Intimal thickening develops without humoral immunity in a mouse aortic allograft model of chronic vascular rejection

Circulation

Volumn 94, Issue 12, 1996, Pages 3079-3082

  Chow, Lawrence H ^a,c,d,e   Huh, Susanna ^a   Jiang, Jifu ^b   Zhong, Robert ^b,d,e   Pickering, J Geoffrey ^a,c,e  

^a Vascular Biology Group   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c Department of Medicine ^*  (Canada)

^d LONDON HEALTH SCIENCES CENTRE   (Canada)

^e UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

arteriosclerosis; coronary disease; immune system; rejection; transplantation

Indexed keywords

ALLOGRAFT; ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA GRAFT; ARTERY INTIMA PROLIFERATION; ARTICLE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; GRAFT REJECTION; HUMORAL IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; MALE; MOUSE; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL;

EID: 0030454204     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.12.3079     Document Type: Article

References (11)

1. Hess ML, Hastillo A, Mohanakumar T, Cowley MJ, Vetrovac G, Szentpetery S, Wolfgang TC, Lower RR. Accelerated atherosclerosis in cardiac transplantation: role of cytotoxic B-cell antibodies and hyperlipidemia. Circulation. 1983;68(suppl II):II-94-II-101.
2. Hammond EH, Yowell RL, Price GD, Menlove RL, Olsen SL, O'Connell JB, Bristow MR, Doty DB, Millar RC, Karwande SV, Jones KW, Gay WA Jr, Renlund DG. Vascular rejection and its relationship to allograft coronary artery disease. J Heart Lung Transplant. 1992;11:S111-S119.
3. Hosenpud JD, Everett JP, Morris TE, Mauck KA, Shipley GD, Wagner CR. Cardiac allograft vasculopathy: association with cell-mediated but not humoral alloimmunity to donor-specific vascular endothelium. Circulation. 1995;92:205-211.
4. H locus, Int Immunol. 1993;5:647-656.
5. Jakobovits A, Vergara GJ, Kennedy JL, Hales JF, McGuinness RP, Casentini-Borocz DE, Brenner DG, Otten GR. Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production. Proc Natl Acad Sci USA. 1993;90:2551-2555.
6. Clausell N, Molossi S, Sett S, Rabinovitch M. In vivo blockade of tumor necrosis factor-α in cholesterol-fed rabbits after cardiac transplant inhibits acute coronary artery neointimal formation. Circulation. 1994;89:2768-2779.
7. Russell ME, Hancock WW, Akalin E, Wallace AF, Glysing-Jensen T, Willett TA, Sayegh MH. Chronic cardiac rejection in the LEW to F344 rat model: blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis. J Clin Invest. 1996;97:833-838.
8. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. II: importance of humoral immunity. J Immunol. 1994;152:5135-5141.
9. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts, I: time course and immunogenetic and immunopathological considerations. Am J Pathol. 1994; 144:260-274.
10. Shi C, Lee W-S, He Q, Zhang D, Fletcher DL Jr, Newell JB, Haber E. Immunologic basis of transplant-associated arteriosclerosis. Proc Natl Acad Sci U S A. 1996;93:4051-4056.
11. Gadson PF Jr, Rossignol C, McCoy J, Rosenquist TH. Expression of elastin, smooth muscle alpha-actin, and c-jun as a function of the embryonic lineage of vascular smooth muscle cells. In Vitro Cell Dev Biol Animal. 1993;29A:773-781.