Interferon-γ-secreting T-cell populations in rejecting murine cardiac allografts: Assessment by flow cytometry

American Journal of Pathology

Volumn 153, Issue 5, 1998, Pages 1383-1392

  Stinn, Jennifer L ^a   Taylor, Marta K ^a   Becker, Gerold ^a   Nagano, Hiroaki ^b   Hasegawa, Satoru ^c   Furakawa, Yutaka ^a   Shimizu, Koichi ^a   Libby, Peter ^a   Mitchell, Richard N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; FLOW CYTOMETRY; GRAFT REJECTION; HEART TRANSPLANTATION; HELPER CELL; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031738064     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65725-2     Document Type: Article

References (32)

1. Schoen FJ, Libby P: Cardiac transplant graft arteriosclerosis. Trends Cardiovasc Med 1991, 1:216-223
2. Takeuchi T, Lowry RP, Konieczny B: Heart allografts in murine systems: differential activation of Th2 like effector cells in peripheral tolerance. Transplantation 1992, 53:1281-1294
3. Duquesnoy R, Demetris A: Immunopathology of cardiac transplant rejection. Curr Opin Cardiol 1995, 10:193-206
4. Mosmann TR, Li L, Hengartner H, Kagi D, Fu W, Sad S: Differentiation and function of T cell subsets. Ciba Found Symp 1997, 204:148-154
5. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T-lymphocytes. Nature 1996, 383:787-793
6. Cunningham DA, Dunn MJ, Yacoub MH, Rose ML: Local production of cytokines in the human cardiac allograft: a sequential study. Transplantation 1995, 57:1333-1337
7. Piccotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK: IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. J Immunol 1996, 157:1951-1957
8. + T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 1995, 59:1155-1161
9. Salom R, Maguire J, Esmore D, Hanock W: Endothelial cell activation and cytokine expression during acute graft rejection. Transplant Proc 1995, 27:2164-2165
10. Shaw G, Kamen R: Conserved AU sequence from a 3′-untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986, 46:659-667
11. Sander B, Andersson J, Andersson U: Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure. Immunol Rev 1991, 119:65-93
12. Jung T, Schauer U, Heusser C, Neumann C, Reiger C: Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993, 159:197-207
13. Carter LL, Swain SL: Single cell analyses of cytokine production. Curr Opin Immunol 1997, 9:177-182
14. Murray LJ, Lee R, Martens C: In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse. Eur J Immunol 1990, 20:163-170
15. Corry RJ, Winn HJ, Russell P: Primary vascularized allografts of hearts in mice. Transplantation 1973, 16:343-350
16. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby PL: Interferon-γ deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest 1997, 100:550-557
17. Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Becker G, Tilney NL, Mitchell RN: Coronary arteriosclerosis following T cell-mediated injury in murine cardiac allografts: role of interferon-γ. Am J Pathol 1998, 152:1187-1197
18. Platzer C, Richter G, Uberla K, Muller W, Blocker H, Diamantstein T, Blankenstein T: Analysis of cytokine mRNA levels in interleukin-4 transgenic mice by quantitative polymerase chain reaction. Eur J Immunol 1992, 22:1179-1184
19. O'Garra A, Murphy K: Role of cytokines in determining T cell function (mouse). Handbook of Experimental Immunology. Edited by Weir DM. Cambridge, UK, Blackwell Science, 1996, pp 221-226
20. Openshaw P, Murphy EE, Hosken NA, Maino V, Davis K, Murphy K, O'Garra A: Heterogeneity of intracellular cytokine synthesis at the single cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 1995, 182:1357-1367
21. Anderson SJ, Coleclough C: Regulation of CD4 and CD8 expression on mouse T cells. J Immunol 1993, 151:5123-5134
22. Picker LJ, Singh MK, Zdraveski Z, Treer JR, Waldrop SL, Bergstressa PR, Maino VC: Direct demonstration of cytokine heterogeneity among human memory/effector cells by flow cytometry. Blood 1995, 1408-1419
23. Sander B, Hoiden I, Andersson U, Moller E, Abrams J: Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. J Immunol Methods 1993, 166:201-214
24. + T cells. J Immunol 1996, 156:232-237
25. Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H: Differential production of interferon-γ and interleukin-4 in response to Th1-and Th2-stimulating pathogens by γδ T cells in vivo. Nature 1995, 373:255-257
26. Nadeau KC, Azuma H, Tilney NL: Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1. Proc Natl Acad Sci USA 1995, 92:8729-8733
27. Salio M, Valitutti S, Lanzavecchia A: Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation. Eur J Immunol 1997, 27:1769-1773
28. - lymphocyte subpopulation. J Immunol 1995, 154:4294-4301
29. Meyaard L, Hovenkamp E, Keet IPM, Hooibrink B, Jong IHD, Otto SA, Miedema F: Single-cell analysis of IL-4 and IFN-γ production by T cells from HIV-infected individuals. J Immunol 1996, 157:2712-2718
30. Dallman MJ, Larsen CP, Morris PJ: Cytokine gene transcription in vascularized organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med 1991, 174:493-496
31. Suthanthiran M, Strom TB: Mechanisms and management of acute renal allograft rejection. Surg Clin North Am 1998, 78:77-94
32. Suthanthiran M: Molecular analyses of human renal allografts: differential intragraft gene expression during rejection. Kidney Int Suppl 1997, 58:S15-S21