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Volumn 3, Issue 3, 1996, Pages 203-208

Current status of clinical development of interleukin-10

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR; COMPLEMENTARY DNA; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN RECEPTOR; LIPOPOLYSACCHARIDE; RECOMBINANT INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

EID: 0029908539     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199603030-00007     Document Type: Review
Times cited : (28)

References (55)
  • 1
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse T helper cell IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989, 170:2081-2095.
    • (1989) J Exp Med , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 2
    • 0025335354 scopus 로고
    • Homology of cytokine synthesis Inhibiting factor (IL-10) to the Epstein-Barr virus gene BCRF1
    • Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR: Homology of cytokine synthesis Inhibiting factor (IL-10) to the Epstein-Barr virus gene BCRF1. Science 1990, 248:1230-1234
    • (1990) Science , vol.248 , pp. 1230-1234
    • Moore, K.W.1    Vieira, P.2    Fiorentino, D.F.3    Trounstine, M.L.4    Khan, T.A.5    Mosmann, T.R.6
  • 5
    • 0027131207 scopus 로고
    • Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis
    • Wanidworanun C, Strober W: Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. J Immunol 1993, 12:6853-6861.
    • (1993) J Immunol , vol.12 , pp. 6853-6861
    • Wanidworanun, C.1    Strober, W.2
  • 6
    • 0026094306 scopus 로고
    • IL-10 inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • De Waal Malefyt R, Abrams J, Bennet B, Figdor C, de Vries J: IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991, 174:1209-1220.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennet, B.3    Figdor, C.4    De Vries, J.5
  • 12
    • 0029148046 scopus 로고
    • Functional regions of the mouse interleukin-10 receptor cytoplasmic domain
    • Ho ASY, Wei SHY, Mui ALF, Miyajima A, Moore KW: Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol Cell Biol 1995, 15:5043-5053.
    • (1995) Mol Cell Biol , vol.15 , pp. 5043-5053
    • Ho, A.S.Y.1    Wei, S.H.Y.2    Mui, A.L.F.3    Miyajima, A.4    Moore, K.W.5
  • 13
    • 0027934846 scopus 로고
    • Monocyte deactivation by interleukin-10 via Inhibition of tyroslne kinase activity and the Ras signaling pathway
    • Geng Y, Gulbins E, Altman A, Lotz M: Monocyte deactivation by interleukin-10 via Inhibition of tyroslne kinase activity and the Ras signaling pathway. Proc Natl Acad Sci U S A 1994, 91:8602-8606.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8602-8606
    • Geng, Y.1    Gulbins, E.2    Altman, A.3    Lotz, M.4
  • 14
    • 0028361841 scopus 로고
    • IL-10-induced factors belonging to the p91 family of proteins bind to IFN-gamma-responsive promoter elements
    • Lehmann J, Seegert D, Strehlow I, Schindler C, Lohmann-Matthes ML, Decker T: IL-10-induced factors belonging to the p91 family of proteins bind to IFN-gamma-responsive promoter elements. J Immunol 1994, 153:165-172.
    • (1994) J Immunol , vol.153 , pp. 165-172
    • Lehmann, J.1    Seegert, D.2    Strehlow, I.3    Schindler, C.4    Lohmann-Matthes, M.L.5    Decker, T.6
  • 16
    • 0026000892 scopus 로고
    • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
    • De Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, Johnson K, Kastelein R, Yssel H, de Vries JE: Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991, 174:915-924.
    • (1991) J Exp Med , vol.174 , pp. 915-924
    • De Waal Malefyt, R.1    Haanen, J.2    Spits, H.3    Roncarolo, M.G.4    Te Velde, A.5    Figdor, C.6    Johnson, K.7    Kastelein, R.8    Yssel, H.9    De Vries, J.E.10
  • 17
    • 0026529405 scopus 로고
    • IL-10 Inhibits parasite killing and nitrogen oxide production by IFN-gamma activated macrophages
    • Gazzinelli RT, Oswald IP, James SL, Sher A: IL-10 Inhibits parasite killing and nitrogen oxide production by IFN-gamma activated macrophages. J Immunol 1992, 148:1792-1796.
    • (1992) J Immunol , vol.148 , pp. 1792-1796
    • Gazzinelli, R.T.1    Oswald, I.P.2    James, S.L.3    Sher, A.4
  • 19
    • 85035167300 scopus 로고
    • Differential effects of IL-4 and IL-10 on the expression of the c3bi receptor on human monocytes/macrophages
    • Reiter E, Öhler L, Agis H, Valent P, Jäger U, Lechner K, Geissler K: Differential effects of IL-4 and IL-10 on the expression of the c3bi receptor on human monocytes/macrophages [abstract]. Blood 1993, 84:31a.
