메뉴 건너뛰기




Volumn 2, Issue 4, 1999, Pages 293-303

Development of somatostatin receptor subtype selective agonists through combinatorial chemistry

Author keywords

Combinatorial chemistry; Compound library; Mixture screening; Somatostatin receptor

Indexed keywords

BIM 23268; DC 23 99; DC 25100; DC 3297; GLUCAGON; GROWTH HORMONE; INSULIN; L 363377; NC 8 12; OCTREOTIDE; RECEPTOR SUBTYPE; SEGLITIDE; SK 28; SOMATOSTATIN 14; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR SELECTIVE AGONIST; SS 28; UNCLASSIFIED DRUG;

EID: 0032804805     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (14)

References (56)
  • 2
    • 0022500305 scopus 로고    scopus 로고
    • Somatostatin in the central nervous system.physiology and pathological modifications
    • 198627:63-100.
    • Epelbaum JC.Somatostatin in the central nervous system.physiology and pathological modifications. Prog Neuroblol (1986)27:63-100.
    • Prog Neuroblol
    • Epelbaum, J.C.1
  • 3
    • 0026544424 scopus 로고    scopus 로고
    • Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney
    • 1992 89:251 -255.
    • Yamada Y, Post SR, Wang K, Tager HS, Bell Gl, Seino S.Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. P roc Natl Acad Sei USA (1992) 89:251 -255.
    • P Roc Natl Acad Sei USA
    • Yamada, Y.1    Post, S.R.2    Wang, K.3    Tager, H.S.4    Bell, G.5    Seino, S.6
  • 4
    • 0026551305 scopus 로고    scopus 로고
    • Expression cloning of a rat brain somatostatin receptor cDNA
    • 199289:4618-4622.
    • Kluxen F-W, Bruns C, Lübbert H.Expression cloning of a rat brain somatostatin receptor cDNA. Proc Natl Acad Sei USA (1992)89:4618-4622.
    • Proc Natl Acad Sei USA
    • Kluxen, F.-W.1    Bruns, C.2    Lübbert, H.3
  • 5
    • 0026673028 scopus 로고    scopus 로고
    • Cloning and expression of a novel mouse somatostatin receptor (SSTR2B)
    • 1992 311:290-294.
    • Vanetti M, Kouba M, Wang X, Vogt G, Höllt V.Cloning and expression of a novel mouse somatostatin receptor (SSTR2B). FEBS Lett (1992) 311:290-294.
    • FEBS Lett
    • Vanetti, M.1    Kouba, M.2    Wang, X.3    Vogt, G.4    Höllt, V.5
  • 6
    • 0026669193 scopus 로고    scopus 로고
    • Saper CB, Reisine T, Bell Gl.Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase
    • 1992267:20422-20428.
    • Yasuda K, Rens-Domiano S, Breder CD, Law SF. Saper CB, Reisine T, Bell Gl.Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase. J Biol Chem (1992)267:20422-20428.
    • J Biol Chem
    • Yasuda, K.1    Rens-Domiano, S.2    Breder, C.D.3    Law, S.F.4
  • 7
    • 0026489450 scopus 로고    scopus 로고
    • Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain
    • 1992 89:10267-10271.
    • Meyerhof W, Wulfsen I, Schonrock C, Fehr S, Richter D.Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain. Proc Natl Acad Sei USA (1992) 89:10267-10271.
    • Proc Natl Acad Sei USA
    • Meyerhof, W.1    Wulfsen, I.2    Schonrock, C.3    Fehr, S.4    Richter, D.5
  • 8
    • 0026453393 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a brain-specific somatostatin receptor
    • 1992 89:11151-11155.
    • Bruno JF, Xu Y, Song J, Berelowitz M.Molecular cloning and functional expression of a brain-specific somatostatin receptor. Proc Natl Acad Sei USA (1992) 89:11151-11155.
    • Proc Natl Acad Sei USA
    • Bruno, J.F.1    Xu, Y.2    Song, J.3    Berelowitz, M.4
  • 10
    • 0027086821 scopus 로고    scopus 로고
    • Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28
    • 1992 42:939-946.
    • O'Carroll AM, Lolait SJ, König M, Mahan LC.Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28. Mol Pharmacol (1992) 42:939-946.
    • Mol Pharmacol
    • O'Carroll, A.M.1    Lolait, S.J.2    König, M.3    Mahan, L.C.4
  • 13
    • 0030996381 scopus 로고    scopus 로고
    • Immunohistochemical localization of somatostatin receptor SST2A in the rat pancreas
    • 1997 138:2632-2635.
    • Hunyady B, Hipkin RW, Schonbrunn A, Mezey E.Immunohistochemical localization of somatostatin receptor SST2A in the rat pancreas. Endocrinology (1997) 138:2632-2635.
