Growth hormone receptor antagonism prevents early renal changes in nonobese diabetic mice

Journal of the American Society of Nephrology

Volumn 10, Issue 11, 1999, Pages 2374-2381

  Segev, Yael ^a   Landau, Daniel ^a   Rasch, Ruth ^b   Flyvbjerg, Allan ^c   Phillip, Moshe ^a,d  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b AARHUS UNIVERSITY   (Denmark)

^c Institute of Experimental Clinical Research   (Denmark)

^d SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; MESSENGER RNA; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; FEMALE; GROWTH HORMONE BLOOD LEVEL; KIDNEY HYPERTROPHY; KIDNEY MASS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA;

EID: 0032732024     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Deckert T, Poulsen JE, Larsen M: Prognosis of diabetics with diabetes onset before age of thirty-one. Diabetologia 14: 363-370, 1978
2. Wiseman MJ, Mangili R, Alberetto M, Keen H, Viberti G: Glomerular response mechanisms to glycemic changes in insulin-dependent diabetics. Kidney Int 31: 1012-1018, 1987
3. Steffes MW, Østerby R, Chavers B, Mauer SM: Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes 38: 1077-1081, 1989
4. Viberti GC: Early function and morphological changes in diabetic nephropathy. Clin Nephrol 12: 47-53, 1979
5. LeRoith D, Adamo M, Werner H, Roberts CT Jr: Insulin-like growth factors, their binding proteins and receptors as growth regulators in normal physiology and pathological states. Trends Endocrinol Metab 2: 134-141, 1991
6. Landau D, Chin E, Bondy C, Domene H, Roberts CT Jr, Grönbaek H, Flyvbjerg A, LeRoith D: Expression of insulin-like growth factor binding proteins in the rat kidney: Effects of long-term diabetes. Endocrinology 136: 1835-1842, 1995
7. Flyvbjerg A: Role of growth hormone, insulin-like growth factors (IGFs) and IGF-binding proteins in the renal complications of diabetes. Kidney Int 52: S12-S19, 1997
8. Chin E, Zhou J, Bondy C: Renal growth hormone gene expresssion: Relationship to renal insulin-like growth factor system. Endocrinology 131: 3061-3066, 1992
9. Kelly PA, Alic S, Rozakis M, Goujon L, Nagano M, Pellegrini I, Gould D, Djiane J, Edery M, Finidori J: The growth hormone/ prolactin receptor family. Recent Prog Horm Res 48: 123-165, 1993
10. Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA: Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 253: 821-825, 1991
11. Argetsinger LS, Campbell GS, Yang X, Witthuhn BA, Silvennoinen O, Ihle JN, Carter-Su C: Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74: 237-244, 1993
12. Chen WY, Chen NY, Yun J, Wight DC, Wang XZ, Wagner TE, Kopchick JJ: Amino acid residues in the third alpha-helix of growth hormone involved in growth promoting activity. Mol Endocrinol 9: 292-302, 1995
13. Silva CM, Weber MJ, Thorner MO: Stimulation of tyrosine phosphorylation in human cells by activation of the growth hormone receptor. Endocrinology 132: 101-108, 1993
14. Ilondo MM, Damholt AB, Cunningham BC, Wells JA: Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. Endocrinology 134: 2397-2404, 1994
15. Landau D, Segev Y, Eshet R, Flyvbjerg A, Phillip M: Growth hormone IGF-I axis changes associated with renal hypertrophy in nonobese diabetic mice imitate human disease [Abstract]. J Am Soc Nephrol 8: A2990, 1997
16. Flyvbjerg A, Bennett W, Rasch R, Kopchick JJ, Scarlett JA: Inhibitory effect of a growth hormone receptor antagonist (G120K-PEG) on renal enlargement, glomerular hypertrophy and urinary albumin excretion in experimental diabetes in mice. Diabetes 48: 377-382, 1999
17. Clark R, Ross C, Olsen K, Fuj G, Marian M, Mortensen D, Teshima G, Chang S, Chu H, Mukku V, Canova-Davis E, Somers T, Cronin M, Winkler M, Wells JA: Long acting growth hormones produced by conjugation with polyethylene glycol. J Biol Chem 271: 21969-21977, 1996
18. Takahashi K, Daughaday WH, Kipnis DM: Regulation of immunoreactive growth hormone secretion in male rats. Endocrinology 88: 909-917, 1971
19. Flyvbjerg A, Marshall SM, Frystyk J, Hansen KW, Harris AJ, Ørskov H: Octreotide administration in diabetic rats: Effects on renal hypertrophy and urinary albumin excretion. Kidney Int 41: 805-812, 1992
20. Flyvbjerg A, Frystyk J, Østerby R, Ørskov H: Kidney IGF-I and renal hypertrophy in GH deficient dwarf rats. Am J Physiol 262: E956-E962, 1992
