Actions of CRF and its analogs

Current Medicinal Chemistry

Volumn 6, Issue 11, 1999, Pages 1035-1053

  Eckart, Klaus ^b   Radulovic, Jelena ^b   Radulovic, Marko ^b   Jahn, Olaf ^b   Blank, Thomas ^b   Stiedl, Oliver ^b   Spiess, Joachim ^a  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; SAUVAGINE; UROCORTIN; UROTENSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HORMONE ACTION; HORMONE DETERMINATION; HORMONE RELEASE; IMMUNOMODULATION; MOUSE; NONHUMAN; PROTEIN SECONDARY STRUCTURE; RAT; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 0032743375     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (162)

1. Spiess, J.; Rivier, J.; Rivier, C.; Vale, W. W. Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc. Natl. Acad. Sci. USA 1981, 78, 6517-21.
2. Vale, W. W.; Spiess, J.; Rivier, C.; Rivier, J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 1981, 213, 1394-7.
3. Spiess, J.; Rivier, J.; Vale, W. Sequence analysis of rat hypothalamic corticotropin-releasing factor with the orthophthaladehyde strategy. Biochemistry 1983, 22, 4341-6.
4. Rivier, J.; Spiess, J.; Vale, W. Characterization of rat hypothalamic corticotropin-releasing factor. Proc. Natl. Acad. Sci. USA 1983, 80, 4851-5.
5. Jingami, H.; Mizuno, N.; Takahashi, H.; Sibahara, S.; Furutani, Y.; Imura, H.; Numa, S. Cloning and sequence analysis of cDNA for rat corticotropin-releasing factor precursor. FEBS Lett. 1985, 191, 63-6.
6. Patty, M.; Horvath, J.; Mason-Garcia, M.; Szoke, B.; DH, S.; Schally, A. Isolation and amino acid sequence of corticotropin-releasing factor from pig hypothalami. Proc. Natl. Acad. Sci. USA 1985, 82, 8762-6.
7. Esch, F.; Ling, N.; Bohlen, P.; Baird, A.; Benoit, R.; Guillemin, R. Isolation and characterization of the bovine hypthalamic corticotropin-releasing factor. Biochem. Biophys. Res. Commun. 1984, 722, 899-905.
8. Stenzel-Poore, M. P.; Heldwein, K. A.; Stenzel, P.; Lee, S.; Vale, W. W. Characterization Of the Genomic Corticotropin-Releasing Factor Crf Gene From Xenopus-Laevis Two Members Of the Crf Family Exist In Amphibians. Mol. Endocrinol. 1992, 6, 1716-24.
9. Vaughan, J.; Donaldson, C.; Bittencourt, J.; Perrin, M. H.; Lewis, K.; Sutton, S.; Chan, R.; Turnbull, A. V.; Lovejoy, D.; Rivier, C.; Rivier, J.; Sawchenko, P. E.; Vale, W. W. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 1995, 378, 287-92.
10. Donaldson, C. J.; Sutton, S. W.; Perrin, M. H.; Corrigan, A. Z.; Lewis, K. A.; Rivier, J.; Vaughan, J. M.; Vale, W. W. Cloning and characterization of human urocortin. Endocrinology 1996, 137, 2167-70.
11. Montecucchi, P.; Henschen, A. Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei. Int. J. Peptide Protein Res. 1981, 18, 113-20.
12. Lederis, K.; Letter, A.; McMAster, D.; Moore, G. Complete amino acid sequence of urotensin-l, a hypotensive and corticotropin-releasing neuropeptide from Castostomus. Science 1982, 218, 162-4.
13. Spina, M.; Merlo, P. E.; Chan, R. K. W.; Basso, A. M.; Rivier, J.; Vale, W. W.; Koob, G. F. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 1996, 273, 1561-4.
14. Dathe, M.; Fabian, H.; Gast, K.; Zirwer, D.; Winter, R.; Beyermann, M.; Schumann, M.; Bienert, M. Conformational differences of ovine and human corticotropin releasing hormone - a CD, IR, NMR and dynamic light scattering study. Int. J. Peptide Protein Res. 1996, 47, 383-93.
15. Gulyas, J.; Rivier, C.; Perrin, M.; Koerber, S. C.; Sutton, S.; Corrigan, A.; Lahrichi, S. L.; Craig, A. G.; Vale, W. W.; Rivier, J. Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc. Natl. Acad. Sci. USA 1995, 92, 10575-9.
16. Rivier, J.; Rivier, C.; Galyean, R.; Miranda, A.; Miller, C.; Craig, A. G.; Yamamoto, G.; Brown, M.; Vale, W. W. Single point D-substituted corticotropin-releasing factors analogues effects on potency and physicochemical characteristics. J. Med. Chem. 1993, 36, 2851-9.
17. Rothemund, S.; Krause, E.; Beyermann, M.; Bienert, M. Hydrophobically induced conformation in ovine corticotropin-releasing hormone. Int. J. Peptide Protein Res. 1997, 50, 184-92.
