Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death

Scandinavian Journal of Immunology

Volumn 50, Issue 2, 1999, Pages 223-227

  Aladdin, Hassan ^a   Ullum, H ^a   Cozzi Lepri, A ^b   Leffers, H ^a   Katzenstein, T ^a   Gerstoft, J ^a   Gjedde, S B ^a   Phillips, A N ^b   Skinhoj P ^a   Pedersen, B Klarlund ^a  

^a Rigshospitalet   (Denmark)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN; VIRUS RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DISEASE COURSE; FOLLOW UP; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; PRIORITY JOURNAL; RISK; VIRUS IMMUNITY;

ADULT; CD4 LYMPHOCYTE COUNT; CELLS, CULTURED; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GENE PRODUCTS, GAG; GENE PRODUCTS, NEF; GENE PRODUCTS, POL; HIV ANTIGENS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; RNA, VIRAL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032802419     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1999.00585.x     Document Type: Article

References (26)

1. 1 McMichael A, Walker BD. Cytotoxic T lymphocyte epitopes: implications for HIV vaccines. AIDS 1994;8:S155-73.
2. 2 Koup RA, Safrit JT, Cao Y et al. Temporal association of cellular immune responses with initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994;68:4650-5.
3. 3 Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone M-BA. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 1994;68:6103-10.
4. 4 Phillips AN. Reduction of HIV concentration during acute infection: independence from a specific immune response. Science 1996;271: 497-9.
5. 5 Rowland Jones S, Tan R, McMichael A. Role of cellular immunity in protection against HIV infection. Adv Immunol 1997;65:277-346.
6. 6 Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath J. Cytotoxic-T-cell responses, viral load and disease progression in early human immunodeficiency virus type 1 infection. N Engl J Med 1997;337:1267-74.
7. 7 Jassoy C, Johnson RP, Navia BA, Worth J, Walker BD. Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected person with AIDS dementia complex. J Immunol 1992;149:3113-19.
8. 8 Rowland JS, Sutton J, Ariyoshi K et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nature Med 1995;1:59-64.
9. MN. J Infect Dis 1994;169:274-80.
10. 10 Grant MD, Smaill FM, Singal DP, Rosenthal KL. The influence of lymphocyte counts and disease progression on circulating and inducible anti-HIV-1 cytotoxic T-cell activity in HIV-1-infected subjects. AIDS 1992;6:1085-94.
11. 11 Luzuriaga K, Koup RA, Pikora CA, Brettler DB. Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children. J Pediatr 1991;119:230-6.
12. 12 Carmichael A, Jin X, Sissons P, Borysiewicz L. Quantitative analyses of the human immunodeficiency virus type 1 (HIV 1)-specific cytotoxic T lymphocyte (CTL) responses at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 1993;177:249-56.
13. 13 Koup RA, Sullivan JL, Levune PH et al. Detection of major histocompatibility complex class I-restricted, HIV-specific cytotoxic T lymphocytes in the blood of infected hemophiliacs. Blood 1989;73:1909-14.
14. 14 Buseyne F, Blanche S, Schmitt D, Griscelli C, Riviere Y. Detection of HIV-specific cell-mediated cytotoxicity in the peripheral blood from infected children. J Immunol 1993;150:3569-81.
15. 15 Riviere Y, Tanneau SF, Regnault A et al. Human immunodeficiency virus-specific cytotoxic responses of seropositive individuals: distinct types of effector cells mediate killing of targets expressing gag and env proteins. J Virol 1989;63:2270-7.
16. 16 Rinaldo CRJ, Beltz LA, Huang XL, Gupta P, Fan Z, Torpey DJ. Anti-HIV type 1 cytotoxic T lymphocyte effector activity and disease progression in the first 8 years of HIV type 1 infection of homosexual men. AIDS Res Hum Retroviruses 1995;11: 481-9.
17. 17 Riviere Y, McChesney MB, Porrot F, et al. Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS. AIDS Res Hum Retroviruses 1995;11:903-7.
18. 18 de Wolf F. Spijkerman I, Schellekens PT et al. AIDS prognosis based on HIV-1 RNA CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion. AIDS 1997;11:1799-806.
19. 19 Weinhold KJ, Matthews TJ, Ahearne PM et al. Cellular anti-GP120 cytolytic reactivities in HIV-1 seropositive individuals. Lancet 1988; 1:902-5.
20. 20 Hofmann B, Lindhart BO, Gerstoft J et al. Lymphocyte transformation response to pokeweed mitogen as a predictive marker for development of AIDS and AIDS related symptoms in homosexual men with HIV antibodies. Br Med J (Clin Res Edn) 1987;295:293-6.
21. 21 Roos MT, Miedema F, Koot M et al. T cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus-infected asymptomatic subjects. J Infect Dis 1995; 171:531-6.
22. 22 Ullum H, Cozzi Lepri A, Aladdin H et al. Natural immunity and HIV diseases progression. AIDS 1999;13:557-63.
23. 23 McChesney M, Tanneau F, Regnault A et al. Detection of primary cytotoxic T lymphocytes specific for the envelope glycoprotein of HIV-1 by deletion of the env amino-terminal signal sequence. Eur J Immunol 1990;20:215-20.
24. 24 Doherty PC, Topham DJ, Tripp RA. Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory. Immunol Rev 1996;150:23-44.
25. 25 Ogg GS, Jin X, Bonhoeffer S et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 1998;279:2103-6.
26. 26 Altman JD, Moss PH, Goulder PR et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996;274:94-6.