Inhibition of gastric mucosal regeneration by tyrphostin: Evaluation of the role of epidermal growth factor receptor tyrosine kinase

Journal of Laboratory and Clinical Medicine

Volumn 128, Issue 2, 1996, Pages 173-180

  Majumdar, Adhip P N ^a   Fligiel, Suzanne E G ^b   Jaszewski, Richard ^b   Tureaud, John ^b   Dutta, Sukla ^b   Chelluderai, Bhadrani ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030205133     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(96)90009-8     Document Type: Article

References (49)

1. Critchlow J, Magee D, Ito S, Takeuchi K, Silen W. Requirements for restitution of the surface epithelium of frog stomach after mucosal injury. Gastroenterology 1985;88:247-9.
2. Ito S, Lacy ER. Morphology of gastric mucosal damage, defense and restitution in the presence of luminal ethanol. Gastroenterology 1895;88:250-60.
3. Ito S, Lacy ER, Rutten MJ, Critchlow J, Silen W. Rapid repair of injured gastric mucosa. Scand J Gastroenterol 1984; 19(suppl 101):87-95.
4. Lacy ER, Cowart HS, Hund P III. Effect of chronic superficial injury on the rat gastric mucosa. Gastroenterology 1992; 103:1179-91.
5. Svanes K, Ito S, Takeuchi K, Silen W. Restitution of the surface epithelium of frog gastric mucosa after damage with hypermolar sodium chloride. Gastroenterology 1982;82:1409-26.
6. Yeomans ND. Electron microscopic study of the repair of aspirin-induced gastric erosions. Am J Dig Dis 1976;21:533-41.
7. Yeomans ND, St. John DJB, De Boer WGRM. Regeneration of gastric mucosa after aspirin-induced injury in the rat. Dig Dis Sci 1973;18:773-80.
8. Rutten MJ, Ito S. Morphology and physiology of guinea pig gastric mucosal repair in vitro. Am J Physiol 1983;244:G171-83.
9. Fligiel SEG, Relan NK, Dutta S, Tureaud J, Hatfield J, Majumdar APN. Aging diminishes gastric mucosal regeneration: relationship to tyrosine kinases. Lab Invest 1994;70: 764-74.
10. Johnson LR. Regulation of gastrointestinal growth. In: Johnson LR, ed. Physiology of the gastrointestinal tract. New York: Raven Press, 1987:301-33.
11. Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany A, Slomiany BL. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992;27:649-55.
12. Konturek SJ. Role of growth factors in gastroduodenal protection and healing of peptic ulcers. Gastroenterol Clin North Am 1990;19:41-65.
13. Takeuchi K, Johnson LR. Pentagastrin protects against stress ulceration in rats. Gastroenterology 1979;76:327-34.
14. Brozozowski T, Konturek SJ, Majka J, Dembinski A, Drozdowicz D. Epidermal growth factor, polyamines, and prostaglandins in healing of stress-induced gastric lesions in rats. Dig Dis Sci 1993;38:276-83.
15. Wang JY, Johnson LR. Luminal polyamines substitute for tissue polyamines in duodenal mucosal repair after stress in rats. Gastroenterology 1992;102:1109-17.
16. Adamson ED. Oncogenes in development. Development 1987;99:449-71.
17. Hunter T, Cooper JA. Protein-tyrosine kinases. Ann Rev Biochem 1985;54:897-930.
18. Yarden Y, Ullrich A. Growth factor receptor tyrosine kinases. Ann Rev Biochem 1988;57:443-87.
19. Majumdar APN, Moshier JA, Arlow FL, Luk GD. Biochemical changes in the gastric mucosa after injury in young and aged rats. Biochim Biophys Acta 1989;992:35-40.
20. Majumdar APN. Gastric mucosal injury and aging: role of tyrosine kinases (Tyr-k) and epidermal growth factor receptor (EGF-R) in mucosal cell proliferation. Gastroenterology 1990;98:A422.
21. Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990;61:203-12.
22. Tarnawski A, Stachura J, Durbin T, Sarfeh IJ, Gergely H. Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats. Gastroenterology 1992; 102:695-8.
23. Tarnawski A, Lu SY, Stachura J, Sarfeh IJ. Adaptation of gastric mucosa to chronic alcohol administration is associated with increased mucosal expression of growth factors and their receptor. Scand J Gastroenterol 1992;27:59-63.
24. Polk WH, Dempsey PJ, Russell WE, Brown PI, Beauchamp D, Barnard JA, et al. Increased production of transforming growth factor-α following acute gastric injury. Gastroenterology 1992;102:1467-74.
