Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential

Cancer

Volumn 73, Issue 5, 1994, Pages 1324-1331

  Iino, Hiroshi ^a,d   Fukayama, Masashi ^a   Maeda, Yoshiharu ^a   Koike, Morio ^a   Mori, Takeo ^a   Takahashi, Takashi ^a   Kikuchi‐Yanoshita, Rei ^b   Miyaki, Michiko ^b   Mizuno, Shoichi ^c   Watanabe, Shaw ^c  

^a TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

colorectal carcinoma; DCC; immunohistochemistry; invasiveness; loss of heterozygosity; metastasis; molecular genetics; p53; restriction fragment length polymorphism; reverse transcription polymerase chain reaction

Indexed keywords

GENE PRODUCT; MESSENGER RNA; PROTEIN P53;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER INVASION; CANCER LOCALIZATION; CHROMOSOME 17P; CHROMOSOME 18Q; CHROMOSOME 22Q; CHROMOSOME 5Q; COLORECTAL CARCINOMA; FEMALE; GENE EXPRESSION; HETEROZYGOTE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS POTENTIAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; CHROMOSOMES, HUMAN, 16-18; CHROMOSOMES, HUMAN, 21-22 AND Y; CHROMOSOMES, HUMAN, 4-5; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, DCC; HETEROZYGOTE; HUMAN; LYMPHATIC METASTASIS; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTEIN P53; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T;

EID: 0028293408     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/1097-0142(19940301)73:5<1324::AID-CNCR2820730503>3.0.CO;2-W     Document Type: Article

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