Radiosensitivity in ataxia telangiectasia fibroblasts is not associated with deregulated apoptosis

Radiation Research

Volumn 150, Issue 1, 1998, Pages 11-16

  Enns, Louise ^a   Barley, Randy D C ^a   Paterson, Malcolm C ^b   Mirzayans, Razmik ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^c CROSS CANCER INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; DNA FRAGMENT; PROTEIN P53;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IONIZING RADIATION; MUTATION; PRIORITY JOURNAL; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; SKIN FIBROBLAST;

APOPTOSIS; ATAXIA TELANGIECTASIA; DNA; DNA DAMAGE; FIBROBLASTS; HL-60 CELLS; HUMANS; RADIATION TOLERANCE; SKIN; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

ATAXIA; ATAXIA TELANGIECTASIA;

EID: 0031803352     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579639     Document Type: Article

References (47)

1. R. P. Sedgwick and E. Boder, Ataxia-telangiectasia. Handb. Clin. Neurol. 16, 347-423 (1991).
2. M. F. Lavin, Biochemical defects in ataxia-telangiectasia. In Ataxia-telangiectasia (R. A. Gatti and R. B. Painter, Eds.), pp. 234-255. NATO ASI series H, Vol. 77, Springer-Verlag, Berlin, 1993.
3. M. B. Kastan, Q. Zhan, W. S. El-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein and A. J. Fornace, Jr., A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597 (1992).
4. L. H. Hartwell and M. B. Kastan, Cell cycle control and cancer. Science 266, 1821-1828 (1994).
5. R. Mirzayans, K. S. Famulski, L. Enns, M. Fraser and M. C. Paterson, Characterization of the signal transduction pathway mediating γ ray-induced inhibition of DNA synthesis in human cells: Indirect evidence for involvement of calmodulin but not protein kinase C nor p53. Oncogene 11, 1597-1605 (1995).
6. 1/S-phase transition in normal human fibroblasts elicited by a heat-labile trans-acting factor in gamma-irradiated HeLa cell extracts. Radiat. Res. 147, 13-21 (1997).
7. WAF1 signalling pathway. Oncogene 12, 1077-1082 (1996).
8. K. Savitsky, A. Bar-Shira, S. Gilad, G. Rotman, Y. Ziv, L. Vanagaite, D. A. Tagle, S. Smith, T. Uziel, S. Sfez, M. Ashkenazi, I. Pecker, M. Frydman, R. Harnik, S. R. Patanjali, A. Simmons, G. A. Clines, A. Sartiel, R. A. Gatti, L. Chessa, O. Sanal, M. F. Lavin, N. G. J. Jaspers, A. M. R. Taylor, C. F. Arlett, T. Miki, S. M. Weissman, M. Lovett, F. S. Collins and Y. Shiloh, A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753 (1995).
9. K. Savitsky, S. Sfez, D. A. Tagle, Y. Ziv, A. Sartiel, F. S. Collins, Y. Shiloh and G. Rothman, The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 4, 2025-2032 (1995).
10. R. Yao and G. M. Cooper, Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006 (1995).
11. K. A. Knox and J. Gordon, Protein tyrosine kinases couple the surface immunoglobulin of germinal center B cells to phosphatidylinositol-dependent and -independent pathways of rescue from apoptosis. Cell Immunol. 155, 62-76 (1994).
12. M. S. Meyn, Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res. 55, 5991-6001 (1995).
13. T. Enoch and C. Norbury, Cellular responses to DNA damage: Cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. Trends Biochem. Sci. 20, 426-430 (1995).
14. J. B. Little, Failla Memorial Lecture: Changing views of cellular radiosensitivity. Radiat. Res. 140, 299-311 (1994).
15. M. J. Arends, R. G. Morris and A. H. Wyllie, Apoptosis. The role of the endonuclease. Am. J. Pathol. 136, 593-608 (1990).
16. M. L. Gaido and J. A. Cidlowski, Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes: NUC18 is not histone H-B. J. Biol. Chem. 266, 18580-18585 (1991).
17. S. V. Lennon, S. J. Martin and T. G. Cotter, Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif. 24, 203-214 (1991).
18. M. Abend, A. Rhein, K-P. Gilbertz, W. F. Blakely and D. van Beuningen, Correlation of micronucleus and apoptosis assays with reproductive cell death. Int. J. Radiat. Biol. 67, 315-326 (1995).
19. Ö. Algan, C. C. Stobbe, A. M. Helt, G. E. Hanks and J. D. Chapman, Radiation inactivation of human prostate cancer cells: The role of apoptosis. Radiat. Res. 146, 267-275 (1996).
20. K. L. Hopcia, Y. L. McCarey, F. C. Sylvester and K. D. Held, Radiation-induced apoptosis in HL60 cells: Oxygen effect, relationship between apoptosis and loss of clonogenicity, and dependence of time to apoptosis on radiation dose. Radiat. Res. 145, 315-323 (1996).