21. Hossenlopp P, Seurin D, Segovia-Quinson B, Hardouin S, Binoux M: Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of method for titration of the binding proteins and competitive binding studies. Anal Biochem 154: 138-143, 1986
22. Flyvbjerg A, Kessler U, Dorka B, Funk B, Ørskov H, Kiess W: Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats. Diabetologia 35: 589-593, 1992
23. Phillip M, Werner H, Palese T, Kowarski AA, Stene M: Differential accumulation of insulin-like growth factor-I in kidneys of pre-and postpubertal streptozotocin-diabetic rats. J Mol Endocrinol 12: 215-224, 1994
24. Weibel ER: Stereological Methods: Practical Methods for Biological Morphometry, London, Academic Publishers, 1979, pp 51-57
25. Pagtalunan ME, Rasch R, Rennke HG, Meyer TW: Morphometric analysis of effects of angiotensin II on glomerular structure in rats. Am J Physiol 268: F82-F88, 1995
26. Yang CW, Striker LJ, Pesce C, Chen WY, Peten EP, Elliot S, Doi T, Kopchick JJ, Striker GE: Glomerulosclerosis and body growth are mediated by different portions of bovine growth hormone: Studies in transgenic mice. Lab Invest 68: 62-70, 1993
27. Grønbæk H, Nielsen B, Frystyk J, Flyvbjerg A, Ørskov H: Effect of lanreotide, a somatostatin analogue, on diabetic renal hypertrophy, kidney and serum IGF-I and IGF binding proteins. Exp Nephrol 4: 295-303, 1996
28. Grønbæk H, Vogel I, Lancranjan I, Flyvbjerg A, Ørskov H: Effect of octreotide, captopril or insulin on renal changes and UAE in long-term experimental diabetes. Kidney Int 53: 173-180, 1998
29. Segev Y, Landau D, Marbach M, Schadeh N, Flyvbjerg A, Phillip M: Renal hypertrophy in hyperglycemic non-obese diabetic mice is associated with renal accumulation of insulin-like growth factor (IGF) I. J Am Soc Nephrol 8: 436-444, 1997
30. Chen NY, Chen WY, Bellush L, Yang CW, Striker LJ, Striker GE, Kopchick JJ: Effects of streptozotocin treatment in growth hormone (GH) and GH antagonist transgenic mice. Endocrinology 136: 660-667, 1995
31. Chen NY, Chen WY, Kopchick JJ: A growth hormone antagonist protects mice against streptozotocin induced glomerulosclerosis even in the presence of elevated levels of glucose and glycated hemoglobin. Endocrinology 137: 5163-5165, 1996
32. Esposito C, Liu ZH, Striker GE, Phillips C, Chen NY, Chen WY, Kopchick JJ, Striker LJ: Inhibition of diabetic nephropathy by a GH antagonist: A molecular analysis. Kidney Int 50: 506-514, 1996
33. Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y: Breeding of a non-obese diabetic strain of mice. Jikken Dobutsu 29: 1-13, 1980
34. Velasquez MT, Kimmel PL, Michaelis OE: Animal models of spontaneous diabetic kidney disease. FASEB J 4: 2850-2859, 1990
35. Wicker L, Miller BJ, Mullen Y: Transfer of autoimmune diabetes mellitus with splenocytes from the non-obese diabetic (NOD) mice. Diabetes 35: 855-860, 1986
36. Doi T, Hattori M, Agodoa LYC, Sato T, Yoshida H, Striker LJ, Striker GE: Glomerular lesions in nonobese diabetic mouse: Before and after the onset of hyperglycemia. Lab Invest 63: 204-212, 1990
37. Yde H: Abnormal growth hormone response to ingestion of glucose in juvenile diabetes. Acta Med Scand 186: 499-504, 1969
38. Hayford JT, Danney MM, Hendrix JA, Thompson RG: Integrated concentration of growth hormone in juvenile-onset diabetes. Diabetes 29: 391-398, 1980
39. Massa G, Verhaeghe J, Vanderschueren-Lodeweyckx M, Bouillon R: Normalization of decreased plasma concentrations of growth hormone-binding protein by insulin treatment in spontaneously diabetic BB rats. Horm Metab Res 25: 325-326, 1993
40. Maes M, Ketelslegers JM, Underwood LE: Low plasma somatomedin-C in streptozotocin-induced diabetes mellitus: Correlation with changes in somatogenic and lactogenic liver binding sites. Diabetes 32: 1060-1069, 1983
41. Bornfeldt KE, Arnqvist KE, Enberg B, Mathews LS, Norstedt G: Regulation of insulin-like growth factor I and growth hormone receptor gene expression by diabetes and nutritional states in rat tissues. J Endocrinol 122: 651-656, 1988
42. Landau D, Domene H, Flyvbjerg A, Grønbæk H, Roberts CT Jr, Argov S, LeRoith D: Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus. Growth Horm IGF Res 8: 39-45, 1998