Detection of anti-vacA antibody responses in serum and gastric juice samples using type s1/m1 and s2/m2 Helicobacter pylori vacA antigens

Clinical and Diagnostic Laboratory Immunology

Volumn 6, Issue 4, 1999, Pages 489-493

  Perez Perez, Guillermo I ^a   Peek Jr , Richard M ^a,b   Atherton, John C ^a,d   Blaser, Martin J ^a,b,c   Cover, Timothy L ^a,b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL TOXIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY;

ADULT; AGED; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HELICOBACTER PYLORI; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PEPTIC ULCER; PRIORITY JOURNAL; RISK FACTOR; SERUM; STOMACH JUICE; STOMACH PH;

EID: 0032788958     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/cdli.6.4.489-493.1999     Document Type: Article

References (33)

1. Anonymous. 1994. NIH consensus development panel on Helicobacter pylori in peptic ulcer disease. Helicobacter pylori in peptic ulcer disease. JAMA 272:65-69.
2. Anonymous. 1994. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr. Eval. Carcinog. Risks Hum. 61:177-240.
3. Atherton, J. C., P. Cao, R. M. Peek, Jr., M. K. R. Tummuru, M. J. Blaser, and T. L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of H. pylori: association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 270:17771-17777.
4. Atherton, J. C., R. M. Peek, Jr., K. T. Tham, T. L. Cover, and M. J. Blaser. 1997. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112:92-99.
5. Blaser, M. J., G. I. Perez-Perez, H. Kleanthous, T. L. Cover, R. M. Peek, P. H. Chyou, G. N. Stemmermann, and A. Nomura. 1995. Infection with H. pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 55:2111-2115.
6. Cover, T. L. 1996. The vacuolating cytotoxin of Helicobacter pylori. Mol. Microbiol. 20:241-246.
7. Cover, T. L., D. E. Berg, and M. J. Blaser. 1997. VacA and the cag pathogenicity island of H. pylori, p. 75-90. In P. B. Ernst, P. Michetti, and P. D. Smith (ed.), "The immunobiology of H. pylori: from pathogenesis to prevention." Lippincott-Raven Publishers, Philadelphia, Pa.
8. Cover, T. L., and M. J. Blaser. 1992. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J. Biol. Chem. 267:10570-10575.
9. Cover, T. L., P. Cao, C. D. Lind, K. T. Tham, and M. J. Blaser. 1993. Correlation between vacuolating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo. Infect. Immun. 61:5008-5012.
10. Cover, T. L., P. Cao, U. K. Murthy, M. S. Sipple, and M. J. Blaser. 1992. Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori. J. Clin. Investig. 90:913-918.
11. Cover, T. L., P. I. Hanson, and J. E. Heuser. 1997. Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly. J. Cell Biol. 138:759-769.
12. Cover, T. L., M. K. R. Tummuru, P. Cao, S. A. Thompson, and M. J. Blaser. 1994. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J. Biol. Chem. 269:10566-10573.
13. Drumm, B., G. I. Perez-Perez, M. J. Blaser, and P. M. Sherman. 1990. Intrafamilial clustering of Helicobacter pylori infection. N. Engl. J. Med. 322:359-363.
14. Dunn, B. E., H. Cohen, and M. J. Blaser. 1997. Helicobacter pylori. Clin. Microbiol. Rev. 10:720-741.
15. Forsyth, M. H., J. C. Atherton, M. J. Blaser, and T. L. Cover. 1998. Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains. Infect. Immun. 66:3088-3094.
16. Ito, Y., T. Azuma, S. Ito, H. Miyaji, M. Hirai, Y. Yamazaki, F. Sato, T. Kato, Y. Kohli, and M. Kuriyama. 1997. Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J. Clin. Microbiol. 35:1710-1714.