21. J. F. R. Kerr, C. M. Winterford and B. V. Harmon, Apoptosis. Its significance in cancer and cancer therapy. Cancer 73, 2013-2026 (1994).
22. P. Santana, L. A. Peña, A. Haimovitz-Friedman, S. Martin, D. Green, M. McLoughlin, C. Cordon-Cardo, E. H. Schumchman, Z. Fuks and R. Kolesnick, Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86, 189-199 (1996).
23. R. Mirzayans, B. Andrais and M. C. Paterson, Synergistic effect of aphidicolin and 1-β-D-arabinofuranosylcytosine on the repair of γ-ray-induced DNA damage in normal human fibroblasts. Int. J. Radiat. Biol. 62, 417-425 (1992).
24. W. D. Jarvis, A. J. Turner, L. F. Povirk, R. S. Traylor and S. Grant, Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 54, 1707-1714 (1994).
25. L. L. Vindeløv, I. J. Christensen and N. I. A. Nissen, Detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3, 323-327 (1983).
26. X. Lu and D. P. Lane, Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes? Cell 75, 765-778 (1993).
27. M. Pritsche, C. Haessler and G. Brandner, Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 8, 307-318 (1993).
28. K. Sakaguchi, H. Sakamoto, M. S. Lewis, C. W. Anderson, J. W. Erickson, E. Appella and D. Xie, Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. Biochemistry 36, 10117-10124 (1997).
29. X. W. Wang, M. K. Gibson, W. Vermeulen, H. Yeh, K. Forrester, H-W. Stürzbecher, J. H. J. Hoeijmakers and C. C. Harris, Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 55, 6012-6016 (1995).
30. R. S. Hansen and A. W. Braithwaite, The growth-inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by 1a and ras. Oncogene 13, 995-1007 (1996).
31. J. M. Ford and P. C. Hanawalt, Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proc. Natl. Acad. Sci. USA 92, 8876-8880 (1995).
32. M. Ljungman and F. Zhang, Blockage of polymerase as a possible trigger for u.v. light-induced apoptosis. Oncogene 13, 823-831 (1996).
33. T. J. Jorgensen and Y. Shiloh, The ATM gene and the radiobiology of ataxia-telangiectasia. Int. J. Radiat. Biol. 69, 527-537 (1996).
34. M. S. Meyn, L. Strasfeld and C. Allen, Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia. Int. J. Radiat. Biol. 66, S141-S149 (1994).
35. M. S. Meyn, Reply to Letter to the Editor. Cancer Res. 57, 2314 (1997).
36. C. Lücke-Huhle, Alterations in oncogene expression and radiosensitivity in the most frequently used SV40-transformed human skin fibroblasts. Int. J. Radiat. Biol. 65, 665-673 (1994).
37. G. Packham, C. W. Porter and J. L. Cleveland, c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways. Oncogene 13, 461-469 (1996).
38. D. Sakamuro, P. Sabbatini, E. White and G. C. Prendergast, The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 15, 887-898 (1997).
39. F. J. O'Neill, Y. Hu, T. Chen and H. Carney, Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen. Oncogene 14, 955-965 (1997).
40. M. Jung, S. A. Lee, Y. Zhang and A. Dritschilo, Regulation of p53 in response to ionizing radiation in ataxia telangiectasia fibroblasts. Int. J. Radiat. Oncol. Biol. Phys. 37, 417-422 (1997).
41. D. Blöcher, D. Sigut and M. A. Hannan, Fibroblasts from ataxia-telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rate γ-irradiation as assayed by pulsed field gel electrophoresis. Int. J. Radiat. Biol. 60, 791-802 (1991).
42. N. Foray, A. Priestley, G. Alsbeih, C. Badie, E. P. Capulas, C. F. Arlett and E. P. Malaise, Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. Int. J. Radiat. Biol. 72, 271-283 (1997).
43. J. M. Brown, Letter to the Editor. Cancer Res. 57, 2313 (1997).
44. H. Beamish and M. F. Lavin, Radiosensitivity in ataxia-telangiectasia: Anomalies in radiation-induced cell cycle delay. Int. J. Radiat. Biol. 65, 175-184 (1994).
45. Y. Shiloh, Ataxia-telangiectasia: Closer to unraveling the mystery. Eur. J. Hum. Genet. 3, 116-138 (1995).
46. P. J. McKinnon, Ataxia-telangiectasia: An inherited disorder of ionizing-radiation sensitivity in man. Hum. Genet. 75, 197-208 (1987).
47. R. Mirzayans, B. P. Smith and M. C. Paterson, Hypersensitivity to cell killing and faulty repair of 1-β-D-arabinofuranosylcytosine-detectable sites in human (ataxia-telangiectasia) fibroblasts treated with 4-nitroquinoline 1-oxide. Cancer Res. 49, 5523-5529 (1989).