Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease

Neuroscience Letters

Volumn 272, Issue 3, 1999, Pages 155-158

  Rebeck, G William ^a   Cheung, Bonnie S ^a   Growdon, Whitfield B ^a   Deng, Amy ^a   Akuthota, Praveen ^a   Locascio, Joseph ^a   Greenberg, Steven M ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Allelic imbalance; Apolipoprotein E; Genetic linkage; Th1 E47

Indexed keywords

APOLIPOPROTEIN E;

ALLELE; ALZHEIMER DISEASE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTRON; MAJOR CLINICAL STUDY; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR;

ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E2; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CEREBRAL AMYLOID ANGIOPATHY; DNA; DNA PRIMERS; HUMANS; INTRONS; LINKAGE (GENETICS); POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS;

EID: 0032855024     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00602-3     Document Type: Article

References (17)

1. Artiga M.J., Bullido M.J., Sastre I., Recuero M., Garcia M.A., Aldudo J., Vazquez J., Valdivieso F. Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene. FEBS Lett. 421:1998;105-108.
2. Bales K.R., Verina T., Dodel R.C., Du Y., Altstiel L., Bender M., Hyslop P., Johnstone E.M., Little S.P., Cummins D.J., Piccardo P., Ghetti B., Paul S.M. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat. Genet. 17:1997;263-264.
3. Bullido M.J., Artiga M.J., Recuero M., Sastre I., Garcia M.A., Aldudo J., Lendon C., Han S.W., Morris J.C., Frank A., Vazquez J., Goate A., Valdivieso F. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia. Nat. Genet. 18:1998;69-71.
4. Gomez-Isla T., West H.L., Rebeck G.W., Harr S.D., Growdon J.H., Locasio J.J., Perls T.T., Lipsitz L.A., Hyman B.T. Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer disease. Ann. Neurol. 39:1996;62-70.
5. Greenberg S.M., Rebeck G.W., Vonsattel J.P.G., Gomez-Isla T., Hyman B. Apolipoprotein E e4 and cerebral hemorrhage associated with amyloid angiopathy. Ann. Neurol. 38:1995;254-259.
6. Hyman B.T., Gomez-Isla T., Briggs M., Chung H., Nichols S., Kohout F., Wallace R. Apolipoprotein E and cognitive change in an elderly population. Ann. Neurol. 40:1996;55-66.
7. Lambert J.C., Berr C., Pasquier F., Delacourte A., Frigard B., Cottel D., Perez-Tur J., Mouroux V., Mohr M., Cecyre D., Galasko D., Lendon C., Poirier J., Hardy J., Mann D., Amouyel P., Chartier-Harlin M.C. Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE expression and risk of developing Alzheimer's disease. Hum. Mol. Genet. 7:1998;1511-1516.
8. Lambert J.C., Pasquier F., Cottel D., Frigard B., Amouyel P., Chartier-Harlin M.C. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Hum. Mol. Genet. 7:1998;533-540.
9. Lambert J.C., Perez-Tur J., Dupire M.J., Galasko D., Mann D., Amouyel P., Hardy J., Delacourte A., Chartier-Harlin M.C. Distortion of allelic expression of apolipoprotein E in Alzheimer disease. Hum. Mol. Genet. 6:1997;2151-2154.
10. Laws S.M., Taddei K., Martins G., Paton A., Fisher C., Clarnette R., Hallmayer J., Brooks W.S., Gandy S.E., Martins R.N. The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease. NeuroReport. 10:1999;879-882.
11. Mui S., Briggs M., Chung H., Wallace R.B., Gomez-Isla T., Rebeck G.W., Hyman B.T. A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the e4 allele. Neurology. 47:1996;196-201.
12. Myers R.H., Schaefer E.J., Wilson P.W., D'Agostino R., Ordovas J.M., Espino A., Au R., White R.F., Knoefel J.E., Cobb J.L., McNulty K.A., Beiser A., Wolf P.A. Apolipoprotein E epsilon 4 allele association with dementia in a population based study: the Framingham study. Neurology. 46:1996;673-677.
13. Rebeck G.W., Perls T.T., West H.L., Sodhi P., Lipsitz L.A., Hyman B.T. Reduced apolipoprotein E4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. Neurology. 44:1994;1513-1516.
14. Song Y.Q., Rogaeva E., Premkumar S., Brindle N., Kawarai T., Orlacchio A., Yu G., Levesque G., Nishimura M, Ikeda M., Pei Y., O'Toole C., Duara R., Barker W., Sorbi S., Freedman M., Farrer L., St. George-Hyslop P. Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE Neurosci. Neurosci Lett. 250:1998;189-192.
15. Strittmatter W., Roses A. Apolipoprotein E and Alzheimer's disease. Annu. Rev. Neurosci. 19:1996;53-77.
16. Toji H., Maruyama H., Sasaki K., Nakamura S., Kawakami H. Aploipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population. Neurosci. Lett. 259:1999;56-58.
17. Town T., Paris D., Fallin D., Duara R., Barker W., Gold M., Crawford F., Mullan M. The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism. Neurosci. Lett. 252:1998;95-98.