18. Beyermann, M.; Fechner, K.; Furkert, J.; Krause, E.; Bienert, M. A single-point slight alteration set as a tool for structure-activity relationship studies of ovine corticotropin releasing factor. J. Med. Chem. 1996, 39, 3324-30.
19. Kornreich, W. D.; Galyean, R.; Hernandez, J. F.; Craig, A. G.; Donaldson, C. J.; Yamamoto, G.; Rivier, C.; Vale, W. W.; Rivier, J. Alanine series of ovine corticotropin releasing factor oCRF a structure-activity relationship study. J. Med. Chem. 1992, 35, 1870-6.
20. Miranda, A.; Lahrichi, S. L.; Gulyas, J.; Koerber, S. C.; Craig, A. G.; Corrigan, A.; Rivier, C.; Vale, W. W.; Rivier, J. Constrained corticotropin-releasing factor antagonists with i-(i + 3) Glu-Lys bridges. J. Med. Chem. 1997, 40, 3651-8.
21. Rivier, J.; Lahrichi, S. L.; Gulyas, J.; Erchegyi, J.; Koerber, S. C.; Craig, A. G.; Corrigan, A.; Rivier, C.; Vale, W. W. Minimal-size, constrained corticotropin-releasing factor agonists with I-(I+3) Glu-Lys and Lys-Gln bridges. J. Med. Chem. 1998, 41, 2614-20.
22. Rühmann, A.; Bonk, I.; Lin, C. J. R.; Rosenfeld, M. G.; Spiess, J. Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2 beta-selective antisauvagine-30. Proc. Natl. Acad. Sci. USA 1998, 95, 15264-9.
23. Vale, W. W.; Vaughan, J.; Perrin, M. corticotropin-releasing factor (CRF) family of ligands and their receptors. Endocrinologist, 1997, 7, S 3-S 9.
24. Rivier, J.; Rivier, C.; Vale, W. W. Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science 1984, 224, 889-91.
25. Chen, R.; Lewis, K. A.; Perrin, M. H.; Vale, W. W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc. Natl. Acad. Sci. USA 1993, 90, 8967-71.
26. Segre, G. V.; Goldring, S. R. Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends in Endocrinological Metabolism 1993, 4, 309-14.
27. Vita, N.; Laurent, P.; Lefort, S.; Chalon, P.; Lelias, J. M.; Kaghad, M.; Le Fur, G.; Caput, D.; Ferrara, P. Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors. FEBS Lett. 1993, 335, 1-5.
28. Chang, C. P.; Pearse, R. V. d.; O'Connell, S.; Rosenfeld, M. G. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 1993, 11, 1187-95.
29. Perrin, M.; Donaldson, C.; Chen, R.; Blount, A.; Berggren, T.; Bilezikjian, L.; Sawchenko, P.; Vale, W. W. Identification of a second corticotropin-ruleasing factor receptor gene and characterization of a cDNA expressed in heart. Proc. Natl. Acad. Sci. USA 1995, 92, 2969-73.
30. Yu, J.; Xie, L. Y.; Abou-Samra, A.-B. Molecular cloning of a type A chicken corticotropin-releasing factor receptor with high affinity for urotensin I. Endocrinology 1996, 137, 192-7.
31. Dautzenberg, F. M.; Wille, S.; Lohmann, R.; Spiess, J. Mapping of the ligand-selctive dorr ain of the Xenopus laevis corticotropin-releasing factor receptor: Implications for the ligand-binding-site. Proc. Natl. Acad. Sci. USA 1998, 95, 4941-6.
32. Lovenberg, T. W.; Liaw, C. W.; Grigoriadis, D. E.; Clevenger, W.; Chalmers, D. T.; De Souza, E. B.; Oltersdorf, T. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc. Natl. Acad. Sci. USA 1995, 92, 836-40.
33. Lovenberg, T. W.; Chalmers, D. T.; Liu, C.; De Souza, E. B. CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology 1995, 136, 4139-42.
34. Kishimoto, T.; Pearse, F. V. n.; Lin, C. R.; Rosenfeld, M. G. A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc. Natl. Acad. Sci. USA 1995, 92, 1108-12.
35. Stenzel, P.; Kesterson, FI.; Yeung, W.; Cone, R. D.; Rittenberg, M. B.; Stenzel-Poore, M. P. Identification of a novel murine receptor for corticotropin-releasing hormone expressed in heart. Mol. Endocrinol. 1995, 9, 637-45.
36. Perrin, M. H.; Sutton, S.; Bain, D. L.; Berggren, W. T.; Vale, W. W. The first extracellular domain of corticotropin releasing factor-receptor1 conta ns major binding determinants for urocortin and astressin. Endocrinology 1998, 139, 566-70.
37. Qi, L. Y.; Leung, A. T.; Xiong, Y.; Marx, K. A.; Abou-Sambra, A.-B. Extracellular cysteines of the corticotropin-releasing factor receptor are critical for ligand interaction. Biochemistry 1997, 36, 12442.
38. Sydow, S.; Flaccus, A.; Fischer, A.; Spiess, J. The role of the fourth extracellular domain of the rat corticotropin-releasing factor receptor type 1 in ligand binding. Eur. J. Biochem. 1998, 259, 55-62.
39. Sydow, S.; Radulovic, J.; Dautzenberg, F. M.; Spiess, J. Structure function relationship of different domains of the rat corticotropin-releasing factor receptor. Mol. Brain Res. 1997, 52, 182-93.
40. Hoyer, D.; Boddeke, H. W. G. M. Partial agonists, full agonists, antagonists: dilemmas of definition. TIPS 1993, 14, 270-5.
41. Linton, E. A.; Wolfe, O. D.; Behan, D. P.; Lowry, P. J. A specific carrier substance for human corticotropin releasing factor in late gestational maternal plasma which could mask the ACTH-releasing activity. Clin. Endocrinol. 1988, 28, 315-24.
42. Behan, D. P.; Linton, E. A.; Lowry, P. J. Isolation of the human plasma corticotrophin-releasing factor-binding protein. J. Endocrinol. 1989, 122, 23-31.
43. Potter, E.; Behan, D. P.; Fischer, W. H.; Linton, E. A.; Lowry, P. J.; Vale, W. W. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature 1991, 349, 423-6.
44. Behan, D. P.; Potter, E.; Lewis, K. A.; Jenkins, N. A.; Copeland, N.; Lowry, P. J.; Vale, W. W. Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP). Genomics 1993, 16, 63-8.
45. Fischer, W. H.; Behan, D. P.; Park, M.; Potter, E.; Lowry, P. J.; Vale, W. W. Assignment of disulfide bonds in corticotropin-releasing factor-binding protein. Journal of Biological Chemistry 1994, 269, 4313-6.
46. Cortright, D. N.; Nicoletti, A.; Seasholtz, A. F. Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein. Mol. Cell. Endocrinol. 1995, 111, 147-57.
47. Behan, D. P.; Cepoi, D.; Fischer, W. H.; Park, M.; Sutton, S.; Lowry, P. J.; Vale, W. W. Characterization of a sheep brain corticotropin releasing factor binding protein. Brain Res. 1996, 732, 265-74.
48. Woods, R. J.; Kemp, C. F.; David, J.; Lowry, P. J. Heterogeneity of the human corticotropin-releasing factor-binding protein. J. Clin. Endocrinol. Metabol. 1997, 82, 1566-71.
49. Kemp, C. F.; Woods, R. J.; Lowry, P. J. The corticotrophin-releasing factor-binding protein: an act of several parts. Peptides 1998, 19, 1119-28.
50. Sutton, S. W.; Behan, D. P.; Lahrichi, S. L.; Kaiser, R.; Corrigan, A.; Lowry, P.; Potter, E.; Perrin, M. H.; Rivier, J.; Vale, W. W. Ligand requirements of the human corticotropin-releasing factor-binding protein. Endocrinology 1995, 136, 1097-102.
51. Potter, E.; Behan, D. P.; Linton, E. A.; Lowry, P. J.; Sawchenko, P. E.; Vale, W. W. The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF. Proc. Natl. Acad. Sci. USA 1992, 89, 4192-6.
52. Behan, D. P.; Potter, E.; Sutton, S.; Fischer, W.; Lowry, P. J.; Vale, W. W. Corticotropin-releasing factor-binding protein. A putative peripheral and central modulator of the CRF family of neuropeptides. Ann. New York Acad. Sci 1993, 697, 1-8.
53. Petraglia, F.; Potter, E.; Cameron, V. A.; Sutton, S.; Behan, D. P.; Woods, R. J.; Sawchenko, P. E.; Lowry, P. J.; Vale, W. W. Corticotropin-releasing factor-binding protein is produced by human placenta and intrauterine tissues. J. Clin. Endocrinol. Metabol. 1993, 77, 919-24.
54. Saphier, P. W.; Faria, M.; Grossman, A.; Coy, D. H.; Besser, G. M.; Hodson, B.; Parkes, M.; Linton, E. A.; Lowry, P. J. A comparison of the clearance of ovine and human corticotrophin-releasing hormone (CRH) in man and sheep: a possible role for CRH-binding protein. J. Endocrinol. 1992, 133, 487-95.
55. Woods, R. J.; Grossman, A.; Saphier, P.; Kennedy, K.; Ur, E.; Behan, D.; Potter, E.; Vale, W. W.; Lowry, P. J. Association of human corticotropin-releasing hormone to its binding protein in blood may trigger clearance of the complex. J. Clin. Endocrinol. Metabol. 1994, 78, 73-6.