17. Leunk, R. D., P. T. Johnson, B. C. David, W. G. Kraft, and D. R. Morgan. 1988. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J. Med. Microbiol. 26:93-99.
18. Lupetti, P., J. E. Heuser, R. Manetti, P. Massari, S. Lanzavecchia, P. L. Bellon, R. Dallai, R. Rappuoli, and J. L. Telford. 1996. Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin. J. Cell Biol. 133:801-807.
19. Marchetti, M., B. Arico, D. Burroni, N. Figura, R. Rappuoli, and P. Ghiara. 1995. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science 267:1655-1658.
20. Molinari, M., M. Salio, C. Galli, N. Norais, R. Rappuoli, A. Lanzavecchia, and C. Montecucco. 1998. Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA. J. Exp. Med. 87:135-140.
21. Pagliaccia, C., M. de Bernard, P. Lupetti, J. Xuhuai, D. Burroni, T. L. Cover, E. Papini, R. Rappuoli, J. L. Telford, and J.-M. Reyrat. 1998. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity. Proc. Natl. Acad. Sci. USA 95:10212-10217.
22. Pan, Z.-J., D. E. Berg, R. W. M. van der Hulst, W.-W. Su, A. Raudonikiene, S.-D. Xiao, J. Dankert, G. N. J. Tytgat, and A. van der Ende. 1998. Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China. J. Infect. Dis. 178:220-226.
23. Papini, E., B. Satin, N. Norais, M. de Bernard, J. L. Telford, R. Rappuoli, and C. Montecucco. 1998. Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin. J. Clin. Investig. 102:813-820.
24. + Helicobacter pylori strains. Lab. Investig. 71:760-770.
25. Perez-Perez, G. I., B. M. Dworkin, J. E. Chodos, and M. J. Blaser. 1988. Campylobacter pylori antibodies in humans. Ann. Intern. Med. 109:11-17.
26. Perez-Perez, G. I., K. T. Tham, R. M. Peek, J. C. Atherton, and M. J. Blaser. 1994. Not all Helicobacter pylori-infected persons produce specific IgA in gastric juice. Gastroenterology 112:A1061.
27. Satin, B., N. Norais, J. Telford, R. Rappuoli, M. Murgia, C. Montecucco, and E. Papini. 1997. Effect of Helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation. J. Biol. Chem. 272:25022-25028.
28. Strobel, S., S. Bereswill, P. Balig, P. Allgaier, H.-G. Sonntag, and M. Kist. 1998. Identification and analysis of a new vacA genotype variant of Helicobacter pylori in different patient groups in Germany. J. Clin. Microbiol. 36:1285-1289.
29. Telford, J. L., P. Ghiara, M. Dell-Orco, M. Comanducci, D. Burroni, M. Bugnoli, M. F. Tecce, S. Censini, A. Covacci, Z. Xiang, E. Papini, C. Montecucco, L. Parente, and R. Rappuoli. 1994. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J. Exp. Med. 179:1653-1658.
30. van Doom, L. J., C. Figueiredo, R. Rossau, G. Jannes, M. van Asbroeck, J. C. Sousa, F. Carneiro, and W. G. V. Quint. 1998. Typing of Helicobacter pylori vacA gene and detection of cagA gene hy PCR and reverse hybridization. J. Clin. Microbiol. 36:1271-1276.
31. van Doom, L.-J., C. Figueiredo, R. Sanna, S. Pena, P. Midolo, E. K. W. Ng, J. C. Atherton, M. J. Blaser, and W. G. V. Quint. 1998. Expanding allelic diversity of Helicobacter pylori vacA. J. Clin. Microbiol. 36:2597-2603.
32. Wang, H.-J., C.-H. Kuo, A. A. M. Yeh, P. C. L. Chang, and W.-C. Wang. 1998. Vacuolating toxin production in clinical isolates of Helicobacter pylori with different vacA genotypes. J. Infect. Dis. 178:207-212.
33. Wirth, H. P., P. Vogt, R. Ammann, and J. Altorfer. 1993. IgA antibodies against Helicobacter pylori in gastric secretions: gastric secretory immune response or salivary contamination? Schweiz. Med. Wochenschr. 123:1106-1110.