U937-SCID mouse xenografts: A new model for acute in vivo HIV-1 infection suitable to test antiviral strategies

Antiviral Research

Volumn 36, Issue 2, 1997, Pages 81-90

  Lapenta, Caterina ^a   Fais, Stefano ^a   Rizza, Paola ^a   Spada, Massimo ^a   Logozzi, Maria Antonia ^a   Parlato, Stefania ^a   Santini, Stefano M ^a   Pirillo, Maria ^a   Belardelli, Filippo ^a   Proietti, Enrico ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Antiviral therapy; HIV 1; In vivo model; SCID mice

Indexed keywords

ANTIVIRUS AGENT; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KINETICS; MOUSE; NONHUMAN; PERSISTENT INFECTION; PRIORITY JOURNAL; SCID MOUSE; VIRUS EXPRESSION; XENOGRAFT;

ANIMALS; ANTI-HIV AGENTS; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MICE; MICE, SCID; MODELS, BIOLOGICAL; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; ZIDOVUDINE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030778483     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(97)00041-7     Document Type: Article

References (27)

1. Alder J., Hui Y.H., Clement J. Efficacy of AZT therapy in reducing p24 antigen burden in a modified SCID mouse model of HIV infection. Antiviral. Res. 27:1995;85-97.
2. Cordell J.L., Falini B., Erber W.N., Ghosh A.K., Abdulaziz Z., Mac Donald S., Pulford K.A.F., Stein H., Mason D.Y. Immunoenzymatic labeling of monoclonal antibodies using immunecomplexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complex). J. Histochem. Cytochem. 32:1984;219-229.
3. Fais S., Capobianchi M.R., Abbate I., Castilletti C., Gentile M., Cordiali Fei P., Ameglio F., Dianzani F. Unidirectional budding of HIV-1 at the site of cell-to-cell contact is associated with co-polarization of intercellular adhesion molecules and HIV-1 viral matrix protein. AIDS. 9:1984;329-335.
4. Ferrantini M., Giovarelli M., Modesti A., Musiani P., Modica A., Venditti M., Peretti E., Lollini P.L., Nanni P., Forni G., Belardelli F. IFN-α 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T-cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-γ-producing TS/A cells. J. Immunol. 153:1994;4604-4615.
5. Folks T.M., Powell D., Lightfoote M., Koenig S., Fauci A.S., Benn S., Hoggan M.D., Venkatesan S., Martin M.A. Biological and biochemical characterization of a cloned Leu-3-cell surviving infection with the acquired immune deficiency syndrome retrovirus. J. Exp. Med. 164:1986;280-290.
6. Gresser I., Tovey M.G., Bandu M.T., Maury C., Brouty-Boye D. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum.I. Rapid evolution of encephalomyocarditis virus infection. J. Exp. Med. 144:1976;1305-1315.
7. Hesselton R.A., Greiner D.L., Mordes J.P., Rajan T.V., Sullivan J.L., Shultz L.D. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-SCID/SCID mice. J. Inf. Dis. 172:1995;974-982.
8. Lacerda J.F., Ladanyi M., Jagiello C., O'Reilly R.J. Administration of rabbit antiasialo GM1 antiserum facilitates the development of human Epstein-Barr virus-induced lymphoproliferations in xenografted C.B-17 SCID/SCID mice. Transplantation. 61:1996;492-497.
9. Levy J.A., Ramachandran B., Barker E., Guthrie J., Elbeik T. Plasma viral load, CD4+ cell counts and HIV-1 production by cells. Science. 271:1996;670-671.
10. Locardi C., Puddu P., Ferrantini M., Parlanti E., Sestili P., Varano F., Belardelli F. Persistent infection of normal mice with human immunodeficiency virus. J. Virol. 66:1992;1649-1654.