56. Woods, R. J.; Kennedy, K. M.; Gibbins, J. M.; Behan, D.; Vale, W. W.; Lowry, P. J. Corticotropin-releasing factor binding protein dimerizes after association with ligand. Endocrinology 1994, 135, 768-73.
57. Linton, E. A.; Behan, D. P.; Saphier, P. W.; Lowry, P. J. Corticotropin-releasing hormone (CRH)-binding protein: reduction in the adrenocorticotropin-releasing activity of placental but not hypothalamic CRH. J. Clin. Endocrinol. Metabol. 1990, 70, 1574-80.
58. Linton, E. A.; Perkins, A. V.; Woods, R. J.; Eben, F.; Wolfe, C. D.; Behan, D. P.; Potter, E.; Vale, W. W.; Lowry, P. J. Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy. J. Clin. Endocrinol. Metabol. 1993, 76, 260-2.
59. De Souza, E. B. Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution. J. Neuroscience 1987, 7, 88-100.
60. Turnbull, A. V.; Rivier, C. Corticotropin-releasing factor (CRF) and endocrine responses to stress: CRF receptors, binding protein, and related peptides. Proc. Soc. Exp. Biol. Med. 1997, 215, 1-10.
61. Behan, D. P.; De, S. E. B.; Potter, E.; Sawchenko, P.; Lowry, P J.; Vale, W. W. Modulatory actions of Corticotropin-releasing factor-binding protein. Ann. New York Acad. Sci 1996, 780, 81-95.
62. Cummings, S.; Elde, R.; Ells, J.; Lindall, A. Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study. J. Neuroscience 1983, 3, 1355-68.
63. Swanson, L. W.; Sawchenko, P. E.; Rivier, J.; Vale, W. W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 1983, 36, 165-86.
64. Giraldi, F. P.; Cavagnini, F. Corticotropin-releasing hormone is produced by rat corticotropes and modulates ACTH secretion in a paracrine/autocrine fashion. J. Clin. Invest. 1998, 101, 2478-84.
65. Wong, M. L.; al-Shekhlee, A.; Bongiorno, P. B.; Esposito, A.; Khatri, P.; Sternberg, E. M.; Gold, P. W.; Licinio, J. Localization of urocortin messenger RNA in rat brain and pituitary. Mol. Psychiatry 1996, 1, 307-12.
66. Muglia, L.; Jacobson, L.; Dikkes, P.; Majzoub, J. A. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 1995, 373, 427-32.
67. Potter, E.; Sutton, S.; Donaldson, C.; Chen, R.; Perrin, M.; Lewis;, K.; Sawchenko, P. E.; Vale, W. W. Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Proc. Natl. Acad. Sci. USA 1994, 91, 8777-81.
68. Chalmers, D. T.; Lovenberg, T. W.; De Souza, E. B. Localization of novel corticotropin-releasing factor receptor (CRF-2) mRNA expression to specific subcortical nuclei in rat brain: Comparison with CRF-1 receptor mRNA expression. J. Neuroscience 1995, 15, 6340-50.
69. De Souza, E. B. Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinol. 1995, 20, 789-819.
70. Olschowka, J. A.; O'Donohue, T. L.; Mueller, G. P.; Jacobowitz, D. M. The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain. Peptides 1982, 3, 995-1015.
71. Kozicz, T.; Yanaihara, H.; Arimura, A. Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. J. Comp. Neurol. 1998, 391, 1-10.
72. Thompson, R. C.; Seasholtz, A. F.; Douglass, J. O.; Herbert, E. Cloning and distribution of the rat corticotropin-releasing factor (CRF) gene. In: Corticotropin-releasing factor: basic and clinical studies of the neuropeptide; De Souza, E. B. and Nemeroff, C. B. Ed.; CRC Press: Boca Raton, 1990, p 1-12.
73. Radulovic, J.; Sydow, S.; Spiess, J. Characterization of native corticotropin-releasing factor receptor type 1 (CRFR1) in the rat and mouse central nervous system. J. Neurosci. Res. 1998, 54, 507-21.
74. Fendt, M.; Koch, M.; Schnitzler, H. U. Lesions of the central gray block conditioned fear as measured with the potentiated startle paradigm. Behav. Brain Res. 1996, 74, 127-34.
75. Fendt, M.; Koch, M.; Schnitzler, H. U. Corticotropin-releasing factor in the caudal pontine reticular nucleus mediates the expression of fear-potentiated startle in the rat. Eur. J. Neurosci. 1997, 9, 299-305.
76. Dunn, A. J.; Berridge, C. W. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Brain Res Rev 1990, 15, 71-100.
77. Owens, M. J.; Nemeroff, C. B. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol. Rev. 1991, 43, 425-73.
78. Brown, M. R.; Fisher, L. A.; Spiess, J.; Rivier, C.; Rivier, J.; Vale, W. W. Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology 1982, 111, 928-31.