    • Endocrinology
    • Hunyady, B.1    Hipkin, R.W.2    Schonbrunn, A.3    Mezey, E.4
  • 15
    • 85011465009 scopus 로고    scopus 로고
    • Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary
    • 1998 139:414-419.
    • Mezey E, Hunyady B, Mitra S, Hayes E, Liu Q, Schaeffer J, Schonbrunn A.Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary. Endocrinology (1998) 139:414-419.
    • Endocrinology
    • Mezey, E.1    Hunyady, B.2    Mitra, S.3    Hayes, E.4    Liu, Q.5    Schaeffer, J.6    Schonbrunn, A.7
  • 16
    • 0030690535 scopus 로고    scopus 로고
    • Development of selective antibodies against the human somatostatin receptor subtypes sst1-sst5
    • 199749:82-88.
    • Helboe L, Moller M, Norregaard L, Schiodt M, Stidsen CE.Development of selective antibodies against the human somatostatin receptor subtypes sst1-sst5. Mol Brain Res (1997)49:82-88.
    • Mol Brain Res
    • Helboe, L.1    Moller, M.2    Norregaard, L.3    Schiodt, M.4    Stidsen, C.E.5
  • 21
    • 0029829062 scopus 로고    scopus 로고
    • Receptor-specific somatostatin analogs.Correlations with biological activity
    • 199645(SuppM):21-23.
    • Coy DH, Taylor JE.Receptor-specific somatostatin analogs.Correlations with biological activity. Metabolism (1996)45(SuppM):21-23.
    • Metabolism
    • Coy, D.H.1    Taylor, J.E.2
  • 22
    • 0028050630 scopus 로고    scopus 로고
    • Specific inhibition of rat pancreatic insulin or glucagon release by receptor-selective somatostatin analogs
    • 1994205:341-346.
    • Rossowski WJ, Coy DH.Specific inhibition of rat pancreatic insulin or glucagon release by receptor-selective somatostatin analogs. Biochem Biophys Res Commun (1994)205:341-346.
    • Biochem Biophys Res Commun
    • Rossowski, W.J.1    Coy, D.H.2
  • 23
    • 0027287377 scopus 로고    scopus 로고
    • Moreau JP, Yasuda K, Bell Gl, Reisine T.Cloned somatostatin receptors.Identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides
    • 1993 43:838-844.
    • Raynor K, Murphy WA, Coy DH, Taylor JE. Moreau JP, Yasuda K, Bell Gl, Reisine T.Cloned somatostatin receptors.Identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol Pharmacol (1993) 43:838-844.
    • Mol Pharmacol
    • Raynor, K.1    Murphy, W.A.2    Coy, D.H.3    Taylor, J.E.4
  • 25
    • 0029859983 scopus 로고    scopus 로고
    • Buckwalter BL, Patel BP, Pausen MH, Price LA, Stmad J, Hadcock JR.Identification and characterization of novel somatostatin antagonists
    • 1996 50:709-715.
    • Bass RT. Buckwalter BL, Patel BP, Pausen MH, Price LA, Stmad J, Hadcock JR.Identification and characterization of novel somatostatin antagonists. Mol Pharmacol (1996) 50:709-715.
    • Mol Pharmacol
    • Bass, R.T.1
  • 28
    • 0031755689 scopus 로고    scopus 로고
    • Carrick TA, Pausen MH, Bingham B, Carmignac D, Robinson 1C, Houghten R, Eppler CM, Price LA, Zysk JR.A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats
    • 1998 54:864-873.
    • Baumbach WR, Carrick TA, Pausen MH, Bingham B, Carmignac D, Robinson 1C, Houghten R, Eppler CM, Price LA, Zysk JR.A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats. Mol Pharmacol (1998) 54:864-873.
    • Mol Pharmacol
    • Baumbach, W.R.1
  • 30
    • 0028170656 scopus 로고    scopus 로고
    • Vandlen RL.6 agonist selectivity determinants in somatostatin receptor subtypes i and II
    • 1994 269:24621-24626.
    • Fitzpatrick VD, Vandlen RL.6 agonist selectivity determinants in somatostatin receptor subtypes I and II. J Biol Chem (1994) 269:24621-24626.
    • J Biol Chem
    • Fitzpatrick, V.D.1
  • 31
    • 0029812686 scopus 로고    scopus 로고
    • Identification of ligand binding determinants in the somatostatin receptor subtypes 1 and 2
    • 1996271:20331-20339.
    • Liapakis G, Fitzpatrick D, Hoeger C, Rivier J, Vandlen R, Reisine T.Identification of ligand binding determinants in the somatostatin receptor subtypes 1 and 2. J Biol Chem (1996)271:20331-20339.
    • J Biol Chem
    • Liapakis, G.1    Fitzpatrick, D.2    Hoeger, C.3    Rivier, J.4    Vandlen, R.5    Reisine, T.6
