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Volumn 45, Issue 5, 1999, Pages 289-297

Mitochondrial genome lesions in the pathogenesis of sporadic Alzheimer's disease

Author keywords

amyloid generation; Alzheimer's disease; ATP; Experimental pharmacology; Mitochondrial genome lesions; Oxidative phosphorylation; Pathogenesis

Indexed keywords

ACETYL COENZYME A; ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLINE; CHOLINE ACETYLTRANSFERASE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; MITOCHONDRIAL DNA; PROTEINASE;

EID: 0032839281     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022104     Document Type: Article
Times cited : (20)

References (96)
  • 3
    • 0020331745 scopus 로고
    • Alzheimer's disease. Down's syndrome and aging: The genetic approach
    • Sinex ME, Merril CR: Alzheimer's disease. Down's syndrome and aging: The genetic approach. Ann NY Acad Sci 1982;396:3-13.
    • (1982) Ann NY Acad Sci , vol.396 , pp. 3-13
    • Sinex, M.E.1    Merril, C.R.2
  • 7
    • 0027021442 scopus 로고
    • Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
    • Soong NW, Hinton DR, Cortopassi G, Amheim N: Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature Genet 1992;2:318-328.
    • (1992) Nature Genet , vol.2 , pp. 318-328
    • Soong, N.W.1    Hinton, D.R.2    Cortopassi, G.3    Amheim, N.4
  • 9
    • 0028309490 scopus 로고
    • What is primary and what secondary for amyloid in Alzheimer's disease
    • Meier-Ruge W, Iwangoff P, Bertoni-Freddari C: What is primary and what secondary for amyloid in Alzheimer's disease. Ann NY Acad Sci 1994;719:230-237.
    • (1994) Ann NY Acad Sci , vol.719 , pp. 230-237
    • Meier-Ruge, W.1    Iwangoff, P.2    Bertoni-Freddari, C.3
  • 11
    • 0032575687 scopus 로고    scopus 로고
    • Is apoptosis key in Alzheimer's disease?
    • Baringa M: Is apoptosis key in Alzheimer's disease? Science 1998;281:1303-1304.
    • (1998) Science , vol.281 , pp. 1303-1304
    • Baringa, M.1
  • 12
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration and Alzheimer's disease
    • Cotman CW, Anderson AJ: A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 1995;10:19-45.
    • (1995) Mol Neurobiol , vol.10 , pp. 19-45
    • Cotman, C.W.1    Anderson, A.J.2
  • 13
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 14
    • 0030708717 scopus 로고    scopus 로고
    • Pathogenesis of decreased glucose turnover and oxidative phosporylation in ischemic and traumainduced dementia of the Alzheimer type
    • Meier-Ruge WA, Bertoni-Freddari C: Pathogenesis of decreased glucose turnover and oxidative phosporylation in ischemic and traumainduced dementia of the Alzheimer type. Ann NY Acad Sci 1997;826:229-241.
    • (1997) Ann NY Acad Sci , vol.826 , pp. 229-241
    • Meier-Ruge, W.A.1    Bertoni-Freddari, C.2
  • 15
    • 0029820524 scopus 로고    scopus 로고
    • The other human genome. Mitochondrial DNA and disease
    • Johns DR: The other human genome. Mitochondrial DNA and disease. Nature Med 1996: 2:1065-1068.
    • (1996) Nature Med , vol.2 , pp. 1065-1068
    • Johns, D.R.1
  • 17
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases?
    • Wallace DC: Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 1992;256:628-632.
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 18
    • 0031664279 scopus 로고    scopus 로고
    • Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients
    • Redjems-Bennani N, Jeandel C, Lefebre E, Blain H, Vidailhet M, Guéant J-L: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology 1998;44:300-304.
    • (1998) Gerontology , vol.44 , pp. 300-304
    • Redjems-Bennani, N.1    Jeandel, C.2    Lefebre, E.3    Blain, H.4    Vidailhet, M.5    Guéant, J.-L.6
  • 19
    • 0026408618 scopus 로고
    • Abnormalities of glucose metabolism in Alzheimer's disease
    • Hoyer S: Abnormalities of glucose metabolism in Alzheimer's disease. Ann NY Acad Sci 1991; 640:53-58.