79. Fisher, L. A. Corticotropin-releasing factor: endocrine and autonomic integration of responses to stress. TIPS 1989, 10, 189-93.
80. Diamant, M.; de Wied, D. Structure-related effects of CRF and CRF-derived peptides: dissociation of behavioral, endocrine and autonomic activity. Neuroendocrinology 1993, 57, 1071-81.
81. Wiersma, A.; Bohus, B.; Koolhaas, J. M. Corticotropin-releasing hormone microinfusion in the central amygdala diminishes a cardiac parasympathetic outflow under stress-free conditions. Brain Res. 1993, 625, 219-27.
82. Richter, R. M.; Mulvany, M. J. Comparison of hCRF and oCRF effects on cardiovascular responses after central, peripheral, and in vitro application. Peptides 1995, 16, 843-9.
83. Buwalda, B.; Van Kalkeren, A. A.; d Boer, S. F.; Koolhaas, J. M. Behavioral and physiological consequences of repeated daily intracerebroventricular injection of corticotropin-releasing factor in the rat. Psychoneuroendocrinol. 1998, 23, 205-18.
84. Brown, M. R.; Gray, T. S.; Fisher, L. A. Corticotropin-releasing factor receptor antagonist: effects on the autonomic nervous system and cardiovascular function. Regul. Pept. 1986, 16, 321-9.
85. Wiersma, A.; Konsman, J. P.; Knollema, S.; Bohus, B.; Koolhaas, J. M. Differential effect of CRH infusion into the central nucleus of the amygdala in the roman high-avoidance and low-avoidance rats. Psychoneuroendocrinol. 1998, 23, 261-74 .
86. Saitoh, M.; Hasegawa, J.; Vlashira, H. Effect of corticotropin-releasing factor on the electrical and mechanical activities of the guinea-pig ventricular myocardium. Gen. Pharmac 1990, 21, 337-42.
87. Irwin, M.; Hauger, R. L.; Brown, M.; Britton, K. T. CRF activates autonomic nervous system and reduces natural killer cytotoxicity. Am. J. Physiol. 1988, 255, R744-R7.
88. Sapolsky, R.; Rivier, C.; Yamamoto, G.; Plotsky, P.; Vale, W. W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor Science 1987, 238, 522-4.
89. Besedovsky, R. O.; Del Rey, A.; Klusman, I.; Furukawa, H.; Arditi, G. M.; Kabiersch, A. Cytokines as modulators of the hypothalamus-pituitary-adrenal axis. J. Steroid Biochem. Mol. Biol. 1991, 40, 613-8.
90. Dinarello, C. A. The interleukin-1 family: 10 years of discovery. FASEB J. 1994, 8, 1314-25.
91. Brouxhon, S. M.; Prasad, A. V.; Joseph, S. A.; Felten, D. L.; Bellinger, D. L. Localization of corticotropin-releasing factor in primary and secondary lymphoid organs of the rat. Brain. Behav. Immun. 1998, 12, 107-22.
92. Bileviciute, I.; Ahmed, M.; Bergstrom, J.; Ericsson Dahlstrand, A.; Kreicbergs, A.; Lundeberg, T. Expression of corticotropin-releasing factor in the peripheral nervous system of the rat. Neuroreport 1997, 8, 3127-30.
93. Hargreaves, K. M.; Costello, A. H.; Joris, J. L. Release from inflamed tissue of a substance with properties similar to corticotropin-releasing factor. Neuroendocrinology 1989, 49, 476-82.
94. Karalis, K.; Sano, H.; Redwine, J.; Listwak, S.; Wilder, R. L.; Chrousos, G. P. Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone in-vivo. Science 1991, 254, 421-3.
95. Crofford, L. J.; Sano, H.; Karalis, K.; Friedman, T. C.; Epps, H. R.; Remmers, E. F.; Mathern, P.; Chrousos, G. P.; Wilder, R. L. Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis. J. Immunol. 1993, 151, 1587-9 6.
96. Webster, E. L.; Tracey, D. E ; Jutila, M. A.; Wolfe, S. A., Jr.; De Souza, E. B. Corticotropin-roleasing factor receptors in mouse spleen identification of receptor-bearing cells as resident macrophages. Endocrinology 1990, 127, 440-52.
97. Singh, V. K.; Fudenberg, H. H. Binding of [125l]corticotropin releasing factor to blood inmunocytes and its reduction in Alzheimer's disease. Immunol. Lett. 1988, 18, 5-8.
98. Audhya, T.; Jain, R.; Hollander, C. S. Receptor-mediated immunomodulation by corticotropin-releasing factor. Cellular Immunology 1991, 134, 77-84.
99. Singh, V. K.; Leu, S. J. C. Enhancing effect of corticotropin-releasing neurohormone on .he production of interleukin-1 and interleukin-2. Neurosci. Lett. 1990, 120, 151-4.