11. McCune J.M., Namikawa R., Kanemisha H., Shultz L.D., Lieberman M., Weissman I.L. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation end function. Science. 241:1988;1632-1639.
12. McCune J.M., Namikawa R., Shih C.C., Rabin L., Kaneshima H. Suppression of HIV infection in AZT-treated SCID-hu mice. Science. 247:1990;564-566.
13. Mosier D.E., Gulizia R.J., Baird S.M., Wilson D.B. Transfer of functional human mmune system to mice with severe combined immunodeficiency. Nature. 335:1988;256-259.
14. Mosier D.E., Gulizia R.J., Baird S.M., Wilson D.B., Spector D.H., Spector S.A. Human immunodeficiency virus infection of human PBL-SCID mice. Science. 251:1991;791-794.
15. Mosier D.E., Gulizia R.J., MacIsaac P., Torbett B., Levy J.A. Rapid loss of CD4+ T-cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science. 260:1993;689-692.
16. Murphy W.J., Kumar V., Bennet M. Rejection of bone marrow allografts by mice with severe combined immune deficiency (SCID). Evidence that natural killer cells can mediate the specificity of marrow graft rejection. J. Exp. Med. 165:1987;1212-1217.
17. Namikawa R., Kanemisha H., Lieberman M., Weissman I.L., McCune J.M. Infection of the SCID-hu mouse by HIV-1. Science. 242:1988;1684-1686.
18. Parren P.W.H.I., Ditzel H.J., Gulizia R.J., Binley J.M., Barbas III C.F., Burton D.R., Mosier D.E. Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site. AIDS. 9:1995;F1-F6.
19. Poli G., Orenstein J.M., Kinter A., Folks T.M., Fauci A.S. Interferon α but not AZT suppresses HIV expression in chronicrdly infected cell lines. Science. 244:1989;575-577.
20. Puddu P., Locardi C., Sestili P., Varano F., Petrini C., Modesti A., Masuelli L., Gresser I., Belardelli F. Human immunodeficiency virus (HIV)-infected tumor xenografts as an in vivo model for antiviral therapy: role of alpha/beta interferon in restriction of tumor growth in nude mice injected with HIV-infected U937 tumor cells. J. Virol. 65:1991;2245-2253.
21. Rizza P., Santini S.M., Logozzi M.A., Lapenta C., Sestili P., Gherardi G., Lande R., Spada M., Parlato S., Belardelli F., Fais S. T-cell dysfunctions in hu-PBL-SCID mice ini ected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells. J. Virol. 70:1996;7958-7964.
22. Santini, S.M., Rizza, P., Logozzi, M.A., Sestili, P., Gherardi, G., Lande, R., Lapenta, C., Belardelli, F., Fais, S., 1995. The SCID mouse reaction to human peripheral blood mononuclear leukocyte engraftment. Transplantation 60, 1306-1314.
23. Sato A., Kodama M., Abe K., Miki S., Nishimura M., Suyama A., Ogata M., Toyoda T., Sugimoto H., Yoshie O., Fujiwara T. A simple and rapid method for preliminary evaluation of in vivo efficacy of anti-HIV compounds in mice. Antiviral. Res. 27:1995;151-163.
24. Shpitz B., Chambers C.A., Singhal A.B., Hozumi N., Fernandes B.J., Roifman C.M., Weiner L.M., Roder J.C., Galliger S. High level functional engraftment of severe combined immune deficiency mice with human peripheral blood lymphocytes following pretreatment with radiation and anti-asialo GMT. J. Immunol. Methods. 169:1994;1-15.
25. Sunstrom C., Nilsson K. Establishment and characterization of a human histiocytic lymphoma cell line (U937). Int. J. Cancer. 17:1976;565-567.
26. Van Kuyk R., Torbett B.E., Gulizia R.J., Leath S., Mosier D.E., Koenig S. Cloned human CD8+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism. J. Immunol. 53:1994;4826-4833.
27. Zack J.A., Arrigo S.J., Weissman S.R., Go A.S., Haislip A., Chen I.S.Y. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell. 61:1990;213-222.