Cdc4, a protein required for the onset of S phase, serves an essential function during G2/M transition in Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 19, Issue 8, 1999, Pages 5512-5522

  Goh, Phuay Yee ^a   Surana, Uttam ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN;

ANAPHASE; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; GENE DELETION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0032798597     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.8.5512     Document Type: Article

References (54)

1. Amon, A. 1997. Regulation of B-type cyclin proteolysis by Cdc28-associated kinase in budding yeast. EMBO J. 15:2693-2702.
2. Bai, C., P. Sen, K. Hofmann, L. Ma, M. Goebl, J. W. Harper, and S. J. Elledge. 1996. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86:263-274.
3. Barrai, Y., S. Jentsch, and C. Mann. 1995. G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev. 9:399-409.
4. Choi, W.-J., M. W. Clark, J. X. Chen, and A. Y. Jong. 1990. The CDC4 gene product is associated with the yeast nuclear skeleton. Biochem. Biophys. Res. Commun. 172:1324-1330.
5. Clarke, D. J., M. Segal, G. Mondesert, and S. Reed. 1999. The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast. Curr. Biol. 9:365-368.
6. Cohen-Fix, O., J.-M. Peters, M. W. Kirschner, and D. Koshland. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10: 3081-3093.
7. Connelly, C., and P. Heiter. 1996. Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell 84:275-285.
8. Cross, F., and A. H. Tinkelenberg. 1991. A positive feedback loop controlling CLN1 and CLN2 gene expression at the START of yeast cell cycle. Cell 65:875-883.
9. Dawson, I. A., S. Roth, and S. Artavanis-Tsakonas. 1995. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129:725-737.
10. SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev. 8:1640-1653.
11. Drury, L. S., G. Perkins, and J. F. X. Diffley. 1997. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast. EMBO J. 16:5966-5976.
12. Feldman, R. M. R., C. C. Cornell, K. B. Kaplan, and R. J. Deshaies. 1997. A complex of Cdc4p, Skp1p, and Cdc53/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91:221-230.
13. 12a. Goh, P.-Y., and U. Surana. Unpublished observations.
14. Hartwell, L. H. 1971. Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation. Genetics 59:183-194.
15. Hartwell, L. H., R. K. Mortimer, J. Culotti, and M. Culotti. 1973. Genetic control of cell division cycle in yeast. V. Genetic analysis of cdc mutants. Genetics 74:267-286.
16. Hoyt, M. A. 1997. Eliminating all obstacles: regulated proteolysis in the eukaryotic cell cycle. Cell 91:149-151.
17. Irniger, S., and K. Nasmyth. 1997. The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase. J. Cell Sci. 110:1523-1531.
18. Irniger, S., S. Piatti, C. Michaelis, and K. Nasmyth. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81:269-277.
19. Grr1 complex. EMBO J. 17:5360-5373.
20. Juang, V. L., J. Huang, J.-M. Peters, M. E. McLaughlin, C. Y. Tai, and D. Pellman. 1997. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 275:1311-1314.
21. Kaiser, P., R. A. L. Sia, E. G. S. Bardes, D. J. Lew, and S. I. Reed. 1998. Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. Genes Dev. 12:2587-2597.
22. Kaplan, K. B., A. A. Hyman, and P. K. Sorger. 1997. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell 91:491-500.
23. Kilmartin, J. V. K., and A. M. E. Adams. 1984. Structural arrangement of tubulin and actin during the cell cycle of Saccharomyces. J. Cell Biol. 98: 922-933.
24. King, R. W., J.-M. Peters, S. Tugendreich, M. Rolfe, P. Heiter, and M. W. Kirschner. 1995. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81:279-288.
25. Lamb, J. R., W. A. Michaud, R. S. Sikorski, and P. A. Heiter. 1994. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. EMBO J. 13:4321-4328.
26. Lim, H. H., P.-Y. Goh, and U. Surana. 1996. Spindle pole body in Saccharomyces cerevisiae requires dephosphotylation of the tyrosine 19 residue of Cdc28. Mol. Cell. Biol. 16:6385-6397.