  • 32
    • 0028925786 scopus 로고    scopus 로고
    • Two amino acids located in transmembrane domains VI and VII determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptor
    • 1995 14:727-735.
    • Kaupmann K, Bruns C, Raulf F, Weber H, Mattes H, Lubbert H.Two amino acids located in transmembrane domains VI and VII determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptor. EMBO J (1995) 14:727-735.
    • EMBO J
    • Kaupmann, K.1    Bruns, C.2    Raulf, F.3    Weber, H.4    Mattes, H.5    Lubbert, H.6
  • 33
    • 0027248530 scopus 로고    scopus 로고
    • Butler B, Chan WW, Chaung LY, Judith F, Taylor J, Wyvratt MJ, Fisher MH.A nonpeptidyl growth hormone secretagogue
    • 1993 260:1640-1643.
    • Smith RG, Cheng K, Schoen WR, Pong SS, Hickey G, Jacks T. Butler B, Chan WW, Chaung LY, Judith F, Taylor J, Wyvratt MJ, Fisher MH.A nonpeptidyl growth hormone secretagogue. Sc/ence(1993) 260:1640-1643.
    • Sc/ence
    • Smith, R.G.1    Cheng, K.2    Schoen, W.R.3    Pong, S.S.4    Hickey, G.5    Jacks, T.6
  • 37
    • 13144306065 scopus 로고    scopus 로고
    • Berk SC, Rohrer SP, Mosley RT, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Poor F, Pasternak A, Pan R, Suva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patched AA.Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2
    • 1998 95:10836-10841.
    • Yang L, Berk SC, Rohrer SP, Mosley RT, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Poor F, Pasternak A, Pan R, Suva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patched AA.Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sei USA (1998) 95:10836-10841.
    • Proc Natl Acad Sei USA
    • Yang, L.1
  • 44
  • 47
    • 0032561511 scopus 로고    scopus 로고
    • Birzin ET. Mosley R, Berk SC, Hutchins S, Shen DM, Xiong Y, Hayes E, Parmar R, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM.Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry
    • 1998 282:737-740.
    • Rohrer SP, Birzin ET. Mosley R, Berk SC, Hutchins S, Shen DM, Xiong Y, Hayes E, Parmar R, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM.Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science (1998) 282:737-740.
    • Science
    • Rohrer, S.P.1
  • 50
    • 15444347630 scopus 로고    scopus 로고
    • Hynes J Jr, Cichy-Knight MA, van Rijn RD, Sprengeler PA, Spoors PG, Shakespeare WC, Pietranico-Cole S, Barbosa J, Yao W, Rohrer S, Smith AB.Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity
    • 1998 41:1382-1391.
    • Hirschmann R, Hynes J Jr, Cichy-Knight MA, van Rijn RD, Sprengeler PA, Spoors PG, Shakespeare WC, Pietranico-Cole S, Barbosa J, Yao W, Rohrer S, Smith AB.Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis. JMedChem (1998) 41:1382-1391.
    • A New Route to Ether Synthesis. JMedChem
    • Hirschmann, R.1
  • 52
    • 0030063814 scopus 로고    scopus 로고
    • Borer X.A non-peptide ligand for the somatostatin receptor having a benzodiazepinone structure
    • 1996 6:267-272.
    • Papageorgiou C, Borer X.A non-peptide ligand for the somatostatin receptor having a benzodiazepinone structure. Bioorg Med Chem Lett (1996) 6:267-272.
    • Bioorg Med Chem Lett
    • Papageorgiou, C.1
  • 54
    • 0032548003 scopus 로고    scopus 로고
    • Nonpeptide somatostatin agonists with sst4 selectivity.synthesis and structure-activity relationships of thioureas
    • 1998 41 =4693-4705.
    • Liu S, Tang C, Ho B, Ankersen M, Stidsen CE, Crider AM.Nonpeptide somatostatin agonists with sst4 selectivity.synthesis and structure-activity relationships of thioureas. J Med Chem (1998) 41 =4693-4705.
    • J Med Chem
    • Liu, S.1    Tang, C.2    Ho, B.3    Ankersen, M.4    Stidsen, C.E.5    Crider, A.M.6
  • 55
    • 0006497774 scopus 로고    scopus 로고
    • Non-peptide somatostatin receptor ligands
    • 1999 in press.
    • Yang L.Non-peptide somatostatin receptor ligands. Ann Rep Med Chem (1999) in press.
    • Ann Rep Med Chem
    • Yang, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.