25. Relan NK, Fligiel SEG, Dutta S, Tureaud J, Chauhan DP, Majumdar APN. Induction of EGF-receptor tyrosine kinase during early reparative phase of gastric mucosa and effects of aging. Lab Invest 1995;73:717-26.
26. Levitzki A. Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents of signal transduction. FASEB J 1992;6:3275-82.
27. Lyall RM, Zilberstein A, Gazit A, Gilon C, Levitzki A, Schlessinger J. Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J Biol Chem 1989;264: 14503-9.
28. Dvir A, Milner Y, Chomsky O, Gilon C, Gazir A, Levitzki A. The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers. J Cell Biol 1991; 113:857-65.
29. Margolis B, Rhee SG, Felder S, Lyall R, Levitzki A, Ullrich A, et al. EGF induces tyrosine phosphorylation of phospholipase C. II. A potential mechanism for EGF-receptor signaling. Cell 1989;57:1101-7.
30. Thirumalai CHR, Tseng CC, Tabata K, Fitzpatrick LR, Johnson LR. Relationship between ornithine decarboxylase activity and gastric damage. Am J Physiol 1987;253:G1-6.
31. Wang JY, Viar MJ, Johnson LR. Transglutaminase in response to hypertonic NaCl-induced gastric mucosal injury in rats. Gastroenterology 1992;104:65-74.
32. Edgerton EA, Fligiel SEG, Moshier JA, Hatfield JS, Luk GD, Majumdar APN. Effect of gastric mucosal injury on ornithine decarboxylase in young and aged rats. Exp Gerontol 1991;26:45-55.
33. c-src in gastric mucosa of aged rats. J Gerontol 1994;49:B110-6.
34. Majumdar APN, Tureaud J. Role of tyrosine kinases in bombesin regulation of gastric mucosal proliferative activity in young and aged rats. Peptides 1992;13:795-800.
35. Bravo R, Frank R, Blundell PA, MacDonald-Bravo. Cyclin/ PCNA is the auxiliary protein of DNA-polymerase-5. Nature 1987;326:515-7.
36. Celis JE, Celis A. Cell cycle dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc Natl Acad Sci (USA) 1985;82:3262-6.
37. Mathews MB, Bernstein RM, Franza BR, Garrels JI. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984;309:374-6.
38. Chang CD, Ottavio L, Travalli S, Lipson KE, Baserga R. Transcriptional and posttranscriptional regulation of the proliferating cell nuclear antigen gene. Mol Cell Biol 1990;10: 3289-96.
39. Yamada K, Yoshitake K, Sato M, Ahnen DJ. Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat. Gastroenterology 1992;103:160-7.
40. Rutten MJ, Dempsey PJ, Solomon TE, Coffey RJ Jr. TGF-α is a potent mitogen for primary cultures of guinea pig gastric mucous epithelial cells. Am J Physiol 1993;265:G361-9.
41. Johnson LR, Guthrie PD. Stimulation of rat oxyntic gland mucosal growth by epidermal growth factor 1980;238:G45-9.
42. Pegg AE, McCann PP. Polyamine metabolism and function. Am J Physiol 1982;243:C212-21.
43. Luk GD, Marton LJ, Baylin SB. Ornithine decarboxylase is important in intestinal maturation and recovery from injury in rats. Science 1980;210:195-8.
44. Ito T, Hayashi N, Sasaki Y, Morita Y, Kawano S, Fusamoto H, et al. Sequential protooncogene expression during regeneration in rat stomach. Gastroenterology 1990;98:1525-31.
45. Wang JY, Johnson LR. Expression of protooncogene c-fos and c-myc in healing of gastric mucosal stress ulcers. Am J Physiol 1994;266:G878-86.
46. Relan NK, Saeed A, Ponduri K, Fligiel SEG, Dutta S, Majumdar APN. Indentification and evaluation of the role of endogenous tyrosine kinases in azoxymethane induction of proliferative processes in the colonic mucosa of rats. Biochim Biophys Acta 1995;1244:368-76.
47. Yoneda T, Lyall R, Alsine MM, Persons PE, Spada AP, Levitzki A, et al. The antiproliferative effect of tyrosine kinase inhibitor of tyrphostin on a human squamous cell carcinoma in vitro and nude mice. Cancer Res 1990;51:4430-5.
48. Bennett C, Paterson IM, Corbishley CM, Luqmani YA. Expression of growth factor and epidermal growth factor receptor encoded transcripts in human gastric tissues. Cancer Res 1989;49:2104-11.
49. DiFiore PP, Pierce JH, Fleming TP, Hazan R, Ullrich A, King J, et al. Overexpression of the human EGF-receptor confers and EGF-dependent transformed phenotype to NIH 3T3 cells. Cell 1987;51:1063-70.