Take your partners, please - Signal diversification by the erbB family of receptor tyrosine kinases

Growth Factors

Volumn 16, Issue 4, 1999, Pages 255-263

  Daly, Roger J ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

EGF; erbB; Growth factor; Heregulin; Neuregulin; Receptor tyrosine kinase; Signal transduction; TGF

Indexed keywords

EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; NEU DIFFERENTIATION FACTOR; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR;

APOPTOSIS; CELL DIFFERENTIATION; CELL MOTILITY; CELL PROLIFERATION; CELL TRANSFORMATION; DIMERIZATION; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION;

EID: 0032791110     PISSN: 08977194     EISSN: None     Source Type: Journal    
DOI: 10.3109/08977199909069144     Document Type: Review

References (70)

1. Alimandi, M., Wang, L.-M., Bottaro, D., Lee, C.-C., Kuo, A., Frankel, M., Fedi, P., Tang, C., Lippman, M. and Pierce, J. (1997) Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors. EMBO J. 16, 5608-5617.
2. Barbacci, E., Guarino, B., Stroh, J., Singleton, D., Rosnack, K., Moyer, J. and Andrews, G. (1995) The structural basis for the specificity of epidermal growth factor and heregulin binding. J. Biol. Chem. 270, 9585-9589.
3. Batzer, A.G., Blaikie, P., Nelson, K., Schlessinger, J. and Margolis, B. (1995) The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor. Mol. Cell. Biol. 15, 4403-4409.
4. Batzer, A.G., Rotin, D., Urena, J.M., Skolnik, E.Y. and Schlessinger, J. (1994) Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol. Cell. Biol. 14, 5192-5201.
5. Baulida, J., Kraus, M., Alimandi, M., Di Fiore, P. and Carpenter, G. (1996) All erbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem. 271, 5251-5257.
6. Beerli, R. and Hynes, N. (1996) Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J. Biol. Chem. 271, 6071-6076.
7. Busfield, S., Michnick, D., Chickering, T., Revett, T., Ma, J., Woolf, E., Comrack, C., Dussault, B., Woolf, J., Goodearl, A. and Gearing, D. (1997) Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. Mol. Cell. Biol. 17, 4007-4014.
8. Carraway III, K., Weber, J., Unger, M., Ledesma, J., Yu, N., Gassman, M. and Lai, C. (1997) Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 387, 512-516.
9. Carraway III, K.L., Sliwkowski, M.X., Akita, R., Platko, J.V., Guy, P.M., Nuijens, A., Diamonti, A.J., Vandlen, R.L., Cantley, L.C. and Cerione, R.A. (1994) The erbB3 gene product is a receptor for heregulin. J. Biol. Chem. 269, 14303-14306.
10. Chang, H., Riese II, D., Gilbert, W., Stern, D. and McMahan, U. (1997) Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature 387, 509-512.
11. Cohen, B., Green, J., Foy, L. and Fell, H. (1996) HER4-mediated biological and biochemical properties in NIH-3T3 cells. J. Biol. Chem. 271, 4813-4818.
12. Crovello, C., Lai, C., Cantley, L. and Carraway III., K. (1998) Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J. Biol. Chem. 273, 26954-26961.
13. Di Fiore, P.P., Pierce, J.H., Kraus, M.H., Segatto, O., King, C.R. and Aaronson, S.A. (1987) erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237, 178-182.
14. Elenius, K., Paul, S., Allison, G., Sun, J. and Klagsbrun, M. (1997) Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J. 16, 1268-1278.
15. Fazioli, F., Kim, U., Rhee, S., Molloy, C., Segatto, O. and Di Fiore, P. (1991) The erbB-2 mitogenic signalling pathway: tyrosine phosphorylation of phospholipase C-γ and GTPase-activating protein does not correlate with erbB-2 mitogenic potency. Mol. Cell. Biol. 11, 2040-2048.
