Activated T Cells from Draining Lymph Nodes and an Effector Site Differ in Their Responses to TCR Stimulation

Journal of Immunology

Volumn 159, Issue 3, 1997, Pages 1182-1191

  Baumgarth, Nicole ^a,b   Egerton, Mark ^a   Kelso, Anne ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE ANTIGEN; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; COMPARATIVE STUDY; CYTOLOGY; FEMALE; IMMUNOLOGY; IMMUNOPHENOTYPING; KINETICS; LUNG; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MESENTERY; METABOLISM; MOUSE; ORTHOMYXOVIRUS INFECTION; PHYSIOLOGY; RESPIRATORY TRACT INFECTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, SURFACE; BIOLOGICAL MARKERS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYTOKINES; FEMALE; IMMUNOPHENOTYPING; KINETICS; LUNG; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MESENTERY; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, ANTIGEN, T-CELL; RESPIRATORY TRACT INFECTIONS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0031202295     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. + T cells. Annu. Rev. Immunol. 12:635.
2. Ehlers, S., and K. A. Smith. 1991. Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J. Exp. Med. 173:25.
3. Byrne, J. A., J. L. Butler, and M. D. Cooper. 1988. Differential activation requirements for virgin and memory T cells. J. Immunol. 141:3249.
4. Crott, M., L. M. Bradley, and S. L. Swain. 1994. Naive versus memory CD4 T cell response to antigen: memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 152:2675.
5. + T cells differing in CD45R expression. J. Immunol. 149:2300.
6. Lafferty, K. J., and A. Cunningham. 1975. A new analysis of allogeneic interactions. Aust. J. Exp. Biol. Med. Sci. 53:27.
7. Jenkins, M. K. 1994. The ups and downs of T cell costimulation. Immunity. 1:443.
8. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991.
9. Baumgarth, N., and A. Kelso. 1996. Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection. Eur. J. Immunol. 26:2189.
10. Gray, D. 1993. Immunological memory. Annu. Rev. Immunol. 11:49.
11. Vitetta, E. S., M. T. Berton, C. Burger, M. Kepron, W. T. Lee, and X. Yin. 1991. Memory B and T cells. Annu. Rev. Immunol. 9:193.
12. Bell, E. B., and S. M. Sparshott. 1990. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 348:163.
13. Jung, T. M., W. M. Gallatin, I. L. Weissman, and M. O. Dailey. 1986. Down-regulation of homing receptors after T cell activation. J. Immunol. 141:4110.
14. + T cells from aged mice display functional and phenotypic characteristics of memory cells. Int. Immunol. 6:1227.
15. Walker, P. R., T. Ohteki, J. A. Lopez, H. R. MacDonald, and J. L. Maryanski. 1995. Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response. J. Immunol. 155:3443.
16. + memory T cells in virus-infected hosts. J. Exp. Med. 183:1367.
17. + and can be selectively activated with phorbol ester and calcium ionophore. Cell. Immunol. 113:268.
18. - helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon γ. J. Exp. Med. 174:547.
19. + cytotoxic T cell activation and memory in virus infection. J. Immunol. 149:1326.
20. Mobley, J. L., and M. O. Dailey. 1992. I. Differential regulation of gp90MEL-14 (LECAM-1), Pgp-1, LFA-1, and VLA-4α during the differentiation of cytotoxic T lymphocytes induced by allografts. J. Immunol. 148:2348.
21. - effector/memory cells in mice vaccinated with attenuated cercariae of Schistosoma mansoni. J. Immunol. 151:3663.
22. + memory T cells. J. Immunol. 154:5870.
23. Bommhardt, U., J.-C. Cerottini, and H. R. MacDonald. 1994. Heterogeneity in P-glycoprotein (multidrug resistance) activity among murine peripheral T cells: correlation with surface phenotype and effector function. Eur. J. Immunol. 24:2974.
24. Baumgarth, N., L. Brown, D. Jackson, and A. Kelso. 1994. Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10. J. Virol. 68:7575.
25. Kelso, A., and D. Metcalf. 1985. Clonal heterogeneity in colony stimulating factor production by murine T lymphocytes. J. Cell. Physiol. 123:101.
26. + T cells activated in a graft-versus-host reaction. J. Immunol. 145:2167.
27. Assenmacher, M., J. Schmitz, and A. Radbruch. 1994. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells. Eur. J. Immunol. 24:1097.
28. Sander, B., S. Cardell, H. Heremans, U. Andersson, and G. Moller. 1989. Detection of individual interleukin 4- and gamma interferon-producing murine splenic cells after activation with T-cell mitogens. Scand. J. Immunol. 30:315.
29. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
30. Egerton, M., D. R. Fitzpatrick, A. D. Catling, and A. Kelso. 1996. Differential activation of T cell cytokine production by the extracellular signal-regulated kinase (ERK) signaling pathway. Eur. J. Immunol. 26:2279.
31. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. Saltiel. 1995. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489.
32. Derijard, B., J. Raingeaud, T. Barrett, I.-H. Wu, J. Han, R. J. Ulevtich, and R. J. Davis. 1995. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682.
33. ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J. Exp. Med. 178:1199.
34. + T cells in respiratory virus infections. J. Immunol. 154:6013.
35. Whitehurst, C. E., and T. D. Geppert. 1996. MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells. J. Immunol. 156:1020.
36. Genot, E., S. Cleverley, S. Henning, and D. Cantrell. 1996. Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J. 15:3923.
37. Alberola-Ila, J., K. A. Forbush, R. Seger, E. G. Krebs, and R. M. Perlmutter. 1995. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620.