Dynamic Error Correction in Autocatalytic Peptide Networks

Angewandte Chemie - International Edition

Volumn 37, Issue 1-2, 1998, Pages 126-128

  Severin, Kay ^a   Lee, David H ^a   Martinez, Jose A ^a   Vieth, Michael ^a   Ghadiri, M Reza ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Autocatalysis; Error correction; Networks; Peptides; Self replication

Indexed keywords

EID: 0031906757     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19980202)37:1/2<126::AID-ANIE126>3.0.CO;2-4     Document Type: Article

References (12)

1. a) M. Eigen, P. Schuster, Naturwissenschaften 1971, 58, 465;
2. b) B.-O. Küppers, Information and the Origin of Life, MIT Press, Cambridge, MA (USA) 1990;
3. S. A. Kauffman, The Origins of Order, Oxford Univ. Press, New York, 1993.
4. a) A hypercyclic peptide network that displays symbiosis among otherwise competitive peptide replicators: D. H. Lee, K. Severin, Y. Yokobayashi, M. R. Ghadiri, Nature 1997, 390, 591-594; b) nucleotide-based oligomers that display cross-catalytic behavior: D. Sievers, G. von Kiedrowski, ibid. 1994, 369, 221-224; c) synthetic structures that show cooperative behavior: J.-I. Hong, Q. Feng, V. Rotello, J. Rebek, Jr., Science 1992, 255, 848-850.
5. b) nucleotide-based oligomers that display cross-catalytic behavior: D. Sievers, G. von Kiedrowski, ibid. 1994, 369, 221-224;
6. c) synthetic structures that show cooperative behavior: J.-I. Hong, Q. Feng, V. Rotello, J. Rebek, Jr., Science 1992, 255, 848-850.
7. a) D. H. Lee, J. R. Granja, J. A. Martinez, K. Severin, M. R. Ghadiri, Nature 1996, 382, 525-528;
8. b) K. Severin, D. H. Lee, J. A. Martinez, M. R. Ghadiri, Chem. Eur. J. 1997, 3, 1017-1024.
9. [3] Also see: J. C. Hu, E. K. O'Shea, P. S. Kim, R. T. Sauer, Science 1990, 250, 1400-1403.
10. M. Eigen, P. Schuster, The Hypercycle. A Principle of Natural Self-Organization, Springer, Berlin, 1979.
11. A sigmoidal growth profile is a characteristic signature of efficient autocatalytic processes. This feature is clearly visible in reactions (1)-(3) (Figure 1).
12. D. H. Lee, K. Severin, M. R. Ghadiri, Curr. Opin. Chem. Biol. 1997, 1, 491-496.