16. Fedi, P., Pierce, J.H., Di Fiore, P.P. and Kraus, M.H. (1994) Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase Cγ or GTPase activating protein, distinguishes erbB-3 signaling from that of other erbB/ EGFR family members. Mol. Cell. Biol. 14, 492-500.
17. Fiddes, R.J., Campbell, D.H., Janes, P.W., Sivertsen, S.P., Sasaki, H., Wallasch, C. and Daly, R.J. (1998) Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. J. Biol. Chem. 273, 7717-7724.
18. Fiddes, R.J., Janes, P.W., Sanderson, G.M., Sivertsen, S.P., Sutherland, R.L. and Daly, R.J. (1995) Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/ PE40 ligand toxin in human breast cancer cells. Cell Growth Differ. 6, 1567-1577.
19. Gassman, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R. and Lemke, G. (1995) Aberrant neural and cardiac development in mice lacking the erbB4 neuregulin receptor. Nature 378, 390-394.
20. Graus-Porta, D., Beerli, R.R., Daly, J.M. and Hynes, N.E. (1997) ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 16, 1647-1655.
21. erbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. U S A 91, 8132-8136.
22. Holgado-Madruga, M., Emlet, D., Moscatello, D., Godwin, A. and Wong, A. (1996) A Grb2-associated docking protein in EGF-and insulin-receptor signalling. Nature 379, 560-564.
23. erbB-2. Science 256, 1205-1210.
24. Hu, P., Margolis, B., Skolnik, E.Y., Lammers, R., Ullrich, A. and Schlessinger, J. (1992) Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol. Cell. Biol. 12, 981-990.
25. Jacobsen, N., Abadi, N., Sliwkowski, M., Reilly, D., Skelton, N. and Fairbrother, W. (1996) High-resolution solution structure of the EGF-like domain of heregulin-alpha. Biochemistry 35, 3402-3417.
26. Janes, P.W., Daly, R.J., deFazio, A. and Sutherland, R.L. (1994) Activation of the Ras signalling pathway in human breast cancer cell lines overexpressing erbB-2. Oncogene 9, 3601-3608.
27. Karunagaran, D., Tzahar, E., Beerli, R., Chen, X., Graus-Porta, D., Ratzkin, B., Seger, R., Hynes, N. and Yarden, Y. (1996) ErbB2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 15, 254-264.
28. Kim, H.-H., Sierke, S.L. and Koland, J.G. (1994) Epidermal growth factor-dependent association of phosphatidyl 3-kinase with the erbB3 gene product. J. Biol. Chem. 269, 24747-24755.
29. King, C.R., Borrello, I., Bellot, F., C̄omoglio, P. and Schlessinger, J. (1988) EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3. EMBO J. 7, 1647-1651.
30. Komurasaki, T., Toyoda, H., Uchida, D. and Morimoto, S. (1997) Epiregulin binds to epidermal growth factor receptor and ErbB4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB2, ErbB3 and ErbB4. Oncogene 15, 2841-2848.
31. Lee, K.-F., Simon, H., Chen, H., Bates, B., Hung, M.-C. and Hauser, C. (1995) Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398.
32. Lenferink, A., Pinkas-Kramarski, R., van de Poll, M., van Vugt, M., Klapper, L., Tzahar, E., Waterman, H., Sela, M., van Zoelen, E. and Yarden, Y. (1998) Differential endocytic routing of homo-and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17, 3385-3397.
33. Levkowitz, G., Klapper, L.N., Tzahar, E., Freywald, A., Sela, M. and Yarden, Y. (1996) Coupling of the c-Cbl proto-oncogene to erbB-1/EGF-receptor but not to other erbB proteins. Oncogens 12, 1117-1125.
34. Lonardo, F., Di Marco, E., King, C.R., Pierce, J.H., Segatto, O., Aaronson, S.A. and Di Fiore, P.P. (1990) The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand. New Biol. 2, 992-1003.