100. Salas, M. A.; Brown, O. A.; Ferone, M. J.; Castro, M. G.; Goya, R. G. Effect of the corticotropin releasing hormone precursor on interleukin-6 release by human mononuclear cells. Clin. Immunol. Immunopathol. 1997, 85, 35-9.
101. Singh, V. K. Stimulatory effect of corticotropin-releasing neurohormone on human lymphocyte proliferation and interleukin-2 receptor expression. J. Neuroimmunol. 1989, 23, 257-62.
102. Radulovic, M.; Dautzenberg, F.; Sydow, S.; Radulovic, J.; Spiess, J. Corticotropin-releasing factor receptor in mouse spleen: expression after immune stimulation and identification of receptor-bearing cells. J. Immunol. 1999, 162, 3013-21.
103. Radulovic, M.; Spiess, J. Journal of Neuroimmunology. Special Issue: Abstracts of the International Society of Neuroimmunology, Fifth International Congress, Montreal, Canada, 23-27 August, 1998, 90, 43 (abstract no. 232).
104. Seligmann, B.; Malech, H. L.; Melnick, D. A.; Gallin, J. I. An antibody binding to human neutrophils demonstrates antigenic heterogeneity detected early in myeloid maturation which correlates with functional heterogeneity of mature neutrophils. J. Immunol. 1985, 135, 2647-53.
105. Alexander, H. R.; Doherty, G. M.; Buresh, C. M.; Venzon, D. J.; Norton, J. A. A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice. J. Exp. Med. 1991, 173, 1029-32.
106. Ulich, T. R.; Guo, K.; Yin, S.; del Castillo, J.; Yi, E. S.; Thompson, R. C.; Eisenberg, S. P. Endotoxin-induced cytokine gene expression in vivo. IV. Expression of interleukin-1 alpha/beta and interleukin-1 receptor antagonist mRNA during endotoxemia and during endotoxin-initiated local acute inflammation. Am. J. Pathol. 1992, 141, 61-8.
107. Williams, J. H., Jr.; Patel, S. K.; Hatakeyama, D.; Arian, R.; Guo, K.; Hickey, T. J.; Liao, S. Y.; Ulich, T. R. Activated pulmonary vascular neutrophils as early mediators of endotoxin-induced lung inflammation. Am. J. Resp. Cell Mol. Biol. 1993, 8, 134-44.
108. Hagan, P.; Poole, S.; Bristow, A. F. Immunosuppressive activity of corticotrophin-releasing factor. Inhibition of interleukin-1 and interleukin-6 production by human mononuclear cells. Biochem. J. 1992, 281, 251-4.
109. Paez Pereda, M.; Sauer, J.; Perez Castro, C.; Finkielman, S.; Stalla, G. K.; Holsboer, F.; Arzt, E. Corticotropin-releasing hormone differentially modulates the interleukin-1 system according to the level of monocyte activation by endotoxin. Endocrinology 1995, 136, 5504-10.
110. Labrie, F.; Gagne, B.; Lefevre, G. Corticotrpoin-releasing factor stimulates adenylate cyclase activity in the anterior pituitary gland. Life Sci. 1982, 31, 1117-21.
111. Wei, E. T.; Gao, G. C.; Thomas, H. A. Peripheral anti-inflammatory actions of corticotropin-releasing factor. Ciba Foundation Symposium 1993, 172, 258-68.
112. Correa, S.; Riera, C. M.; Spiess, J.; Bianco, I. D. Modulation of the inflammatory response by corticotropin releasing factor. Eur. J. Pharmacol. 1997, 319, 85-90.
113. Poliak, S.; Mor, F.; Conlon, P.; Wong, T.; Ling, N.; Rivier, J.; Vale, W. W.; Steinman, L. Stress and autoimmunity: the neuropeptides corticotropin-releasing factor and urocortin suppress encephalomyelitis via effects on both the hypothalamic-pituitary-adrenal axis and the immune system. J. Immunol. 1997, 158, 5751-6.
114. Schafer, M.; Carter, L.; Stein, C. Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue. Proc. Natl. Acad. Sci. USA 1994, 91, 4219-23.
115. Mousa, S. A.; Schafer, M.; Mitchell, W. M.; Hassan, A. H.; Stein, C. Local upregulation of corticotropin-releasing hormone and interleukin-1 receptors in rats with painful hindlimb inflammation. Eur. J. Pharmacol. 1996, 311, 221-31.
116. Fox, E. A.; Gruol, D. L. Corticotropin-Releasing Factor Suppresses the Afterhyperpolarization in Cerebellar Purkinje Neurons. Neurosci. Lett. 1993, 149, 103-7.
117. Yamashita, H.; Kasai, M.; Inenaga, K. Effects of corticotropin-releasing factor on neurons in the hypothalamic paraventricular nucleus in-vitro. Brain Res. Bull. 1991, 27, 321-6.
