Unbiased stereological estimation of the number of neurons in the human hippocampus

Journal of Comparative Neurology

Volumn 296, Issue 1, 1990, Pages 1-22

  West, Mark J ^a   Gundersen, H J G ^a  

^a University Institute of Pathology Arhus   (Denmark)

Author keywords

aging; cortex; morphometry; neurobiology

Indexed keywords

ADULT; AGE; AGED; ARTICLE; AUTOPSY; BRAIN CORTEX; CELL COUNT; CLINICAL ARTICLE; HIPPOCAMPUS; HISTOLOGY; HUMAN; HUMAN CELL; MALE; MORPHOMETRICS; NERVE CELL; NORMAL HUMAN; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; CELL COUNT; HIPPOCAMPUS; HUMAN; MIDDLE AGE; SUPPORT, NON-U.S. GOV'T;

EID: 0025327731     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.902960102     Document Type: Article

References (48)

1. Estimation of nuclear populations from microtome sections
2. Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A Quantitative study
3. Further methodological problems in cell counting
4. Changes in the brain in aging and Alzheimer's disease assessed by neuronal counts
5. Zur pigmentarchitektonik der Grosshirnrinde des Menschen, II
6. The impact of recent stereo‐logical advances on quantitative studies of the nervous system
7. Total number of neurons in human neocortex unbiasedly estimated using optical disectors
8. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
9. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
10. Computer‐assisted morphometry using video‐mixed microscopic images and computer graphics
11. Epilepsy and neuron loss in the hippocampus
12. Untersuchungen über den Bau der menschlichen Hypophyse mit besonderer Berücksichtigung der quantitativen mikromorphologischen Verhältnisse
13. Neuron numbers and sizes in aging brain: Comparisons of human, monkey, and rodent data
14. Distribution of acetylcholinesterase in the hippocampal region of the rabbit
15. Floating on a water bath and mounting glycol methacrylate and hydroxypropyl methacrylate sections influence final dimensions
16. Structural variations in the rostral human hippocampus
17. Notes on the estimation of the numerical density of arbitrary profiles: The edge effect
18. Stereology of arbitrary particles
19. The efficiency of systematic sampling in stereology and its prediction
20. The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
21. Unbiased estimation of particle density in the tandem scanning reflected light microscope
22. A versatile and simple method for staining nervous tissue using Giemsa dye
23. Differences between early and late‐onset Alzheimer's disease
24. Computer graphics enhancement of measures in stereology
25. Sampling problems in a heterogeneous organ: quantitation of relative and total volume of pancreatic islets by light microscopy
26. Studies on the structure of the cerebral cortex. II. Continuation of the study of the ammonic system
27. Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4
28. Glutamate dysfunction in Alzheimer's disease: An hypothesis
29. Total number of neurons and glial cells in human brain nuclei estimated by the disector and the fractionator
30. Brain weight of Danes
31. The hippocampal formation of the primate brain
32. The value of alternative morphological approaches to Alzheimer's disease
33. Methodological considerations when assessing age related changes
34. Erkrankung des Ammonshorns als aetiologisches Moment der Kpilepsie
35. Allocortex
36. Evolutionary trends in limbic structures
37. The unbiased estimation of number and sizes of arbitrary particles using the disector
38. Density measures: Parameters to avoid
39. A quantitative comparison of the hippocampal subdivisions of diverse species including hedgehogs, laboratory rodents, wild mice and men
40. Estimating the number of granule cells in the dentate gyrus with the disector
41. Three‐dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material
42. Erratum and Addendum, Three‐dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material
43. Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus