Sequence-specific binding of antitumour bisquaternary ammonium heterocycles to DNA and inhibition of polymerase activity in vitro

Anti-Cancer Drug Design

Volumn 11, Issue 2, 1996, Pages 101-115

  Kittler, L ^a   Wahnert U ^a   Baguley, B C ^b   Bailly, C ^c   Waring, M J ^c   Lober G ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Bisquaternary ammonium heterocycles; DNA binding; Polymerase inhibition; Sequence specificity

Indexed keywords

AMMONIUM DERIVATIVE; ANTINEOPLASTIC AGENT; DNA POLYMERASE; RNA POLYMERASE; SN 6132; SN 6999; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA FOOTPRINTING; DNA SEQUENCE; DNA SYNTHESIS; DRUG DNA BINDING; DRUG STRUCTURE; ENZYME INHIBITION; PLASMID; PRIORITY JOURNAL; RESTRICTION FRAGMENT; RNA SYNTHESIS;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DNA; DNA-DIRECTED DNA POLYMERASE; DNA-DIRECTED RNA POLYMERASES; MOLECULAR SEQUENCE DATA; QUATERNARY AMMONIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029921518     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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