rao AS, Fontes P, Zeevi A, Jordan M, Scantlebury VP, Vivas C, Gritsch HA, Corry RJ, Egidi F, Rugeles MT, Rilo H, Aitouche A, Demetris AJ, Rosner G, Trucco M, Rybka W, Irish W, Fung JJ, Starzl TE: Combined simultaneous kidney/bone marrow transplantation. Transplantation 60:1421, 1995
22. Main JM, Prehn RT: Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow. J Natl Cancer Inst 15:1023, 1955
23. Cobbold SP, Martin G, Qin S, Waldmann H: Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 323:164, 1986
24. Li H, Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST: Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in non-obese diabetic (NOD) mice. J Immunol 156:380, 1996
25. Colson YL, Wren SM, Schuchert MJ, Patrene KD, Johnson PC, Boggs SS, Ildstad ST: A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriers. J Immunol 155:4179, 1995
26. Sharabi Y, Abraham VS, Sykes M, Sachs DH: Mixed allogeneic chimeras prepared by a non-myeloablative regimen: Requirement for chimerism to maintain tolerance. Bone Marrow Transplant 9:191, 1992
27. Tomita Y, Sachs DH, Khan A, Sykes M: Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. Transplantation 61:469, 1996
28. Tomita Y, Khan A, Sykes M: Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. Transplantation 61:477, 1996
29. Lee LA, Sergio JJ, Sykes M: Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells. Transplantation 61:125, 1996
30. Kawai T, Cosimi AB, Colvin RB, Powelson J, Eason J, Kozlowski T, Sykes M, Monroy R, Tanaka M, Sachs DH: Mixed allogeneic chimerism and renal allograft tolerance in Cynomolgus monkeys. Transplantation 59:256, 1995
31. Watanabe K, Ito I, Otani F, Obata F, Sato K, Ishida K, Masaki Y, Maruyama S, Kashiwagi N: Factors influencing long-term operational tolerance in dogs treated with fractionated lymphoid irradiation, donor bone marrow infusion and FK506. Transplant Proc 27:221, 1995