Type 1- and type 2-like lesional skin-derived Mycobacterium leprae- responsive T cell clones are characterized by coexpression of IFN-γ/TNF-α and IL-4/IL-5/IL-13, respectively

Journal of Immunology

Volumn 160, Issue 5, 1998, Pages 2380-2387

  Verhagen, Claudia E ^a   Van Der Pouw Kraan, Tineke C T M ^a   Buffing, Anita A M ^a   Chand, Mohamed A ^a   Faber, William R ^a   Aarden, Lucien A ^a   Das, Pranab K ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; HUMAN; HUMAN CELL; LEPROSY; MYCOBACTERIUM LEPRAE; PRIORITY JOURNAL; SKIN BIOPSY; T LYMPHOCYTE;

CLONE CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; INTERLEUKINS; LEPROSY; MYCOBACTERIUM LEPRAE; SKIN; STATISTICS, NONPARAMETRIC; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032032141     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Romagnani, S. 1991. Human TH1 and TH2 subsets: doubt no more. Immunol. Today 12:256.
2. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T cell subsets: Th1, Th2 and more. Immunol. Today 17:139.
3. Ridley, D. S., and W. H. Jopling. 1966. Classification of leprosy according to immunity; a five-group system. Int. J. Lepr. 34:255.
4. Salgame, P. R., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T-cell clones. Science 254:279
5. Haanen, J., R. de Waal Malefijt, R. R. P. de Vries. and H. Spits. 1991. Selection of a human Th1-like T cell subset by Mycobacterium leprae antigens. J. Exp. Med. 174:583.
6. Verhagen, C. E., E. A. Wierenga, A. A. M. Buffing, M. A. Chand, W. R. Faber, and P. K. Das 1997. Reversal reaction in borderline leprosy is associated with a polarized shift to type 1-like Mycobacterium leprae T cell reactivity in lesional skin: a follow-up study. J. Immunol. 159:4474.
7. Ridley, D. S. 1969. Reactions in leprosy. Lepr. Rev. 40:77.
8. Barnetson, R. StC., G. Bjune, J. M. H. Pearson, and G. Kronvall. 1976. Cell mediated and humoral immunity in "reversal reaction." Int. J. Lepr. 44:267.
9. Misra, N., A. Murtaza, B. Walker, N. P. S. Narayan, R. S. Misra, V. Ramesh, S. Singh, M. J. Colston, and I. Nath. 1995. Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. Immunology 86:97.
10. Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385.
11. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
12. Barnes, P. F., J. A. Abrams, S. Lu, P. A. Siegling, T. H. Rea, and R. L. Modlin. 1993. Patterns of cytokine production by Mycobacterium-reactive human T cell clones. Infect. Immun. 61:197.
13. Schlaak, J. F., M. Buslau, W. Jochum, E. Hermann, M. Girndt, H. Gallati, K.-H. Meyer zum Buschenfelde, and B. Fleischer. 1994. T cells involved in psoriasis vulgaris belong to the Th1 subset. J. Invest. Dermatol. 102:145.
14. Al-Janadi, M., S. Al-Balla, A. Al-Dalaan, and S. Raziuddin. 1993. Cytokine production by helper T cell populations from the synovial fluid and blood in patients with rheumatoid arthritis. J. Rheumatol. 20:1647.
15. Wierenga, E. A., M. Snoek, H. M. Jansen, J. D. Bos, R. A. W. van Lier, and M. L. Kapsenberg. 1991. Human atopen-specific types 1 and 2 T helper cell clones. J. Immunol. 147:2942.
16. Gutgesell, C., H. Yssel, D. Scheel, J. Gerdes, and C. Neumann. 1994. IL-10 secretion of allergen-specific skin derived T cells correlates positively with that of Th2 cytokines IL-4 and IL-5. Exp. Dermatol. 3:304.
17. + T-cell clones from blood and skin lesions of leprosy patients: identification of T-cell clones distinct from Th0, Th1 and Th2. Immunology 84:585.
18. Wierenga, E. A., M. Snoek, J. D. Bos, H. M. Jansen, and M. L. Kapsenberg. 1990. Comparison of diversity and function of housedust mite-specific T lymphocyte clones from atopic and nonatopic donors. Eur. J. Immunol. 20:1519.
19. Parronchi, P., D. Macchia, M.-P. Piccinni, P. Bisswas, C. Simonelli, E. Maggi, M. Ricci, A. A. Ansari, and S. Romagnani. 1991. Allergen- and bacterial antigen-specific T cell clones established from atopic donors show a different profile of cytokine production. Proc. Natl. Acad. Sci. USA 88:4538.
20. Van der Meide, P. H., M. Dubbeld, and H. Schellekens. 1985. Monoclonal antibodies to human immune interferon and their use in a sensitive solid-phase ELISA. J. Immunol. Methods 79:293.