35. Lowenstein, E.J., Daly, R.J., Batzer, A.G., Li, W., Margolis, B., Lammers, R., Ullrich, A., Skolnik, E.Y., Bar-Sagi, D. and Schlessinger, J. (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signalling. Cell 70, 431-442.
36. c-src with two major signalling pathways in human breast cancer. Proc. Natl. Acad. Ssci. U S A 91, 83-87.
37. Margolis, B., Rhee, S.G., Felder, S., Mervic, M., Lyall, R., Levitzki, A., Ullrich, A., Zilberstein, A. and Schlessinger, J. (1989) EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell 57, 1101-1107.
38. Margolis, B., Silvennoinen, O., Comoglio, F., Roonprapunt, C., Skolnik, E., Ullrich, A. and Schlessinger, J. (1992) High-efficiency expression/cloning of epidermal growth factor receptor-binding proteins with src homology 2 domains. Proc. Natl. Acad. Sci. U S A 89, 8894-8898.
39. Massague, J. (1990) Transforming growth factor-α, a model for membrane-anchored growth factors. J. Biol. Chem. 265, 21393-21396.
40. McInnes, C. and Sykes, B. (1998) Growth factor receptors: structure, mechanism and drug discovery. Biopolymers 43, 339-366.
41. Muthuswamy, S. and Muller, W. (1995) Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor. Oncogene 11, 271-279.
42. Nagata, K., Kohda, D., Hatanaka, H., Ichikawa, S., Matsuda, S., Yamamoto, T., Suzuki, A. and Inagaki, F. (1994) Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4. EMBO J. 13, 3517-3523.
43. Olayioye, M., Graus-Porta, D., Beerli, R., Rohrer, J., Gay, B. and Hynes, N. (1998) ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol. Cell. Biol. 18, 5042-5051.
44. Peles, E., Levy, R., Or, E., Ullrich, A. and Yarden, Y. (1991) Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase Cγ. EMBO J. 10, 2077-2086.
45. Pinkas-Kramarski, R., Alroy, I. and Yarden, Y. (1997) ErbB receptors and EGF-like ligands: cell lineage determination and oncogenesis through combinatorial signaling. J. Mammary Gland Biol. Neoplasia 2, 97-107.
46. Pinkas-Kramarski, R., Lenferink, A., Bacus, S., Lyass, L., van de Poll, M., Klapper, L., Tzahar, E., Sela, M., van Zoelen, E. and Yarden, Y. (1998a) The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin. Oncogene 16, 1249-1258.
47. Pinkas-Kramarski, R., Shelly, M., Glathe, S., Ratzkin, B. and Yarden, Y. (1996) Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations. J. Biol. Chem. 271, 19029-19032.
48. Pinkas-Kramarski, R., Shelly, M., Guarino, B., Wang, L., Lyass, L., Alroy, I., Alamandi, M., Kuo, A., Moyer, J., Lavi, S., Eisenstein, M., Ratzkin, B., Seger, R., Bacus, S., Pierce, J., Andrews, G. and Yarden, Y. (1998b) ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. Mol. Cell. Biol. 18, 6090-6101.
49. erbB4. Nature 366, 473-475.
50. Prigent, S.A. and Gullick, W.J. (1994) Identification of c-erbB-3 binding sites for phosphatidylinosito13-kinase and SHC using an EGF receptor/c-erbB-3 chimera. EMBO J. 13, 2831-2841.
51. Ricci, A., Lanfrancone, L., Chiari, R., Belardo, G., Pertica, C., Natali, P.G., Pelicci, P.G. and Segatto, O. (1995) Analysis of protein-protein interactions involved in the activation of the Shc/Grb2 pathway by the erbB-2 kinase. Oncogene 11, 1519-1529.
52. Riese II, D., van Raaij, T., Plowman, G., Andrews, G. and Stern, D. (1995) The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol. Cell. Biol. 15, 5770-5776.
53. Riese II, D.J., Bermingham, Y., van Raaij, T.M., Buckley, S., Plowman, G.D. and Stern, D.F. (1996) Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-β. Oncogene 12, 345-353.
54. Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Lewin, G. and Birchmeier, C. (1997) Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 389, 725-729.
55. Sepp-Lorenzino, L., Eberhard, I., Ma, Z., Cho, C., Serve, H., Liu, F., Rosen, N. and Lupu, R. (1996) Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells. Oncogene 12, 1679-1687.
56. Sibilia, M. and Wagner, E. (1995) Strain-dependent epithelial defects in mice lacking EGF receptor. Science 269, 234-238.
57. Slamon, D.J., Godolphin, W., Jones, L.A., Holt, J.A., Wong, S.G., Keith, D.E., Levin, W.J., Stuart, S.G., Udove, J., Ullrich, A. and Press, M.F. (1989) Studies of the HER2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-712.
58. Sliwkowski, M.X., Schaefer, G., Akita, R.W., Lofgren, J.A., Fitzpatrick, V.D., Nuijens, A., Fendly, B.M., Cerione, R.A., Vandlen, R.L. and Carraway, K.L. (1994) Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J. Biol. Chem. 269, 14661-14665.
59. Soltoff, S.P., Carraway, K.L., Prigent, S.A., Gullick, W.G. and Cantley, L.C. (1994) ErbB3 is involved in activation of phosphatidyl 3-kinase by epidermal growth factor. Mol. Cell. Biol. 14, 3550-3558.
60. Stover, D., Becker, M., Liebetanz, J. and Lydon, N. (1995) Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and p85α. J. Biol. Chem. 270, 15591-15597.
61. Threadgill, D., Dlugosz, A., Hansen, L., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R., Barnard, J., Yuspa, S., Coffey, R. and Magnuson, T. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269, 230-234.
62. Tzahar, E., Levkowitz, G., Karunagaran, D., Yi, L., Peles, E., Lavi, S., Chang, D., Liu, N., Yayon, A., Wen, D. and Yarden, Y. (1994) ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all neu differentiation factor/heregulin isoforms. J. Biol. Chem. 269, 25226-25233.
63. Tzahar, E., Pinkas-Kramarski, R., Moyer, J., Klapper, L., Alroy, I., Levkowitz, G., Shelly, M., Henis, S., Eisenstein, S., Ratzkin, B., Sela, M., Andrews, G. and Yarden, Y. (1997) Bivalence of EGF-like ligands drives the ErbB signaling network. EMBO J. 16, 4938-4950.
64. Tzahar, E., Waterman, H., Chen, X., Levkowitz, G., Karunagaran, D., Lavi, S., Ratzkin, B. and Yarden, Y. (1996) A hierarchical network of interreceptor interactions determines signal transduction by neu differentiation factor/ neuregulin and epidermal growth factor. Mol. Cell. Biol. 16, 5276-5287.
65. neu protein and EGF receptor modulates EGF receptor function. Cell 61, 1339-1347.
66. Wallasch, C., Weiss, F., Niederfellner, G., Jallal, B., Issing, W. and Ullrich, A. (1995) Heregulin-dependent regulation of HER2/ neu oncogenic signaling by heterodimerization with HER3. EMBO J. 14, 4267-4275.
67. Wen, D., Peles, E., Cupples, R., Suggs, S.V., Bacus, S.S., Luo, Y., Trail, G., Hu, S., Silbiger, S.M., Levy, R.B., Ben Levy, R., Koski, R.A., Lu, H.S. and Yarden, Y. (1992) Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell 69, 559-572.
68. Wong, A., Ruppert, J., Bigner, S., Grzeschik, C., Humphrey, P., Bigner, D. and Vogelstein, B. (1992) Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc. Natl. Acad. Sci (U S A) 89, 2965-2969.
69. Zhang, D., Sliwkowski, M., Mark, M., Frantz, G., Akita, R., Sun, Y., Hillan, K., Crowley, C., Brush, J. and Godowski, P. (1997) Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc. Natl. Acad. Sci (U S A) 94, 9562-9567.
70. Zhang, K., Sun, J., Liu, N., Wen, D., Chang, D., Thomason, A. and Yoshinaga, S. (1996) Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2. J. Biol. Chem. 271, 3884-3890.