Achievement of complete cytogenetic remission after two very low-dose donor leucocyte infusions in a patient with extensive cGVHD relapsing in accelerated phase post allogeneic BMT for CML

Bone Marrow Transplantation

Volumn 21, Issue 9, 1998, Pages 955-956

  Rahman, S L ^a   Mahendra, P ^a   Nacheva, E ^a   Sinclair, P ^a   Arno, J ^a   Marcus, R E ^a  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Allogeneic bone marrow transplantation; Chronic myeloid leukaemia; Donor leucocyte infusion; Graft versus host disease

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN A;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER REGRESSION; CASE REPORT; CHRONIC MYELOID LEUKEMIA; CYTOGENETICS; DONOR LYMPHOCYTE INFUSION; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; LEUKOCYTE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; WHOLE BODY RADIATION;

EID: 0031953004     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1701195     Document Type: Article

References (6)

1. Apperley JF, Jones L, Hale G et al. Bone marrow transplantation for patients with chronic myeloid leukemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the incidence of relapse. Bone Marrow Transplant 1986; 1: 53-68.
2. Kolb H-J, Mittermuller J, Clemm CH et al. Donor leucocyte transfusions for treatment of recurrent chronic myelogenous leukaemia in marrow transplant patients. Blood 1990; 76: 2462-2465.
3. Kolb H-J, Schattenberg A, Goldman JM et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995; 86: 2041-2050.
4. Mackinnon S, Papadopoulos EB, Carasbasi MH et al. Adoptive immunotherapy evaluating doses of donor leucocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease. Blood 1995; 86: 1261-1268.
5. van Rhee F, Savage D, Blackwell J et al. Donor lymphocyte infusions (DLI) for relapse of CML post BMT: higher cell doses induce more rapid responses. Blood 1996; 88 (Suppl. 1): 681a.
6. Perry AR, Mackinnon S. Adoptive immunotherapy post bone marrow transplantation. Blood Rev 1996; 10: 237-241.