Mitochondrial calcium accumulation following activation of vanilloid (VR1) receptors by capsaicin in dorsal root ganglion neurons

Neuroscience

Volumn 95, Issue 1, 1999, Pages 183-188

  Dedov, V N ^a   Roufogalis, B D ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Calcium channels; Capsaicin; Dorsal root ganglion neurons; Mitochondria; Uncoupler; Vanilloid receptor (VR1)

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM CHANNEL; CAPSAICIN; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; POTASSIUM CHLORIDE; POTASSIUM ION; VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; DEPOLARIZATION; MITOCHONDRION; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

ANIMALS; CALCIUM; CAPSAICIN; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CYTOSOL; GANGLIA, SPINAL; INTRACELLULAR MEMBRANES; MITOCHONDRIA; NEURONS; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; UNCOUPLING AGENTS;

EID: 0032745394     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(99)00423-6     Document Type: Article

References (29)

1. 2+ network. J. Cell Biol. 136:1997;833-844.
2. 2+ signaling. Curr. Opin. Neurobiol. 8:1998;398-404.
3. Bleakman D., Brorson J.R., Miller R.J. The effect of capsaicin on voltage-gated calcium currents and calcium signals in cultured dorsal root ganglion cells. Br. J. Pharmac. 101:1990;423-431.
4. Budd S.L., Nicholls D.G. Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurochem. 67:1996;2282-2291.
5. 2+ homeostasis. J. Neurochem. 66:1996;403-411.
6. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389:1997;816-824.
7. Cholewinski A., Burgess G.M., Bevan S. The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons. Neuroscience. 55:1993;1015-1023.
8. 2+. Neurosci. Lett. 248:1998;151-154.
9. Duchen M.R. Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones. J. Physiol. 424:1990;387-409.
10. Duchen M.R., Valdeolmillos M., O'Neill S.C., Eisner D.A. Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones. J. Physiol. 424:1990;411-426.
11. Eimerl S., Schramm M. The quantity of calcium that appears to induce neuronal death. J. Neurochem. 62:1994;1223-1226.
12. 2+ indicators with greatly improved fluorescence properties. J. biol. Chem. 260:1985;3440-3450.
13. Gunter K.K., Gunter T.E. Transport of calcium by mitochondria. J. Bioenerg. Biomembr. 26:1994;471-485.
14. Gunter T.E., Pfeiffer D.R. Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258:1990;C755-C786.
15. 2+ concentration increases in cultured rat forebrain neurons. Molec. Pharmac. 53:1998;742-749.
16. 2+ changes in rat forebrain neurones. J. Physiol. 509:1998;103-116.
17. Jouaville L.S., Ichas F., Mazat J.P. Modulation of cell calcium signals by mitochondria. Molec. cell. Biochem. 184:1998;371-376.
18. Kostyuk P. G. and Verkhratsky A. N. (1995) Calcium Signalling in the Nervous System, p. 206. J. Wiley and Sons, Chichester.
19. i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons. J. Physiol. 507:1998;131-145.
20. 2+ release in mouse DRG neurones. NeuroReport. 8:1997;3929-3932.
21. Thayer S.A., Miller R.J. Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurons in vitro. J. Physiol. 425:1990;85-115.
22. Tominaga M., Caterina M.J., Malmberg A.B., Rosen T.A., Gilbert H., Skinner K., Raumann B.E., Basbaum A.I., Julius D. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron. 21:1998;531-543.
23. Verkhratsky A.J., Petersen O.H. Neuronal calcium stores. Cell Calcium. 24:1998;333-343.
24. 2+ loads by mitochondria in cultured rat hippocampal neurons. J. Neurophysiol. 76:1996;1611-1621.
25. Werth J.L., Thayer S.A. Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons. J. Neurosci. 14:1994;348-356.
26. Werth J.L., Usachev Y.M., Thayer S.A. Modulation of calcium efflux from cultured rat dorsal root ganglion neurons. J. Neurosci. 16:1996;1008-1015.
27. 2+ following intense glutamate stimulation of cultured rat forebrain neurons. J. Physiol. 498:1997;31-47.
28. Wood J. N. (1993) Capsaicin in the Study of Pain, p. 268. Academic, New York.
29. Wood J.N., Winter J., James I.F., Rang H.P., Yeats J., Bevan S. Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J. Neurosci. 8:1988;3208-3220.