Alloreactive CD4+ T lymphocytes can exert cytotoxicity to chronic myeloid leukaemia cells processing and presenting exogenous antigen

British Journal of Haematology

Volumn 93, Issue 3, 1996, Pages 606-612

  Jiang, Yin Zheng ^a   Mavroudis, Dimitrios ^a   Dermime, Said ^a   Hensel, Nancy ^a   Couriel, Daniel ^a   Molldrem, Jeffrey ^a   Barrett, A John ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CD4+ CTL; CML; Fas antigen; GVL; T cell cloning

Indexed keywords

BREFELDIN; CD4 ANTIGEN; CHLOROQUINE; HLA DR ANTIBODY; TUBERCULIN; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; PRIORITY JOURNAL;

EID: 0029888468     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1676.x     Document Type: Article

References (41)

1. Adorini, L., Moreno, J., Momburg, F., Hammerling, G.J., Guery, J.C., Valli, A. & Fuchs, S. (1991) Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility complex class II-restricted T cells. Journal of Experimental Medicine, 174, 945-948.
2. Antin, J.H. (1993) Graft-versus-leukemia: no longer an epiphenomenon. Blood, 82, 2273-2277.
3. Barrett, A.J. & Jiang, Y.Z. (1992) Immune response to chronic myeloid leukemia. Bone Marrow Transplantation, 9, 305-311.
4. Barrett, A.J. & Malkovska, V. (1996) Graft-versus-leukaemia: understanding and using the alloimmune response to treat haematological malignancies. British Journal of Haematology, 93, 754-761.
5. Biddison, W.E. & Shaw, S. (1989) CD4 expression and function in HLA class II-specific T cells. Immunology Reviews, 109, 5-15.
6. Bortin, M.M., Truitt, R.L., Rimm, A.A. & Bach, F.H. (1979) Graft-versus-leukaemia reactivity induced by alloimmunization without augmentation of graft-versus-host reactivity. Nature, 281, 490-491.
7. Brenner, M.K. & Heslop, H.E. (1991) Graft-versus-leukaemia effects after marrow transplantation in man. Bailliere's Clinical Haematology, 4, 727-749.
8. Broxmeyer, H.E., Williams, D.E., Lu, L., Cooper, S., Anderson, S.L., Beyer, G.S., Hoffman, R. & Rubin, B.Y. (1986) The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma. Journal of Immunology, 136, 4487-4495.
9. Champlin, R., Jansen, J., Ho, W., Gajewski, J., Nimer, S., Lee, K., Territo, M., Winston, D., Tricot, G. & Reichert, T. (1991) Retention of graft-versus-leukemia using selective depletion of CD8-positive T-lymphocytes for prevention of graft-versus-host disease following bone marrow transplantation for chronic myeloid leukemia. Transplantation Proceedings, 23, 1695-1696.
10. Cullis, J.O., Jiang, Y.Z., Schwarer, A.P., Hughes, T.P., Barrett, A.J. & Goldman, J.M. (1992) Donor leukocyte infusion in the treatment of chronic myeloid leukemia in relapse following allogeneic bone marrow transplantation. Blood, 79, 1379-1381.
11. Delain, M., Tiberghien, P., Racadot, E., Billot, M., Pariset, J., Chod, J., Cahn, J.Y. & Herve, P. (1994) Variability of the alloreactivity T-cell response to human leukemia blasts. Leukemia, 8, 642-647.
12. Dermime, S., Marchesi, E., Ravagnani, F., Blaser, K., Corneo, G.M., Pogliani, E., Parmiani, G. & Gambacorti-Passerini, C. (1996) Inefficient T cell mediated recognition of the fusion region of the PML/RARa hybrid protein by lymphocytes of acute promyelocytic leukemia patients. Clinical Cancer Research (in press).
13. Faber, L.M., van Luxemberg-Heijs, R., Willemze, R. & Falkenberg, J.H.F. (1992) Generation of cytotoxic T lymphocyte clones from the HLA-identical bone marrow donor of a patient with leukaemia. Journal of Experimental Medicine, 176, 1283-1289.
14. Falkenburg, J.H.F., Goselink, H.M., van der Harst, D., van Luxemberg-Heijs, S.A.P., Kooy-Winkelaar, Y.M.C., Faber, L.M., de Kroon, J., Brand, A., Fibbe, W.E., Willemze, R. & Goulmy, E. (1991) Growth inhibition of clonogeneic leukaemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes. Journal of Experimental Medicine, 174, 27-33.
15. Fialkow, P.J., Jacobson, R.J. & Panayannopoulou, T. (1977) Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet, and monocyte/macrophage. American Journal of Medicine, 63, 125-130.
16. Germain, R.N. (1986) The ins and outs of antigen processing and presentation. Nature, 322, 687-689.
17. Goulmy, E. (1988) Minor histocompatibility antigens in man and their role in transplantation. Transplantation Reviews, 2, 29.
