Etoposide causes illegitimate V(D)J recombination in human lymphoid leukemic cells

Blood

Volumn 88, Issue 6, 1996, Pages 2210-2218

  Chen, Chun Lin ^b   Fuscoe, James C ^b   Liu, Qing ^b   Relling, Mary V ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; BONE MARROW CULTURE; CONTROLLED STUDY; EXON; GENE DELETION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0029844281     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.6.2210.bloodjournal8862210     Document Type: Article

References (52)

1. Clark PI, Slevin ML: The clinical pharmacology of etoposide and teniposide. Clin Pharmacokinet 12:223, 1987
2. Pui C-H, Ribeiro R, Hancock ML, Rivera GK, Evans WE, Raimondi S, Head DR, Behm FG, Mahmoud MH, Sandlund JT, Crist W: Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphocytic leukemia. N Engl J Med 325:1682, 1991
3. Pui C-H, Behm FG, Raimondi SC, Dodge RK, George SL, Rivera GK, Mirro J, Kalwinsky DK, Dahl GV, Murphy SB, Crist WM, Williams DL: Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia. N Engl J Med 321:136, 1989
4. Ratain MJ, Kaminer LS, Bitran JD, Larson RA, LeBeau MM, Skosey C, Purl S, Hoffman PC, Wade J, Vardiman JW, Kaly K, Rowley JD, Golomb HM: Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung. Blood 70:1412, 1987
5. Winick NJ, McKenna RW, Shuster JJ, Schneider NR, Borowitz MJ, Bowman WP, Jacaruso D, Kamen BA, Buchanan GR: Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide. J Clin Oncol 11:209, 1993
6. Pedersen-Bjergaard J, Philip P, Larsen SO, Andersson M, Daugaard G, Ersboll J, Hansen SW, Hou-Jensen K, Nielsen D, Sigsgaard TC, Specht L, Osterlind K: Therapy-related myelodysplasia and acute myeloid leukemia. Cytogenetic characteristics of 115 consecutive cases and risk in seven cohorts of patients treated intensively for malignant diseases in the Copenhagen series. Leukemia 7:1975, 1993
7. Smith MA, Rubinstein L, Ungerleider RS: Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: Estimating the risks. Med Pediatr Oncol 23:86, 1995
8. Pedersen-Bjergaard J, Rowley JD: The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood 83:2780, 1994
9. Gu Y, Alder H, Nakamura T, Schichman SA, Prasad R, Canaani O, Saito H, Croce CM, Canaani E: Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia. Cancer Res 54:2327, 1994
10. Gu Y, Cimino G, Alder H, Nakamura T, Prasad R, Canaani O, Moir DT, Jones C, Nowell PC, Croce CM, Canaani E: The (4;11)(q21;q23) chromosome translocations acute leukemias involve the VDJ recombinase. Proc Natl Acad Sci USA 89:10464, 1992
11. Morrissey J, Tkachuk DC, Milatovich A, Francke U, Link M, Cleary ML: A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias. Blood 81:1124, 1993
12. Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, Croce CM, Canaani E: Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci USA 90:4631, 1993
13. Ridge SA, Wiedemann LM: Chromosome 11q23 abnormalities in leukaemia. Leuk Lymphoma 14:11, 1994
14. Tkachuk DC, Kohler S, Cleary ML: Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71:691, 1992
15. Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ: Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci USA 90:7884, 1993
16. Djabali M, Seileri L, Parry P, Bower M, Young BD, Evans GA: A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet 2:113, 1992
17. Berger NA, Chatterjee S, Schmotzer JA, Helms SR: Etoposide induced gene alterations: Potential contribution to cell death. Proc Natl Acad Sci USA 33:8740, 1991
18. Han Y, Austin MJF, Pommier Y, Povirk LF: Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro. J Mol Biol 220:52, 1993
19. Maraschin J, Dutrillaux B, Aurias A: Chromosome aberrations induced by etoposide are not random. Int J Cancer 46:808, 1990
20. Bae YS, Chiba M, Ohira M, Ikeda H: A shuttle vector for analysis of illegitimate recombination in mammalian cells: Effects of DNA topoisomerase inhibitors on deletion frequency. Gene 101:285, 1991
21. Danks MK, Yalowich JC, Beck WT: Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26). Cancer Res 47:1297, 1987
22. Ross W, Rowe T, Glisson B, Yalowich J, Liu L: Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage. Cancer Res 44:5857, 1984
23. Froelich-Ammon SJ, Gale KC, Osheroff N: Site-specific cleavage of a DNA hairpin by topoisomerase II. DNA secondary structure as a determinant of enzyme recognition/cleavage. J Biol Chem 269:7719, 1994
24. Ikeda H: DNA topoisomerase-mediated illegitimate recombination. Adv Pharmacol 29A:147, 1995