    • (1993) Blood , vol.84
    • Reiter, E.1    Öhler, L.2    Agis, H.3    Valent, P.4    Jäger, U.5    Lechner, K.6    Geissler, K.7
  • 21
    • 0027240219 scopus 로고
    • Interleukin-10 (IL-10) inhibits human lymphocyte interferon-gamma production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G: Interleukin-10 (IL-10) inhibits human lymphocyte interferon-gamma production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993, 178:1041-1048.
    • (1993) J Exp Med , vol.178 , pp. 1041-1048
    • D'Andrea, A.1    Aste-Amezaga, M.2    Valiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 22
    • 0027281346 scopus 로고
    • Human interteukin-10 can directly Inhibit T cell growth
    • Taga K, Mostowski H, Tosato G: Human interteukin-10 can directly Inhibit T cell growth. Blood 1993, 81:2964-2971.
    • (1993) Blood , vol.81 , pp. 2964-2971
    • Taga, K.1    Mostowski, H.2    Tosato, G.3
  • 23
    • 0028281708 scopus 로고
    • Interleukin-10 Inhibits Interleukin-8 production in human neutrophils
    • Wang P, Wu P, Anthes JC, Siegel MI, Egan RW, Billah MM: Interleukin-10 Inhibits Interleukin-8 production in human neutrophils. Blood 1994, 83:2678-2683.
    • (1994) Blood , vol.83 , pp. 2678-2683
    • Wang, P.1    Wu, P.2    Anthes, J.C.3    Siegel, M.I.4    Egan, R.W.5    Billah, M.M.6
  • 25
    • 0028283903 scopus 로고
    • Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eoslnophils
    • Takanaski S, Nonaka R, Xing Z, O'Byrne P, Dolovich J, Jordana M: Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eoslnophils. J Exp Med 1994, 180:711-715.
    • (1994) J Exp Med , vol.180 , pp. 711-715
    • Takanaski, S.1    Nonaka, R.2    Xing, Z.3    O'Byrne, P.4    Dolovich, J.5    Jordana, M.6
  • 26
    • 0025673971 scopus 로고
    • Interleukin 10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunodeficiency B cells
    • Go NF, Castle BE, Barrett R, Kastlelein R, Dang W, Mosmann TR, Moore KW, Howard M: Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 1990, 172:1625-1631.
    • (1990) J Exp Med , vol.172 , pp. 1625-1631
    • Go, N.F.1    Castle, B.E.2    Barrett, R.3    Kastlelein, R.4    Dang, W.5    Mosmann, T.R.6    Moore, K.W.7    Howard, M.8
  • 28
    • 0027440245 scopus 로고
    • Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes
    • Ruckiger AC, Garrone P, Durand I, Galizzi JP, Banchereau J: Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J Exp Med 1993, 178:1473-1481.
    • (1993) J Exp Med , vol.178 , pp. 1473-1481
    • Ruckiger, A.C.1    Garrone, P.2    Durand, I.3    Galizzi, J.P.4    Banchereau, J.5
  • 30
    • 85035168798 scopus 로고
    • IL-10 increases BCL-2 expression in primary human CD34+ hematopoietic progenitor cells derived from bone marrow or peripheral blood
    • Weber-Nordt RM, Henschler R, Schott E, Wehinger J, Behringer D, Mertelsmann R, Finke J: IL-10 increases BCL-2 expression in primary human CD34+ hematopoietic progenitor cells derived from bone marrow or peripheral blood. Blood 1995, 86:149a.
    • (1995) Blood , vol.86
    • Weber-Nordt, R.M.1    Henschler, R.2    Schott, E.3    Wehinger, J.4    Behringer, D.5    Mertelsmann, R.6    Finke, J.7
  • 32
    • 0026510903 scopus 로고
    • Biological properties of interleukin 10
    • Howard M, O'Garra A: Biological properties of interleukin 10. Immunol Today 1992, 13:198-200.
    • (1992) Immunol Today , vol.13 , pp. 198-200
    • Howard, M.1    O'Garra, A.2
  • 33
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn R, Lohler J, Rennick D, Rajewsky K, Muller W: Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75:263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kühn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 34
    • 0342868591 scopus 로고
    • Immunosuppressive role of interleukin-10 inflammatory bowel disease
    • Mitsuyama K, Toyonaga A, Tanikawa K, Ishida H: Immunosuppressive • role of interleukin-10 inflammatory bowel disease [abstract]. Gastroenterology 1995, 108:877a. This in vitro study demonstrates a beneficial effect of exogenous interleukin-10 on production of proinflammatory cytokines in colonic tissue obtained from patients with ulcerative colitis and Crohn's disease.
