Synthesis, DNA binding, cytotoxicity and sequence specificity of a series of imidazole-containing analogs of the benzoic acid mustard distamycin derivative tallimustine containing an alkylating group at the C-terminus

Anti-Cancer Drug Design

Volumn 12, Issue 7, 1997, Pages 591-606

  Brooks, Natalie ^a   Lee, Moses ^b   Wright, Stephen R ^b   Woo, Shirley ^b   Centioni, Sara ^b   Hartley, John A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b FURMAN UNIVERSITY   (United States)

Author keywords

DNA alkylation; Minor groove binding agents

Indexed keywords

ANTINEOPLASTIC AGENT; AZIRIDINE DERIVATIVE; BENZOIC ACID DERIVATIVE; DISTAMYCIN A DERIVATIVE; DNA; IMIDAZOLE DERIVATIVE; POLYNUCLEOTIDE; TALLIMUSTINE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN K 562; CONTROLLED STUDY; DNA ALKYLATION; DNA CROSS LINKING; DNA SEQUENCE; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALKYLATING AGENTS; ANTINEOPLASTIC AGENTS; BINDING SITES; DISTAMYCINS; DNA; DNA DAMAGE; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MOLECULAR STRUCTURE; NITROGEN MUSTARD COMPOUNDS; SPECTRUM ANALYSIS; TUMOR CELLS, CULTURED;

EID: 0030732956     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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