25. Tycko B, Sklar J: Chromosomal translocations in lymphoid neoplasia: A reappraisal of the recombinase model. Cancer Cells 2:1, 1990
26. Menetski JP, Gellert M: V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP. Proc Natl Acad Sci USA 87:9324, 1990
27. Lipkowitz S, Garry VF, Kirsch IR: Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies. Proc Natl Acad Sci USA 89:5301, 1992
28. Abdallah JM, Lombardi DP, Kirsch IR: Genetic instability in patients with Hodgkin's disease undergoing chemotherapy. J Clin Invest 96:2744, 1995
29. McGregor WG, Maher VM, McCormick JJ: Kinds and locations of mutations induced in the hypoxanthine-guanine phosphoribosyltransferase gene of human T-lymphocytes by 1-nitrosopyrene, including those caused by V(D)J recombinase. Cancer Res 54:4207, 1994
30. Fuscoe JC, Zimmerman LJ, Lippen MJ, Nicklas JA, O'Neill JP, Albertini RJ: V(D)J recombinase-like activity mediates HPRT gene deletion in human fetal T-lymphocytes. Cancer Res 51:6001, 1991
31. Edwards A, Voss H, Rice P, Civitello A, Stegemann J, Schwager C, Zimmerman J, Erfle H, Caskey CT, Ansorge W: Automated DNA sequencing of the human HPRT locus. Genomics 6:593, 1990
32. Gibbs RA, Nguyen PN, Edwards A, Civitello AB, Caskey CT: Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families. Genomics 7:235, 1990
33. Fuscoe JC, Zimmerman LJ, Harrington-Brock K, Burnette L, Moore MM, Nicklas JA, O'Neill JP, Albertini RJ: V(D)J recombinase-mediated deletion of the HPRT gene in T-lymphocytes from adult humans. Mutation Res 283:13, 1992
34. Alexander DC: A rapid method for determining clone frequency in complex populations using PCR and the Poisson distribution. Nucleic Acids Res 18:7453, 1991
35. Krawczak M, Cooper DN: Gene deletions causing human genetic disease: Mechanisms of mutagenesis and the role of the local DNA sequence environment. Hum Genet 86:425, 1991
36. Spitzner JR, Muller MT: A consensus sequence for cleavage by vertebrate topoisomerase II. Nucleic Acids Res 16:5533, 1988
37. Spitzner JR, Chung IK, Gootz TD, McGuirk PR, Muller MT: Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 drug-dependent and -independent recognition elements. Mol Pharmacol 48:238, 1995
38. Hesse JE, Lieber MR, Mizuuchi K, Gellert M: V(D)J recombination: A functional definition of the joining signals. Genes Dev 3:1053, 1989
39. Brown L, Cheng Q, Siciliano MJ, Crist W, Buchanan G, Baer R: Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J 9:3343, 1990
40. Neale GAM, Fitzgerald TJ, Goorha RM: Expression of the V(D)J recombinase gene RAG-1 is tightly regulated and involves both transcriptional and post-transcriptional control. Mol Immunol 29:1457, 1992
41. Laquerbe A, Moustacchi E, Fuscoe JC, Papadopoulo D: The molecular mechanism underlying formation of deletions in Fanconi anemia cells may involve a site-specific recombination. Proc Natl Acad Sci USA 92:831, 1995
42. Lavaille JJ, DeCloux A, Bonneville M, Tagagaki Y, Tonegawa S: Junctional sequences of T cell receptor gamma-delta genes: Implications for gamma-delta T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59:859, 1989
43. Gellert M: Molecular analysis of V(D)J recombination. Annu Rev Genet 26:425, 1992
44. Konopka AK: Compilation of DNA strand exchange sites for non-homologous recombination in somatic cells. Nucleic Acids Res 16:1739, 1988
45. Lieber MR, Hesse JE, Mizuuchi K, Gellert M: Developmental stage specificity of the lymphoid V(D)J recombination activity. Genes Dev 1:751, 1987
46. Spitzner JR, Chung IK, Muller MT: Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats. Nucleic Acids Res 18:1, 1990
47. Andersen AH, Svejstrup JQ, Westergaard O: The DNA binding, cleavage, and religation reactions of eukaryotic topoisomerase I and II. Adv Pharmacol 29A:83, 1994
48. Felix CA, Lange BJ, Hosler MR, Fertala J, Bjornsti M: Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites. Cancer Res 55:4287, 1995
49. Riou JF, Grondard L, Petitgenet O, Abitbol M, Lavelle F: Altered topoisomerase I activity and recombination activating gene expression in a human leukemia cell line resistant to doxorubicin. Biochem Pharm 46:851, 1993
50. Oettinger MA, Schatz DG, Gorka C, Baltimore D: RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517, 1990
51. Schatz DG, Oettinger MA, Baltimore D: The V(D)J recombinase activating gene (RAG-1). Cell 59:1035, 1989
52. Hunger SP, Sklar J, Link MP: Acute lymphoblastic leukemia occurring as a second malignant neoplasma in childhood: Report of three cases and review of the literature. J Clin Oncol 10:156, 1992