    • (1995) Gastroenterology , vol.108
    • Mitsuyama, K.1    Toyonaga, A.2    Tanikawa, K.3    Ishida, H.4
  • 35
    • 0028907439 scopus 로고
    • Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease
    • Schreiber S, Reinking R, Panzer U, Raedler A: Immunoregulatory role of • interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995, 108:1434-1444. In addition to demonstrating the downregulation of proinflammatory cytokines in inflammatory bowel disease mononuclear phagocytes by exogenous interleukin-10 in vitro, this paper shows for the first time that inhibition of cytokine synthesis can be achieved by treatment with a topical interleukin-10 enema
    • (1995) Gastroenterology , vol.108 , pp. 1434-1444
    • Schreiber, S.1    Reinking, R.2    Panzer, U.3    Raedler, A.4
  • 36
    • 0343504560 scopus 로고
    • Interleukin 10 inhibits inflammatory mediator production in ulcerative colitis
    • Wardle TD: Interleukin 10 inhibits inflammatory mediator production in ulcerative colitis [abstract]. Gut 1994, 35:S48.
    • (1994) Gut , vol.35
    • Wardle, T.D.1
  • 37
    • 4243397875 scopus 로고
    • Involvement of interleukin-10 (IL-10) in inflammatory bowel disease (IBD)
    • Koppen T, Nielsen OH, Eriksen J, Kirman I, et al.: Involvement of interleukin-10 (IL-10) in inflammatory bowel disease (IBD) [abstract]. Gastroenterology 1995, 108:851a.
    • (1995) Gastroenterology , vol.108
    • Koppen, T.1    Nielsen, O.H.2    Eriksen, J.3    Kirman, I.4
  • 38
    • 8944245730 scopus 로고
    • Interleukin-10 stimulates ion absorption in mammalian small intestine
    • Madsen KL, Tavemini MM, Federak RN: Interleukin-10 stimulates ion • absorption in mammalian small intestine [abstract]. Gastroenterology 1995, 108:868a. This functional study using the small intestine of rats and rabbits shows an antidiarrheal effect of interleukin-10, further suggesting the use of interleukin-10 in inflammatory bowel disease.
    • (1995) Gastroenterology , vol.108
    • Madsen, K.L.1    Tavemini, M.M.2    Federak, R.N.3
  • 39
    • 85035161146 scopus 로고
    • Down-regulation of interleukin (IL)-8 production from peripheral blood mononuclear cells from patients with acute pancreatitis by IL-4 and IL-10
    • De Beaux AC, Ross JA, Fearon KCH, Carter DC: Down-regulation of interleukin (IL)-8 production from peripheral blood mononuclear cells from patients with acute pancreatitis by IL-4 and IL-10 [abstract]. Gut 1994, 35:S45.
    • (1994) Gut , vol.35
    • De Beaux, A.C.1    Ross, J.A.2    Kch, F.3    Carter, D.C.4
  • 40
    • 85035167669 scopus 로고
    • Interleukin-10 (IL-10) decreases severity of acute necrotizing pancreatitis in mice
    • Van Laethem JL, Marchant A, Delvaux A, Deviere J, et al.: Interleukin-10 •• (IL-10) decreases severity of acute necrotizing pancreatitis in mice [abstract]. Gastroenterology 1995, 108:397a. In this preclinical model a beneficial effect of interleukin-10 on necrotizing acute pancreatitis induced in mice by cerulein is shown and thus provides an important basis for interleukin-10 therapy of acute pancreatitis in humans.
    • (1995) Gastroenterology , vol.108
    • Van Laethem, J.L.1    Marchant, A.2    Delvaux, A.3    Deviere, J.4
  • 41
    • 0029164732 scopus 로고
    • Neutralization of IL-10 Increases lethality in endotoxemia: Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor
    • Standiford TJ, Strieter RM, Lukacs NW, Kunkel SL: Neutralization of IL-10 Increases lethality in endotoxemia: cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J Immunol 1995, 155:2222-2229.
    • (1995) J Immunol , vol.155 , pp. 2222-2229
    • Standiford, T.J.1    Strieter, R.M.2    Lukacs, N.W.3    Kunkel, S.L.4
  • 43
    • 85035163557 scopus 로고
    • Interleukin-10 inhibits procoagulant activity related to tissue factor expression induced by LPS on monocytes
    • Pradier O, Gerard C, Delvaux A, Capel P: Interleukin-10 inhibits procoagulant activity related to tissue factor expression induced by LPS on monocytes [abstract]. Blood 1993, 82:343a.
    • (1993) Blood , vol.82
    • Pradier, O.1    Gerard, C.2    Delvaux, A.3    Capel, P.4
  • 44
    • 0027408695 scopus 로고
    • Interleukin-10 protects mice from lethal endotoxemia
    • Howard M, Muchamel T, Andrade S, Menon S: Interleukin-10 protects mice from lethal endotoxemia. J Exp Med 1993, 177:1205-1208.
