Topoisomerase II inhibitors fail to induce chromosome-type aberrations in etoposide-resistant cells: Evidence for essential contribution of the cleavable complex formation to the induction of chromosome-type aberrations

Mutagenesis

Volumn 12, Issue 1, 1997, Pages 29-33

  Suzuki, Hiroshi ^a   Tarumoto, Yasuo ^a   Ohsawa, Motoyasu ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; TRITIUM;

ARTICLE; CELL MUTANT; CELL STRAIN KB; CHROMATID ABERRATION; CHROMOSOME ABERRATION; COMPLEX FORMATION; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; DRUG RESISTANCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMOSOME ABERRATIONS; DNA; DNA TOPOISOMERASES, TYPE II; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; ETOPOSIDE; HUMANS; KB CELLS; TRITIUM;

EID: 0031018456     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/12.1.29     Document Type: Article

References (25)

1. Anderson,R.D. and Berger,N.A. (1994) Mutagenicity and carcinogenicity of topoisomerase-interactive agents. Mutat. Res., 309, 109-142.
2. Beck,W.T., Kim,R. and Chen,M. (1994) Novel actions of inhibitors of DNA topoisomerase II in drug resistant tumor cells. Cancer Chemother. Pharmacol., 34 (Suppl.), S14-S18.
3. Belani,C.P., Doyle,L.A. and Aisner,J. (1994) Etoposide: current status and future perspectives in the management of malignant neoplasms. Cancer Chemother. Pharmacol., 34 (Suppl.), S118-S126.
4. Bertrand,R., Sarang,M., Jenkin,J., Kerrigan,D. and Pommier,Y. (1991) Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression. Cancer Res., 51, 6280-6285.
5. Deaven,L.L., Oka,M.S. and Tobey,R.A. (1978) Cell-cycle-specific chromosome damage following treatment of cultured Chinese hamster cells with 4′-[(9-acridinyl)-amino] methanesulphon-m-anisidide-HCl. J. Natl. Cancer Inst., 60, 1155-1161.
6. Funayama,Y., Nishio,K., Wakabayashi,K., Nagao,M., Shimoi,K., Ohira,T., Hasegawa,S. and Saijo,N. (1996) Effects of β-and γ-carboline derivatives on DNA topoisomerase activities. Mutat. Res., 349, 183-191.
7. Ho,A.D., Lipp,T., Ehninger,G., Illiger,H.J., Meyer,P., Freund,M. and Hunstein,W. (1988) Combination of nitoxantrone and etoposide in refactory acute myelogenous leukemia - an active and well-tolerated regimen. J. Clin. Oncol., 6, 213-217.
8. Jensen,P.B., Sörensen,B.S., Demant,E.J.F., Sehested,M., Jensen,P.S., Vindelöv,L. and Hansen,H.H. (1990) Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino) methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage. Cancer Res., 50, 3311-3316.
9. Kaufmann,S.H. (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin and other cytotoxic anticancer drugs: a cautionary note. Cancer Res., 49, 5870-5878.
10. Kohno,K., Danks,M.K., Matsuda,T., Nitiss,J.L., Kuwano,M. and Beck,W.T. (1995) A novel mutation of DNA topoisomerase II α gene in an etoposide-resistant human cancer cell line. Cell. Pharmacol., 2, 87-90.
11. Ling,Y.H., Priebe,W. and Perez-Soler,R. (1993) Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells. Cancer Res., 53, 1845-1852.
12. Liu,L.F. (1989) DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58, 351-375.
13. Liu,L.F., Rowe,T.C., Yang,L., Tewey,K.M. and Chen,G.L. (1983) Cleavage of DNA by mammalian DNA topoisomerase II. J. Biol. Chem., 258, 15365-15370.
14. Long,B.H., Musial,S.T. and Brattain,M.G. (1985) Single-and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide. Cancer Res., 45, 3106-3112.
15. Matsuo,K., Kohno,K., Takano,H., Sato,S., Kiue,A. and Kuwano,M. (1990) Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cells. Cancer Res., 50, 5819-5824.
16. Muggia,F.M. (1994) Teniposide: overview of its therapeutic potential in adult cancers. Cancer Chemother. Pharmacol., 34 (Suppl.), S127-S133.
17. Negri,C., Bernardi,R., Braghetti,A., Ricotti,G.C.B.A. and Scovassi,A.I. (1993) The effect of the chemotherapeutic drug VP-16 on poly (ADP-ribosylation) in apoptotic Hela cells. Carcinogenesis, 14, 2559-2564.
18. Popanda,O. and Thielmann,H.X. (1992) The function of DNA topoisomerases in UV-induced DNA excision repair: studies with specific inhibitors in permeabilized human fibroblasts. Carcinogenesis, 13, 2321-2328.
19. Schneider,E., Hsiang,Y.H. and Liu,L.F. (1990) DNA topoisomerases as anticancer drug targets. In August,T., Anders,M.W., Murad,F. and Niel,A. (eds), Advances in Pharmacology. Vol. 21. Academic Press, New York, pp. 149-183.
20. Suzuki,H. and Nakane,S. (1994) Differential induction of chromosomal aberrations by topoisomerase inhibitors in cultured Chinese hamster cells. Biol. Pharma. Bull., 17, 222-226.
21. Suzuki,H., Ikeda,T. Yamagishi,T., Nakaike,S., Nakane,S. and Ohsawa,M. (1995) Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells. Mutat. Res., 328, 151-161.
22. Takano,H., Kohno,K., Ono,M., Uchida,Y. and Kuwano,M. (1991) Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells. Cancer Res., 51, 3951-3957.
23. Tewey,K.M., Rowe,T.C, Yang,L., Halligan,B.D. and Liu,L.F. (1984) Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase. Science, 226, 466-468.
24. Uemura,T.H., Ohkura,H., Adachi,Y., Morino,K., Shiozaki,K. and Yanagida,M. (1989) DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S.pombe. Cell, 50, 917-925.
25. Walker,P.R., Smith,C., Youdale,T., Leblanc,J., Whitfield,J.F. and Sikorska,M. (1991) Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res., 51, 1078-1085.