118. Siggins, G. R.; Gruol, D.; Aldenhoff, J.; Pittman, Q. Electrophysiological actions of corticotropin-releasing factor in the central nervous system. Fed. Proc. 1985, 44, 237-42.
119. Ehlers, C. L.; Henriksen, S. J.; Wang, M.; Rivier, J.; Vale, W. W.; Bloom, F. E. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res. 1983, 278, 332-6.
120. Baram, T. Z.; Schultz, L. Corticotropin-releasing hormone Is a rapid and potent convulsant in the infant rat. Brain Res. Developm. Brain Res. 1991, 61, 97-102.
121. Baram, T. Z. Pathophysiology of massive infantile spasms perspective on the putative role of the brain adrenal axis. Ann. Neurol. 1993, 33, 231-6.
122. Aldenhoff, J. B.; Gruol, D. L; Rivier, J.; Vale, W. W.; Siggins, G. R. Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons. Science 1983, 221, 875-7.
123. Smith, B. N.; Dudek, F. E. Age-related epileptogenic effects of corticotropin-releasing hormone in the isolated CA1 region of rat hippocampal slices. J. Neurophysiol. 1994, 72, 2328-33.
124. Wang, H. L.; Wayner, M. J.; Chai, C. Y.; Lee, E. H. Y. Corticotrophin-releasing factor produces a long-lasting enhancement of synaptic efficacy in the hippocampus. Eur. J. Neurosci. 1998, 10, 3428-37.
125. Koob, G. F.; Britton, K. T. Behavioral effects of corticotropin-releasing factor. In: Corticotropin-releasing factor: basic and clinical studies of the neuropeptide; De Souza, E. B. and Nemeroff, C. B. Ed.; CRC Press: Boca Raton, 1990, p 275-89.
126. Sutton, R. E.; Koob, G. F.; Le Moal, M.; Rivier, J.; Vale, W. W. Corticotropin releasing factor produces behavioural activation in rats. Nature 1982, 297, 331-3.
127. Britton, D. R.; Koob, G. F.; Rivier, J.; Vale, W. W. Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci. 1982, 31, 363-7.
128. Dunn, A. J.; File, S. E. Corticotropin-releasing factor has an anxiogenic action in the social interaction test. Hormones Behav. 1987, 21, 193-202.
129. Swerdlow, N. R.; Geyer, M. A.; Vale, W. W.; Koob, G. F. Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide. Psychopharmacol. 1986, 88, 147-52.
130. Berridge, C. W.; Dunn, A. J. CRF and restraint-stress decrease exploratory behavior in hypophysectomized mice. Pharmacol. Bioch. Behav. 1989, 34, 517-9.
131. Gosnell, B. A.; Morley, J. E.; Levine, A. S. A comparison of the effects of corticotropin releasing factor and sauvagine on food intake. Pharmacol. Bioch. Behav. 1983, 19, 771-5.
132. Sirinathsinghji, D. J.; Rees, L. H.; Rivier, J.; Vale, W. W. Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat. Nature 1983, 305, 232-5.
133. Moreau, J. L.; Kilpatrick, G.; Jenck, F. Urocortin, a novel neuropeptide with anxiogenic-like properties. Neuroreport 1997, 8, 1697-701.
134. Smagin, G. N.; Howell, L. A.; Ryan, D. H.; De Souza, E. B.; Harris, R. B. The role of CRF2 receptors in corticotropin-releasing factor- and urocortin-induced anorexia. Neuroreport 1998, 9, 1601-6.
135. Timpl, P.; Spanagel, R.; Sillaber, I.; Kresse, A.; Reul, J.; Stalla, G. K.; Blanquet, V.; Steckler, T.; Holsboer, F.; Wurst, W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics 1998, 19, 162-6.
136. Smith, G.; Aubry, J.-M.; Dellu, F.; Contarino, A.; Bilezikjian, L.; Gold, L.; Chen, R.; Marchuk, Y.; Hauser, C.; Bentley, C.; Sawchenko, P.; Koob, G.; Vale, W.; Lee, K.-F. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 1998, 20, 1093-102.
137. Koob, G. F.; Bloom, F. E. Corticotropin-releasing factor and behavior. Fed. Proc. 1985, 44, 259-63.
138. Krahn, D. D.; Gosnell, B. A.; Grace, M.; Levine, A. S. CRF antagonist partially reverses CRF- and stress-induced effects on feeding. Brain Res. Bull. 1986, 17, 285-9.
139. Berridge, C. W.; Dunn, A. J. A corticotropin-releasing factor antagonist reverses the stress-induced changes of exploratory behavior in mice. Hormones Behav. 1987, 21, 393-401.
140. Tazi, A.; Dantzer, R.; Le Moal, M.; Rivier, J.; Vale, W. W.; Koob, G. F. Corticotropin-releasing factor antagonist blocks stress-induced fighting in rats. Regul. Pept. 1987, 18, 37-42.