    • (1993) J Exp Med , vol.177 , pp. 1205-1208
    • Howard, M.1    Muchamel, T.2    Andrade, S.3    Menon, S.4
  • 45
    • 0028999998 scopus 로고
    • Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses
    • Rogy MA, Auffenberg T, Espat NJ, Philip R, Remick D, Wollenberg GK, •• Copeland EM III, Moldawer LL: Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses. J Exp Med 1995, 181:2289-2293. In this study, interleukin-10 delivered to mice by means of cationic liposome-mediated human gene transfer is shown to reduce mortality in these animals after challenge with endotoxins. It suggests for the first time gene transfer with cytokines as a promising option for the treatment of septic shock.
    • (1995) J Exp Med , vol.181 , pp. 2289-2293
    • Rogy, M.A.1    Auffenberg, T.2    Espat, N.J.3    Philip, R.4    Remick, D.5    Wollenberg, G.K.6    Copeland III, E.M.7    Moldawer, L.L.8
  • 46
    • 0026784556 scopus 로고
    • Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10
    • Benjamin D, Knobloch TJ, Dayton MA: Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10. Blood 1992, 80:1289-1298.
    • (1992) Blood , vol.80 , pp. 1289-1298
    • Benjamin, D.1    Knobloch, T.J.2    Dayton, M.A.3
  • 50
    • 0029121415 scopus 로고
    • IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell Immune response
    • Kim J, Modlin RL, Moy RL, Dubinett SM, McHugh T, Nickoloff BJ, Uyemura K: IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell Immune response. J Immunol 1995, 155:2240-2247.
    • (1995) J Immunol , vol.155 , pp. 2240-2247
    • Kim, J.1    Modlin, R.L.2    Moy, R.L.3    Dubinett, S.M.4    McHugh, T.5    Nickoloff, B.J.6    Uyemura, K.7
  • 51
    • 0027955125 scopus 로고
    • Interleukin 10 Induces apoptotic cell death of B-chronic lymphocytlc leukemia cells
    • Fluckiger AC, Durand I, Banchereau J: Interleukin 10 Induces apoptotic cell death of B-chronic lymphocytlc leukemia cells. J Exp Med 1994, 179:91-99.
    • (1994) J Exp Med , vol.179 , pp. 91-99
    • Fluckiger, A.C.1    Durand, I.2    Banchereau, J.3
  • 53
    • 0029069423 scopus 로고
    • The role of IL-10 in human B cell activation, proliferation, and differentiation
    • Itoh K, Hirohata S: The role of IL-10 in human B cell activation, proliferation, and differentiation. J Immunol 1995, 154:4341-4350.
    • (1995) J Immunol , vol.154 , pp. 4341-4350
    • Itoh, K.1    Hirohata, S.2
  • 54
    • 85035159790 scopus 로고
    • Inhibitory effect of interleukin-10 on the autonomous in vitro growth of chronic myelomonocytic leukemia cells
    • Geissler K, Öhler L, Reiter E, Kabrna E, Rogy M, Födinger M, Mannhalter • C, Jäger U, Lechner K: Inhibitory effect of interleukin-10 on the autonomous in vitro growth of chronic myelomonocytic leukemia cells [abstract]. Blood 1995, 86:664a. This paper suggests a novel concept of interrupting the autocrine growth mechanism in chronic myelomonocytic leukemia by in vitro studies.
    • (1995) Blood , vol.86
    • Geissler, K.1    Öhler, L.2    Reiter, E.3    Kabrna, E.4    Rogy, M.5    Födinger, M.6    Mannhalter, C.7    Jäger, U.8    Lechner, K.9
  • 55
    • 0029070119 scopus 로고
    • A randomized, controlled trial of IL-10 in humans. Inhibition of Inflammatory cytokine production and immune responses
    • Chemoff AE, Granowitz EV, Shapiro L, Vannier E, Lonnemann G, •• Angel JB, Kennedy JS, Rabson AR, Wolff SM, Dinarello CA: A randomized, controlled trial of IL-10 in humans. Inhibition of Inflammatory cytokine production and immune responses. J Immunol 1995, 154:5492. Reports the administration of interleukin-10 in humans for the first time and shows that interleukin-10 is safe, has inhibitory effects on T cells, and suppresses production of proinflammatory cytokines in vivo.
    • (1995) J Immunol , vol.154 , pp. 5492
    • Chemoff, A.E.1    Granowitz, E.V.2    Shapiro, L.3    Vannier, E.4    Lonnemann, G.5    Angel, J.B.6    Kennedy, J.S.7    Rabson, A.R.8    Wolff, S.M.9    Dinarello, C.A.10


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