    • (1991) Ann NY Acad Sci , vol.640 , pp. 53-58
    • Hoyer, S.1
  • 20
    • 0025903323 scopus 로고
    • Impaired metabolic activation in Alzheimer's disease: A PET study during continuous visual recognition
    • Kessler J, Herholz K, Grand M, Heiss WD: Impaired metabolic activation in Alzheimer's disease: A PET study during continuous visual recognition. Neuropsychologia 1991;29:229-243.
    • (1991) Neuropsychologia , vol.29 , pp. 229-243
    • Kessler, J.1    Herholz, K.2    Grand, M.3    Heiss, W.D.4
  • 21
    • 0029994450 scopus 로고    scopus 로고
    • The significance of glucose turnover in the brain in the pathogenetic mechanisms of Alzheimer's disease
    • Meier-Ruge W, Bertoni-Freddari C: The significance of glucose turnover in the brain in the pathogenetic mechanisms of Alzheimer's disease. Rev Neurosci 1996;7:1-19.
    • (1996) Rev Neurosci , vol.7 , pp. 1-19
    • Meier-Ruge, W.1    Bertoni-Freddari, C.2
  • 22
    • 0028300513 scopus 로고
    • Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease
    • Meier-Ruge W, Bertoni-Freddari C. Iwangoff P: Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease. Gerontology 1994;40:246-252.
    • (1994) Gerontology , vol.40 , pp. 246-252
    • Meier-Ruge, W.1    Bertoni-Freddari, C.2    Iwangoff, P.3
  • 24
    • 0026406816 scopus 로고
    • Abnormalities of energy metabolism in Alzheimer's disease studied with PET
    • Heiss WD, Szelies B, Kessler J, Herholz K: Abnormalities of energy metabolism in Alzheimer's disease studied with PET. Ann NY Acad Sci 1991;640:65-71.
    • (1991) Ann NY Acad Sci , vol.640 , pp. 65-71
    • Heiss, W.D.1    Szelies, B.2    Kessler, J.3    Herholz, K.4
  • 26
    • 0023898284 scopus 로고
    • Longitudinal studies of regional cerebral metabolism in Alzheimer's disease
    • Jagust W, Frieland R, Budinger T, Koss E, Ober B: Longitudinal studies of regional cerebral metabolism in Alzheimer's disease. Neurology 1993;38:909-912.
    • (1993) Neurology , vol.38 , pp. 909-912
    • Jagust, W.1    Frieland, R.2    Budinger, T.3    Koss, E.4    Ober, B.5
  • 28
    • 0029874365 scopus 로고    scopus 로고
    • Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET
    • Piert M, Koeppe RA, Giordani B, Berent S, Kuhl DE: Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET. J Nucl Med 1996;37:201-208.
    • (1996) J Nucl Med , vol.37 , pp. 201-208
    • Piert, M.1    Koeppe, R.A.2    Giordani, B.3    Berent, S.4    Kuhl, D.E.5
  • 29
    • 0025914324 scopus 로고
    • Abnormal brain glucose metabolism in Alzheimer's disease, as measured by positron emission tomography
    • Rapoport SJ, Honwitz B, Grady CL, Haxby JV, DeCarli C, Schapiro MB: Abnormal brain glucose metabolism in Alzheimer's disease, as measured by positron emission tomography. Adv Exp Med Biol 1991;291:321-248.
    • (1991) Adv Exp Med Biol , vol.291 , pp. 321-1248
    • Rapoport, S.J.1    Honwitz, B.2    Grady, C.L.3    Haxby, J.V.4    DeCarli, C.5    Schapiro, M.B.6
  • 31
  • 34
    • 0029045389 scopus 로고
    • Cognitive impairment in Alzheimer's disease correlates with ventricular width and atrophy-corrected cortical glucose metabolism
    • Slansky J, Herholz K, Pietrzyk U, Kessler J, Grond M, Mielke R, Heiss WD: Cognitive impairment in Alzheimer's disease correlates with ventricular width and atrophy-corrected cortical glucose metabolism. Neuroradiology 1995;37:270-277.