18. + cytotoxic T cells induce apoptosis of APC. European Journal of Immunology, 22, 267-272.
19. Guillet, J.G., Lai, M.Z., Briner, T.J., Buus, S., Sette, A., Grey, H.M., Smith, J.A. & Gefter, J.A. (1987) Immunological self, nonself discrimination. Science, 235, 865-870.
20. Horowitz, M.M., Gale, R.P., Sondel, P.M., Goldman, J.M., Kersey, J., Kolb, H.J., Rimm, A.A., Ringden, O., Rozman, C., Speck, B., Truitt, R.L., Zwaan, F.E. & Bortin, M.M. (1990) Graft-versus-leukemia reactions after bone marrow transplantation. Blood, 75, 555-562.
21. Hughes, T.P. & Goldman, J.M. (1991) Chronic myeloid leukaemia. Haematology: Basic Principles and Practice (ed. by R. Hoffman, S. J. Shattil, B. Furie and H. J. Cohen), p. 857. Churchill Livingstone, London.
22. + T lymphocyte lines generated in vitro against chronic myeloid leukemia. Experimental Hematology, 23, 1167-1172.
23. Jiang, Y.Z., Kanfer, K.J., MacDonald, D., Cullis, J.O., Goldman, J.M. & Barrett, A.J. (1991) Graft versus leukemia effect following allogeneic bone marrow transplantation: emergence of cytotoxic T lymphocytes to host leukemia cells. Bone Marrow Transplantation, 8, 253-258.
24. + cytotoxic T cells. Proceedings of the National Academy of Sciences of the United States of America, 91, 4185-4189.
25. Kagi, D., Vignaux, F., Ledermenn, B., Burki, K., Depraetere, V., Nagata, S., Hengartner, H. & Golstein, P. (1994) Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science, 265, 528-530.
26. Kourilsky, P. & Claverie, J.M. (1989) MHC-antigen interaction: what does the T cell receptor see? Advances in Immunology, 45, 107-193.
27. Martin, P.J., Hanson, J.A. & Buckner, C.D. (1985) Effects of in vitro depletion of T cells in HLA identical allogeneic marrow graft. Blood, 66, 664-672.
28. Munker, R., Lubbert, M., Yonehara, S., Tuhnitz, A., Mertelsmann, R. & Wilmanns, W. (1995) Expression of the fas antigen on primary human leukemia cells. Annals of Hematology, 70, 15-17.
29. Nuchtern, J.G., Biddison, W.E. & Klausner, R.D. (1990) Class II MHC molecules can use the endogenous pathway of antigen presentation. Nature, 343, 74-76.
30. Perreault, C., Decary, F., Brochu, S., Gyger, M., Belanger, R. & Roy, D.C. (1990) Minor histocompatibility antigens. Blood, 76, 1269-1280.
31. Pinet, V., Malnati, M.S. & Long, E.O. (1994) Two processing pathways for the MHC class II restricted presentation of exogenous influenza virus antigen. Journal of Immunology, 152, 4852-4860.
32. Rivoltini, L., Kawakami, Y., Sakaguchi, K., Southwood, S., Sette, A., Robbins, P.F., Marincola, F.M., Salgaller, M.L., Yannelli, J.R., Appella, E. & Rosenberg, S.A. (1995) Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1. Journal of Immunology, 154, 2257-2265.
33. Rudensky, A.Y., Preston-Hurlburt, P., Hong, S-C., Barlow, A. & Janeway, C.A. (1991) Sequence analysis of peptides bound to MHC class II molecules. Nature, 353, 622-627.
34. Sosman, J.A., Oettel, K.R., Hank, J.A., Fisch, P. & Sondel, P.M. (1989) Specific recognition of human leukemia cells by allogeneic T cell line. Transplantation, 48, 486-495.
35. Sosman, J.A., Oettel, K.R., Smith, S.D., Hank, J.A., Fisch, P. & Sondel, P.M. (1990) Specific recognition of human leukemia cells by allogeneic T cells. II. Evidence for HLA-D restricted determinants on leukemia cells that are crossreactive with determinants present on unrelated nonleukemia cells. Blood, 75, 2005-2016.
36. + T-cell-mediated cytotoxicity. Journal of Immunology, 152, 1127-1133.
37. St.-Pierre, Y. & Watts, T.H. (1990) MHC class-II-restricted presentation of native protein antigens by B cells is inhibited by cyclohexamide and brefeldin A. Journal of Immunology, 145, 812-818.
38. + T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow. Bone Marrow Transplantation, 8, 51-58.
39. Truitt, R.L., Bortin, M.M. & Rimm, A.A. (1980) Alloimmunization: induction of anti-leukemic reactivity without modification of anti-host reactivity in H-2-compatible mice. Transplantation Proceedings, 12, 143-146.
40. Wang, X.M., Terasaki, P.I., Rankin, G.W., Chia, D., Zhong, H.P. & Hardy, S. (1995) A new microcellular cytotoxicity test based on calcein AM release. Human Immunology, 34, 264-270.
41. Zychlinsky, A., Zheng, L.M., Liu, C.C. & Young, J.D.E. (1991) Cytolytic lymphocytes induce both apoptosis and necrosis in target cells. Journal of Immunology, 146, 393-400.