21. Van der Pouw-Kraan, T., I. Rensink, and L. Aarden. 1993. Characterization of monoclonal antibodies to human IL-4: application in an ELISA and differential inhibition of IL-4 bioactivity on B cells and T cells. Eur. Cytokine Network 4:343.
22. McNamee, L. A., D. I. Fattah, T. J. Baker, S. K. Bains, and P. H. Hissey. 1991. Production, characterization and use of monoclonal antibodies to human interleukin-5 in enzyme-linked immunosorbent assay. J. Immunol. Methods 141:81.
23. Van der Pouw Kraan, T. C. T. M., L. C. Boeije, J. T. M. Troon, S. K. Rutschmann, J. Wijdenes, and L. A. Aarden. 1996. Human IL-13 production is negatively influenced by CD3 engagement: enhancement of IL-13 production by cyclosporin A. J. Immunol. 156:1818.
24. Helle, M., L. Boeije, E. R. De Groot, A. De Vos, and L. A. Aarden. 1991. Sensitive ELISA for IL-6: detection of IL-6 in biological fluids: synovial fluids and sera. J. Immunol. Methods 138:47.
25. Aarden, L. A., E. R. De Groot, O. L. Schaap, and P. M. Lansdorp. 1987. Production of hybridoma growth factor by human monocytes. Eur. J. Immunol. 17:1411.
26. 2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775.
27. Nakane, A., T. Minagawa, and K. Kato. 1988. Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection. Infect. Immun. 56:2563.
28. Akira, S., T. Hirano, T. Taga, and T. Kishimoto. 1990. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 4:2860.
29. De Waal Malefyt, R., J. Haanen, H. Spits, M.-G. Roncarolo, A. te Velde, C. G. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J. E. de Vries. 1991. Interleukin 10 (IL-1) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression. J. Exp. Med. 174:915.
30. De Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of 1L-10 by monocytes. J. Exp. Med. 174:1209.
31. Zurawski, G., and J. E. de Vries. 1994. Interleukin 13 an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today 15:19.
32. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011.
33. Del Prete, G., M. De Carli, F. Almergogna, M. G. Giudizi, R. Biagiotti, and S. Romagnani. 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol. 150:353.
34. Essayan, D. M., W.-F. Han, X.-M. Li, H.-Q. Xiao, J. Kleine-Tebbe, and S.-Ku Huang. 1996. Clonal diversity of IL-4 and IL-13 expression in human allergen-specific T lymphocytes. J. Allergy Clin. Immunol. 98:1035.
35. h2 T cell clones and EBV-transformed B cells. Int. Immunol. 7:1405.
36. Kindler, V., A.-P. Sappino, G. E. Grau, P.-F. Pquet, and P. Vassalli. 1989. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 56:731.
37. Selmaj, K. W., and C. S. Raine. 1988. Tumour necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23:339.
38. Khanolkar-young, S., N. Rayment, P. M. Brickell, D. R. Katz, S. Vinayakumar, M. J. Colston, and D. N. J. Lockwood. 1995. Tumour necrosis factor-alpha (TNF-α) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reaction. Clin. Exp. Immunol. 99:196.
39. Sullivan, L., S. Sano, C. Pirmez, P. Salgame, C. Mueller, F. Hofman, K. Uyemura, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Expression of adhesion molecules in leprosy lesions. Infect. Immun. 59:4154.
40. McKenzie, A. N. J., J. A. Culpepper, R. de Waal Malefyt, F. Briere, J. Punnonen, G. Aversa, A. Sato, B. G. Cocks, S. Menon, J. E. de Vries, J. Bancherau, and G. Zurawski. 1993. Interleukin-13 a T cell derived cytokine that regulates human monocytes and B-cell function. Proc. Natl. Acad. Sci. USA 90:3735.
41. Kelso, A. 1995. Th1 and Th2 subsets, paradigms lost? Immunol. Today 16:374.
42. + T cell clones and peripheral blood T cells. J. Immunol. 149:2378.
43. Murray, P. J., L. Wang, C. Onufryk, R. I. Tepper, and R. A. Young. 1997. T cell-derived IL-10 antagonizes macrophage's function in mycobacterial infection. J. Immunol. 158:315.
44. Mutis, T., E. M. Kraakman, Y. E. Cornelisse, J. B. A. G. Haanen, H. Spits, R. R. P. De Vries, and T. H. M. Ottenhoff. 1993. Analysis of cytokine production by Mycobacterium-reactive T cells: failure to explain Mycobacterium leprae-reactive nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients. J. Immunol. 150:4641.
45. Conradt, P., and S. H. E. Kaufmann. 1995. Impact of antigen-presenting cells on cytokine profiles of human Th clones established after stimulation with Mycobacterium tuberculosis antigens. Infect. Immun. 63:2079.