    • (1995) Neuroradiology , vol.37 , pp. 270-277
    • Slansky, J.1    Herholz, K.2    Pietrzyk, U.3    Kessler, J.4    Grond, M.5    Mielke, R.6    Heiss, W.D.7
  • 35
    • 0026378669 scopus 로고
    • Reactive capacities of the central nervous system in physiological aging and senile dementia of the Alzheimer type
    • Bertoni-Freddari C, Fattoretti P, Casoli T, Meier-Ruge W, Ulrich J: Reactive capacities of the central nervous system in physiological aging and senile dementia of the Alzheimer type. Ann NY Acad Sci 1991;621:98-103.
    • (1991) Ann NY Acad Sci , vol.621 , pp. 98-103
    • Bertoni-Freddari, C.1    Fattoretti, P.2    Casoli, T.3    Meier-Ruge, W.4    Ulrich, J.5
  • 39
    • 0019142890 scopus 로고
    • Glycolytic enzymes from human autoptic brain cortex: Normal and demented cases
    • Iwangoff P, Armbruster R, Enz A, Meier-Ruge W: Glycolytic enzymes from human autoptic brain cortex: Normal and demented cases. Mech Ageing Dev 1980;14:203-209.
    • (1980) Mech Ageing Dev , vol.14 , pp. 203-209
    • Iwangoff, P.1    Armbruster, R.2    Enz, A.3    Meier-Ruge, W.4
  • 41
    • 0021181568 scopus 로고
    • Neurochemical enzyme changes in Alzheimer's and Pick's disease
    • Meier-Ruge W: Neurochemical enzyme changes in Alzheimer's and Pick's disease. Arch Gerontol Geriatr 1984;3:161-165.
    • (1984) Arch Gerontol Geriatr , vol.3 , pp. 161-165
    • Meier-Ruge, W.1
  • 42
    • 33646796790 scopus 로고
    • Free radical theory of aging: A hypothesis on pathogenesis of senile dementia of the Alzheimer's type
    • Harman D: Free radical theory of aging: A hypothesis on pathogenesis of senile dementia of the Alzheimer's type. Age 1991;16:23-30.
    • (1991) Age , vol.16 , pp. 23-30
    • Harman, D.1
  • 44
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contribution to aging and degenerative diseases
    • Linnane AW, Marzuki S, Ozawa T, Tanaka M: Mitochondrial DNA mutations as an important contribution to aging and degenerative diseases. Lancet 1989;i:642-645.
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 45
    • 0025864512 scopus 로고
    • An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells
    • Miquel J: An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells. Arch Gerontol Geriatr 1991; 12:99-117.
    • (1991) Arch Gerontol Geriatr , vol.12 , pp. 99-117
    • Miquel, J.1
  • 46
    • 0029930021 scopus 로고    scopus 로고
    • Deleterious network hypothesis of Alzheimer's disease
    • Ying W: Deleterious network hypothesis of Alzheimer's disease. Med Hypotheses 1996;46: 421-428.
    • (1996) Med Hypotheses , vol.46 , pp. 421-428
    • Ying, W.1
  • 47
    • 0031081488 scopus 로고    scopus 로고
    • Deleterious network hypothesis of aging
    • Ying W: Deleterious network hypothesis of aging. Med Hypotheses 1997;48:143-148.
    • (1997) Med Hypotheses , vol.48 , pp. 143-148
    • Ying, W.1
  • 48
    • 0030897739 scopus 로고    scopus 로고
    • Genetic and functional changes in mitochondria associated with aging
    • Ozawa T: Genetic and functional changes in mitochondria associated with aging. Physiol Rev 1997;77:425-464.
    • (1997) Physiol Rev , vol.77 , pp. 425-464
    • Ozawa, T.1
  • 49
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • Corlopassi GA, Shibata D, Soong N-W, Arnheim N: A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA 1992;89: 7370-7374.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7370-7374
    • Corlopassi, G.A.1    Shibata, D.2    Soong, N.-W.3    Arnheim, N.4
  • 52
    • 0028235259 scopus 로고
    • Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria
    • Hsieh RH, Hou JH, Hsu HS, Wei YH: Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria. Biochem Mol Biol Int 1994;32:1009-1022.
