Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation

International Immunology

Volumn 11, Issue 8, 1999, Pages 1283-1293

  Friedrich, Karlheinz ^a   Kammer, Winfried ^b   Erhardt, Ingrid ^a   Brändlein, Stephanie ^a   Sebald, Walter ^a   Moriggl, Richard ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c St Jude Children's Research Hospital   (United States)

Author keywords

Cytokine receptors; JAK STAT pathway; Pro B cells; Signal transduction

Indexed keywords

INTERLEUKIN 4 RECEPTOR; PHOSPHOTRANSFERASE; PROLINE; STAT5 PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; DNA SYNTHESIS; ENZYME ACTIVITY; GENE CONTROL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REPORTER GENE; TRANSCRIPTION REGULATION;

B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; HUMANS; INTERLEUKIN-4; JANUS KINASE 1; JANUS KINASE 2; LYMPHOCYTE ACTIVATION; MILK PROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, INTERLEUKIN-4; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

EID: 0032799029     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.8.1283     Document Type: Article

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