27. Lim, H. H., P.-Y. Goh, and U. Surana. 1998. Cdc20 is essential for APC-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast. Curr. Biol. 8:231-234.
28. Mathias, N., S. L. Johnson, M. Winey, A. E. Adams, L. Goetsch, J. R. Pringle, B. Byers, and M. G. Goebl. 1996. Cdc53 acts in concert with Cdc4, Cdc34 to control the G1 to S-phase transition and identifies a conserved family of proteins. Mol. Gen. Genet. 253:138-148.
29. cdc2. Mol. Cell. Biol. 17:742-750.
30. Michaelis, C., R. Ciosk, and K. Nasmyth. 1997. Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91:35-45.
31. Mulrad, D., R. Hunter, and R. Parker. 1992. A rapid method for localized mutagenesis of yeast genes. Yeast 8:79-82.
32. Neer, E. J., C. J. Schmidt, R. Nambudripad, and T. Smith. 1994. The ancient regulatory-protein family of WD-repeat proteins. Nature 371:297-300.
33. Neer, E. J., and T. F. Smith. 1996. G protein heterodimers: new structures propel new questions. Cell 84:175-178.
34. O'Toole, E. T., D. N. Mastronarde, T. H. Giddings, Jr., M. Winey, D. Burke, and J. R. McIntosh. 1997. Three-dimensional analysis and ultrastructural design of mitotic spindles from the cdc20 mutant of Saccharomyces cerevisiae. Mol. Biol. Cell 8:1-11.
35. Patton, E. E., A. R. Willems, D. Sa, L. Kuras, D. Thomas, K. L. Craig, and M. Tyers. 1998. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12:692-705.
36. Piatti, S., T, Bohm, J. H. Cocker, J. F. X. Diffley, and K. Nasmyth. 1996. Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev. 10:1516-1531.
37. Price, C., K. Nasmyth, and T. Schuster. 1991. A general approach to the isolation of cell cycle-regulated genes in the budding yeast Saccharomyces cerevisiae. J. Mol. Biol. 218:543-556.
38. Rothstein, R. J. 1983. One-step disruption in yeast. Methods Enzymol. 101: 202-210.
39. Schwab, M., A. S. Lutum, and W. Seufert. 1997. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90:683-693.
40. SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79:233-244.
41. Sethi, N., C. Monteagudo, D. Koshland, E. Hogan, and D. Burke. 1991. The CDC20 gene product of Saccharomyces cerevisiae, a β-transducin homolog, is required for a subset of microtubule-dependent cellular processes. Mol. Cell. Biol. 11:5592-5602.
42. Shirayama, M., W. Zachariae, R. Ciosk, and K. Nasmyth. 1998. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17:1336-1349.
43. Sigrist, S. J., H. Jacobs, R. Stratmann, and C. F. Lehner. 1995. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. EMBO J. 14:4827-4838.
44. Sigrist, S. J., and C. F. Lehner. 1997. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90:671-681.
45. Skowyra, D., K. L. Craig, M. Tyers, S. J. Elledge, and J. W. Harper. 1997. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91:209-219.
46. Stemmann, O., and J. Lechner. 1996. The S. cerevisiae kinetochore contains a cyclin-CDK complex homolog, as identified in in vitro reconstitution. EMBO J. 15:3611-3620.
47. Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hershko, F. C. Luca, J. V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6:185-198.
48. Tugendreich, S., J. Tomkiel, W. Earnshaw, and P. Hieter. 1995. CDC27Hs colocalizes with CDC16Hs to the centromere and mitotic spindle and is essential for the metaphase to anaphase transition. Cell 81:261-268.
49. Verma, R., R. S. Annan, M. J. Huddleston, S. A. Carr, G. Reynard, and R. J. Deshaies. 1997. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278:455-459.
50. Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278:460-463.
51. Weinstein, J., F. W. Jacobsen, J. Hsu-Chen, T. Wu, and L. G. Baum. 1994. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. Mol. Cell. Biol. 14:3350-3363.
52. Willems, A. R., S. Lanker, E. E. Patton, K. L. Craig, T. F. Nason, N. Mathias, R. Kobayashi, C. Wittenberg, and M. Tyers. 1996. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 84:453-463.
53. Yamamoto, A., V. Guacci, and D. Koshland. 1996. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathways. J. Cell Biol. 133:99-110.
54. Zachariae, W., T. H. Shin, M. Galova, B. Obermaier, and K. Nasmyth. 1996. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274:1201-1204.