    • (1994) Biochem Mol Biol Int , vol.32 , pp. 1009-1022
    • Hsieh, R.H.1    Hou, J.H.2    Hsu, H.S.3    Wei, Y.H.4
  • 54
    • 0031740638 scopus 로고    scopus 로고
    • Long-term cultivation of a neuroblastoma cell line in medium with reduced serum content as a model system of neuronal aging?
    • Kalka D, Hoyer S: Long-term cultivation of a neuroblastoma cell line in medium with reduced serum content as a model system of neuronal aging? Arch Gerontol Geriatr 1998;27: 251-268.
    • (1998) Arch Gerontol Geriatr , vol.27 , pp. 251-268
    • Kalka, D.1    Hoyer, S.2
  • 56
    • 0027939105 scopus 로고
    • Oxidative damage and mitochondrial dysfunction in neurodegenerative diseases
    • Browne SE, Beal MF: Oxidative damage and mitochondrial dysfunction in neurodegenerative diseases. Biochem Soc Trans 1994;20: 1002-1006.
    • (1994) Biochem Soc Trans , vol.20 , pp. 1002-1006
    • Browne, S.E.1    Beal, M.F.2
  • 57
    • 0028128386 scopus 로고
    • Free radicals, proteo lysis, and the degeneration of neurons in Alzheimer's disease: How essential is the betaamyloid link?
    • Nixon RA, Cataldo MA: Free radicals, proteo lysis, and the degeneration of neurons in Alzheimer's disease: How essential is the betaamyloid link? Neurobiol Aging 1994;15:463-469.
    • (1994) Neurobiol Aging , vol.15 , pp. 463-469
    • Nixon, R.A.1    Cataldo, M.A.2
  • 59
    • 0024456491 scopus 로고
    • Presenile dementia associated with mosaic trisomy 21 in a patient with a Down syndrome child
    • Hardy J, Goate A, Owen M, Rossor N: Presenile dementia associated with mosaic trisomy 21 in a patient with a Down syndrome child. Lancet 1989;ii:743.
    • (1989) Lancet , vol.2 , pp. 743
    • Hardy, J.1    Goate, A.2    Owen, M.3    Rossor, N.4
  • 60
    • 0029038949 scopus 로고
    • No evidence that common allclic variation in the amyloid precursor protein (APP) gene confers susceptibility to Alzheimer's disease
    • Liddell MB, Bayer AJ, Owen MJ: No evidence that common allclic variation in the amyloid precursor protein (APP) gene confers susceptibility to Alzheimer's disease. Hum Mol Genet 1995;4:853-858.
    • (1995) Hum Mol Genet , vol.4 , pp. 853-858
    • Liddell, M.B.1    Bayer, A.J.2    Owen, M.J.3
  • 61
    • 0025801967 scopus 로고
    • Review and hypothesis: Alzheimer's disease and Down syndrome: Chromosome 21 nondisjunction may underlie both disorders
    • Potter H: Review and hypothesis: Alzheimer's disease and Down syndrome: Chromosome 21 nondisjunction may underlie both disorders. Am J Hum Genet 1991;48:1192-1200.
    • (1991) Am J Hum Genet , vol.48 , pp. 1192-1200
    • Potter, H.1
  • 62
    • 0343505622 scopus 로고
    • Apolipoprotein E-4 and apolipoprotein E-2 are susceptibility genes that affect the rate of disease expressivity of late-onset familial and sporadic Alzheimer's disease
    • Dall JLC, Ermini M, Herrling PL, Meier-Ruge W, Stähelin HB, Staufenbiel M (eds): London, Academic Press
    • Roses AD: Apolipoprotein E-4 and apolipoprotein E-2 are susceptibility genes that affect the rate of disease expressivity of late-onset familial and sporadic Alzheimer's disease; in Dall JLC, Ermini M, Herrling PL, Meier-Ruge W, Stähelin HB, Staufenbiel M (eds): Adaptations in Aging. London, Academic Press, 1995, pp 171-186.
