Genetic contribution to pathological gambling: Possible association between a functional DNA polymorphism at the serotonin transporter gene (5-HTT) and affected men

Pharmacogenetics

Volumn 9, Issue 3, 1999, Pages 397-400

  Pérez De Castro, Ignacio ^a   Ibáñez, Angela ^b   Saiz Ruiz, Jerónimo ^b   Fernández Piqueras, José ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

5 HTT; Association studies; Functional polymorphism; Pathological gambling; Serotonin transporter gene

Indexed keywords

DNA; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; COMPULSION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOLOGICAL GAMBLING; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; BEHAVIOR, ADDICTIVE; CARRIER PROTEINS; FEMALE; GAMBLING; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0032768065     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. American Psychiatric Association. Diagnostic and statistical manual of the American Psychiatric Association IV. Washington, DC. American Psychiatric Association 1994.
2. Billet EA, Richter MA, King N, Heils A, Lesch KP, Kennedy JL. Obssesive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene. Mol Psychiatry 1997; 2:403-406.
3. Biver F, Lotstra F, Monclus M, Wikler D, Mendlewicz J, Goldman S. Sex difference in 5-HT2 receptor in the living human brain. Neurosci Lett 1996; 204:25-28.
4. Blum KI, Sheridan PJ. Wood RC, Braverman ER, Cheng TJ, Comings DE. Dopamine D2 receptor gene variants: association and linkage studies in impulsive - addictive - compulsive behaviour. Pharmacogenetics 1995; 5:121-141.
5. Collier DA, Stuber G, Li T, Heils A, Catalano M, Di Bella D, et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry 1996; 1:453-460.
6. 2 receptor gene in pathological gambling. Pharmacogenetics 1996; 6:223-234.
7. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66:2621-2624.
8. Hoehe MR, Wendel B, Grunewald I, Chiaroni P, Levy N, Morris-Rosendahl D, et al. Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet 1998; 81:1-3.
9. Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T, et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 1997; 2:457-462.
10. Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274:1527-1531.
11. Mendes de Oliveira JR, Otto PA, Vallada H, Lauriano V, Elkis H, Lafer B, et al. Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia. Am J Med Genet 1998; 81:225-227.
12. Moreno I, Siz-Ruiz J, Lùpez-Ibor JJ. Serotonin and gambling dependence. Hum Psychopharmacol 1991; 6:S9-S12.
13. Oruc L, Verheyen GR, Furac I. Jakovlejevic M, Ivezic S, Raeymaekers P, Van Broeckhoven C. Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder. Am J Med Genet 1997; 74:504-506.
14. Pèrez de Castro I, Ibòez A, Torres P, Siz-Ruiz J, Fernandez-Piqueras J. Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. Pharmacogenetics 1997; 7:345-348.
15. Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M, et al. Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res 1997; 21:1356-1359.
16. Stober G, Jatzke S, Heils A, Jungkunz G, Fuchs E, Knapp M, et al. Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter region of the serotonin transporter gene. Eur Arch Psy Clin N 1998; 248:82-86.
17. Westenberg HG, Murphy DL, Den Boer JA, eds. Advances in the neurobiology of anxiety disorders. New York: Wiley, 1996.
18. World Health Organization. The ICD-10 classification of mental and behavioral disorders. World Health Organization 1992.