141. Swerdlow, N. R.; Britton, K. T.; Koob, G. F. Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41). Neuropsychopharmacology 1989, 2, 285-92.
142. Britton, K. T.; Lee, G.; Vale, W. W.; Rivier, J.; Koob, G. F. Corticotropin releasing factor (CRF) receptor antagonist blocks activating and 'anxiogenic' actions of CRF in the rat. Brain Res. 1986, 369, 303-6.
143. Baldwin, H. A.; Rassnick, S.; Rivier, J.; Koob, G. F.; Britton, K. T. CRF antagonist reverses the anxiogenic response to ethanol withdrawal in the rat. Psychopharmacol. 1991, 103, 227-32.
144. Griebel, G.; Perrault, G.; Sanger, D. J. Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone. Psychopharmacol. 1998, 138, 55-66.
145. Heinrichs, S. C.; Pich, E. M.; Miczek, K. A.; Britton, K. T.; Koob, G. F. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Res. 1992, 581, 190-7.
146. Rassnick, S.; Heinrichs, S. C.; Britton, K. T.; Koob, G. F. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res. 1993, 605, 25-32.
147. Swiergiel, A. H.; Takahashi, L. K.; Kalin, N. H. Attenuation of stress-induced behavior by antagonism of corticotropin-releasing factor receptors in the central amygdala in the rat. Brain Res. 1993, 623, 229-34.
148. Liebsch, G.; Landgraf, R.; Gerstberger, R.; Probst, J. C.; Wotjak, C. T.; Engelmann, M.; Holsboer, F.; Montkowski, A. Chronic infusion of a CRH-1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats. Regul. Pept. 1995, 59, 229-39.
149. Lee, Y.; Davis, M. Role of the hippocampus, the bed nucleus of the stria terminalis, and the amygdala in the excitatory effect of corticotropin-releasing hormone on the acoustic startle reflex. J. Neuroscience 1997, 17, 6434-46.
150. Radulovic, J.; Rühmann, A.; Liepold, T.; Spiess, J. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J. Neuroscience 1999, 19, 5016-25.
151. Behan, D. P.; Heinrichs, S. C.; Troncoso, J. C.; Liu, X. J.; Kawas, C. H.; Ling, N.; De, S. E. B. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature 1995, 378, 284-7.
152. Liang, K. C.; Lee, E. H. Intra-amygdala injections of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavicr in rats. Psychopharmacol. 1988, 96, 232-6.
153. Heinrichs, S. C.; Vale, E. A.; Lapsansky, J.; Behan, D. P.; McClure, L. V.; Ling, N.; De, S. E. B.; Schulteis, G. Enhancement of performance in multiple learning tasks by corticotropin-releasing factor-binding protein ligand inhibitors. Peptides 1997, 18, 711-6.
154. Veldhuis, H. D.; De Wied, D. Differential behavioral actions of corticotropin-releasing factor (CRF). Pharmacol. Bioch. Behav. 1984, 21, 707-13.
155. Nemeroff, C. B.; Widerlov, E.; Bissette, G.; Walleus, H.; Karlsson, I.; Eklund, K.; Kilts, C. D.; Loosen, P. T.; Vale, W. W. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984, 226, 1342-4.
156. Roy-Byrne, P. P.; Uhde, T. W.; Post, R. M.; Gallucci, W.; Chrousos, G. P.; Gold, P. W. The corticotropin-releasing hormone stimulation test in patients with panic disorder. Am. J. Psychiatry 1986, 143, 896-9.
157. Behan, D. P.; Grigoriadis, D. E.; Lovenberg, T.; Chalmers, D.; Heinrichs, S.; Liaw, C. De, S. E. B. Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders. Mol. Psychiatry 1996, 1, 265-77.
158. Chen, C.; Dagnino, R., Jr.; De, S. E. B.; Grigoriadis, D. E.; Huang, C. Q.; Kim, K. I. Liu, Z.; Moran, T.; Webb, T. R.; Whitten, J. P.; Xie, Y. F.; McCarthy, J. R. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J. Med. Chem. 1996, 39, 4358-60.
159. Schulz, D. W.; Mansbach, R. S.; Sprouse, J.; Braselton, J. P.; Collins, J.; Corman, M.; Dunaiskis, A.; Faraci, S.; Schmidt, A. W.; Seeger, T.; Seymour, P.; Tingley, F. D. r.; Winston, E. N.; Chen, Y. L.; Heym, J. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc. Natl. Acad. Sci. USA 1996, 93, 10477-82.
160. Christos, T. E.; Arvanitis, A. Corticotrophin-releasing factor receptor antagonists. Expert Opin. Therap. Pat. 1998, 8, 143-52.
161. Harris, A. Review: clinical opportunities provided by the nasal administration of peptides. J. Drug Target. 1993, 1, 101-16.
162. Egleton, R.; Davis, T. Bioavailability and transport of peptides and peptide drugs into the brain. Peptides 1997, 18, 1431-9.