    • (1995) Adaptations in Aging , pp. 171-186
    • Roses, A.D.1
  • 63
    • 0019847654 scopus 로고
    • Aging decreases oxidative metabolism and the release and synthesis of acctylcholine
    • Gibson GE, Peterson C: Aging decreases oxidative metabolism and the release and synthesis of acctylcholine. J Neurochem 1984;37:978-984.
    • (1984) J Neurochem , vol.37 , pp. 978-984
    • Gibson, G.E.1    Peterson, C.2
  • 65
    • 0025020770 scopus 로고
    • Advances in the biology of cholinergic neurons
    • Tucek S, Ricny J: Dolezal V: Advances in the biology of cholinergic neurons. Adv Neurobiol 1990;51:109-115.
    • (1990) Adv Neurobiol , vol.51 , pp. 109-115
    • Tucek, S.1    Ricny, J.2    Dolezal, V.3
  • 66
    • 0020045188 scopus 로고
    • Effect of choline and glucose on atropine-induced alterations of acetylcholine synthesis and content in brain of rats
    • Dolczal V, Tucek S: Effect of choline and glucose on atropine-induced alterations of acetylcholine synthesis and content in brain of rats. Brain Res 1982;240:285-293.
    • (1982) Brain Res , vol.240 , pp. 285-293
    • Dolczal, V.1    Tucek, S.2
  • 67
    • 0022006126 scopus 로고
    • Regulation of acetylcholine synthesis in the brain
    • Tucek S: Regulation of acetylcholine synthesis in the brain. J Neurochem 1985;44:11-21.
    • (1985) J Neurochem , vol.44 , pp. 11-21
    • Tucek, S.1
  • 68
    • 0025782928 scopus 로고
    • Cholinergic mechanisms in learning, memory and dementia: A review of recent evidence
    • Fibiger HC. Cholinergic mechanisms in learning, memory and dementia: A review of recent evidence. Trends Neurosci 1991;14:2991.
    • (1991) Trends Neurosci , vol.14 , pp. 2991
    • Fibiger, H.C.1
  • 69
    • 0028203390 scopus 로고
    • Alzheimer's disease: Therapeutic strategies for the 1990s
    • Pendlebury WW, Solomon PR: Alzheimer's disease: Therapeutic strategies for the 1990s. Neurobiol Aging 1994;15:287-289.
    • (1994) Neurobiol Aging , vol.15 , pp. 287-289
    • Pendlebury, W.W.1    Solomon, P.R.2
  • 70
    • 0018826694 scopus 로고
    • Coenzyme A acetylating enzymes in Alzheimer's disease: Possible cholinergic 'compartment' of pyruvate dehydrogcnase
    • Perry EK, Perry RH, Tomlinson BE, Blessed G, Gibson PH: Gibson PH: Coenzyme A acetylating enzymes in Alzheimer's disease: Possible cholinergic 'compartment' of pyruvate dehydrogcnase. Neurosci Lett 1980;18:105-110.
    • (1980) Neurosci Lett , vol.18 , pp. 105-110
    • Perry, E.K.1    Perry, R.H.2    Tomlinson, B.E.3    Blessed, G.4    Gibson, P.H.5    Gibson, P.H.6
  • 71
    • 0344122123 scopus 로고
    • Biochemical and neuropathological changes in the brain and their correlation to the severity of dementia in Alzheimer's disease
    • Shagass C, Josiassen RC. Bridger WH, Weiss KJ, Stoff D, Sipsom GM (eds): New York. Elsevier
    • Mountjoy CQ, Rossor MN, Evans NJR. Reynolds GP, Evans H, Roth M. Iverson LL. Emson P: Biochemical and neuropathological changes in the brain and their correlation to the severity of dementia in Alzheimer's disease: in Shagass C, Josiassen RC. Bridger WH, Weiss KJ, Stoff D, Sipsom GM (eds): Biological Psychiatry. New York. Elsevier, 1986, pp 1415-1417.
    • (1986) Biological Psychiatry , pp. 1415-1417
    • Mountjoy, C.Q.1    Rossor, M.N.2    Evans, N.J.R.3    Reynolds, G.P.4    Evans, H.5    Roth, M.6    Iverson, L.L.7    Emson, P.8
  • 72
    • 0021922691 scopus 로고
    • Some strategies for tackling the problems of senile dementia and related disorders within the next dceade
    • Roth M: Some strategies for tackling the problems of senile dementia and related disorders within the next dceade. Dan Med Bull 1985;35 (suppl 1):92-111.
    • (1985) Dan Med Bull , vol.35 , Issue.SUPPL. 1 , pp. 92-111
    • Roth, M.1
  • 73
    • 0027181221 scopus 로고
    • Brain protein kinasc PK 40 converts TAU into a PHF-like form as found in Alzheimer's disease
    • Roder HM, Eden PA, Ingram VM: Brain protein kinasc PK 40 converts TAU into a PHF-like form as found in Alzheimer's disease. Biochem Biophys Res Commun 1993;193:639-647.
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 639-647
    • Roder, H.M.1    Eden, P.A.2    Ingram, V.M.3
  • 74
    • 0025183062 scopus 로고
    • Induction of Alzheimer antigens by an uncouplcr of oxidative phosphorylation
    • Blass JP, Baker AC, Ko LW, Black RS: Induction of Alzheimer Antigens by an uncouplcr of oxidative phosphorylation. Arch Neurol 1990; 47:864-869.
    • (1990) Arch Neurol , vol.47 , pp. 864-869
    • Blass, J.P.1    Baker, A.C.2    Ko, L.W.3    Black, R.S.4
  • 75
    • 0028200649 scopus 로고
    • Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
    • Gabuzda DH, Bugiciglio J, Cohen LB, Matsudaira P, Yankner BA: Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 1994;269: 13623-13628.
    • (1994) J Biol Chem , vol.269 , pp. 13623-13628
    • Gabuzda, D.H.1    Bugiciglio, J.2    Cohen, L.B.3    Matsudaira, P.4    Yankner, B.A.5
  • 76
    • 0025719976 scopus 로고
    • Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios
    • Roder HM, Ingram VM: Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios. J Neurosci 1991;11:3325-3343.
    • (1991) J Neurosci , vol.11 , pp. 3325-3343
    • Roder, H.M.1    Ingram, V.M.2
  • 77
    • 0001067847 scopus 로고
    • Beta-amyloid precursor protein of Alzheimer's disease occurs at 110 to 135 kilodalton membrane-associated proteins in neural and nonneural tissues
    • Selkoe DJ, Polisny MD, Joachim C, Vickcrs EA, Lee G, Fritz LC, Oltersdorf T: Beta-amyloid precursor protein of Alzheimer's disease occurs at 110 to 135 kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci USA 1988;85:7341-7345.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7341-7345
    • Selkoe, D.J.1    Polisny, M.D.2    Joachim, C.3    Vickcrs, E.A.4    Lee, G.5    Fritz, L.C.6    Oltersdorf, T.7
  • 82
    • 0026071081 scopus 로고
    • Proteolytic cleavage of Alzheimer's disease amyloid A4 precursor protein
    • Ishiura S: Proteolytic cleavage of Alzheimer's disease amyloid A4 precursor protein. J Neurochem 1991;56:363-369.
    • (1991) J Neurochem , vol.56 , pp. 363-369
    • Ishiura, S.1
  • 84
    • 0026721943 scopus 로고
    • β-Amyloid precursor protein cleavage by a membrane-bound protease
    • Sisodia SS: β-Amyloid precursor protein cleavage by a membrane-bound protease. Proc Natl Acad Sci USA 1992;89:6075-6079.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6075-6079
    • Sisodia, S.S.1
  • 85
    • 0345617838 scopus 로고
    • Altered protein kinase and amyloid β-protein precursor in Alzheimer's disease: Which comes first?
    • Boiler F, Rascol A, Christen Y, Kazman R, Signorct JL (eds): Berlin, Springer
    • Saitoh T, Jimoto DS: Altered protein kinase and amyloid β-protein precursor in Alzheimer's disease: Which comes first?; in Boiler F, Rascol A, Christen Y, Kazman R, Signorct JL (eds): Biological Markers of Alzheimer's disease. Berlin, Springer, 1989, pp 103-117.
    • (1989) Biological Markers of Alzheimer's Disease , pp. 103-117
    • Saitoh, T.1    Jimoto, D.S.2
  • 86
    • 0028338306 scopus 로고
    • Pathological correlation of dementia in Alzheimer's disease
    • Mann DMA: Pathological correlation of dementia in Alzheimer's disease. Neurobiol Aging 1994;15:357-360.
    • (1994) Neurobiol Aging , vol.15 , pp. 357-360
    • Mann, D.M.A.1
  • 87
    • 0026393430 scopus 로고
    • Senile dementia: A threshold phenomenon of normal aging? A contribution of the functional reserve hypothesis of the brain
    • Meier-Ruge W, Hunziker O, Iwangoff P: Senile dementia: A threshold phenomenon of normal aging? A contribution of the functional reserve hypothesis of the brain. Ann NY Acad Sci 1991;621:104-118.
    • (1991) Ann NY Acad Sci , vol.621 , pp. 104-118
    • Meier-Ruge, W.1    Hunziker, O.2    Iwangoff, P.3
  • 89
    • 0345185706 scopus 로고
    • Deposition of beta-amyloid associated with cerebral hypoxia
    • Jendroska K, Cervos-Navarro J, Poewe W: Deposition of beta-amyloid associated with cerebral hypoxia (abstract). Clin Neuropathol 1993:12:252.
    • (1993) Clin Neuropathol , vol.12 , pp. 252
    • Jendroska, K.1    Cervos-Navarro, J.2    Poewe, W.3
  • 90
    • 0028168114 scopus 로고
    • Excitotoxic mechanisms in the pathogencsis of dementia
    • Dodd PR, Scott HL, Westphalen RJ: Excitotoxic mechanisms in the pathogencsis of dementia. Neurochem Int 1994;25:203-219.
    • (1994) Neurochem Int , vol.25 , pp. 203-219
    • Dodd, P.R.1    Scott, H.L.2    Westphalen, R.J.3
  • 91
    • 0028174629 scopus 로고
    • Beta amyloid protein deposition in the brain after severe head injury: Implications for the pathogenesis of Alzheimer's disease
    • Roberts GW, Gentleman SM, Lynch A, Murray L, Landon M, Graham DI: Beta amyloid protein deposition in the brain after severe head injury: Implications for the pathogenesis of Alzheimer's disease. J Neurol Neurosurg Psychiatry 1994;57:419-425.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 419-425
    • Roberts, G.W.1    Gentleman, S.M.2    Lynch, A.3    Murray, L.4    Landon, M.5    Graham, D.I.6
  • 92
    • 0029981820 scopus 로고    scopus 로고
    • Amyloid beta-protein, APOE genotype and head injury
    • Nicoll JA, Roberts GW, Graham DI: Amyloid beta-protein, APOE genotype and head injury. Ann NY Acad Sci 1996;777:271-275.
    • (1996) Ann NY Acad Sci , vol.777 , pp. 271-275
    • Nicoll, J.A.1    Roberts, G.W.2    Graham, D.I.3
  • 93
  • 94
    • 0032491507 scopus 로고    scopus 로고
    • Experimental therapeutics of neurodegenerative disorders: Unmet needs
    • Shoulson J: Experimental therapeutics of neurodegenerative disorders: Unmet needs. Science 1998;282:1072-1074.
    • (1998) Science , vol.282 , pp. 1072-1074
    • Shoulson, J.1
  • 95
    • 0029904388 scopus 로고    scopus 로고
    • Neurotrophins and Alzheimer's disease: Beyond the cholinergic neurons
    • Knusel B, Bao H: Neurotrophins and Alzheimer's disease: Beyond the cholinergic neurons. Life Sci 1996;58:2019-2027.
    • (1996) Life Sci , vol.58 , pp. 2019-2027
    • Knusel, B.1    Bao, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.